Transcript PREPARATION OF ACETYLSALICYLIC ACID (ASPIRIN) Aspirin    Used as an analgesic (pain killer) for headaches, toothaches, neuralgia (nerve pain), muscle pain and joint pain. Also effective as.

PREPARATION OF
ACETYLSALICYLIC ACID
(ASPIRIN)
Aspirin
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Used as an analgesic (pain killer) for headaches,
toothaches, neuralgia (nerve pain), muscle pain and
joint pain.
Also effective as a fever reducer and antiinflammatory.
Has anticoagulant properties – prevents strokes and
heart attacks.
Salicylic Acid
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Salicylic acid is the active agent that allows aspirin
to have its medicinal properties.
Because salicylic acid contains the functional groups
carboxylic acid and phenol, it is too harsh for the
mouth, esophagus and stomach lining.
It was made into an ester (acetylsalicylic acid) in
1899 and given the name “aspirin.”
Hydrolysis of Acetylsalicylic Acid
Acetylsalicylic acid is
hydrolyzed in the small intestine
to salicylic acid which can then
be absorbed into the blood
stream.
Preparation of Aspirin
Testing the Purity of your Product
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If any salicylic acid is left unreacted at the end of
our experiment, we can detect its presence with 1%
iron(III) chloride solution.
The phenol group present in salicylic acid will turn
purple.
“Pure” aspirin will not react with iron(III)chloride.
Procedural Tips
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Pre-weigh your watch glass to make the calculation
of your % yield from the weight of your salicylic
acid easier.
Make sure your filtering system is operating without
leaks
(quiet = good suction)
Be sure to WET your filter paper before
pouring your aspirin crystals onto the filter paper in
the funnel.
Filtration Setup
Caution!
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Do NOT take your aspirin home and use it on
yourself. 
Be careful not to inhale the salicylic acid when
weighing it out at the balances!!!
Question: What is the purpose of putting our
dissolved product into ice water and submerging
this container into an ice bath?
Potential Health Concerns
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Inhalation: irritant, allergen, coughing, drowsiness, damage to the
lungs, shortness of breath, labored breathing, loss of appetite and
delayed lung edema
Ingestion: corrosive, burning, headaches, gastritis, intoxication,
blindness, pain of the mouth and stomach, anorexia, thirst, diarrhea,
dizziness, nausea, vomiting, irritability, confusion, low blood pressure,
tachycardia, tachypnia, mental disturbances, skin discoloration,
circulatory collapse, clammy skin, weak pulse, shallow respirations,
coma and death
Skin contact: irritant, delayed burns, redness, cracking, flaking,
dermatitis, defatting of the skin, absorption through the skin and
white and wrinkled skin later
Eye contact: irritant, corrosion of the eyes with burns, tearing,
redness, pain, blurred vision, permanent damage and blindness
Tumorigen, mutagen, teratogen and reproductive effector