Medical Mycology Systemic Mycoses Hugh B. Fackrell Filename; fungi_system.ppt 11/6/2015 Fungal Infections Opportunistic Infections Superficial fungal infections Cutaneous Mycoses Subcutaneous Mycoses Systemic Mycoses 11/6/2015
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Transcript Medical Mycology Systemic Mycoses Hugh B. Fackrell Filename; fungi_system.ppt 11/6/2015 Fungal Infections Opportunistic Infections Superficial fungal infections Cutaneous Mycoses Subcutaneous Mycoses Systemic Mycoses 11/6/2015
Medical Mycology
Systemic Mycoses
Hugh B. Fackrell
Filename; fungi_system.ppt
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Fungal Infections
Opportunistic Infections
Superficial fungal infections
Cutaneous Mycoses
Subcutaneous Mycoses
Systemic
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Mycoses
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Systemic or Deep Mycoses
Histoplasmosis
Coccidiomycosis
Blastomycosis
Cryptococcosis
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Histoplasmosis before HIV
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Before the appearance of HIV, approximately 95%
of the cases reported of histoplasmosis capsulati
where inapparent, subclinical, or benign and five
percent of them where a chronic progressive lung
disease with chronic cutaneous or systemic
disease, or an acute fulminating fatal systemic
disease.
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Histoplasmosis After HIV
Now the disease is almost always seen in
HIV positive patients or other
immunocompromised individuals.
All stages of this disease may mimic
tuberculosis.
Histoplasmosis may coexist with
actinomycosis, other mycoses, sarcoidosis,
or tuberculosis.
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Histoplasmosis
Histoplasma capsulatum
Ohio,Mississippi valleys
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v
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Coccidiomycosis
SW
deserts, San Joaquin
Coccidioides immitus
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Valley Fever
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Blastomycosis
Blastomyces dermatitidi
as histo but rarer.
Canada- Manitoba and St.Lawrence river
valley
Disease in horses.
– Veternarians at risk.
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Cryptococcosis
Cryptococcus neoformans
Sporadic
Pigeons
Meningitis form
– fatal
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Click on image for more details
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Systemic Mycoses:
Disease Patterns
Subacute
respiratory infection
Acute infection
Severe disseminated infection
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Systemic Mycoses:
Subacute Respiratory Infection
Low fever
Non-productive cough
Mild & self limiting
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Systemic Mycoses:
Acute Infections
Productive cough
purulent sputum
pain in chest
Weight loss.
night sweats
X-ray positive
one,many lesions
consolidation
Differential diagnosis: pneumonia, tumour.
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Systemic Mycoses:
Severe Disseminated Infections
Acute Infections +
– spread to other organs
– chronic
Differential diagnosis t.b.
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Systemic Mycoses:
Diagnosis
X-ray
Immunochemical
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skin test
serology
Microscopy
Sputum
biopsy
autopsy
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Systemic Mycoses:
Transmission
Fungal spores inhaled ...pneumonitis..no
human to human transmission
Primary source bird and bat droppings and
roosts. If roosts disturbed- dust, aerosol .
Chickens, Pigeons,starlings.
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Systemic Mycoses:
Treatment
Amphotericin B
and/or
5-fluorocytosine
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