Transcript CMACS Workshop 2011 group2 Avessie Amedome, Diquan Moore, Dana Pardi. Changing the Parameters • Tau-Fi • Tau-Si • Fast sodium channel vs calcium channel.

CMACS Workshop 2011
group2
Avessie Amedome, Diquan Moore,
Dana Pardi.
Changing the Parameters
• Tau-Fi
• Tau-Si
• Fast sodium channel vs calcium channel
Difference in action potential from the
same set of parameters TFI=0.05 and TSI=1.75
Apcell102
Apcell922
Tau Fi = 0.05
TSI_2.25
TSI_2.0
Tau Fi= 0.075
TSI=1.50
TSI=1.75
Tau Fi=0.1
TSI=1.75
TSI=2.25
Tau –Fi=0.2
TSI= 1.75
TSI=2.25
Tip Trajectory Data
.The tip trajectory graph shows the shape of the
tip in a given simulation.
.The X axis represent various TSI values and the
Y-axis represent the TFI values.
.An important point to notice is that when
TFI>.20 and TSI> 1.5, the simulations do not
produce stable spiral wave.
*
.20
.15
.10
.07
.05
TFI
TSI 1.5
1.75
2.00
2.25
2.5
2.75
0 stable spiral wave
*TFI > .20 and TSI >1.5 does not produce
3.00 *
Difficulties in Running Simulations
• The computers were slow at time, but the
super computers really helped.
• Changing the parameters at the end of every
simulation was very tricky especially having to
remember to “clean” after every simulation.
• We were not able to run all the simulation(
total of 49). We had about half of the
simultations.
Questions we have
• Why is the spiral wave unstable ( start to
break up) when TFI>.20 and TSI>1.5.
• What cause the spiral wave to start with one
tip and then finish as two tips.
• What is the future of 4vmodel
Our Experiences at CMACS
• It is a great experience working with
accomplished people in their fields such as Mr
Flavio Fenton, great speakers such as Mr
Glimm.
• More importantly it been very great meeting
and working with student from different
academic background.
• Learning is so great and challenging when the
subject in questions are new
Conclusion
• We are very happy to be part of this CMACS
workshop.
• This workshop would not have been the same
with the amazing help of Professor Nancy
Griffeth, Flavio Fenton, Robert Gilmour, Teri
Grosso, Ezio Bartocci, Kai Zhao, Rupinder
Shingh and Joshua Rogers. We Thank you for
your help.