Transcript 新生儿胆红素代谢 Neonatal Bilirubin Metabolism Chen Dapeng MD, PhD Pediatric Department West China Second University Hospital Objective To understand the characteristics of neonatal bilirubin metabolism. Jaundice(黄疸) Incidence in Newborn Term baby (>37w) 50% Preterm.

新生儿胆红素代谢
Neonatal Bilirubin Metabolism
Chen Dapeng MD, PhD
Pediatric Department
West China Second University Hospital
Objective
To understand the characteristics of
neonatal bilirubin metabolism.
Jaundice(黄疸)
Incidence in Newborn
Term
baby (>37w)
50%
Preterm baby(<37w)
80%
Core of Bilirubin Metabolism
Unconjugated bilirubin
(未结合胆红素)
glucuronic acid
（葡萄糖醛酸）
Conjugated bilirubin
（结合胆红素）
Metabolism of Bilirubin
Metabolism of Bilirubin
1.
Increase of bilirubin production
Adult 3.8mg/L
Newborn 8.5mg/L
Red Blood Cell
RBC life span
120 d
80 d
RBC Quantity
4.5x1012/L
6.5x1012/L
2.Lack of Albumin(白蛋白)
3.Poor hepatic function
One protein
Unconjugated Bilirubin
Y/Z Protein(Y/Z蛋白)
One enzyme
Unconjugated Bilirubin
glucuronyl transferase(葡萄糖醛酸转移酶)
Conjugated bilirubin
4.Increasing of
Enterohepatic circulation
(肠肝循环)
Enterohepatic circulation
Definition: Circulation of bilirubin, which was absorbed
from the intestine and carried to the liver, where it
was secreted into the bile and again enter the
intestine.
Neonatal Enterohepatic circulation
Glycuronidase 葡萄糖醛酸苷酶
Summary of Neonatal Bilirubin Metabolism
1.
Increase of bilirubin production
2.
Lack of albumin
3.
Poor hepatic function
4.
Increase of enterohepatic circulation
Physical and Pathologic
Jaundice of Newborn
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