Clinical and Personality Disorder Differences between

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Transcript Clinical and Personality Disorder Differences between

Slide 1

Psychometric Development of a New
Inventory to Assess Symptoms
Across the Spectrum of Autism
Presented By
Presented
by
Peter D. Marle, B.A.

Peter D. Marle, B.A.

Coolidge Autistic Symptoms Survey


Slide 2

• History and Popular Conceptions of Autism


Possible accounts written as early as the 16th century (Martin Luther)



First psychiatric evaluations – early 20th century (De Sanctis, Earl, & Potter)



First scientific research – 1943 (Leo Kanner) and 1944 (Hans Asperger)


Comparing Kanner’s and Asperger’s narratives


Both differentiated autistic behaviors in the children from schizophrenia



Children studied had milder forms of autism



Asperger emphasized the malicious behaviors of the children



Kanner suspected the origin of autism to come from cold parents

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Slide 3

• Controversies


Bettelheim and “refrigerator mothers”



Rimland



Jenny McCarthy


Vaccinations causal to autism?

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Slide 4

• History of the Diagnosis of Autism




Diagnostic and Statistical Manual of Mental Disorders (DSM; 1952)


No diagnosable autistic condition



Most synonymous diagnosis: Schizophrenic reaction, childhood type

DSM-II (1968)




DSM-III (1980)




Largely unchanged regarding the diagnosis of autism

Infantile autism

DSM-III-R (1987)


Autistic disorder



Pervasive developmental disorder – not otherwise specified

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Slide 5

• History of the Diagnosis of Autism




DSM-IV (1994)


Autistic Disorder



Childhood disintegrative disorder



Asperger’s Disorder



Pervasive developmental disorder – not otherwise specified

DSM-IV-TR (2000)




Largely unchanged regarding the diagnosis of autism

DSM-5 (2013)


Autism Spectrum Disorder


Continuum, with three degrees of severity

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Slide 6

• Proposed DSM-5 Diagnostic Criteria for Autism Spectrum Disorder
A. Persistent deficits in social communication and social interaction across contexts,
not accounted for by general developmental delays

B. Restricted, repetitive patterns of behavior, interests, or activities
C. Symptoms must be present in early childhood
D. Symptoms together limit and impair everyday functioning

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Slide 7

• Proposed DSM-5 Diagnostic Criteria for Autism Spectrum Disorder
A. Persistent deficits in social communication and social interaction across contexts,
not accounted for by general developmental delays, manifested by
all three of the following:
1. Social Interactions:
abnormal social approach, conversation, reduced sharing of interests and emotions
2. Nonverbal Communication (includes verbal):
abnormal eye contact, body language, facial expressions, and gestures

3. Peer Relationships:
adjustment of behavior to suit social contexts, imaginative play, seems not interested
in people

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Slide 8

• Proposed DSM-5 Diagnostic Criteria for Autism Spectrum Disorder
B. Restricted, repetitive patterns of behavior, interests, or activities as manifested by
at least two of the following:

1. Stereotypies:
repetitive speech, motor movements, use of objects
2. Routine:
need for routine, patterns of behavior, resists change
3. Fixations:
fixated interests
4. Sensory Integration:
hyper and/or hypo-reactive to environmental stimuli

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Slide 9

• Current Methods for Diagnosing Autism


Prevalence rate between 1:88 and 1:2000 (males 4 x more likely)



Combination of clinical observation, use of diagnostic tools, and parental reports



Current diagnostic tools


Autism Diagnostic Interview-Revised



Autism Diagnostic Observation Schedule



Childhood Autism Rating Scale

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Slide 10

• Need for an Updated Diagnostic Tool


Current tools may soon be outdated

• Development of the Coolidge Autistic Spectrum Survey


Created to examine similarities between Asperger’s disorder and high functioning
autism (2007)



Another study later investigated the differentiation of milder forms of ASD and
schizoid personality disorder traits (in press)

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Slide 11

• Purpose
To redesign the CASS in order to provide coverage for the new criteria in DSM-5 and to

extend the lower age range of the CASS to approximately 2 to 3 years

• Hypotheses
1. A 1-component solution (as determined by principal components analysis) would best fit
the structures of the new 83-item CASS and 39-item CASS-T (based on a previous study);

although, DSM-5 diagnostic criteria for ASD may suggest multiple components.
2. The new CASS and CASS-T would show good internal reliability (Cronbach’s α ≥ .80).
3. The surveys would have an adequate split-half reliability (r ≥ .80).
4. The surveys would significantly differentiate among children with
a) milder forms of autism (e.g., Asperger’s disorder and high-functioning autism)

b) moderate-to-severe forms of autistic spectrum disorders
c) no diagnoses (i.e., a group-matched control group)
5. There would be a strong, positive correlation between the CASS-T and the CASS means.
Coolidge Autistic Symptoms Survey


Slide 12






Table 1
Participant Data for Mild ASD, Moderate-to-Severe ASD, Group-Matched Control
Participants
Group, and Full Dataset
Materials
n
* Age
* Age
% in Therapy Length * Age Dx
(% male) Range (M, SD) Therapy (Months; M, SD) (M, SD)
• Informed Consent FormMild ASD
22 (77%) 6 – 16 (9.6, 2.5)
52%
(30.5, 21.8)
(6.4, 3.1)
M-S ASD
23 (83%) 5 – 16 (9.2, 3.3)
81%
(60.1, 37.6)
(3.0, 1.6)
• Demographic Sheet
Control
22 (59%) 5 – 17 (9.6, 3.9)
0%
----Full DS (CASS-T) 88 (63%) 5 – 17 (9.9, 3.5)
38%
(45.4, 32.6)
(4.7, 3.1)
• 39-item CASS-T (Retrospective)
Full DS (CASS)
86 (63%) 5 – 17 (9.9, 3.6)
34%
(48.2, 33.7)
(4.6, 3.0)
• 83-item CASS
Note. M-S = Moderate-to-Severe. DS = Dataset. Dx = Diagnosed. * in years.

Procedure


All data were collected with approval from the University’s institutional review board



Packets were either


hand-delivered to parents via a CITI-trained researcher (i.e., Peter D. Marle) or



given in an electronic format (via a secure online survey host; i.e., PsychData.com)



Packets took approximately 30 min to complete



Participants were given the option of returning the materials via a SASE or returning
the materials to the CITI-trained researcher
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Slide 13

Hypothesis 1
A 1-component solution would provide the best fit for the CASS and the CASS-T
(accounting for at least 50% of the variance)



83-item CASS




A 1-component solution accounted for about 52% of the variance

39-item CASS-T


Either aTable
4-component
(total variance explained = 65.5%) or
2
Cronbach’s α Computations for the CASS-T 4- and 5-Component Solutions
5-component
solution (total variance explained = 69.5%) best fit the data
4-Component Solution

5-Component Solution

# Items

α

# Item
Overlap

1: DSM Dx Criteria

20

.96

14

19

.97

2: Physical Contact

9

.91

6

7

.90

3: Development

6

.83

4

4

.79

4: Sensory Issues

4

.91

4

4

.91

5: Stereotypy/Humor

--

--

0

5

.84

Component

# Items

α

Note. For all analyses, n = 88. # Item Overlap refers to the number of items in the 5-component
solution that also appear in the respective 4-component solution component.

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* Supplemental Information
on Component Solutions


Slide 14

Hypothesis 2
The new CASS and CASS-T would show good internal reliability (Cronbach’s α ≥ .80)


83-item CASS




Cronbach’s α = .99 (n = 86)

39-item CASS-T


Cronbach’s α = .97 (n = 88)
Table 2
Cronbach’s α Computations for the CASS-T 4- and 5-Component Solutions
4-Component Solution

5-Component Solution

# Items

α

# Item
Overlap

1: DSM Dx Criteria

20

.96

14

19

.97

2: Physical Contact

9

.91

6

7

.90

3: Development

6

.83

4

4

.79

4: Sensory Issues

4

.91

4

4

.91

5: Stereotypy/Humor

--

--

0

5

.84

Component

# Items

α

Note. For all analyses, n = 88. # Item Overlap refers to the number of items in the 5-component
solution that also appear in the respective 4-component solution component.

Coolidge Autistic Symptoms Survey


Slide 15

Hypothesis 3
The CASS and CASS-T would have adequate split-half reliabilities (r ≥ .80)


83-item CASS




r(87) = .98, p < .001

39-item CASS-T


r(90) = .95, p < .001

Coolidge Autistic Symptoms Survey


Slide 16

Hypothesis 4
There would be significant differences among the group means for the CASS and CASS-T
a) the moderate-to-severe autism group would have the significantly highest mean,

b) the mild autism group would have the second highest mean, and



83-item CASS
F(2, 64) = 199.93,

p < .0005; η2 = .86


39-item CASS-T
F(2, 64) = 165.56,
p < .0005; η2 = .84

Possible Means ranged from
1 (Strongly False) to 4 (Strongly True)

c) the group-matched control group would have the significantly lowest mean
4

3

2
CASS Mean
1

CASS-T Mean

Figure 1. Comparison of CASS and CASS-T group means. 95% CIs are given.

Coolidge Autistic Symptoms Survey


Slide 17

Hypothesis 4
There would be significant differences among the group means for the CASS and CASS-T
a) the moderate-to-severe autism group would have the significantly highest mean,

b) the mild autism group would have the second highest mean, and



83-item CASS
F(2, 64) = 199.93,

p < .0005; η2 = .86


39-item CASS-T
F(2, 64) = 165.56,
p < .0005; η2 = .84

Possible Means ranged from
1 (Strongly False) to 4 (Strongly True)

c) the group-matched control group would have the significantly lowest mean
4

3

2
CASS Mean
1

CASS-T Mean

Figure 1. Comparison of CASS and CASS-T group means. 95% CIs are given.

Coolidge Autistic Symptoms Survey


Slide 18

Hypothesis 5
There would be a strong, positive correlation between the CASS-T and the CASS means

Correlation coefficient

4

r(92) = .89, p < .0005
3

CASS-T Mean



Control
2

Mild ASD
Moderate-to-Severe
ASD

1

0
0

1

2
CASS Mean

3

4

Figure 2. Scatterplot of CASS and CASS-T means marked by group.

Coolidge Autistic Symptoms Survey


Slide 19

Hypothesis 1
A 1-component solution would provide the best fit for the CASS and the CASS-T
(accounting for at least 50% of the variance)





83-item CASS


A 1-component solution accounted for about 52% of the variance



Hypothesis supported

39-item CASS-T


Either a 4-component (total variance explained = 65.5%) or

5-component solution (total variance explained = 69.5%) best fit the data


Hypothesis not supported
1. DSM-5 diagnostic criteria for ASD, sans sensory issues
2. Physical contact
3. Developmental milestones
4. Sensory issues
5. The 5-component solution added a stereotypies and humor component

Coolidge Autistic Symptoms Survey


Slide 20

Hypothesis 1




39-item CASS-T


DSM-5 diagnostic criteria for ASD, sans sensory issues



Physical contact



Developmental milestones



Sensory issues



The 5-component solution added a stereotypies and humor component

DSM-5 Criteria
• Social Interactions
• Nonverbal Communication
• Peer Relationships





Stereotypies
Routine
Fixations
Sensory Integration

}

manifested by all three

}

manifested by at least two

Coolidge Autistic Symptoms Survey


Slide 21

Hypothesis 2
The new CASS and CASS-T would show good internal reliability (Cronbach’s α ≥ .80)






83-item CASS



Cronbach’s α = .99 (n = 86)



Hypothesis supported

39-item CASS-T


Cronbach’s α = .97 (n = 88)



Hypothesis supported

Alphas too high?

Coolidge Autistic Symptoms Survey


Slide 22

Hypothesis 3
The CASS and CASS-T would have adequate split-half reliabilities (r ≥ .80)







83-item CASS


r(87) = .98



Hypothesis supported

39-item CASS-T



r(90) = .95



Hypothesis supported

Comparing split-half reliability and Cronbach’s α

Coolidge Autistic Symptoms Survey


Slide 23

Hypothesis 4
There would be significant differences among the group means for the CASS and CASS-T
a) the moderate-to-severe autism group would have the significantly highest mean,

b) the mild autism group would have the second highest mean, and



83-item CASS


F(2, 64) = 199.93,

p < .0005; η2 = .86



Hypothesis supported

39-item CASS-T


F(2, 64) = 165.56,

Possible Means ranged from
1 (Strongly False) to 4 (Strongly True)

c) the group-matched control group would have the significantly lowest mean
4

3

2
CASS Mean
1

CASS-T Mean

p < .0005; η2 = .84


Hypothesis supported
Figure 1. Comparison of CASS and CASS-T group means. 95% CIs are given.

Coolidge Autistic Symptoms Survey


Slide 24

Hypothesis 5
There would be a strong, positive correlation between the CASS-T and the CASS means

Correlation coefficient


r(92) = .89, p < .0005



Hypothesis supported

4

3

CASS-T Mean



Control
2

Mild ASD
Moderate-toSevere ASD

1

0
0

1

2
CASS Mean

3

4

Figure 2. Scatterplot of CASS and CASS-T means marked by group.

Coolidge Autistic Symptoms Survey


Slide 25

Hypothesis 5
There would be a strong, positive correlation between the CASS-T and the CASS means

Correlation coefficient


r(92) = .89, p < .0005



Hypothesis supported

4

3

CASS-T Mean



Control
2

Mild ASD
Moderate-toSevere ASD

1

0
0

1

2
CASS Mean

3

4

Figure 2. Scatterplot of CASS and CASS-T means marked by group.
Only midpoints given.

Coolidge Autistic Symptoms Survey


Slide 26

Hypothesis 5
There would be a strong, positive correlation between the CASS-T and the CASS means

Correlation coefficient


r(92) = .89, p < .0005



Hypothesis supported

4

3

CASS-T Mean



Control
Mild ASD

2

Moderate-toSevere ASD

1

0
0

1

2
CASS Mean

3

4

Figure 2. Scatterplot of CASS and CASS-T means marked by group.
Midpoints with 1 standard deviation projection given.

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Slide 27



This study did not investigate the differentiation of moderate ASD




This study used parent-as-respondent data






Future research into the CASS and the CASS-T should explore this.

Cost vs. accuracy/error

Small sample size for the PCA


This study served as a preliminary component structure assessment of the surveys.



Future PCA with a larger pool of participants is recommended.

Test-retest reliability was not assessed


This study assessed split-half reliability.



Future studies should investigate time-based reliability.

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Slide 28



Sensitivity and specificity of surveys not assessed


Future research investigating the accuracy of the surveys to accurately categorize ASD

into groups, as well as to accurately assess any non-ASD diagnosis.



Gender and age differences regarding the surveys should be analyzed




Future research should explore differences in item responses by age and gender.

Sensory integration disorder and the CASS


Because of the possible current trend of misdiagnosing children with an ASD who may
only have sensory integration problems, future research with the CASS should assess
the differentiation of these children.

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Slide 29

Thank you!
Questions?

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