Transcript Finding Research Support Donald R. Mattison, NICHD [email protected] BMJ, doi:10.1136/bmj.38768.420139.80 (published 17 March 2006

Finding
Research
Support
Donald R. Mattison, NICHD
[email protected]
BMJ, doi:10.1136/bmj.38768.420139.80 (published 17 March 2006
http://www.hhmi.org/grants/office/graduate/lab_book.html
Biomedical research today is a complex enterprise that spans
multiple biological levels, requires a variety of equipment and
staff, and demands success with limited funds. Each one of you
is really an entrepreneur running your own new small business.
—Enriqueta Bond, Burroughs Wellcome Fund
In theory, everything is negotiable. That said, every
department and institution has constraints.
—Chris M. Golde, from “Be Honorable and Strategic,”
Science’s Next Wave (November 2001)
http://www.aaas.org/
Funding Sources
► $109





Billion spent on health research in 2004
54% Industry ($59.1 Billion)
34% Federal ($37.9 Billion)
6% University ($7.1 Billion)
2% State and Local Govt ($2.5 Billion)
2% Others ($2.3 Billion); philanthropic, voluntary
health associations, independent research institutes,
HHMI
► Data
from Research!America
► http://www.researchamerica.org
Institutional Support – FIRST!
Department (NEGOTIATE!, Negotiate!!, Negotiate!!!)
 Help identify a mentor
 Start-up funds (travel, equipment, renovations)
 Support for technician
 Guaranteed salary (expectation for salary generation)
 Graduate students (graduate faculty appointment)
 Fellow support
 Protected time
Institutional Support
College or school
 Funding for preliminary or pilot experiments
 Assistance in preparation and processing of grants
 Access to development, major gifts, advancement officer
or staff
 Funding for release time
 Incentives for successful applications
 Core facilities
 IRB
Institutional Support
Health sciences or university
 Funding for preliminary or pilot experiments
 Grants office - identification of VHO’s, foundations,
industrial and federal opportunities
 Access to development, major gifts, advancement
officer or staff
 Matching funds, incentives
 Patent and licensing support
Institutional Support
School, health sciences or university
 Information networks to enhance extramural
grant success
 Review and critique of grants
 Seminars on funding opportunities
 Information packages, email notification,
announcement scanning and forwarding
 Grant writing workshops and assistance
 Workshops to bring funders into the university
http://www.grantsnet.org
Funding Sources
► $109





Billion spent on health research in 2004
54% Industry ($59.1 Billion)
34% Federal ($37.9 Billion)
6% University ($7.1 Billion)
2% State and Local Govt ($2.5 Billion)
2% Others ($2.3 Billion); philanthropic, voluntary
health associations, independent research institutes,
HHMI
► Data
from Research!America
► http://www.researchamerica.org
http://www.phrma.org
http://www.phrmafoundation.org/
http://www.astrazeneca-us.com
http://en.sanofi-aventis.com/index.asp
http://www.bms.com/sr/philanthropy/data/introx.html
http://www.physicianscientist.com
http://www.pfizer.com/subsites/philanthropy/programs.html
Funding Sources
► $109





Billion spent on health research in 2004
54% Industry ($59.1 Billion)
34% Federal ($37.9 Billion)
6% University ($7.1 Billion)
2% State and Local Govt ($2.5 Billion)
2% Others ($2.3 Billion); philanthropic, voluntary
health associations, independent research institutes,
HHMI
► Data
from Research!America
► http://www.researchamerica.org
NIH Campus
NIH Organization
Office of the Director
NIA
NIAAA
NIAID
NIAMS
NCI
NICHD
NIDCD
NIDCR
NIDDK
NIDA
NIEHS
NEI
NIGMS
NHLBI
NIMH
NINDS
NINR
NHGRI
FIC
NCCAM
NCRR
NCMHD
NLM
NIBIB
CC
CIT
CSR
The National Institute of Child
Health and Human Development
(NICHD)
Public Law 87-838 (1962)
“…an institute for the conduct and support of
research and research training related to maternal
health, child health, and human development,
including…the special health problems of mothers
and children…”
NICHD Mission
►To help people have healthy babies when
they want them
►To avoid harm to women from the
reproductive process
►To help all children reach adulthood able to
achieve their full potential
►To optimize rehabilitation and achieve
minimal disability
A Typical Institute
Office of the
Institute
Director
National
Advisory
Council
Extramural
Board of
Scientific
Counselors
Intramural
Scientific
Programs
Grants
Contracts
Laboratory
Studies
Clinical
Studies
NICHD Organization
Board of Scientific
Counselors
National Advisory Board on
Medical Rehabilitation
Research
Division of
Scientific Review
Center for
Research for
Mothers and
Children
Office
of the
Director
Office of Science
Policy, Analysis &
Communication
National Center
for Medical
Rehabilitation
Research
National Advisory Child
Health and Human
Development Council
Office of
Administrative
Management
Center for
Developmental
Biology and
Perinatal
Medicine
Center for
Population
Research
Division of
Intramural
Research
Division of
Epidemiology,
Statistics, and
Prevention
Research
NIH Extramural Program
Mechanism
Grant
NIH Role
Patron
(Assistance & Encouragement)
Contract
Purchaser
(Procurement)
Cooperative
Agreement
Partner
(Assistance with Substantial Program
Involvement)
Stages of Research Training and
Career Development
Institutional
Research Training
(T32, T35)
Pre-doctoral
Training
Mentored
PatientPost-doctoral Oriented
Training
Research
(T32, F32)
(K23)
Midcareer
Academic Career Investigator in
Patient-Oriented
Award (K07)
Research (K24)
Mentored Clinical
Scientist
(K08, K12)
Post-doctoral
Training
Research
Grant
(R01, R03,
R21, R24)
Senior
Scientist/
Fellowship
(K05/F33)
Career Development and Research
NIH Grant Process
Initiates Research
Idea and Prepares
Application
Investigator
Submits
Application
Center for
Scientific Review
(CSR) Assigns to
Scientific Review
Group (SRG) and
Institute
Conducts
Research
Grantee
Institution
Manages
Funds
NIH
SRG
Evaluates
for
Scientific
Merit
Institute
Evaluates for
Program
Relevance
and Need
National
Advisory
Council/Board
Recommends
Action
Institute
Makes
Funding
Selections &
Issues Grant
Awards
Referral and Review Process
NIH Center for Scientific
Review (CSR)
Referral
and/or
Review
NIH Institutes, Centers,
and Offices
• Program & Policy Considerations
• Funding Decisions
• Scientific Management
Review
CSR
Scientific Merit
How are assignments made?
► To
Scientific Review Group (SRG) Based on:
 Scientific expertise of the membership
► To
Institutes and Centers (ICs) Based on:
 Overall mission of the IC
 Specific programmatic mandates and
interests of the IC
Dual Review Process
First Level of Review
Scientific Review Group (SRG)
• Provides initial scientific review of grant
applications
• Does not set program priorities
• Makes budget recommendations but not
funding decisions
Second Level of Review
National Advisory Council
• Assesses quality of SRG review
• Makes recommendations to Institute
staff on funding
• Evaluates program priorities and
relevance
• Advises on policy
Research Grants Review Criteria
Significance
► Approach
► Innovation
►
►
►
Investigator
Environment
Applications are also reviewed with
respect to the following:
• Plans to include children, minorities, and both genders
• Reasonableness of proposed budget and duration
• Adequacy of protection for humans, animals, and
environment
Study Section Actions
► Scored
 Applications judged by study section to be qualitatively in upper
half of research
 Assigned score of 1.0 to approximately 3.0
►
Unscored (Streamlined Review Procedures)
 Unanimous recommendation of study section that applications
not in upper half of research
 Receives no score
 Principal Investigator (PI) gets summary statement
►
Not Recommended for Further Consideration
 If research risks are sufficiently serious and the protection against
risks is so inadequate as to make the entire application unacceptable for ethical
reasons
►
Deferred
 Not enough information in application for study section
recommendation
Priority Scores
1.0 – 1.5
Outstanding
1.6 – 2.0
Excellent
2.1 – 2.5
Very Good
2.6 – 3.5
Good
3.6 – 5.0
Acceptable
Percentile Procedure
► Based
on priority scores for all applications reviewed
during current and two preceding review cycles by the
particular SRG
► Based on all applications reviewed by an SRG,
including scored, unscored, and not recommended for
further consideration
► Includes only standing study sections in current plus
two preceding review cycles
► Retains priority score sequence as assigned by the
SRG
Program Staff Responsibilities
Program staff:
► Attend
reviews and interact with SRG staff
► Present applications that involve human subjects,
animal subjects, or environmental issues, for which
reviewers have concerns, to the advisory council
► Interact with applicant
Advisory Council Actions
Council can:
► Concur with initial SRG action
► Modify initial SRG action—that is, change time
and amount
► Recommend reaching for applications beyond the
payline or not funding an application within the
payline
► Defer for further review or additional information
What determines which awards are
made?
► Scientific
merit
► Program considerations
► Available funds
Review and Award Schedule
Jan/Feb
June/Jul Submission Dates
Oct/Nov
May/June
Oct/Nov SRG Dates
Feb/Mar
Sept/Oct
Jan/Feb National Advisory Council Dates
May/Jun
Dec 1
Apr 1 Earliest Possible Beginning Date
Jul 1
www.grants.gov
www.ahrq.gov
http://www.epa.gov/ogd/grants/information.htm`
http://www.epa.gov
www.cdc.gov
http://www.cdc.gov/funding.htm
http://www.niaid.nih.gov/default.htm
http://www3.niaid.nih.gov/researchfunding/
http://www.niaid.nih.gov/ncn/grants/default.htm
www.os.dhhs.gov
Funding Sources
► $109





Billion spent on health research in 2004
54% Industry ($59.1 Billion)
34% Federal ($37.9 Billion)
6% University ($7.1 Billion)
2% State and Local Govt ($2.5 Billion)
2% Others ($2.3 Billion); philanthropic, voluntary
health associations, independent research institutes,
HHMI
► Data
from Research!America
► http://www.researchamerica.org
Philanthropic Support
►Foundations
►Community
trusts
►Conversion of not-for-profit health care units
►Look for niche - want to make a difference
 Often provide support for young investigators
 May have narrow disease focus
Philanthropic Support
Finding and linking with philanthropic
organizations
 Print resources
 Web resources
 CD-Rom resources
 Pay-per-view -- proprietary databases
http://www.philanthropy.com/
http://chronicle.com/
www.grantsnet.org
http://www.bwfund.org
Philanthropic Support
Pathways to philanthropic organizations
 Request for proposals
►Discuss
with appropriate philanthropy staff
 Informal funding
►Check
with mentor, department chair
►Review with college, university development office
►Keep informal and regular contact with relevant staff
►Keep college, university development office informed
Voluntary Health Organizations
►Raise
funds from public.
►Focus on specific health issue.
 Cancer, lung, birth defects, infertility, etc.
►Operational
-- conduct programs of
education, advocacy, community
intervention.
►Granting -- fund research through a variety
of mechanisms.
Voluntary Health Organizations
►Finding
and linking with VHOs
►Ascertain relevance to your research or
clinical interests (refer to handouts)
 Print resources
 Web resources
 CD-Rom resources
 Pay-per-view -- proprietary databases
Voluntary Health Organizations
Strengths and limitations of VHOs
 Single or narrow disease focus
 May have geographic focus
 May have informal grant process
►Need to clear with university development office?
 May not be interested in basic research
 May have clinical or community focus for investment
 Staff may need considerable education
Examples of Voluntary Health
Organizations and Foundations
► March
of Dimes (www.marchofdimes.com)
 Basil O’Connor starter scholar research award
 Yr. 2003 research program
 Research prize in developmental biology
 Local chapter grants
► American Heart Association (www.american heart.org)
 Scientist development grant
► American Diabetes Association (www.ada.org)
► Robert Wood Johnston foundation (www.rwjf.org)
http://www.gih.org
www.americanheart.org
www.aacr.org
www.jdrf.org
http://www.kidney.org
http://www.aap.org/research.html
How to Find Potential Funding Sources?
► Know
your research focus
► Search for potential funders
 Institutional grant funding aids
►Senior
faculty in your institution and elsewhere
►Office of grants/contracts
►Specific funding tools (eg SPIN)




Check them out on the internet
Review annual reports
Contact organization and speak to grants dept
Speak to past grantees
http://symptomresearch.nih.gov/
http://www.ampainsoc.org/links/
http://nextwave.sciencemag.org
http://www.cos.com/