Transcript NA-MIC National Alliance for Medical Image Computing http://na-mic.org Dartmouth Brain Imaging Laboratory Site PI: Andrew J.

NA-MIC
National Alliance for Medical Image Computing
http://na-mic.org
Dartmouth Brain Imaging
Laboratory
Site PI: Andrew J. Saykin, Psy.D.
NA-MIC
National Alliance for Medical Image Computing
http://na-mic.org
( http://synapse.hitchcock.org/ )
Brain Imaging Laboratory
- The Dartmouth BIL was established in 1993 as an
fMRI and brain morphometry research program.
- It is a collaborative, multidisciplinary program
including faculty from Psychiatry, Radiology,
Neurology, Neurosurgery, Neuropathology,
Molecular Genetics, Computer Science & beyond.
- Four programmatic goals:
(1) Clinical Neuroscience Research
(2) Advanced Education and Training
(3) Technical Development
(4) Study Normal Human Brain Function
National Alliance for Medical Image Computing
http://na-mic.org
December 2005:
Neuroimaging Research Center 3T Magnet
National Alliance for Medical Image Computing
http://na-mic.org
Brain Imaging Laboratory: People
FACULTY PIs (Psychiatry):
•
Laura A. Flashman, Ph.D.
•
Alan I. Green, M.D.
•
Thomas W. McAllister, M.D.
•
Brenna C. McDonald, Psy.D.
•
Robert M. Roth, Ph.D.
•
Andrew J. Saykin, Psy.D.
•
Heather A. Wishart, Ph.D.
BIL COORDINATOR
•
Heather Pixley, B.A.
POST-DOCTORAL FELLOWS:
•
Howard Cleavinger, Ph.D. (Epilepsy)
•
Ellen Crouse, Ph.D. (MCI, chemotherapy)
•
Nancy Koven, Ph.D. (Schizophrenia)
•
Nadia Paré Ph.D. (MCI, ADNI)
•
Jo Cara Pendergrass, Ph.D. (Schizophrenia)
STUDY COORDINATORS:
•
Mary Hynes, RN (TBI)
•
Ariel Rosen, B.A. (MS)
KEY TECHNICAL COLLABORATORS:
•
Konstantinos Arfanakis, Ph.D. (DTI; IIT)
•
Fillia Makedon , Ph.D. (Computer Science)
•
James C. Ford, Ph.D. (Computer Science)
•
Li Shen, Ph.D. (CS, UMASS-Dartmouth)
•
Jason Moore, Ph.D. (Comp Genetics)
National Alliance for Medical Image Computing
http://na-mic.org
IMAGE ANALYSTS & SYSTEMS ADMIN:
•
John MacDonald, M.A.
•
Tara McHugh, M.A.
•
Paul Wang, B.A.
•
John West, M.S.
NEUROSCIENCE TECHNICIANS:
•
Carrie Kruck, B.A. (chemotherapy)
•
Margaret Nordstrom, B.A. (MCI)
RESEARCH MRI TECHNOLOGISTS:
•
Jorge A. Forero
•
Alice E. Davison
Key Contributors to NA-MIC
Schizophrenia Recruitment/Assessment & fMRI Subproject PIs:
•
•
•
•
•
Laura A. Flashman, Ph.D., Associate Professor (Awareness & Memory)
Robert M. Roth, Ph.D., Assistant Professor (Reward fMRI, Morphometry)
Alan I. Green, M.D., Professor & Chair (Dual Dx and Reward fMRI)
Thomas W. McAllister, M.D., Professor (Awareness & Memory)
Andrew J. Saykin, Psy.D., Professor & Site PI (Memory Systems)
Post-doc Fellows: Nancy Koven, Ph.D & Jo Cara Pendergrass, Ph.D.
Research Staff:
• John West, M.S., Image Analysis and Scripting for fMRI, VBM, & DTI
• Heather Pixley, B.A., Coordination, IRB Issues, Image Analysis
• John MacDonald, M.A., Systems Administration, QC, Data Security
• Tara McHugh, M.A., Brain Morphometry Analysis
• Paul Wang, B.A., Brain Morphometry, Callosum project, Database
National Alliance for Medical Image Computing
http://na-mic.org
Contributors to NA-MIC:
Related Neuroimaging Work
• Robert M. Roth, Ph.D., Assistant Professor
– Bipolar disorder and OCD (NARSAD, ADAA, Hitchcock Foundation, NCD)
• Thomas W. McAllister, M.D., Professor
– fMRI Pharmacology and genetics of traumatic brain injury (NINDS, NICHD)
• Andrew J. Saykin, Psy.D., Professor (Site PI)
– Preclinical Alzheimer’s disease and MCI (fMRI, DTI, morphometry) (NIA)
– Imaging of cognitive effects of cancer chemotherapy (NCI)
– Pending imaging projects on neurogenetics & cytokine biomarkers
• Brenna C. McDonald, Psy.D., Assistant Professor
– Pediatric neuroimaging in epilepsy & TBI, clinical presurgical fMRI (EF)
• Heather A. Wishart, Ph.D., Assistant Professor
– fMRI and lesion analysis in multiple sclerosis (NMSS, NINDS K23)
• Ann Christine Duhaime, M.D. Professor (Neurosurgery)
– fMRI study of pediatric brain injury using a piglet model (NICHD)
National Alliance for Medical Image Computing
http://na-mic.org
How NAMIC Fits into Portfolio
• Every project in the BIL requires advanced image analysis tools – this
makes NAMIC a high priority.
• Most projects combine fMRI, manual and voxel-based morphometry
and DTI – data integration is a special priority.
• The BIL team contributes expertise with fMRI methodology.
• BIL researchers contribute “driving” ideas for needed tools and features,
test prototypes in the “real world” setting, provide feedback and plan to
employ resulting tools in multiple scientific projects cutting across
diseases and brain systems.
• The BIL works closely with the Core 3.1 Harvard Site and the SPL to
achieve these goals.
• The BIL team also collaborates with Cores 1 and 2 including 2 MIT labs,
UNC, the SPL, as well as the Training and Dissemination Cores. We
also look forward to collaborations with other NAMIC components.
National Alliance for Medical Image Computing
http://na-mic.org
Brain Imaging Lab: Sponsored Research
(Current and Previous)
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
•
Alzheimer’s Association*
Anxiety Disorders Association of America
Epilepsy Foundation*
Hitchcock Foundation*
Ira DeCamp Foundation*
McDonnell-Pew Foundation
National Alliance for Research on Schizophrenia & Depression*
National Inst. of Disability & Rehabilitation Research (NIDRR)*
National Institutes of Health*
– NCI, NCRR, NIA, NIBIB, NICHD, NIDA, NIMH, NINDS
National Multiple Sclerosis Society*
National Science Foundation*
Neuroscience Research & Education Foundation
New Hampshire Hospital
Obsessive Compulsive Foundation
Partnership for Pediatric Epilepsy Research
Stanley Research Foundation
* multiple grants
Industry: Pfizer & Novartis
National Alliance for Medical Image Computing
http://na-mic.org
Dartmouth Brain Imaging Laboratory
December, 2005
National Alliance for Medical Image Computing
http://na-mic.org
Dartmouth Brain Imaging Laboratory & Alumni
National Alliance for Medical Image Computing
http://na-mic.org