Institute of Microbiology Chinese Academy of Sciences •Microbial Resources •Applied & Industrial Microbiology •Pathogenic Microbiology Advisory Committee Academic Committee International Advisory Panel Academic Degree Committee National Advisory Panel Development Committee Center.
Download ReportTranscript Institute of Microbiology Chinese Academy of Sciences •Microbial Resources •Applied & Industrial Microbiology •Pathogenic Microbiology Advisory Committee Academic Committee International Advisory Panel Academic Degree Committee National Advisory Panel Development Committee Center.
Slide 1
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 2
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 3
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 4
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 5
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 6
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 7
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 8
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 9
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 10
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 11
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 12
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 13
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 2
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 3
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 4
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 5
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 6
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 7
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 8
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 9
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 10
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 11
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 12
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You
Slide 13
Institute of Microbiology
Chinese Academy of Sciences
•Microbial Resources
•Applied & Industrial Microbiology
•Pathogenic Microbiology
Advisory Committee
Academic Committee
International Advisory Panel
Academic Degree Committee
National Advisory Panel
Development Committee
Center for
Microbial Resources
Center for Agri. Biotech.
Co-op with Inst. Genetics &
Develop. Biol., CAS
State Key Lab of
Microbial Resources
CAS Key Lab of
Syst. Mycol. & Lichenol.
Center for Environ. Biotech.
Center Microb. Metab. Eng.
Center for Microbial
Genome Research
Center for
Molecular Immunology
Center for
Molecular Virology
Center for Energy &
Industrial Biotechnology
Co-op with Beijing
Genomics Inst., CAS
Culture Collect. Center
Microbial Analy. Center
High-throughput
Screening Platform
Tech. Support Platform
Information Center
National Microbial Engineering Center
Administrative System
Developmental Strategy
Construct Modern
Biotechnology
Platforms
Human Resources
Co-op with Industry
International Co-op
Broad International Co-operation
MultiGenome Access Technology
for Industrial Catalysts
(MGATech)
An EU - China Collaboration
Review of FP5
in IMCAS
European Commission Fifth Framework RTD Programme
Quality of Life and Management of Living Resources
Key Action 3: The Cell Factory
RTD Priority 3.3.4: Identification and Sustainable Use of
Metabolic and Genetic Diversity as a Source of New Valuable
Products
MultiGenome Access Technology for Industrial Catalysts
An EU – China Collaboration
European Commission Fifth Framework RTD Programme
Thematic Programme : Quality of Life and Management
of Living Resources
Key Action 3 : The Cell Factory
Hydrothermal outbreak, upper site small pool
Rehai thermal area
Overview
RTD Priority 3.3.4 : Identification and Sustainable Use of
Metabolic and Genetic Diversity as a
Source of New Valuable Products
Project Number: QLK3-CT-2002-01972
Novel genetic methods will be developed for accessing gene products derived from Chinese hot springs
and salt lakes to which we have unique access in a collaboration with the Chinese authorities. These
Chinese extreme environments are of outstanding significance as microbial ecosystems with unique
chemistries. The sites harbour largely unexplored microbial genetic resources that will be harnessed as
sources of new and valuable enzymes.
Gene libraries reflecting the microbial biodiversity at these exceptional sites will be employed for the
identification and production of valuable new enzymes for sustainable applications in biotechnological
processes and consumer products. This special collaboration, which is the first microbial biotechnology
collaboration between the EU and China, will provide substantial opportunities for the development of
European and Chinese biotechnology.
Pearl Spring – Rehai thermal area
Objectives
•
•
•
•
Sampling algal mat at large basin
Langpu geothermal area
Obtain material from a range of unique Chinese hypersaline and
thermal sites
Survey microbial biodiversity, and establish and archive a
collection of novel microbes
Develop methods for the efficient isolation and recovery of
microbial genes from these sites
Identify and produce high added value new biomolecules derived
from these sites and assess these new biomolecules for
commercial exploitation
Deliverables and Achievements
• Sample Acquisition: The mounting of expeditions and collection of samples/nucleic acids from
seldom accessed thermal and hypersaline sites. – The first expedition to the Yunnan Province
(Rehai area) was completed in March 2003 and the second expedition to Inner Mongolia will take
place in September 2003.
• Gene Acquisition: We will recover microbial genes from a variety of samples, some partially
processed on site . There has been good progress with the isolation of DNA from geothermal sites
visited during the first sampling expedition and we have begun to generate bacterial gene libraries
derived from these sites. The first gene library derived from “Higher Microbes” (i.e. fungi, algae
and protozoans) has been constructed from a hot spring algal mat.
• Organism Acquisition: We will generate and archive culture collections of microbes from these
sites. The first joint paper by Consortium members has been submitted for publishing approval.
• Enzyme Acquisition: We will detect and assess industrially-relevant enzymes from the genetic
resources derived from these expeditions and technologies.
The Consortium
Hydrothermal outbreak pool
Rehai thermal area
•Prof. Bill Grant
- University of Leicester, UK
•Prof. Antonio Ventosa
- University of Sevilla, Spain
•Prof. Don Cowan
- University of the Western Cape, South Africa
•Prof. Ma Yanhe
- Institute of Microbiology, Chinese Academy of Sciences
•Prof. Brian Jones
- Genencor International BV, The Netherlands
The Sampling Team
Contacts
Coordinator: Prof. Bill Grant,
EU Scientific Officer: Dr. Indridi Benediktsson
University of Leicester, UK
[email protected]
[email protected]
极端微生物实验室
Extremozyme genes
• DNA library
• Metagenomic
DNA Libraries
• cDNA Library
High thoughput screening
-Mannanase
-Amylase
-Xylanase
Lipase
Catalase
…….
Design of an Integrated Environmental
Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of
Agricultural Wastes in Paper Industry
An EU - China Collaboration
Review of FP4
in IMCAS
European Commission Fourth Framework RTD Programme
Thematic Programme:Basic Natural Resources
Project number:ERBIC18CT980284
Design of an Integrated Environmental Clean Industrial Fungal Process Integrating
Water Management for the Valorisation of Agricultural Wastes in Paper Industry
Objectives:
1.Water pollution prevention: Development of a fungal enzyme
process using mainly laccases for improving annual plant kraft pulp
bleachability.
2.Water pollution treatment and recycling: Design of a fungal
process for effluent detoxification and decolourization in order to
facilitate the subsequent biological treatment and water recycling.
European Commission Fourth Framework RTD Programme
Thematic Programme : Basic Natural Resources
Project Number: ERBIC18CT980284
Coordinator: Prof.Dr. Jean-Claude Sigoillot
Institut National De La recherche Agronomique
[email protected]
The Consortium: -DR.GUIGAN FANG
CHINESE ACADEMY OF FORESTRY
-DR.HEINZ JELLER
ANDRITZ AG, AUSTRIA
-DR.LIN GUO
INSTITUTE OF MICROBIOLOGY, CAS
Activities:
To achieve these objectives, the proposed project has
been constructed with an integrated multidisciplinary
approach combining complementary Chinese and
European industrial partners including small enterprises in
close association with academics originating from both
countries.
Ongoing International Cooperative Projects
•Design new chromegens
Oxoid-Fisher Limited,UK
•Biodiversity and conservation of important bio-resources
Royal Botanic Gardens, Kew, UK
•Biodiversity of mycorrhyzal bacteria in forests of China and UK
Oxford University,UK
•Acidophilic actinomycetes as a source of new natural products
University of Newcastle, UK
IMCAS look forward to establishing the
long-term cooperation with EU
An EU – China
Collaboration
Thank You