Transcript Since 1903 the VSVRI has been established on an area of about 23 square hectares in the Red Mountain area of.

Since 1903 the VSVRI has been established on an area of
about 23 square hectares in the Red Mountain area of the
Abbassia district, east Cairo.
The VSVRI is one of the oldest and prestigious institutes in the
Middle East and Africa.
At the beginning, the scope of its responsibility was limited to
production of vaccine and antiserum, for protection of cattle
against Rinderpest (cattle plague).
The laboratory’s mission has continued to grow.
The next period witnessed considerable laboratory expansions
and new building constructions in response to the demands.
Production of highly efficient vaccines, Sera and Diagnostic
Reagent utilizing both reference and local isolates based on the
international standards to guarantee protection of animals and
poultry from different diseases. In addition,
preparation of combined vaccines to save the effort, time, stress
and money.
Conducting researches for improvement and innovation of
Veterinary Vaccines, Sera and Diagnostic Reagents.
Completion of high Contemned BSl3 Laboratories for production
of
FMD & Avian
Influenza
Vaccines.
Completion
of high
Containment
BSL-3 Laboratories for production
of
FMD & Avian
Influenza
Vaccines. facilities according to GMP
Certified
the current
production
Certified
the current
production
facilities
according to GMP
requirements
for veterinary
vaccine
production.
requirements
veterinary
vaccine
production.
Improvementfor
and
innovation
of Veterinary
Vaccines, Sera
Improvement and innovation of Veterinary Vaccines, Sera
and Diagnostic Reagent.
and Diagnostic Reagent.
Using the molecular biology for improvement the vaccine and
Using the molecular biology for improvement the vaccine and
diagnostic reagents.
diagnostic reagents.
Expanding training on up to date technologies.
Expanding training on up to date technologies.
• Aerobic Bacterial Vaccines
Research Department.
• Anaerobic Bacterial Vaccines
Research Department.
• Bacterial Sera and Antigens
Research Department.
• Bacterial Diagnostic products
Research Department.
• Parasitic Vaccines
Research Department.
• FMD Research Department .
• Rift Valley Fever Vaccine Department.
• Pox Vaccines Research Department.
• Rinderpest Vaccine Research Department.
• Rinderpest like diseases vaccine
Research Department.
• Pet animal Vaccines Research Department.
• Equine Vaccines Research Department.
• Newcastle and other Viral Poultry
Vaccines Department .
Assistant Researchers
35 Consultants
5
Research Assistants
70
26
Chief Researchers
34
48
Researchers
Senior Researchers
Total Research Team 218
Contract Employees
Administrative
226
145
Temporary Workers
209
Workers
Employees and workers 654
74
Attenuated Rift Valley Fever Vaccine.
Attenuated Bovine Ephemeral Fever Vaccine.
P.P.R. Vaccine (Egypt 87).
Sheep Pox Vaccine.
Camel Pox Vaccine.
African Horse Sickness Attenuated Polyvalent Vaccine.
Attenuated Canine Parvo Vaccine.
Bivalent Foot and Mouth Disease Vaccine.
Bivalent Inactivated Foot and Mouth Disease Oil Vaccine
types ( O1 & A ).
Inactivated Rift Valley Fever Vaccine.
Inactivated Bovine Ephemeral Fever Vaccine.
Inactivated Respiratory Virus Diseases Vaccine “Pneumo 3”.
Inactivated Respiratory Virus Diseases Vaccine “Pneumo 4”
Inactivated Bovine Rota (BR), Corona (BC) and Toxigenic
E. Coli K99 Vaccine (Entero-3).
Bivalent Inactivated African Horse Sickness Vaccine.
Monovalent Inactivated Freeze Dried Equine Influenza Vaccine.
Inactivated Rabies Vaccine.
Inactivated Tissue Culture Rabies Vaccine.
Haemorrhagic Septicaemia Oil Adj. Vaccine (For Cattle).
Oil Adjuvinated Polyvalent Pneumo bac Pasteurellosis Vaccine.
Gel Adjuvinated Polyvalent Pneumo bac Pasteurellosis Vaccine.
BCG Vaccine.
Brucella Abortus Vaccine (St. 19).
Brucella Melitensis Vaccine (Rev.1).
Blackleg and Gas Gangrene Vaccine.
Polyvalent Clostridial Vaccine.
Tube Agglutination Brucella Antigen.
Buffer Acidified Plate Brucella Antigen.
Rose Bengal Brucella Antigen.
Milk Ring Test Brucella Antigen.
Rivanol Brucella Antigen.
Rivanol solution.
Mammalian P.P.D. Tuberculin.
Bovine P.P.D. Tuberculin
Rift Valley Fever Antigen.
Antitetanic Serum
Newcastle Vaccine (Hitchner B1).
Newcastle Vaccine (LaSota).
Newcastle Vaccine (Komarov).
Lasota & IB.
Hitchner B1 and Infectious Bronchitis Vaccine.
Infectious Bursal Disease Vaccine (D78 Strain).
Infectious Bursal Disease Vaccine (Bursa Vac. strain).
Fowl Pox Vaccine.
Pigeon Pox Vaccine.
Duck Virus Hepatitis Vaccine.
Duck Plague Vaccine.
Inactivated Newcastle And Gumboro Vaccine.
Inactivated Newcastle , IB and EDS.
Inactivated Newcastle Vaccine (Oil adj.).
Inactivated Oil Emulsion Avian Influenza Vaccine.
Inactivated Pigeon Paramyxo Vaccine.
Inactivated Rabbit Haemorrhagic Virus Vaccine.
Polyvalent Fowl Cholera Vaccine (Oil Adj.)
Polyvalent Rabbit Pasteurellosis Vaccine (Formalized).
Polyvalent Rabbit Pasteurellosis Vaccine (Oil Adj.).
Rabbit Clostridial Entertoxaemia Bloat Vaccine
Infectious Coryza (Oil Adj.) Vaccine.
Inactivated Spirochetosis Vaccine.
Chicken Necrotic Oil Vaccine.
Chicken Necrotic Gel Vaccine.
Salmonella Pullorum Antigen (Tube Agglutination).
Salmonella Pullorum Stained Antigen (polyvalent) .
Paratyphoid Antigen.
Avian P.P.D. Tuberculin.
US Naval American Medical Research Unit (NAMRU 3).
Us Department of State Biosecurity Engagement Program
Food and Ogriculture Organization (FAO).
Offices of International Epizootic (OIE).
World Health Organization ( WHO )
The First HPAI outbreak was announced on February 2007.
The disease is now endemic.
Vaccine started on March 2007 depending on importation of
H5N1 and H5N2 inactivated Vaccines from different counters.
The key to preventing human infections with AI is to control
poultry outbreaks of AI .
Developing of national laboratory for vaccine production to
produce AI vaccine from local isolates is must.
Laboratory location.
Wipe – clean surface.
Heating , ventilation and air – conditioning (HVAC) System .
Directional airflow and cascade negative pressure .
Laboratory furniture and equipment .
Laboratory rooms , size and orientation .
Sample reception .
Double door autoclave and decontamination Chamber for
solid waste materials .
Water supply and sewerage system.
Electrical system.
Primary containment barriers is the barriers between agent
and man.
Gloves, gownt, masks
Biosafety cabinet,
Respiratory protection
Vaccines & autoclaves
Secondary containment barrier is the barrier between
agents and Environment to provide protection for individual
outside the lab.
Air tight rooms.
Air handling.
Air locks.
Showers, laundry.
Sewage treatment.
Waste disposal.
Sterilization.
Equipment.
Walls
Tertiary containment barrier
Fences, Security
Quarantine
The potential threat of Avian flu and need for
appropriate facilities to work with HPAI raise
design issues of protection.
Electric room
Exit
Electricity room
W.C
W.C
Washing
Compact area
Steril.
Blending & Filling & Capping
Control
Kitchen
Hall
Refrigerator
Doctors
Office
Closet
Ref.
Ref.
Pre Inoculation Incubator
Receiving
egg
Compact area
Freez.
Inoculation
Lab.
Dressing Electricity
Dressing
Room
Room
Room
Compact area
Ref.
After Inoculation Incubator
All personnel must met the institutional
expectation in term of high containment
practices
Training of all personnel entering a containment
facility must be done and documented
Training program specific to scientists needs and
knowledge
Training and evaluation should occur before
personnel starts the job
- U.S National Academy of Sciences.
- U.S Department of States Biosecurity
Engagement Program.
-Turkish Academy of Sciences