2014 Industry Snapshot Massachusetts Biopharma Industry Employment 57,642 Employment in the industry has grown 9-10 x faster than state and national growth rates for all employment.* 54,280 54,829 55,342 56,097 56,462 51,518 46,117 43,904 41,128 41 % *4.8% MA.
Download ReportTranscript 2014 Industry Snapshot Massachusetts Biopharma Industry Employment 57,642 Employment in the industry has grown 9-10 x faster than state and national growth rates for all employment.* 54,280 54,829 55,342 56,097 56,462 51,518 46,117 43,904 41,128 41 % *4.8% MA.
2014 Industry Snapshot Massachusetts Biopharma Industry Employment 57,642 Employment in the industry has grown 9-10 x faster than state and national growth rates for all employment.* 54,280 54,829 55,342 56,097 56,462 51,518 46,117 43,904 41,128 41 % *4.8% MA 10-year employment growth, all industries 4.1% US 10-year employment growth, all industries 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 Source: U.S. Bureau of Labor Statistics, Quarterly Census of Employment and Wages (QCEW); MassBio Economic Impact - 2013 57,642 employees $125,056 average salary $7,208,460,412 total MA-based payroll Source: U.S. Bureau of Labor Statistics, Quarterly Census of Employment and Wages (QCEW) 10 - Year Employment Performance: MANUFACTURING The U.S. lost 10,091 biopharma manufacturing jobs since 2004, a 3.6% decrease. Massachusetts grew by 24.2% in biopharma manufacturing in the same time period. California New Jersey North Carolina New York Illinois Pennsylvania Indiana Puerto Rico Texas Massachusetts Michigan Maryland Connecticut Ohio Missouri 2004 2013 40,501 45,141 39,680 26,720 20,646 21,629 21,640 19,918 20,597 17,931 23,308 17,926 20,057 17,820 28,062 13,971 9,241 10,145 6,977 9,322 10,057 8,181 5,241 6,901 9,758 6,158 4,746 5,736 5,239 5,474 =/- % 10.7% -38.1% 4.9% -8.4% -14.7% -24.8% -12.7% -69.8% 9.1% 24.2% -24.1% 26.0% -48.6% 19.1% 4.9% Top 5 in job growth CA MA MD OH NC 4,640 2,345 1,660 990 983 Top 5 in Percentage Growth MD MA OH CA TX 26.0% 24.2% 19.1% 10.7% 9.1% Source: U.S. Bureau of Labor Statistics, Quarterly Census of Employment and Wages (QCEW) 7 - Year Employment Performance: Biotechnology Research & Development Massachusetts has more employment classified as Biotechnology Research and Development than any other state.* *NAICS 541711: Research and development in biotechnology 2007 2013 =/-% Massachusetts 24,656 28,042 13.7% California 19,134 24,196 26.5% Pennsylvania 16,902 10,854 -35.8% Maryland 10,154 8,014 -21.1% New Jersey 8,567 9,362 9.3% North Carolina 7,042 7,080 0.5% Michigan 4,670 2,678 -42.7% Missouri 4,262 3,437 -19.4% Texas 4,229 4,861 14.9% Ohio 2,696 3,100 15.0% New York 2,679 4,119 53.8% Washington 2,499 3,602 44.1% Connecticut 2,452 2,963 20.8% Illinois 2,403 2,963 23.3% Indiana 1,277 1,657 29.8% Florida 737 Top 5 in job growth CA MA FL NY WA 5,062 3,386 1,633 1,440 1,103 Top 5 in Percentage Growth FL NY WA IN CA 221.6% 53.8% 44.1% 29.8% 26.5% 2,370 221.6% Source: U.S. Bureau of Labor Statistics, Quarterly Census of Employment and Wages (QCEW) Apples to Apples As explained in the appendix, MassBio uses 8 industry classifications in determining overall employment in the biopharma industry. This reflects a conservative approach, as other reports include other industry classifications. In estimating employment attributable to the biopharma industry, MassBio uses only a percentage of employment reported for several industry classifications (1.9% of university employment, for example). Our determination of what percentage to utilize in our estimate is determined by the unique composition of these industries in Massachusetts. As the profile of each such industry segment varies by state, it not appropriate to compare these particular industry segments using the percentages that we have developed specifically for Massachusetts. Fortunately, two NAICS classifications, Pharmaceutical Manufacturing (NAICS 3254) and Research and Development in Biotechnology (NAICS 541711) , are considered fully part of the biopharma industry and would be so considered in any state. Additionally, these two industry segments are core segments of the industry. These two industries, therefore, are particularly appropriate for “apples to apples” comparisons to determine industry performance among the biopharma states. Therefore, we have considered ONLY two NAICS codes for the following state-to-state employment performance comparison: NAICS 3254, Pharmaceutical Manufacturing, and NAICS 541711, Research and Development in Biotechnology. Apples to Apples: Core Biopharma employment performance since 2007 California Massachusetts New Jersey Pennsylvania North Carolina New York Illinois Indiana Texas Maryland Puerto Rico Michigan Missouri Ohio Connecticut 2007 63,105 33,795 50,823 39,009 26,266 24,420 21,057 20,802 14,133 16,374 24,580 12,925 9,466 7,770 11,277 2013 69,337 37,364 36,082 28,780 28,709 24,037 20,894 19,477 15,006 14,915 14,004 10,859 8,911 8,836 7,941 =/-# 6,232 3,569 -14,741 -10,229 2,443 -383 -163 -1,325 873 -1,459 -10,576 -2,066 -555 1,066 -3,336 +/- % Top 5 in job growth 9.9% 10.6% CA 6,232 -29.0% MA 3,569 -26.2% NC 2,443 9.3% OH 1,066 -1.6% TX 873 -0.8% Top 5 in -6.4% 6.2% Percentage Growth -8.9% OH 13.7% -43.0% MA 10.6% -16.0% CA 9.9% -5.9% NC 9.3% 13.7% TX 6.2% -29.6% Source: U.S. Bureau of Labor Statistics, Quarterly Census of Employment and Wages (QCEW) Biopharma Manufacturing Employment, 2013 • Massachusetts is also a leading state in biopharma manufacturing, with 1 out of 5 jobs in the industry involved in manufacturing. • With over 600,000 liters of mammalian cell culture manufacturing capacity in the region, Massachusetts is the leader globally in this type of biologics manufacturing expertise. Medical Device Employment in MA Only California and Minnesota employ more in the medical device industry. 22,501 22,390 21,765 22,946 22,155 21,978 23,151 22,127 22,124 21,304 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 Source: U.S. Bureau of Labor Statistics, Quarterly Census of Employment and Wages (QCEW) R&D in Biotech: Industry Concentration 9.00 What is a Location Quotient? 8.00 7.00 6.00 Massachusetts holds a dominant position in terms of industry concentration in “Biotechnology Research and Development” – almost twice the concentration of jobs as the next closest state. 5.00 2009 2013 4.00 3.00 2.00 1.00 0.00 CA MD MA MO NJ NC PA Location Quotients are used by economists to determine the strength of an industry in a geographic region. They measure the concentration and strength of an industry in a region versus the nation as a whole. Location Quotients of more that 1.0 mean that the industry enjoys a greater concentration in a region versus the nation as a whole. WA Source: U.S. Bureau of Labor Statistics, Quarterly Census of Employment and Wages (QCEW) 2013 National Institutes of Health (NIH) Funding - by State Total (millions) and Per Capita Massachusetts trailed only California in total dollars in 2012. $350 CA MA NY MD PA TX NC WA IL US HOWEVER, NIH funding was reduced by 12.2% nationally in 2013. $162 $115 In MA the reduction was 7.3% or $182 million. $98 MA TX WA 2012 $3,475 $2,471 $2,042 $1,598 $1,460 $1,077 $1,061 $918 $798 $23,813 NY $97 NC $86 CA $70 MD $54 $54 Ill PA 2013 $3,216 $2,289 $1,897 $889 $1,354 $937 $922 $776 $697 $20,912 Source: NIH, Research Portfolio Online Reporting, U.S. Census Bureau Job Listings on MassBio.org In June and July of 2014, average daily listings on MassBio.org have been consistently above 1,400 jobs. MassBio.org is not a comprehensive listing of all jobs available in the industry in Massachusetts. Given its significant volume, it does provide a statistically strong sampling in determining job hiring trends. Average Daily # of Job Listings for the Month of May, 2009-2014 1,394 1,320 1,005 1,005 980 786 504 2008 2009 2010 2011 2012 2013 2014 Top NIH Funded Independent Hospitals 2013 The Top 5 NIH-funded independent research hospitals are in Boston. Please note: NIH lists hospitals that are part of universities separately. Hospital MASSACHUSETTS GENERAL HOSP BRIGHAM AND WOMEN'S HOSPITAL CHILDREN'S HOSPITAL CORPORATION City BOSTON BOSTON BOSTON BETH ISRAEL DEACONESS MEDICAL CENTER DANA-FARBER CANCER INST CHILDREN'S HOSP OF PHILADELPHIA CINCINNATI CHILDRENS HOSP MED CTR BOSTON BOSTON PHILADELPHIA CINCINNATI ST. JUDE CHILDREN'S RESEARCH HOSPITAL Awards Funding 783 $323,961,795 576 $315,919,592 303 $126,812,298 267 201 206 257 $118,785,811 $115,844,948 $108,503,611 $105,269,995 MEMPHIS 99 $64,634,574 NEW YORK STATE PSYCHIATRIC INSTITUTE BOSTON MEDICAL CENTER NEW YORK BOSTON 98 83 $45,962,566 $34,357,978 ROSWELL PARK CANCER INSTITUTE CORP TUFTS MEDICAL CENTER BUFFALO BOSTON 63 64 $34,281,239 $30,823,441 Source: NIH, Research Portfolio Online Reporting Top Massachusetts NIH Funded Non-Profits, 2013 Massachusetts non-profits are significant recipients of NIH funding. Johns Hopkins University and its Medical School is tops nationally, with $575 million in total NIH awards. Institution HARVARD UNIVERSITY (MEDICAL SCHOOL) UNIV OF MASSACHUSETTS MED SCH WORCESTER HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) BOSTON UNIVERSITY MEDICAL CAMPUS BROAD INSTITUTE, INC. MASSACHUSETTS INSTITUTE OF TECHNOLOGY HARVARD UNIVERSITY TUFTS UNIVERSITY - Boston BOSTON UNIVERSITY JOSLIN DIABETES CENTER NEW ENGLAND RESEARCH INSTITUTES, INC. BRANDEIS UNIVERSITY NORTHEASTERN UNIVERSITY MASSACHUSETTS EYE AND EAR INFIRMARY IMMUNE DISEASE INSTITUTE, INC. WHITEHEAD INSTITUTE FOR BIOMEDICAL RES UNIVERSITY OF MASSACHUSETTS AMHERST FORSYTH INSTITUTE TUFTS UNIVERSITY MEDFORD SCHEPENS EYE RESEARCH INSTITUTE Funding Grants $185,223,961 388 $130,350,480 312 $115,870,367 188 $107,762,256 240 $98,855,705 57 $94,736,982 234 $51,828,312 124 $48,040,076 136 $45,230,769 122 $37,642,908 40 $29,154,452 11 $25,846,230 85 $22,360,166 53 $19,828,336 35 $13,767,584 23 $11,193,456 26 $10,939,571 37 $8,752,534 20 $8,602,192 33 $6,564,383 15 Source: NIH, Research Portfolio Online Reporting Venture investment in MA was rose to $941 million in 2013. Venture Capital Investment Investment in Massachusetts Biotech Companies, 2002-2013 Massachusetts received over 20% of all VC investment in biotechnology in the U.S. Source: PWC MoneyTree Historical data and Evaluate Pharma. Top 15 VC Financings in MA - 2013 Company $ (million) Series Moderna Therapeutics 110.0 Series B Karyopharm Therapeutics 67.2 Series A, B Dicerna Pharmaceuticals 60.0 Series C Jounce Therapeutics 47.0 Series A Zafgen 45.0 Series E Radius Health 43.0 Series D Avedro 43.0 Series D Aileron Therapeutics 42.0 Series D, E Akebia Therapeutics 41.0 Series C Civitas Therapeutics 38.0 Series B Tokai Pharmaceuticals 35.5 Series E Syros Pharmaceuticals 30.0 Series A Syndax Pharmaceuticals 26.6 Series B Blueprint medicines 25.0 Series B Ocular Therapeutix 23.8 Series D Source: Evaluate Pharma ® Biotech VC in Massachusetts by Location $500+ million dollars in VC went to Cambridge-based biotechs in 2013. Companies in other Massachusetts communities garnered almost $400 million. Source: EvaluatePharma® Seed Stage Funding Seed stage At this initial stage, the company has a concept or product under development, but is probably not fully operational and has usually in existence less than 18 months. Source: PWC MoneyTree Historical data . Massachusetts Seed Stage 5-year trends MA seed stage deals have grown in number and in size since 1999. In the most recent 5 years, MA companies have received 33.4% of all seed funding for biotech in the U.S. Value 1999-2003 $52,054,900 2004-2008 $436,981,800 2009-2013 $761,912,400 Deals 20 76 95 MA share of U.S. Seed stage funding for biotech . . . 33.4% Average Seed Deal Size 23.7% $8,020,131 2009-2013 13.1% 2004-2008 1999-2003 $5,749,761 $2,602,745 1999-2003 2004-2008 2009-2013 Source: PWC MoneyTree Historical data . 5-year Trends in Seed Stage Financing Seed Stage as percentage of overall VC deals . . . 15.8% Over the past decade, MA has outperformed the nation in percentage of deals and investment at the seed stage. 10.2% 10.7% US MA 7.6% 2.4% 2.0% 1999-2003 2004-2008 2009-2013 Seed Stage share of overall biotech VC investment . . . 19.8% 21.1% 18.5% 18.6% US MA 11.7% 8.1% Source: PWC MoneyTree Historical data . 1999-2003 2004-2008 2009-2013 MA Seed Stage Funding by quarter, 1999-2013 $120,000,000 but, there has been a drop since the 20082010 high watermarks. $100,000,000 $80,000,000 $60,000,000 $40,000,000 The “Good Old Days” weren’t so good . . . $20,000,000 $0 Source: PWC MoneyTree Historical data . MA Seed Stage Funding - Annual, 1999-2013 2014 will be a revealing year for seed funding. Will MA move above the 5-year trending in funding? $300,000,000 $250,000,000 $200,000,000 $198,917,200 in Seed funding in MA is needed for the 5-year period ending in 2014 to equal that of the prior 5-year period. 5-yr average, $152,382,480 $150,000,000 $100,000,000 15-yr average, $83,429,940 $50,000,000 $0 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 Source: PWC MoneyTree Historical data . 2013: The IPO Comeback An initial public offering, or IPO, is the first sale of stock by a company to the public. If the company has never issued equity to the public, it's known as an IPO. There were virtually no IPOs in 2008 or 2009, with a modest comeback beginning in 2010. Acceleron $93 million* Agios Pharmaceuticals $122 m Bind Therapeutics $70.5 m Bluebird Bio $116 m Enanta Pharmaceuticals $65 m Epizyme $80 m Foundation Medicine $106 m Karyopharm $109 m Tetraphase Pharmaceuticals $80 m *figures refer to “offer amounts” (investment secured) at time of IPO. Source: Nasdaq.com, BioSpace 2014: IPOs Continued Fourteen IPOs through July of 2014, sets an annual record in IPOs for Massachusetts biotech companies. $90 million* $66 m $91 m $59.5 m $12 m $52 m $90 m $96 m $84 m $32.7 m $65 m $100 m $90 m $65 m *figures refer to “offer amounts” (investment secured) at time of IPO. Source: Nasdaq.com, BioSpace Industry IPOs by Geography, since 2013* Massachusetts Pennsylvania 6 IPOs $399 million aggregate raised $66.5 million average initial offering California 37 IPOs $2.57 billion aggregate raised $69.4 million average initial offering 24 IPOs $1.9 billion aggregate raised $79.2 million average initial offering New York 5 IPOs $402 million aggregate raised $80.3 million average initial offering New Jersey 9 IPOs $520 million aggregate raised $57.8 million average initial offering *through July 25, 2014. Includes leading four states only. Source: Nasdaq.com, BioSpace Drug Development Pipeline, by Phase 535 1,384 drug candidates in development 6% of the global pipeline 12% of the U.S. pipeline 452 164 160 64 9 Research Project Pre-Clinical Phase I Phase II Phase III Filed Source: EvaluatePharma®, July 2014 Behind the Numbers 535 Research Project Phase At this “discovery stage” the goal is to find a new molecule or chemical that can be a useful drug through extensive laboratory work in which drug targets are defined, screened and the formulation and delivery mechanism of the drug candidate is developed. 452 ALSTDI is a Cambridge nonprofit that seeks to end ALS “Lou Gerhrig’s Disease”, a progressive neurodegenerative disease that causes muscle weakness, paralysis, and ultimately, respiratory failure. 164 160 64 9 Projects TDI 174/175 Pathology associated with proteins that normally assist in RNA processing and mutations in the genes that encode them have been associated with ALS. These two projects are aimed at developing therapeutics that will influence RNA binding and metabolism and may stabilize susceptible neurons. Source: Evaluate Pharma ®, ALSTDI website. Behind the Numbers Phase II 535 452 Phase II clinical trials subject typically include 100-300 patients to assess the efficacy and safety of a drug. A drug is not presumed to have therapeutic value at this stage. Phase III trials, with 1000 or more patients, determines therapeutic effect. Synta is a Lexington-based company focused on discovering, developing and commercializing small molecule drugs to extend and enhance the lives of patients with severe medical conditions, including cancer and chronic inflammatory diseases. 164 160 64 9 Elesclomol Elesclomol is in a Phase 2 clinical study in patients with recurrent ovarian cancer, fallopian tube cancer, or primary peritoneal cancer who have progressed while receiving platinum-based therapy. Source: Evaluate Pharma ®,Synta Pharmaceuticals website. Massachusetts Pipeline by Therapeutic Area Gastro-Urinary, 2% Respiratory, 2% Dermatology, 1% Blood, 3% Endorine, 3% Cardiovascular, 3% Gastro-Intestinal, 4% Oncology 35% Therapeutic Area Candidates Oncology 487 Systemic Anti-infectives 222 Central Nervous System 196 Other 102 Sensory 62 Musculoskeletal 75 Gastro-Intestinal 51 Cardiovascular 48 Endorine 42 Blood 34 Gastro-Urinary 24 Respiratory 27 Dermatology 14 Total 1384 Musculoskeletal 5% Sensory 5% Other 7% Central Nervous System 14% Systemic Antiinfectives 16% Source: EvaluatePharma®, May, 2014 Recent Drug Approvals for Massachusetts Companies 2013: Kynamro (Genzyme) to treat rare forms of high cholestorol Tecfidera (Biogen Idec) best-in-class treatment for relapsing multiple sclerosis Aptiom (Sunovion) treats seizures associated with epilepsy 2014: Alproliz (Biogen Idec) for the treatment of hemophilia B Entyvio (Millennium, The Takeda Oncology Company) for treatment of adults with ulcerative colitis and Chrohn’s Disease. Sirextro (Cubist) for treatment of acute bacterial skin and skin structure infections Source: CenterWatch Changing the Lives of Patients Over 160 drugs have been commercialized by current Massachusettsheadquartered companies. Sources: Developed from multiple sources including EvaluatePharma®, emedicine medscape, NCBI, CDC. Largest Industry Employers in MA, 2013 1 2 4 5 6 7 8 9 10 11 12 13 14 Genzyme, a Sanofi Company Biogen Idec Parexel International Pfizer Novartis Hologic Shire Vertex Thermo Fisher Scientific EMD Millipore Millennium: Takeda Oncology Charles River Laboratories AstraZeneca EMD Serono Nova Biomedical 4,356 2,800 2,800 2,700 2,100 1,800 1,500 1,450 1,400 1,261 1,204 960 900 855 855 15 16 18 19 20 21 22 23 24 25 26 PerkinElmer 850 AbbVie 700 Sunovion Pharmaceuticals (DSP) 650 Cubist 638 Merck 500 Bristol-Myers Squibb 400 Lantheus 375 Alkermes 325 New England Biolabs 280 Organogenesis 274 Cell Signaling 270 Immunogen 270 28 Ironwood 260 29 Sanofi 250 Amgen 250 Sources: MassBio Membership Reports & Surveys; Boston Business Journal Book of Lists, 2013 Life Sciences Lab Inventory Growth 2014 Construction Completed in 2013 21,203,999 s.f. 16,063,990 s.f. Vertex, Boston Novartis, Cambridge Pfizer, Cambridge 2007 Lonqwood Center, Boston 2014 Biogen Idec, Cambridge Alexandria Center, Cambridge Source: Colliers Meredith & Grew, Life Science Review, 2007-2013, CBRE- NE BioView, 2014. Industry Geography Top 10 Communities by number of BiopPharma Companies* Cambridge (130) Boston (41) Worcester (31) Waltham (26) Lexington (25) Woburn (24) Watertown (16) Bedford (14) Marlborough (9) Billerica (9) *The Bureau of Labor Statistics indicates 738 biotechnology and pharmaceutical establishments in MA. For this list, MassBio used its own database and the MassBio/MHT 2014 Complete Guide, which include 431 company addresses. What’s in a Number? Please note: Prior to 2012, MassBio used two different federal sources for employment data. In order to present more consistent employment data on a more timely basis, we no longer use County Business Patterns (CBP) data of the U.S. Census Bureau but rely primarily on the U.S. Bureau of Labor Statistics, Quarterly Census of Employment and Wages (QCEW) for this data. As a result, historical employment data found in the 2012 -2014 Snapshots vary from that found in past reports. Though the historical annual employment figures vary by about 5% between the 2012 Snapshot and those of past years, the trend lines are very similar. Why use the QCEW? QCEW data is comprised of employment and wages from unemployment insurance (UI) tax reports submitted by employers and is augmented by both BLS worksite reports and the Annual Re-filing Survey (ARS), which surveys one quarter of all private-sector establishments each year. The QCEW data is available on a more timely basis than the CBP and is directly related to the state’s ES202 data, providing an additional, ongoing corroborative source. What’s in a Number? What is considered “biopharma” employment? Using the North American Industry Classification System (NAICS), with which QCEW data is reported, MassBio has determined that several NAICS classifications can be considered part of the biotechnology and pharmaceutical industry. However, only in certain cases can the industry claim 100% of any one NAICS code. MassBio determined that a percentage of some industry classifications could be used in estimating overall industry employment. In some cases, the percentage determination for certain industry codes was based on reports developed by other organizations. The following NAICS codes are utilized: NAICS 3254: Pharmaceutical MFG, including biologics (100%) NAICS 541711: Research and Development in Biotechnology (100%) NAICS 541712: R&D in Physical, Engineering, and Life Sciences (except biotech) (22%) NAICS 334516: Analytical Laboratory Instrument MFG (30%) NAICS 54138: Testing Laboratories (9%) NAICS 622: Hospitals (4.5%) NAICS 61131: Universities (1.9%) NAICS 621551: Medical testing laboratories (100%) NAICS 4242, Drug merchant wholesalers, is no longer included in any current or annual employment figures. NAICS 621511, Medical Laboratories, is included. Prior to 2013, we omitted Medical Laboratories, as these laboratories are health care services related, providing services to the medical delivery and patient care system, rather than the biopharma research development and manufacturing industry. We now acknowledge that Medical Laboratories are closely connected to the biopharma industry, requiring similar capacity and skills found in the biopharma industry. MassBio also tracks employment for “green biotechnology” classifications: 325199. 325221, 311222, and 311223. However, the QCEW does not reveal employment data for these categories beyond minimum ranges, so this data is not included in the employment figures presented in this Snapshot nor is it factored in comparisons with other states. Questions? As the premier source of information on biotechnology in Massachusetts, MassBio tracks industry statistics over time and issues an overview Industry Snapshot each year. For more information, contact: Peter Abair, Director of Economic Development & Global Affairs 617-674-5130 [email protected]