Slide 1

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Tireless Technician!
The World’s first
robotic, LED based,
smear microscope

for TB screening!

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Facts about the TB burden
•
•
•
•
•
•
•

With 8.8 Mi new cases annually and almost 1,5 Mi deaths, TB is
still a leading mortality factor
TB is the leading killer of people with HIV
22 HBC (High Burden Country) countries account for 80% of the
incidence
Annually over USD 1 Bi was spent on TB diagnostics in 2009, and
the sum is increasing
TB drains 12 billion USD from the annual incomes of the poorest
communities
Loss of productivity attributable to TB approaches 7% of GDP in
some countries
In 2009 there were 9,7 million orphan children a a result of TB
deaths

Nearly 4,000 people die from TB daily,
a curable disease in most cases !!
Source WHO

ConsultASK Management Consulting LLC

Further Facts
•
•

•
•
•

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The most commonly used sputum smear microscopy is more than 100
years old, but is the most affordable for the majority of HBC countries
Traditionally executed, it is also the most ineffective, detects only little
more then half of patients tested with currently used manual method,
mainly due to low sensitivity, lack of well trained personel, tiring
factor.
Todays TB drugs are more then 40 years old and have to be taken for
6-9 months
Todays TB vaccine is more than 85 years old
Delay in assessing proper diagnostics costs time, money and leads to
continued transmission of infectionsThere is huge need for tools that
correspond to the medical need at affordable price (WHO report)

There is urgent need for more accurate and
rapid diagnostic tests (WHO, FIND)

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Burden in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Diagnostics market in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Sputum smear diagnosis of TB:
Light source microscopy ZN
staining
•
•
•
•
•

The fastest and cheapest
available method
Good specificity
Weak sensitivity
Trained staff needed
Time consuming,10– 15 min./slide

Traditional
Fluorescence microscopy
•
•
•
•

Increased sensitivity
More expensive
Faster, less tiresome
Maintenance requirements
(mercury vapour lamps)

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The smear market in 2009

Source WHO

ConsultASK Management Consulting LLC

The Global Revised
WHO Plan 2011-2015

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Microscopy market in 2009

Source WHO

ConsultASK Management Consulting LLC

Market
cont.

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

• Current assumptions:
– Number of microscopy centers was
~70K (58K public, 12K private) in 2009
– 1 smear laboratory/ 100 000 population
should be reached by 2015 (WHO)
– 20% of microscopes should be replaced
by LED by 2015 (WHO)

- Potential smear market
200 M tests (WHO)
Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Fluorobot: the only fully
automated, dedicated solution
• Based on the traditional smear microscopy principle
• Fully automated
– Input / output and moving of the slides
– Image capturing and analysis
– Intelligent bacterium recognition algorythms

• Low cost, robust design suitable for high incidence, high burden
countires
• Huge walk away window, batch processing of 100 – 250 slides
• Small footprint
• High throughput (25 smears/hour)
• Competitive cost/test

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Main Features
• Illumination system using LED technology, much less sensitive,
longer lifetime and cheaper than mercury vapour lamps
• Robust, cost effective X-Y movement
• Special, fast focusing system
• Cost effective, simplified light path, optimised for a single
magnification
• Dedicated image processing and pattern recognition algorithms used
for bacteria identification
• Classification follows WHO reccomendation (neg., scanty, +, ++, +++)
• Standardised quality, no tiring effect
• Images are stored, can be transmitted, archived, revisited
• Opening new Quality Control possibilities
• No trained microscope reading staff needed

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Major milestones
•
•
•
•
•
•
•

•
•

Feasibility Study in Q1 2009
Functional Model stage was successfully reached Q4 2009
Laboratory Sample Stage was reached at Q3 2010
„Proof Of Principle” study was conducted at German TB Reference
Laboratory, WHO Supranational Laboratory at Borstel led by Dr. RüschGerdes in September 2010, with positive outcome
„Letter Of Intent” was signed with FIND (Foundation for Innovative New
Diagnostics, Geneva) in November 2010
Project was exhibited at MEDICA 2012 Dusseldorf and Medical Fair India
2013 in New Delhi, with huge success
Strategic Partner is searched, to carry the project through Prototype
Development (Q3 2013) and Validation (Q4 2013)
Industrialization and Test Production Planned Q3 2014
GoLive of final product (and disposable) planned Q4 2014

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Road
behind our development team
• Core team has more than 15
years experience in medical
imaging and robotic
microscopy
• Main project in the early 90s
was the Seditron urine
sediment analyzer
developed and produced for
Boehringer Mannheim

ConsultASK Management Consulting LLC

Your Invitation!

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Join the Journey!


Slide 2

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Tireless Technician!
The World’s first
robotic, LED based,
smear microscope

for TB screening!

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Facts about the TB burden
•
•
•
•
•
•
•

With 8.8 Mi new cases annually and almost 1,5 Mi deaths, TB is
still a leading mortality factor
TB is the leading killer of people with HIV
22 HBC (High Burden Country) countries account for 80% of the
incidence
Annually over USD 1 Bi was spent on TB diagnostics in 2009, and
the sum is increasing
TB drains 12 billion USD from the annual incomes of the poorest
communities
Loss of productivity attributable to TB approaches 7% of GDP in
some countries
In 2009 there were 9,7 million orphan children a a result of TB
deaths

Nearly 4,000 people die from TB daily,
a curable disease in most cases !!
Source WHO

ConsultASK Management Consulting LLC

Further Facts
•
•

•
•
•

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The most commonly used sputum smear microscopy is more than 100
years old, but is the most affordable for the majority of HBC countries
Traditionally executed, it is also the most ineffective, detects only little
more then half of patients tested with currently used manual method,
mainly due to low sensitivity, lack of well trained personel, tiring
factor.
Todays TB drugs are more then 40 years old and have to be taken for
6-9 months
Todays TB vaccine is more than 85 years old
Delay in assessing proper diagnostics costs time, money and leads to
continued transmission of infectionsThere is huge need for tools that
correspond to the medical need at affordable price (WHO report)

There is urgent need for more accurate and
rapid diagnostic tests (WHO, FIND)

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Burden in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Diagnostics market in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Sputum smear diagnosis of TB:
Light source microscopy ZN
staining
•
•
•
•
•

The fastest and cheapest
available method
Good specificity
Weak sensitivity
Trained staff needed
Time consuming,10– 15 min./slide

Traditional
Fluorescence microscopy
•
•
•
•

Increased sensitivity
More expensive
Faster, less tiresome
Maintenance requirements
(mercury vapour lamps)

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The smear market in 2009

Source WHO

ConsultASK Management Consulting LLC

The Global Revised
WHO Plan 2011-2015

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Microscopy market in 2009

Source WHO

ConsultASK Management Consulting LLC

Market
cont.

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

• Current assumptions:
– Number of microscopy centers was
~70K (58K public, 12K private) in 2009
– 1 smear laboratory/ 100 000 population
should be reached by 2015 (WHO)
– 20% of microscopes should be replaced
by LED by 2015 (WHO)

- Potential smear market
200 M tests (WHO)
Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Fluorobot: the only fully
automated, dedicated solution
• Based on the traditional smear microscopy principle
• Fully automated
– Input / output and moving of the slides
– Image capturing and analysis
– Intelligent bacterium recognition algorythms

• Low cost, robust design suitable for high incidence, high burden
countires
• Huge walk away window, batch processing of 100 – 250 slides
• Small footprint
• High throughput (25 smears/hour)
• Competitive cost/test

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Main Features
• Illumination system using LED technology, much less sensitive,
longer lifetime and cheaper than mercury vapour lamps
• Robust, cost effective X-Y movement
• Special, fast focusing system
• Cost effective, simplified light path, optimised for a single
magnification
• Dedicated image processing and pattern recognition algorithms used
for bacteria identification
• Classification follows WHO reccomendation (neg., scanty, +, ++, +++)
• Standardised quality, no tiring effect
• Images are stored, can be transmitted, archived, revisited
• Opening new Quality Control possibilities
• No trained microscope reading staff needed

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Major milestones
•
•
•
•
•
•
•

•
•

Feasibility Study in Q1 2009
Functional Model stage was successfully reached Q4 2009
Laboratory Sample Stage was reached at Q3 2010
„Proof Of Principle” study was conducted at German TB Reference
Laboratory, WHO Supranational Laboratory at Borstel led by Dr. RüschGerdes in September 2010, with positive outcome
„Letter Of Intent” was signed with FIND (Foundation for Innovative New
Diagnostics, Geneva) in November 2010
Project was exhibited at MEDICA 2012 Dusseldorf and Medical Fair India
2013 in New Delhi, with huge success
Strategic Partner is searched, to carry the project through Prototype
Development (Q3 2013) and Validation (Q4 2013)
Industrialization and Test Production Planned Q3 2014
GoLive of final product (and disposable) planned Q4 2014

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Road
behind our development team
• Core team has more than 15
years experience in medical
imaging and robotic
microscopy
• Main project in the early 90s
was the Seditron urine
sediment analyzer
developed and produced for
Boehringer Mannheim

ConsultASK Management Consulting LLC

Your Invitation!

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Join the Journey!


Slide 3

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Tireless Technician!
The World’s first
robotic, LED based,
smear microscope

for TB screening!

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Facts about the TB burden
•
•
•
•
•
•
•

With 8.8 Mi new cases annually and almost 1,5 Mi deaths, TB is
still a leading mortality factor
TB is the leading killer of people with HIV
22 HBC (High Burden Country) countries account for 80% of the
incidence
Annually over USD 1 Bi was spent on TB diagnostics in 2009, and
the sum is increasing
TB drains 12 billion USD from the annual incomes of the poorest
communities
Loss of productivity attributable to TB approaches 7% of GDP in
some countries
In 2009 there were 9,7 million orphan children a a result of TB
deaths

Nearly 4,000 people die from TB daily,
a curable disease in most cases !!
Source WHO

ConsultASK Management Consulting LLC

Further Facts
•
•

•
•
•

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The most commonly used sputum smear microscopy is more than 100
years old, but is the most affordable for the majority of HBC countries
Traditionally executed, it is also the most ineffective, detects only little
more then half of patients tested with currently used manual method,
mainly due to low sensitivity, lack of well trained personel, tiring
factor.
Todays TB drugs are more then 40 years old and have to be taken for
6-9 months
Todays TB vaccine is more than 85 years old
Delay in assessing proper diagnostics costs time, money and leads to
continued transmission of infectionsThere is huge need for tools that
correspond to the medical need at affordable price (WHO report)

There is urgent need for more accurate and
rapid diagnostic tests (WHO, FIND)

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Burden in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Diagnostics market in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Sputum smear diagnosis of TB:
Light source microscopy ZN
staining
•
•
•
•
•

The fastest and cheapest
available method
Good specificity
Weak sensitivity
Trained staff needed
Time consuming,10– 15 min./slide

Traditional
Fluorescence microscopy
•
•
•
•

Increased sensitivity
More expensive
Faster, less tiresome
Maintenance requirements
(mercury vapour lamps)

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The smear market in 2009

Source WHO

ConsultASK Management Consulting LLC

The Global Revised
WHO Plan 2011-2015

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Microscopy market in 2009

Source WHO

ConsultASK Management Consulting LLC

Market
cont.

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

• Current assumptions:
– Number of microscopy centers was
~70K (58K public, 12K private) in 2009
– 1 smear laboratory/ 100 000 population
should be reached by 2015 (WHO)
– 20% of microscopes should be replaced
by LED by 2015 (WHO)

- Potential smear market
200 M tests (WHO)
Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Fluorobot: the only fully
automated, dedicated solution
• Based on the traditional smear microscopy principle
• Fully automated
– Input / output and moving of the slides
– Image capturing and analysis
– Intelligent bacterium recognition algorythms

• Low cost, robust design suitable for high incidence, high burden
countires
• Huge walk away window, batch processing of 100 – 250 slides
• Small footprint
• High throughput (25 smears/hour)
• Competitive cost/test

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Main Features
• Illumination system using LED technology, much less sensitive,
longer lifetime and cheaper than mercury vapour lamps
• Robust, cost effective X-Y movement
• Special, fast focusing system
• Cost effective, simplified light path, optimised for a single
magnification
• Dedicated image processing and pattern recognition algorithms used
for bacteria identification
• Classification follows WHO reccomendation (neg., scanty, +, ++, +++)
• Standardised quality, no tiring effect
• Images are stored, can be transmitted, archived, revisited
• Opening new Quality Control possibilities
• No trained microscope reading staff needed

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Major milestones
•
•
•
•
•
•
•

•
•

Feasibility Study in Q1 2009
Functional Model stage was successfully reached Q4 2009
Laboratory Sample Stage was reached at Q3 2010
„Proof Of Principle” study was conducted at German TB Reference
Laboratory, WHO Supranational Laboratory at Borstel led by Dr. RüschGerdes in September 2010, with positive outcome
„Letter Of Intent” was signed with FIND (Foundation for Innovative New
Diagnostics, Geneva) in November 2010
Project was exhibited at MEDICA 2012 Dusseldorf and Medical Fair India
2013 in New Delhi, with huge success
Strategic Partner is searched, to carry the project through Prototype
Development (Q3 2013) and Validation (Q4 2013)
Industrialization and Test Production Planned Q3 2014
GoLive of final product (and disposable) planned Q4 2014

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Road
behind our development team
• Core team has more than 15
years experience in medical
imaging and robotic
microscopy
• Main project in the early 90s
was the Seditron urine
sediment analyzer
developed and produced for
Boehringer Mannheim

ConsultASK Management Consulting LLC

Your Invitation!

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Join the Journey!


Slide 4

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Tireless Technician!
The World’s first
robotic, LED based,
smear microscope

for TB screening!

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Facts about the TB burden
•
•
•
•
•
•
•

With 8.8 Mi new cases annually and almost 1,5 Mi deaths, TB is
still a leading mortality factor
TB is the leading killer of people with HIV
22 HBC (High Burden Country) countries account for 80% of the
incidence
Annually over USD 1 Bi was spent on TB diagnostics in 2009, and
the sum is increasing
TB drains 12 billion USD from the annual incomes of the poorest
communities
Loss of productivity attributable to TB approaches 7% of GDP in
some countries
In 2009 there were 9,7 million orphan children a a result of TB
deaths

Nearly 4,000 people die from TB daily,
a curable disease in most cases !!
Source WHO

ConsultASK Management Consulting LLC

Further Facts
•
•

•
•
•

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The most commonly used sputum smear microscopy is more than 100
years old, but is the most affordable for the majority of HBC countries
Traditionally executed, it is also the most ineffective, detects only little
more then half of patients tested with currently used manual method,
mainly due to low sensitivity, lack of well trained personel, tiring
factor.
Todays TB drugs are more then 40 years old and have to be taken for
6-9 months
Todays TB vaccine is more than 85 years old
Delay in assessing proper diagnostics costs time, money and leads to
continued transmission of infectionsThere is huge need for tools that
correspond to the medical need at affordable price (WHO report)

There is urgent need for more accurate and
rapid diagnostic tests (WHO, FIND)

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Burden in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Diagnostics market in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Sputum smear diagnosis of TB:
Light source microscopy ZN
staining
•
•
•
•
•

The fastest and cheapest
available method
Good specificity
Weak sensitivity
Trained staff needed
Time consuming,10– 15 min./slide

Traditional
Fluorescence microscopy
•
•
•
•

Increased sensitivity
More expensive
Faster, less tiresome
Maintenance requirements
(mercury vapour lamps)

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The smear market in 2009

Source WHO

ConsultASK Management Consulting LLC

The Global Revised
WHO Plan 2011-2015

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Microscopy market in 2009

Source WHO

ConsultASK Management Consulting LLC

Market
cont.

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

• Current assumptions:
– Number of microscopy centers was
~70K (58K public, 12K private) in 2009
– 1 smear laboratory/ 100 000 population
should be reached by 2015 (WHO)
– 20% of microscopes should be replaced
by LED by 2015 (WHO)

- Potential smear market
200 M tests (WHO)
Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Fluorobot: the only fully
automated, dedicated solution
• Based on the traditional smear microscopy principle
• Fully automated
– Input / output and moving of the slides
– Image capturing and analysis
– Intelligent bacterium recognition algorythms

• Low cost, robust design suitable for high incidence, high burden
countires
• Huge walk away window, batch processing of 100 – 250 slides
• Small footprint
• High throughput (25 smears/hour)
• Competitive cost/test

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Main Features
• Illumination system using LED technology, much less sensitive,
longer lifetime and cheaper than mercury vapour lamps
• Robust, cost effective X-Y movement
• Special, fast focusing system
• Cost effective, simplified light path, optimised for a single
magnification
• Dedicated image processing and pattern recognition algorithms used
for bacteria identification
• Classification follows WHO reccomendation (neg., scanty, +, ++, +++)
• Standardised quality, no tiring effect
• Images are stored, can be transmitted, archived, revisited
• Opening new Quality Control possibilities
• No trained microscope reading staff needed

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Major milestones
•
•
•
•
•
•
•

•
•

Feasibility Study in Q1 2009
Functional Model stage was successfully reached Q4 2009
Laboratory Sample Stage was reached at Q3 2010
„Proof Of Principle” study was conducted at German TB Reference
Laboratory, WHO Supranational Laboratory at Borstel led by Dr. RüschGerdes in September 2010, with positive outcome
„Letter Of Intent” was signed with FIND (Foundation for Innovative New
Diagnostics, Geneva) in November 2010
Project was exhibited at MEDICA 2012 Dusseldorf and Medical Fair India
2013 in New Delhi, with huge success
Strategic Partner is searched, to carry the project through Prototype
Development (Q3 2013) and Validation (Q4 2013)
Industrialization and Test Production Planned Q3 2014
GoLive of final product (and disposable) planned Q4 2014

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Road
behind our development team
• Core team has more than 15
years experience in medical
imaging and robotic
microscopy
• Main project in the early 90s
was the Seditron urine
sediment analyzer
developed and produced for
Boehringer Mannheim

ConsultASK Management Consulting LLC

Your Invitation!

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Join the Journey!


Slide 5

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Tireless Technician!
The World’s first
robotic, LED based,
smear microscope

for TB screening!

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Facts about the TB burden
•
•
•
•
•
•
•

With 8.8 Mi new cases annually and almost 1,5 Mi deaths, TB is
still a leading mortality factor
TB is the leading killer of people with HIV
22 HBC (High Burden Country) countries account for 80% of the
incidence
Annually over USD 1 Bi was spent on TB diagnostics in 2009, and
the sum is increasing
TB drains 12 billion USD from the annual incomes of the poorest
communities
Loss of productivity attributable to TB approaches 7% of GDP in
some countries
In 2009 there were 9,7 million orphan children a a result of TB
deaths

Nearly 4,000 people die from TB daily,
a curable disease in most cases !!
Source WHO

ConsultASK Management Consulting LLC

Further Facts
•
•

•
•
•

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The most commonly used sputum smear microscopy is more than 100
years old, but is the most affordable for the majority of HBC countries
Traditionally executed, it is also the most ineffective, detects only little
more then half of patients tested with currently used manual method,
mainly due to low sensitivity, lack of well trained personel, tiring
factor.
Todays TB drugs are more then 40 years old and have to be taken for
6-9 months
Todays TB vaccine is more than 85 years old
Delay in assessing proper diagnostics costs time, money and leads to
continued transmission of infectionsThere is huge need for tools that
correspond to the medical need at affordable price (WHO report)

There is urgent need for more accurate and
rapid diagnostic tests (WHO, FIND)

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Burden in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Diagnostics market in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Sputum smear diagnosis of TB:
Light source microscopy ZN
staining
•
•
•
•
•

The fastest and cheapest
available method
Good specificity
Weak sensitivity
Trained staff needed
Time consuming,10– 15 min./slide

Traditional
Fluorescence microscopy
•
•
•
•

Increased sensitivity
More expensive
Faster, less tiresome
Maintenance requirements
(mercury vapour lamps)

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The smear market in 2009

Source WHO

ConsultASK Management Consulting LLC

The Global Revised
WHO Plan 2011-2015

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Microscopy market in 2009

Source WHO

ConsultASK Management Consulting LLC

Market
cont.

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

• Current assumptions:
– Number of microscopy centers was
~70K (58K public, 12K private) in 2009
– 1 smear laboratory/ 100 000 population
should be reached by 2015 (WHO)
– 20% of microscopes should be replaced
by LED by 2015 (WHO)

- Potential smear market
200 M tests (WHO)
Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Fluorobot: the only fully
automated, dedicated solution
• Based on the traditional smear microscopy principle
• Fully automated
– Input / output and moving of the slides
– Image capturing and analysis
– Intelligent bacterium recognition algorythms

• Low cost, robust design suitable for high incidence, high burden
countires
• Huge walk away window, batch processing of 100 – 250 slides
• Small footprint
• High throughput (25 smears/hour)
• Competitive cost/test

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Main Features
• Illumination system using LED technology, much less sensitive,
longer lifetime and cheaper than mercury vapour lamps
• Robust, cost effective X-Y movement
• Special, fast focusing system
• Cost effective, simplified light path, optimised for a single
magnification
• Dedicated image processing and pattern recognition algorithms used
for bacteria identification
• Classification follows WHO reccomendation (neg., scanty, +, ++, +++)
• Standardised quality, no tiring effect
• Images are stored, can be transmitted, archived, revisited
• Opening new Quality Control possibilities
• No trained microscope reading staff needed

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Major milestones
•
•
•
•
•
•
•

•
•

Feasibility Study in Q1 2009
Functional Model stage was successfully reached Q4 2009
Laboratory Sample Stage was reached at Q3 2010
„Proof Of Principle” study was conducted at German TB Reference
Laboratory, WHO Supranational Laboratory at Borstel led by Dr. RüschGerdes in September 2010, with positive outcome
„Letter Of Intent” was signed with FIND (Foundation for Innovative New
Diagnostics, Geneva) in November 2010
Project was exhibited at MEDICA 2012 Dusseldorf and Medical Fair India
2013 in New Delhi, with huge success
Strategic Partner is searched, to carry the project through Prototype
Development (Q3 2013) and Validation (Q4 2013)
Industrialization and Test Production Planned Q3 2014
GoLive of final product (and disposable) planned Q4 2014

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Road
behind our development team
• Core team has more than 15
years experience in medical
imaging and robotic
microscopy
• Main project in the early 90s
was the Seditron urine
sediment analyzer
developed and produced for
Boehringer Mannheim

ConsultASK Management Consulting LLC

Your Invitation!

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Join the Journey!


Slide 6

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Tireless Technician!
The World’s first
robotic, LED based,
smear microscope

for TB screening!

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Facts about the TB burden
•
•
•
•
•
•
•

With 8.8 Mi new cases annually and almost 1,5 Mi deaths, TB is
still a leading mortality factor
TB is the leading killer of people with HIV
22 HBC (High Burden Country) countries account for 80% of the
incidence
Annually over USD 1 Bi was spent on TB diagnostics in 2009, and
the sum is increasing
TB drains 12 billion USD from the annual incomes of the poorest
communities
Loss of productivity attributable to TB approaches 7% of GDP in
some countries
In 2009 there were 9,7 million orphan children a a result of TB
deaths

Nearly 4,000 people die from TB daily,
a curable disease in most cases !!
Source WHO

ConsultASK Management Consulting LLC

Further Facts
•
•

•
•
•

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The most commonly used sputum smear microscopy is more than 100
years old, but is the most affordable for the majority of HBC countries
Traditionally executed, it is also the most ineffective, detects only little
more then half of patients tested with currently used manual method,
mainly due to low sensitivity, lack of well trained personel, tiring
factor.
Todays TB drugs are more then 40 years old and have to be taken for
6-9 months
Todays TB vaccine is more than 85 years old
Delay in assessing proper diagnostics costs time, money and leads to
continued transmission of infectionsThere is huge need for tools that
correspond to the medical need at affordable price (WHO report)

There is urgent need for more accurate and
rapid diagnostic tests (WHO, FIND)

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Burden in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Diagnostics market in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Sputum smear diagnosis of TB:
Light source microscopy ZN
staining
•
•
•
•
•

The fastest and cheapest
available method
Good specificity
Weak sensitivity
Trained staff needed
Time consuming,10– 15 min./slide

Traditional
Fluorescence microscopy
•
•
•
•

Increased sensitivity
More expensive
Faster, less tiresome
Maintenance requirements
(mercury vapour lamps)

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The smear market in 2009

Source WHO

ConsultASK Management Consulting LLC

The Global Revised
WHO Plan 2011-2015

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Microscopy market in 2009

Source WHO

ConsultASK Management Consulting LLC

Market
cont.

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

• Current assumptions:
– Number of microscopy centers was
~70K (58K public, 12K private) in 2009
– 1 smear laboratory/ 100 000 population
should be reached by 2015 (WHO)
– 20% of microscopes should be replaced
by LED by 2015 (WHO)

- Potential smear market
200 M tests (WHO)
Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Fluorobot: the only fully
automated, dedicated solution
• Based on the traditional smear microscopy principle
• Fully automated
– Input / output and moving of the slides
– Image capturing and analysis
– Intelligent bacterium recognition algorythms

• Low cost, robust design suitable for high incidence, high burden
countires
• Huge walk away window, batch processing of 100 – 250 slides
• Small footprint
• High throughput (25 smears/hour)
• Competitive cost/test

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Main Features
• Illumination system using LED technology, much less sensitive,
longer lifetime and cheaper than mercury vapour lamps
• Robust, cost effective X-Y movement
• Special, fast focusing system
• Cost effective, simplified light path, optimised for a single
magnification
• Dedicated image processing and pattern recognition algorithms used
for bacteria identification
• Classification follows WHO reccomendation (neg., scanty, +, ++, +++)
• Standardised quality, no tiring effect
• Images are stored, can be transmitted, archived, revisited
• Opening new Quality Control possibilities
• No trained microscope reading staff needed

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Major milestones
•
•
•
•
•
•
•

•
•

Feasibility Study in Q1 2009
Functional Model stage was successfully reached Q4 2009
Laboratory Sample Stage was reached at Q3 2010
„Proof Of Principle” study was conducted at German TB Reference
Laboratory, WHO Supranational Laboratory at Borstel led by Dr. RüschGerdes in September 2010, with positive outcome
„Letter Of Intent” was signed with FIND (Foundation for Innovative New
Diagnostics, Geneva) in November 2010
Project was exhibited at MEDICA 2012 Dusseldorf and Medical Fair India
2013 in New Delhi, with huge success
Strategic Partner is searched, to carry the project through Prototype
Development (Q3 2013) and Validation (Q4 2013)
Industrialization and Test Production Planned Q3 2014
GoLive of final product (and disposable) planned Q4 2014

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Road
behind our development team
• Core team has more than 15
years experience in medical
imaging and robotic
microscopy
• Main project in the early 90s
was the Seditron urine
sediment analyzer
developed and produced for
Boehringer Mannheim

ConsultASK Management Consulting LLC

Your Invitation!

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Join the Journey!


Slide 7

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Tireless Technician!
The World’s first
robotic, LED based,
smear microscope

for TB screening!

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Facts about the TB burden
•
•
•
•
•
•
•

With 8.8 Mi new cases annually and almost 1,5 Mi deaths, TB is
still a leading mortality factor
TB is the leading killer of people with HIV
22 HBC (High Burden Country) countries account for 80% of the
incidence
Annually over USD 1 Bi was spent on TB diagnostics in 2009, and
the sum is increasing
TB drains 12 billion USD from the annual incomes of the poorest
communities
Loss of productivity attributable to TB approaches 7% of GDP in
some countries
In 2009 there were 9,7 million orphan children a a result of TB
deaths

Nearly 4,000 people die from TB daily,
a curable disease in most cases !!
Source WHO

ConsultASK Management Consulting LLC

Further Facts
•
•

•
•
•

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The most commonly used sputum smear microscopy is more than 100
years old, but is the most affordable for the majority of HBC countries
Traditionally executed, it is also the most ineffective, detects only little
more then half of patients tested with currently used manual method,
mainly due to low sensitivity, lack of well trained personel, tiring
factor.
Todays TB drugs are more then 40 years old and have to be taken for
6-9 months
Todays TB vaccine is more than 85 years old
Delay in assessing proper diagnostics costs time, money and leads to
continued transmission of infectionsThere is huge need for tools that
correspond to the medical need at affordable price (WHO report)

There is urgent need for more accurate and
rapid diagnostic tests (WHO, FIND)

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Burden in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Diagnostics market in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Sputum smear diagnosis of TB:
Light source microscopy ZN
staining
•
•
•
•
•

The fastest and cheapest
available method
Good specificity
Weak sensitivity
Trained staff needed
Time consuming,10– 15 min./slide

Traditional
Fluorescence microscopy
•
•
•
•

Increased sensitivity
More expensive
Faster, less tiresome
Maintenance requirements
(mercury vapour lamps)

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The smear market in 2009

Source WHO

ConsultASK Management Consulting LLC

The Global Revised
WHO Plan 2011-2015

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Microscopy market in 2009

Source WHO

ConsultASK Management Consulting LLC

Market
cont.

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

• Current assumptions:
– Number of microscopy centers was
~70K (58K public, 12K private) in 2009
– 1 smear laboratory/ 100 000 population
should be reached by 2015 (WHO)
– 20% of microscopes should be replaced
by LED by 2015 (WHO)

- Potential smear market
200 M tests (WHO)
Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Fluorobot: the only fully
automated, dedicated solution
• Based on the traditional smear microscopy principle
• Fully automated
– Input / output and moving of the slides
– Image capturing and analysis
– Intelligent bacterium recognition algorythms

• Low cost, robust design suitable for high incidence, high burden
countires
• Huge walk away window, batch processing of 100 – 250 slides
• Small footprint
• High throughput (25 smears/hour)
• Competitive cost/test

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Main Features
• Illumination system using LED technology, much less sensitive,
longer lifetime and cheaper than mercury vapour lamps
• Robust, cost effective X-Y movement
• Special, fast focusing system
• Cost effective, simplified light path, optimised for a single
magnification
• Dedicated image processing and pattern recognition algorithms used
for bacteria identification
• Classification follows WHO reccomendation (neg., scanty, +, ++, +++)
• Standardised quality, no tiring effect
• Images are stored, can be transmitted, archived, revisited
• Opening new Quality Control possibilities
• No trained microscope reading staff needed

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Major milestones
•
•
•
•
•
•
•

•
•

Feasibility Study in Q1 2009
Functional Model stage was successfully reached Q4 2009
Laboratory Sample Stage was reached at Q3 2010
„Proof Of Principle” study was conducted at German TB Reference
Laboratory, WHO Supranational Laboratory at Borstel led by Dr. RüschGerdes in September 2010, with positive outcome
„Letter Of Intent” was signed with FIND (Foundation for Innovative New
Diagnostics, Geneva) in November 2010
Project was exhibited at MEDICA 2012 Dusseldorf and Medical Fair India
2013 in New Delhi, with huge success
Strategic Partner is searched, to carry the project through Prototype
Development (Q3 2013) and Validation (Q4 2013)
Industrialization and Test Production Planned Q3 2014
GoLive of final product (and disposable) planned Q4 2014

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Road
behind our development team
• Core team has more than 15
years experience in medical
imaging and robotic
microscopy
• Main project in the early 90s
was the Seditron urine
sediment analyzer
developed and produced for
Boehringer Mannheim

ConsultASK Management Consulting LLC

Your Invitation!

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Join the Journey!


Slide 8

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Tireless Technician!
The World’s first
robotic, LED based,
smear microscope

for TB screening!

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Facts about the TB burden
•
•
•
•
•
•
•

With 8.8 Mi new cases annually and almost 1,5 Mi deaths, TB is
still a leading mortality factor
TB is the leading killer of people with HIV
22 HBC (High Burden Country) countries account for 80% of the
incidence
Annually over USD 1 Bi was spent on TB diagnostics in 2009, and
the sum is increasing
TB drains 12 billion USD from the annual incomes of the poorest
communities
Loss of productivity attributable to TB approaches 7% of GDP in
some countries
In 2009 there were 9,7 million orphan children a a result of TB
deaths

Nearly 4,000 people die from TB daily,
a curable disease in most cases !!
Source WHO

ConsultASK Management Consulting LLC

Further Facts
•
•

•
•
•

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The most commonly used sputum smear microscopy is more than 100
years old, but is the most affordable for the majority of HBC countries
Traditionally executed, it is also the most ineffective, detects only little
more then half of patients tested with currently used manual method,
mainly due to low sensitivity, lack of well trained personel, tiring
factor.
Todays TB drugs are more then 40 years old and have to be taken for
6-9 months
Todays TB vaccine is more than 85 years old
Delay in assessing proper diagnostics costs time, money and leads to
continued transmission of infectionsThere is huge need for tools that
correspond to the medical need at affordable price (WHO report)

There is urgent need for more accurate and
rapid diagnostic tests (WHO, FIND)

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Burden in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Diagnostics market in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Sputum smear diagnosis of TB:
Light source microscopy ZN
staining
•
•
•
•
•

The fastest and cheapest
available method
Good specificity
Weak sensitivity
Trained staff needed
Time consuming,10– 15 min./slide

Traditional
Fluorescence microscopy
•
•
•
•

Increased sensitivity
More expensive
Faster, less tiresome
Maintenance requirements
(mercury vapour lamps)

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The smear market in 2009

Source WHO

ConsultASK Management Consulting LLC

The Global Revised
WHO Plan 2011-2015

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Microscopy market in 2009

Source WHO

ConsultASK Management Consulting LLC

Market
cont.

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

• Current assumptions:
– Number of microscopy centers was
~70K (58K public, 12K private) in 2009
– 1 smear laboratory/ 100 000 population
should be reached by 2015 (WHO)
– 20% of microscopes should be replaced
by LED by 2015 (WHO)

- Potential smear market
200 M tests (WHO)
Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Fluorobot: the only fully
automated, dedicated solution
• Based on the traditional smear microscopy principle
• Fully automated
– Input / output and moving of the slides
– Image capturing and analysis
– Intelligent bacterium recognition algorythms

• Low cost, robust design suitable for high incidence, high burden
countires
• Huge walk away window, batch processing of 100 – 250 slides
• Small footprint
• High throughput (25 smears/hour)
• Competitive cost/test

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Main Features
• Illumination system using LED technology, much less sensitive,
longer lifetime and cheaper than mercury vapour lamps
• Robust, cost effective X-Y movement
• Special, fast focusing system
• Cost effective, simplified light path, optimised for a single
magnification
• Dedicated image processing and pattern recognition algorithms used
for bacteria identification
• Classification follows WHO reccomendation (neg., scanty, +, ++, +++)
• Standardised quality, no tiring effect
• Images are stored, can be transmitted, archived, revisited
• Opening new Quality Control possibilities
• No trained microscope reading staff needed

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Major milestones
•
•
•
•
•
•
•

•
•

Feasibility Study in Q1 2009
Functional Model stage was successfully reached Q4 2009
Laboratory Sample Stage was reached at Q3 2010
„Proof Of Principle” study was conducted at German TB Reference
Laboratory, WHO Supranational Laboratory at Borstel led by Dr. RüschGerdes in September 2010, with positive outcome
„Letter Of Intent” was signed with FIND (Foundation for Innovative New
Diagnostics, Geneva) in November 2010
Project was exhibited at MEDICA 2012 Dusseldorf and Medical Fair India
2013 in New Delhi, with huge success
Strategic Partner is searched, to carry the project through Prototype
Development (Q3 2013) and Validation (Q4 2013)
Industrialization and Test Production Planned Q3 2014
GoLive of final product (and disposable) planned Q4 2014

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Road
behind our development team
• Core team has more than 15
years experience in medical
imaging and robotic
microscopy
• Main project in the early 90s
was the Seditron urine
sediment analyzer
developed and produced for
Boehringer Mannheim

ConsultASK Management Consulting LLC

Your Invitation!

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Join the Journey!


Slide 9

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Tireless Technician!
The World’s first
robotic, LED based,
smear microscope

for TB screening!

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Facts about the TB burden
•
•
•
•
•
•
•

With 8.8 Mi new cases annually and almost 1,5 Mi deaths, TB is
still a leading mortality factor
TB is the leading killer of people with HIV
22 HBC (High Burden Country) countries account for 80% of the
incidence
Annually over USD 1 Bi was spent on TB diagnostics in 2009, and
the sum is increasing
TB drains 12 billion USD from the annual incomes of the poorest
communities
Loss of productivity attributable to TB approaches 7% of GDP in
some countries
In 2009 there were 9,7 million orphan children a a result of TB
deaths

Nearly 4,000 people die from TB daily,
a curable disease in most cases !!
Source WHO

ConsultASK Management Consulting LLC

Further Facts
•
•

•
•
•

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The most commonly used sputum smear microscopy is more than 100
years old, but is the most affordable for the majority of HBC countries
Traditionally executed, it is also the most ineffective, detects only little
more then half of patients tested with currently used manual method,
mainly due to low sensitivity, lack of well trained personel, tiring
factor.
Todays TB drugs are more then 40 years old and have to be taken for
6-9 months
Todays TB vaccine is more than 85 years old
Delay in assessing proper diagnostics costs time, money and leads to
continued transmission of infectionsThere is huge need for tools that
correspond to the medical need at affordable price (WHO report)

There is urgent need for more accurate and
rapid diagnostic tests (WHO, FIND)

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Burden in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Diagnostics market in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Sputum smear diagnosis of TB:
Light source microscopy ZN
staining
•
•
•
•
•

The fastest and cheapest
available method
Good specificity
Weak sensitivity
Trained staff needed
Time consuming,10– 15 min./slide

Traditional
Fluorescence microscopy
•
•
•
•

Increased sensitivity
More expensive
Faster, less tiresome
Maintenance requirements
(mercury vapour lamps)

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The smear market in 2009

Source WHO

ConsultASK Management Consulting LLC

The Global Revised
WHO Plan 2011-2015

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Microscopy market in 2009

Source WHO

ConsultASK Management Consulting LLC

Market
cont.

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

• Current assumptions:
– Number of microscopy centers was
~70K (58K public, 12K private) in 2009
– 1 smear laboratory/ 100 000 population
should be reached by 2015 (WHO)
– 20% of microscopes should be replaced
by LED by 2015 (WHO)

- Potential smear market
200 M tests (WHO)
Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Fluorobot: the only fully
automated, dedicated solution
• Based on the traditional smear microscopy principle
• Fully automated
– Input / output and moving of the slides
– Image capturing and analysis
– Intelligent bacterium recognition algorythms

• Low cost, robust design suitable for high incidence, high burden
countires
• Huge walk away window, batch processing of 100 – 250 slides
• Small footprint
• High throughput (25 smears/hour)
• Competitive cost/test

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Main Features
• Illumination system using LED technology, much less sensitive,
longer lifetime and cheaper than mercury vapour lamps
• Robust, cost effective X-Y movement
• Special, fast focusing system
• Cost effective, simplified light path, optimised for a single
magnification
• Dedicated image processing and pattern recognition algorithms used
for bacteria identification
• Classification follows WHO reccomendation (neg., scanty, +, ++, +++)
• Standardised quality, no tiring effect
• Images are stored, can be transmitted, archived, revisited
• Opening new Quality Control possibilities
• No trained microscope reading staff needed

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Major milestones
•
•
•
•
•
•
•

•
•

Feasibility Study in Q1 2009
Functional Model stage was successfully reached Q4 2009
Laboratory Sample Stage was reached at Q3 2010
„Proof Of Principle” study was conducted at German TB Reference
Laboratory, WHO Supranational Laboratory at Borstel led by Dr. RüschGerdes in September 2010, with positive outcome
„Letter Of Intent” was signed with FIND (Foundation for Innovative New
Diagnostics, Geneva) in November 2010
Project was exhibited at MEDICA 2012 Dusseldorf and Medical Fair India
2013 in New Delhi, with huge success
Strategic Partner is searched, to carry the project through Prototype
Development (Q3 2013) and Validation (Q4 2013)
Industrialization and Test Production Planned Q3 2014
GoLive of final product (and disposable) planned Q4 2014

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Road
behind our development team
• Core team has more than 15
years experience in medical
imaging and robotic
microscopy
• Main project in the early 90s
was the Seditron urine
sediment analyzer
developed and produced for
Boehringer Mannheim

ConsultASK Management Consulting LLC

Your Invitation!

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Join the Journey!


Slide 10

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Tireless Technician!
The World’s first
robotic, LED based,
smear microscope

for TB screening!

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Facts about the TB burden
•
•
•
•
•
•
•

With 8.8 Mi new cases annually and almost 1,5 Mi deaths, TB is
still a leading mortality factor
TB is the leading killer of people with HIV
22 HBC (High Burden Country) countries account for 80% of the
incidence
Annually over USD 1 Bi was spent on TB diagnostics in 2009, and
the sum is increasing
TB drains 12 billion USD from the annual incomes of the poorest
communities
Loss of productivity attributable to TB approaches 7% of GDP in
some countries
In 2009 there were 9,7 million orphan children a a result of TB
deaths

Nearly 4,000 people die from TB daily,
a curable disease in most cases !!
Source WHO

ConsultASK Management Consulting LLC

Further Facts
•
•

•
•
•

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The most commonly used sputum smear microscopy is more than 100
years old, but is the most affordable for the majority of HBC countries
Traditionally executed, it is also the most ineffective, detects only little
more then half of patients tested with currently used manual method,
mainly due to low sensitivity, lack of well trained personel, tiring
factor.
Todays TB drugs are more then 40 years old and have to be taken for
6-9 months
Todays TB vaccine is more than 85 years old
Delay in assessing proper diagnostics costs time, money and leads to
continued transmission of infectionsThere is huge need for tools that
correspond to the medical need at affordable price (WHO report)

There is urgent need for more accurate and
rapid diagnostic tests (WHO, FIND)

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Burden in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Diagnostics market in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Sputum smear diagnosis of TB:
Light source microscopy ZN
staining
•
•
•
•
•

The fastest and cheapest
available method
Good specificity
Weak sensitivity
Trained staff needed
Time consuming,10– 15 min./slide

Traditional
Fluorescence microscopy
•
•
•
•

Increased sensitivity
More expensive
Faster, less tiresome
Maintenance requirements
(mercury vapour lamps)

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The smear market in 2009

Source WHO

ConsultASK Management Consulting LLC

The Global Revised
WHO Plan 2011-2015

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Microscopy market in 2009

Source WHO

ConsultASK Management Consulting LLC

Market
cont.

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

• Current assumptions:
– Number of microscopy centers was
~70K (58K public, 12K private) in 2009
– 1 smear laboratory/ 100 000 population
should be reached by 2015 (WHO)
– 20% of microscopes should be replaced
by LED by 2015 (WHO)

- Potential smear market
200 M tests (WHO)
Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Fluorobot: the only fully
automated, dedicated solution
• Based on the traditional smear microscopy principle
• Fully automated
– Input / output and moving of the slides
– Image capturing and analysis
– Intelligent bacterium recognition algorythms

• Low cost, robust design suitable for high incidence, high burden
countires
• Huge walk away window, batch processing of 100 – 250 slides
• Small footprint
• High throughput (25 smears/hour)
• Competitive cost/test

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Main Features
• Illumination system using LED technology, much less sensitive,
longer lifetime and cheaper than mercury vapour lamps
• Robust, cost effective X-Y movement
• Special, fast focusing system
• Cost effective, simplified light path, optimised for a single
magnification
• Dedicated image processing and pattern recognition algorithms used
for bacteria identification
• Classification follows WHO reccomendation (neg., scanty, +, ++, +++)
• Standardised quality, no tiring effect
• Images are stored, can be transmitted, archived, revisited
• Opening new Quality Control possibilities
• No trained microscope reading staff needed

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Major milestones
•
•
•
•
•
•
•

•
•

Feasibility Study in Q1 2009
Functional Model stage was successfully reached Q4 2009
Laboratory Sample Stage was reached at Q3 2010
„Proof Of Principle” study was conducted at German TB Reference
Laboratory, WHO Supranational Laboratory at Borstel led by Dr. RüschGerdes in September 2010, with positive outcome
„Letter Of Intent” was signed with FIND (Foundation for Innovative New
Diagnostics, Geneva) in November 2010
Project was exhibited at MEDICA 2012 Dusseldorf and Medical Fair India
2013 in New Delhi, with huge success
Strategic Partner is searched, to carry the project through Prototype
Development (Q3 2013) and Validation (Q4 2013)
Industrialization and Test Production Planned Q3 2014
GoLive of final product (and disposable) planned Q4 2014

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Road
behind our development team
• Core team has more than 15
years experience in medical
imaging and robotic
microscopy
• Main project in the early 90s
was the Seditron urine
sediment analyzer
developed and produced for
Boehringer Mannheim

ConsultASK Management Consulting LLC

Your Invitation!

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Join the Journey!


Slide 11

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Tireless Technician!
The World’s first
robotic, LED based,
smear microscope

for TB screening!

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Facts about the TB burden
•
•
•
•
•
•
•

With 8.8 Mi new cases annually and almost 1,5 Mi deaths, TB is
still a leading mortality factor
TB is the leading killer of people with HIV
22 HBC (High Burden Country) countries account for 80% of the
incidence
Annually over USD 1 Bi was spent on TB diagnostics in 2009, and
the sum is increasing
TB drains 12 billion USD from the annual incomes of the poorest
communities
Loss of productivity attributable to TB approaches 7% of GDP in
some countries
In 2009 there were 9,7 million orphan children a a result of TB
deaths

Nearly 4,000 people die from TB daily,
a curable disease in most cases !!
Source WHO

ConsultASK Management Consulting LLC

Further Facts
•
•

•
•
•

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The most commonly used sputum smear microscopy is more than 100
years old, but is the most affordable for the majority of HBC countries
Traditionally executed, it is also the most ineffective, detects only little
more then half of patients tested with currently used manual method,
mainly due to low sensitivity, lack of well trained personel, tiring
factor.
Todays TB drugs are more then 40 years old and have to be taken for
6-9 months
Todays TB vaccine is more than 85 years old
Delay in assessing proper diagnostics costs time, money and leads to
continued transmission of infectionsThere is huge need for tools that
correspond to the medical need at affordable price (WHO report)

There is urgent need for more accurate and
rapid diagnostic tests (WHO, FIND)

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Burden in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Diagnostics market in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Sputum smear diagnosis of TB:
Light source microscopy ZN
staining
•
•
•
•
•

The fastest and cheapest
available method
Good specificity
Weak sensitivity
Trained staff needed
Time consuming,10– 15 min./slide

Traditional
Fluorescence microscopy
•
•
•
•

Increased sensitivity
More expensive
Faster, less tiresome
Maintenance requirements
(mercury vapour lamps)

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The smear market in 2009

Source WHO

ConsultASK Management Consulting LLC

The Global Revised
WHO Plan 2011-2015

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Microscopy market in 2009

Source WHO

ConsultASK Management Consulting LLC

Market
cont.

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

• Current assumptions:
– Number of microscopy centers was
~70K (58K public, 12K private) in 2009
– 1 smear laboratory/ 100 000 population
should be reached by 2015 (WHO)
– 20% of microscopes should be replaced
by LED by 2015 (WHO)

- Potential smear market
200 M tests (WHO)
Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Fluorobot: the only fully
automated, dedicated solution
• Based on the traditional smear microscopy principle
• Fully automated
– Input / output and moving of the slides
– Image capturing and analysis
– Intelligent bacterium recognition algorythms

• Low cost, robust design suitable for high incidence, high burden
countires
• Huge walk away window, batch processing of 100 – 250 slides
• Small footprint
• High throughput (25 smears/hour)
• Competitive cost/test

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Main Features
• Illumination system using LED technology, much less sensitive,
longer lifetime and cheaper than mercury vapour lamps
• Robust, cost effective X-Y movement
• Special, fast focusing system
• Cost effective, simplified light path, optimised for a single
magnification
• Dedicated image processing and pattern recognition algorithms used
for bacteria identification
• Classification follows WHO reccomendation (neg., scanty, +, ++, +++)
• Standardised quality, no tiring effect
• Images are stored, can be transmitted, archived, revisited
• Opening new Quality Control possibilities
• No trained microscope reading staff needed

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Major milestones
•
•
•
•
•
•
•

•
•

Feasibility Study in Q1 2009
Functional Model stage was successfully reached Q4 2009
Laboratory Sample Stage was reached at Q3 2010
„Proof Of Principle” study was conducted at German TB Reference
Laboratory, WHO Supranational Laboratory at Borstel led by Dr. RüschGerdes in September 2010, with positive outcome
„Letter Of Intent” was signed with FIND (Foundation for Innovative New
Diagnostics, Geneva) in November 2010
Project was exhibited at MEDICA 2012 Dusseldorf and Medical Fair India
2013 in New Delhi, with huge success
Strategic Partner is searched, to carry the project through Prototype
Development (Q3 2013) and Validation (Q4 2013)
Industrialization and Test Production Planned Q3 2014
GoLive of final product (and disposable) planned Q4 2014

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Road
behind our development team
• Core team has more than 15
years experience in medical
imaging and robotic
microscopy
• Main project in the early 90s
was the Seditron urine
sediment analyzer
developed and produced for
Boehringer Mannheim

ConsultASK Management Consulting LLC

Your Invitation!

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Join the Journey!


Slide 12

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Tireless Technician!
The World’s first
robotic, LED based,
smear microscope

for TB screening!

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Facts about the TB burden
•
•
•
•
•
•
•

With 8.8 Mi new cases annually and almost 1,5 Mi deaths, TB is
still a leading mortality factor
TB is the leading killer of people with HIV
22 HBC (High Burden Country) countries account for 80% of the
incidence
Annually over USD 1 Bi was spent on TB diagnostics in 2009, and
the sum is increasing
TB drains 12 billion USD from the annual incomes of the poorest
communities
Loss of productivity attributable to TB approaches 7% of GDP in
some countries
In 2009 there were 9,7 million orphan children a a result of TB
deaths

Nearly 4,000 people die from TB daily,
a curable disease in most cases !!
Source WHO

ConsultASK Management Consulting LLC

Further Facts
•
•

•
•
•

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The most commonly used sputum smear microscopy is more than 100
years old, but is the most affordable for the majority of HBC countries
Traditionally executed, it is also the most ineffective, detects only little
more then half of patients tested with currently used manual method,
mainly due to low sensitivity, lack of well trained personel, tiring
factor.
Todays TB drugs are more then 40 years old and have to be taken for
6-9 months
Todays TB vaccine is more than 85 years old
Delay in assessing proper diagnostics costs time, money and leads to
continued transmission of infectionsThere is huge need for tools that
correspond to the medical need at affordable price (WHO report)

There is urgent need for more accurate and
rapid diagnostic tests (WHO, FIND)

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Burden in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Diagnostics market in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Sputum smear diagnosis of TB:
Light source microscopy ZN
staining
•
•
•
•
•

The fastest and cheapest
available method
Good specificity
Weak sensitivity
Trained staff needed
Time consuming,10– 15 min./slide

Traditional
Fluorescence microscopy
•
•
•
•

Increased sensitivity
More expensive
Faster, less tiresome
Maintenance requirements
(mercury vapour lamps)

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The smear market in 2009

Source WHO

ConsultASK Management Consulting LLC

The Global Revised
WHO Plan 2011-2015

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Microscopy market in 2009

Source WHO

ConsultASK Management Consulting LLC

Market
cont.

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

• Current assumptions:
– Number of microscopy centers was
~70K (58K public, 12K private) in 2009
– 1 smear laboratory/ 100 000 population
should be reached by 2015 (WHO)
– 20% of microscopes should be replaced
by LED by 2015 (WHO)

- Potential smear market
200 M tests (WHO)
Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Fluorobot: the only fully
automated, dedicated solution
• Based on the traditional smear microscopy principle
• Fully automated
– Input / output and moving of the slides
– Image capturing and analysis
– Intelligent bacterium recognition algorythms

• Low cost, robust design suitable for high incidence, high burden
countires
• Huge walk away window, batch processing of 100 – 250 slides
• Small footprint
• High throughput (25 smears/hour)
• Competitive cost/test

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Main Features
• Illumination system using LED technology, much less sensitive,
longer lifetime and cheaper than mercury vapour lamps
• Robust, cost effective X-Y movement
• Special, fast focusing system
• Cost effective, simplified light path, optimised for a single
magnification
• Dedicated image processing and pattern recognition algorithms used
for bacteria identification
• Classification follows WHO reccomendation (neg., scanty, +, ++, +++)
• Standardised quality, no tiring effect
• Images are stored, can be transmitted, archived, revisited
• Opening new Quality Control possibilities
• No trained microscope reading staff needed

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Major milestones
•
•
•
•
•
•
•

•
•

Feasibility Study in Q1 2009
Functional Model stage was successfully reached Q4 2009
Laboratory Sample Stage was reached at Q3 2010
„Proof Of Principle” study was conducted at German TB Reference
Laboratory, WHO Supranational Laboratory at Borstel led by Dr. RüschGerdes in September 2010, with positive outcome
„Letter Of Intent” was signed with FIND (Foundation for Innovative New
Diagnostics, Geneva) in November 2010
Project was exhibited at MEDICA 2012 Dusseldorf and Medical Fair India
2013 in New Delhi, with huge success
Strategic Partner is searched, to carry the project through Prototype
Development (Q3 2013) and Validation (Q4 2013)
Industrialization and Test Production Planned Q3 2014
GoLive of final product (and disposable) planned Q4 2014

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Road
behind our development team
• Core team has more than 15
years experience in medical
imaging and robotic
microscopy
• Main project in the early 90s
was the Seditron urine
sediment analyzer
developed and produced for
Boehringer Mannheim

ConsultASK Management Consulting LLC

Your Invitation!

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Join the Journey!


Slide 13

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Tireless Technician!
The World’s first
robotic, LED based,
smear microscope

for TB screening!

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Facts about the TB burden
•
•
•
•
•
•
•

With 8.8 Mi new cases annually and almost 1,5 Mi deaths, TB is
still a leading mortality factor
TB is the leading killer of people with HIV
22 HBC (High Burden Country) countries account for 80% of the
incidence
Annually over USD 1 Bi was spent on TB diagnostics in 2009, and
the sum is increasing
TB drains 12 billion USD from the annual incomes of the poorest
communities
Loss of productivity attributable to TB approaches 7% of GDP in
some countries
In 2009 there were 9,7 million orphan children a a result of TB
deaths

Nearly 4,000 people die from TB daily,
a curable disease in most cases !!
Source WHO

ConsultASK Management Consulting LLC

Further Facts
•
•

•
•
•

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The most commonly used sputum smear microscopy is more than 100
years old, but is the most affordable for the majority of HBC countries
Traditionally executed, it is also the most ineffective, detects only little
more then half of patients tested with currently used manual method,
mainly due to low sensitivity, lack of well trained personel, tiring
factor.
Todays TB drugs are more then 40 years old and have to be taken for
6-9 months
Todays TB vaccine is more than 85 years old
Delay in assessing proper diagnostics costs time, money and leads to
continued transmission of infectionsThere is huge need for tools that
correspond to the medical need at affordable price (WHO report)

There is urgent need for more accurate and
rapid diagnostic tests (WHO, FIND)

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Burden in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Diagnostics market in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Sputum smear diagnosis of TB:
Light source microscopy ZN
staining
•
•
•
•
•

The fastest and cheapest
available method
Good specificity
Weak sensitivity
Trained staff needed
Time consuming,10– 15 min./slide

Traditional
Fluorescence microscopy
•
•
•
•

Increased sensitivity
More expensive
Faster, less tiresome
Maintenance requirements
(mercury vapour lamps)

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The smear market in 2009

Source WHO

ConsultASK Management Consulting LLC

The Global Revised
WHO Plan 2011-2015

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Microscopy market in 2009

Source WHO

ConsultASK Management Consulting LLC

Market
cont.

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

• Current assumptions:
– Number of microscopy centers was
~70K (58K public, 12K private) in 2009
– 1 smear laboratory/ 100 000 population
should be reached by 2015 (WHO)
– 20% of microscopes should be replaced
by LED by 2015 (WHO)

- Potential smear market
200 M tests (WHO)
Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Fluorobot: the only fully
automated, dedicated solution
• Based on the traditional smear microscopy principle
• Fully automated
– Input / output and moving of the slides
– Image capturing and analysis
– Intelligent bacterium recognition algorythms

• Low cost, robust design suitable for high incidence, high burden
countires
• Huge walk away window, batch processing of 100 – 250 slides
• Small footprint
• High throughput (25 smears/hour)
• Competitive cost/test

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Main Features
• Illumination system using LED technology, much less sensitive,
longer lifetime and cheaper than mercury vapour lamps
• Robust, cost effective X-Y movement
• Special, fast focusing system
• Cost effective, simplified light path, optimised for a single
magnification
• Dedicated image processing and pattern recognition algorithms used
for bacteria identification
• Classification follows WHO reccomendation (neg., scanty, +, ++, +++)
• Standardised quality, no tiring effect
• Images are stored, can be transmitted, archived, revisited
• Opening new Quality Control possibilities
• No trained microscope reading staff needed

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Major milestones
•
•
•
•
•
•
•

•
•

Feasibility Study in Q1 2009
Functional Model stage was successfully reached Q4 2009
Laboratory Sample Stage was reached at Q3 2010
„Proof Of Principle” study was conducted at German TB Reference
Laboratory, WHO Supranational Laboratory at Borstel led by Dr. RüschGerdes in September 2010, with positive outcome
„Letter Of Intent” was signed with FIND (Foundation for Innovative New
Diagnostics, Geneva) in November 2010
Project was exhibited at MEDICA 2012 Dusseldorf and Medical Fair India
2013 in New Delhi, with huge success
Strategic Partner is searched, to carry the project through Prototype
Development (Q3 2013) and Validation (Q4 2013)
Industrialization and Test Production Planned Q3 2014
GoLive of final product (and disposable) planned Q4 2014

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Road
behind our development team
• Core team has more than 15
years experience in medical
imaging and robotic
microscopy
• Main project in the early 90s
was the Seditron urine
sediment analyzer
developed and produced for
Boehringer Mannheim

ConsultASK Management Consulting LLC

Your Invitation!

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Join the Journey!


Slide 14

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Tireless Technician!
The World’s first
robotic, LED based,
smear microscope

for TB screening!

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Facts about the TB burden
•
•
•
•
•
•
•

With 8.8 Mi new cases annually and almost 1,5 Mi deaths, TB is
still a leading mortality factor
TB is the leading killer of people with HIV
22 HBC (High Burden Country) countries account for 80% of the
incidence
Annually over USD 1 Bi was spent on TB diagnostics in 2009, and
the sum is increasing
TB drains 12 billion USD from the annual incomes of the poorest
communities
Loss of productivity attributable to TB approaches 7% of GDP in
some countries
In 2009 there were 9,7 million orphan children a a result of TB
deaths

Nearly 4,000 people die from TB daily,
a curable disease in most cases !!
Source WHO

ConsultASK Management Consulting LLC

Further Facts
•
•

•
•
•

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The most commonly used sputum smear microscopy is more than 100
years old, but is the most affordable for the majority of HBC countries
Traditionally executed, it is also the most ineffective, detects only little
more then half of patients tested with currently used manual method,
mainly due to low sensitivity, lack of well trained personel, tiring
factor.
Todays TB drugs are more then 40 years old and have to be taken for
6-9 months
Todays TB vaccine is more than 85 years old
Delay in assessing proper diagnostics costs time, money and leads to
continued transmission of infectionsThere is huge need for tools that
correspond to the medical need at affordable price (WHO report)

There is urgent need for more accurate and
rapid diagnostic tests (WHO, FIND)

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Burden in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Diagnostics market in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Sputum smear diagnosis of TB:
Light source microscopy ZN
staining
•
•
•
•
•

The fastest and cheapest
available method
Good specificity
Weak sensitivity
Trained staff needed
Time consuming,10– 15 min./slide

Traditional
Fluorescence microscopy
•
•
•
•

Increased sensitivity
More expensive
Faster, less tiresome
Maintenance requirements
(mercury vapour lamps)

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The smear market in 2009

Source WHO

ConsultASK Management Consulting LLC

The Global Revised
WHO Plan 2011-2015

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Microscopy market in 2009

Source WHO

ConsultASK Management Consulting LLC

Market
cont.

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

• Current assumptions:
– Number of microscopy centers was
~70K (58K public, 12K private) in 2009
– 1 smear laboratory/ 100 000 population
should be reached by 2015 (WHO)
– 20% of microscopes should be replaced
by LED by 2015 (WHO)

- Potential smear market
200 M tests (WHO)
Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Fluorobot: the only fully
automated, dedicated solution
• Based on the traditional smear microscopy principle
• Fully automated
– Input / output and moving of the slides
– Image capturing and analysis
– Intelligent bacterium recognition algorythms

• Low cost, robust design suitable for high incidence, high burden
countires
• Huge walk away window, batch processing of 100 – 250 slides
• Small footprint
• High throughput (25 smears/hour)
• Competitive cost/test

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Main Features
• Illumination system using LED technology, much less sensitive,
longer lifetime and cheaper than mercury vapour lamps
• Robust, cost effective X-Y movement
• Special, fast focusing system
• Cost effective, simplified light path, optimised for a single
magnification
• Dedicated image processing and pattern recognition algorithms used
for bacteria identification
• Classification follows WHO reccomendation (neg., scanty, +, ++, +++)
• Standardised quality, no tiring effect
• Images are stored, can be transmitted, archived, revisited
• Opening new Quality Control possibilities
• No trained microscope reading staff needed

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Major milestones
•
•
•
•
•
•
•

•
•

Feasibility Study in Q1 2009
Functional Model stage was successfully reached Q4 2009
Laboratory Sample Stage was reached at Q3 2010
„Proof Of Principle” study was conducted at German TB Reference
Laboratory, WHO Supranational Laboratory at Borstel led by Dr. RüschGerdes in September 2010, with positive outcome
„Letter Of Intent” was signed with FIND (Foundation for Innovative New
Diagnostics, Geneva) in November 2010
Project was exhibited at MEDICA 2012 Dusseldorf and Medical Fair India
2013 in New Delhi, with huge success
Strategic Partner is searched, to carry the project through Prototype
Development (Q3 2013) and Validation (Q4 2013)
Industrialization and Test Production Planned Q3 2014
GoLive of final product (and disposable) planned Q4 2014

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Road
behind our development team
• Core team has more than 15
years experience in medical
imaging and robotic
microscopy
• Main project in the early 90s
was the Seditron urine
sediment analyzer
developed and produced for
Boehringer Mannheim

ConsultASK Management Consulting LLC

Your Invitation!

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Join the Journey!


Slide 15

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Tireless Technician!
The World’s first
robotic, LED based,
smear microscope

for TB screening!

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Facts about the TB burden
•
•
•
•
•
•
•

With 8.8 Mi new cases annually and almost 1,5 Mi deaths, TB is
still a leading mortality factor
TB is the leading killer of people with HIV
22 HBC (High Burden Country) countries account for 80% of the
incidence
Annually over USD 1 Bi was spent on TB diagnostics in 2009, and
the sum is increasing
TB drains 12 billion USD from the annual incomes of the poorest
communities
Loss of productivity attributable to TB approaches 7% of GDP in
some countries
In 2009 there were 9,7 million orphan children a a result of TB
deaths

Nearly 4,000 people die from TB daily,
a curable disease in most cases !!
Source WHO

ConsultASK Management Consulting LLC

Further Facts
•
•

•
•
•

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The most commonly used sputum smear microscopy is more than 100
years old, but is the most affordable for the majority of HBC countries
Traditionally executed, it is also the most ineffective, detects only little
more then half of patients tested with currently used manual method,
mainly due to low sensitivity, lack of well trained personel, tiring
factor.
Todays TB drugs are more then 40 years old and have to be taken for
6-9 months
Todays TB vaccine is more than 85 years old
Delay in assessing proper diagnostics costs time, money and leads to
continued transmission of infectionsThere is huge need for tools that
correspond to the medical need at affordable price (WHO report)

There is urgent need for more accurate and
rapid diagnostic tests (WHO, FIND)

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Burden in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

TB Diagnostics market in 2009

Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Sputum smear diagnosis of TB:
Light source microscopy ZN
staining
•
•
•
•
•

The fastest and cheapest
available method
Good specificity
Weak sensitivity
Trained staff needed
Time consuming,10– 15 min./slide

Traditional
Fluorescence microscopy
•
•
•
•

Increased sensitivity
More expensive
Faster, less tiresome
Maintenance requirements
(mercury vapour lamps)

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The smear market in 2009

Source WHO

ConsultASK Management Consulting LLC

The Global Revised
WHO Plan 2011-2015

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Microscopy market in 2009

Source WHO

ConsultASK Management Consulting LLC

Market
cont.

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

• Current assumptions:
– Number of microscopy centers was
~70K (58K public, 12K private) in 2009
– 1 smear laboratory/ 100 000 population
should be reached by 2015 (WHO)
– 20% of microscopes should be replaced
by LED by 2015 (WHO)

- Potential smear market
200 M tests (WHO)
Source WHO

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Fluorobot: the only fully
automated, dedicated solution
• Based on the traditional smear microscopy principle
• Fully automated
– Input / output and moving of the slides
– Image capturing and analysis
– Intelligent bacterium recognition algorythms

• Low cost, robust design suitable for high incidence, high burden
countires
• Huge walk away window, batch processing of 100 – 250 slides
• Small footprint
• High throughput (25 smears/hour)
• Competitive cost/test

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Main Features
• Illumination system using LED technology, much less sensitive,
longer lifetime and cheaper than mercury vapour lamps
• Robust, cost effective X-Y movement
• Special, fast focusing system
• Cost effective, simplified light path, optimised for a single
magnification
• Dedicated image processing and pattern recognition algorithms used
for bacteria identification
• Classification follows WHO reccomendation (neg., scanty, +, ++, +++)
• Standardised quality, no tiring effect
• Images are stored, can be transmitted, archived, revisited
• Opening new Quality Control possibilities
• No trained microscope reading staff needed

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Major milestones
•
•
•
•
•
•
•

•
•

Feasibility Study in Q1 2009
Functional Model stage was successfully reached Q4 2009
Laboratory Sample Stage was reached at Q3 2010
„Proof Of Principle” study was conducted at German TB Reference
Laboratory, WHO Supranational Laboratory at Borstel led by Dr. RüschGerdes in September 2010, with positive outcome
„Letter Of Intent” was signed with FIND (Foundation for Innovative New
Diagnostics, Geneva) in November 2010
Project was exhibited at MEDICA 2012 Dusseldorf and Medical Fair India
2013 in New Delhi, with huge success
Strategic Partner is searched, to carry the project through Prototype
Development (Q3 2013) and Validation (Q4 2013)
Industrialization and Test Production Planned Q3 2014
GoLive of final product (and disposable) planned Q4 2014

ConsultASK Management Consulting LLC
H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

The Road
behind our development team
• Core team has more than 15
years experience in medical
imaging and robotic
microscopy
• Main project in the early 90s
was the Seditron urine
sediment analyzer
developed and produced for
Boehringer Mannheim

ConsultASK Management Consulting LLC

Your Invitation!

H-1121 Budapest, Konkoly-Thege M. út 29-33.
Tel.: +36-1-391-9400
FAX: +36-1-391-9409

Join the Journey!