Transcript LYMPHOCYTE FUNCTION LYMPHOPOEISIS CD 3, 4, 8 PRO PRO T B THYMUS Lack: Di George’s Syndrome CD 4 LYMPH CD 8 TCR BCR Lack = X-linked agammaglobulinemia Gene Reshuffling TdT ADA Lack = SCID CFU PPT SC CFU L NK S GVHD BONE MARROW.

LYMPHOCYTE
FUNCTION
LYMPHOPOEISIS
CD 3,
4, 8
PRO
PRO
T
B
THYMUS
Lack:
Di George’s
Syndrome
CD 4
LYMPH
CD 8
TCR
BCR
Lack = X-linked agammaglobulinemia
Gene Reshuffling
TdT
ADA
Lack = SCID
CFU
PPT
SC
CFU
L
NK
S
GVHD
BONE MARROW
B-cell Maturation
Humoral Immunity
CALLA
CD-10
Lymph Tissues
Chr 14
Reshuffling
Heavy Chain
Mu
B-cells
PRO B
YYY
Y
EBV
ALL Pre-B
CD-21
Chr 2-22
Reshuffling
Light Chain
PRE B
YY
YY
Antigen
Immature B
Y
Loses TdT
Resp. Tract
GI Tract
Payer's Patches
Lack of IgA:
Selective IgA Deficiency
Switch Class
IgM  IgG
Tumor
Naïve B
Rabbit Ab
To count B cells
Thyroid
Y
Transplant
Hyperacute
reaction
Encapsulated
Bacteria
Diphtheria
Strep
Or
pneumonia
Tetanus Toxin
Plasma Cell
Mainly IgA, IgG
Multiple Myeloma
if found in blood
B Cell
Memory Cell
Adult ALL,
CLL
T-cell Maturation
B
Cell Mediated Immunity
HIV
THYMUS
CD 4
TH
CD 4
CD 8
MAC
TX
TH 1
TB or virus
MHC-I
Endogenous:
I’m infected, kill
me!
BM
LYMPH
CD 4
TH
IL 4, 5, 6, 10, 13
“Make Abs to
this Ag”
IFN
IL 2
TH 2
IL 2
“Remember
this Ag”
TH
Transplant
Delayed Rejection
CD 8
TX
IL 2
HIV
Anergy Test
And contact
dermatitis
CD 4
TH
MHC-II
CD 8
CD 8
TX
Exogenous:
I’ve seen this
bug, make Abs!
TReg
Thyroid
CD 4
Loses
TdT
MAC
IL 1 and
cytokines
Bacteria
TDH
BLOOD
IgE
Histamine
release
Mast
IL and
cytokines