Applied Biotechnology Innovation Centre RESEARCH AND TECHNOLOGY TRANSFER AT THE BIO/NANO/ELECTRONIC INTERFACE Ioanis Katakis Octoner 25, 2004 Tarragona Applied Biotechnology Innovation Centre WHO ARE WE? MEMBERS Evolution Technicians Students PhD 15 BBCAT 0 of membership Applied Biotechnology Innovation.
Download ReportTranscript Applied Biotechnology Innovation Centre RESEARCH AND TECHNOLOGY TRANSFER AT THE BIO/NANO/ELECTRONIC INTERFACE Ioanis Katakis Octoner 25, 2004 Tarragona Applied Biotechnology Innovation Centre WHO ARE WE? MEMBERS Evolution Technicians Students PhD 15 BBCAT 0 of membership Applied Biotechnology Innovation.
Applied Biotechnology Innovation Centre RESEARCH AND TECHNOLOGY TRANSFER AT THE BIO/NANO/ELECTRONIC INTERFACE Ioanis Katakis Octoner 25, 2004 Tarragona Applied Biotechnology Innovation Centre WHO ARE WE? MEMBERS 30 Evolution Technicians Students 25 PhD 20 15 10 BBCAT 5 0 of membership Applied Biotechnology Innovation Centre HOW WE FINANCE OUR WORK? 1200 private public KEUROS 900 600 300 0 BBCAT Applied Biotechnology Innovation Centre HOW WE WORK? Knowledge Creation • • • • • • Biosensors Bioelectronics Nanotechnology Microsystems (Photo)catalysis Biotechnology Innovation Technology Transfer • Clinical & veterinary diagnostics • Biomedical applications • Food & Agriculture • Pharmaceutical & Fine Chemicals • Chemical Industry • Renewable energies • Spin off companies • New educational/vocational models Applied Biotechnology Innovation Centre OUR SECOND RESEARCH PLAN Enzyme (NAD) BIOSENSORS Immunosensors BIOELECTRONICS DNA Biofuel cells Neuron chip NANOTECHNOLOGY Directed deposition Nanocatalysts MICROSYSTEMS NEW AREAS Aptamers Bioreactors Solar Cells Screen printed Microreactors APPLIED RESEARCH Making immuno strips and systems Applied Biotechnology Innovation Centre FROM SUB MOLECULAR TO MACRO ECOSYSTEMS ORGANISMS MULTI MICRO BIOREACTORS BIOELECTRONICS TISSUES CELLS PROTEINS GENES TISSUE ENGINEERING IN VITRO SYSTEMS BIOSENSORS NANOTECHNOLOGY MATERIALS AND MICROSYSTEMS CHEMISTRY ORGANS ENVIRONMENTAL BIOTECHNOLOGY Applied Biotechnology Innovation Centre SOME RESEARCH LINES (1/4) SELF ASSEMBLY FOR THE ULTIMATE (BIO)CHEMICAL CATALYTIC FLEXIBILITY - + - + + - • Narváez et al. Biosens Bioelectr 15:43-52 (2000) • Narváez et al. J Electroanal Chem 430:227-33 (1997) Applied Biotechnology Innovation Centre SOME RESEARCH LINES (2/4) SUPRAMOLECULAR ARCHITECTURES FOR COMPLEX BIOSENSING, AMPLIFICATION, AND CATALYSIS TASKS Sonicate, extrude • Popescu et al. J Electroanal Chem 464:208-14 (1999) (+2 in preparation) • V. Pavlov Thesis (2005) on biosensors, K. Horton DEA (2003) liposomes Applied Biotechnology Innovation Centre SOME RESEARCH LINES (3/4) NANOCOLLOID SYNTHESIS AND MODIFICATION FOR NANOPATTERNING AND ARTIFICIAL INTELLIGENCE conjugation gold colloid oligonucleotide deposition colloidal goldoligonucleotide selective deposition • Campàs & Katakis Int J Env Anal (in press), PCT&US pat. Appl (2002) • M. Campàs PhD Thesis (2003), S. Dondapati DEA Thesis (2004) Applied Biotechnology Innovation Centre SOME RESEARCH LINES (4/4) TOWARDS THE ULTIMATE NANOMACHINE(?): SELF POWERED, SELF PROPELLED, SELF PROPAGATING eOs+ Os+ - Os+ Os+ Os+ Os+ - - - + - + - - + -}N 2 + + + + - ++ + + + - - ++ + }N1 + + + - Os+ - Os+ Os+ Os+ Os+ Os+ Peroxidase uses H2O2 and consumes electrons at E2 Glucose oxidase produces H2O2 Glucose oxidase produces electrons at E1 e• P. Pescador DEA thesis (2004) Biofuel cells Applied Biotechnology Innovation Centre BBG/DINAMIC MOST VALUABLE RESOURCE SENIOR MEMBERS AND PROJECT MANAGERS • Magda Constanti (Lector, Microbiology) • Teresa Hechevarria (Torres Quevedo, Chemical Engineering) • Ioanis Katakis (Associate professor, Chemical Engineering) • Petros Lenas (Ramon y Cajal, Tissue Engineering) • Przemyslaw Los (Visiting Professor, Physical Chemistry) •Josep Ma Montornés (Post doctoral fellow, Org. Synthesis) • Susana Rodríguez (Ramon y Cajal, Bioprocess Engineering) • Jose Luis Toca-Herrera (Ramon y Cajal, Nanotechnology) Applied Biotechnology Innovation Centre BBG/DINAMIC MOST VALUABLE RESOURCE PERMANENT TECHNICIANS AND SUPPORT • Barbara Vastenavond (Administration) • Lea Gragert (Administration and accounting) • Mònica Mir (Technician, Electrochemistry) • Joaquim Solana (Marketing, Project support) • Diego Bejarano (Technician, Chemical & Process Engineering) • Marta Jimenez (Technician, microbiology) • MireiaMassanell (Technician, Immunology) • Cristina Sanz (Technician, Analytical techniques) • Xavier Roch (IT Technician) Applied Biotechnology Innovation Centre BBG/DINAMIC MOST VALUABLE RESOURCE GRADUATE STUDENTS AND TRAINEES • Mònica Mir (PhD Student, Bioelectrochemistry) • Srujan Dondapati (PhD Student, Bioelectrochemistry) • Paula Pescador (PhD Student, Molecular biology/fuel cells) • Veronica Saravia (PhD Student, Tissue engineering) • Viviana Duarte (PhD Student, Immunosensors) • Frank Jeyson (PhD Student, Biofuel cells) • Kelly Briceño (PhD Student, Bioelectrochemistry) • Peter Pfeiffer (PhD Student, Biomolecular interactions) • Rory McNally (MS trainee, Microbiology) • Denise Hogan (MS trainee, Microbiology) • Antoni Montseny (Undergraduate trainee) • David Romero (Undergraduate trainee) • Josep Pamies (Undergraduate trainee) Applied Biotechnology Innovation Centre OUR PRODUCTIVITY IN PERSPECTIVE • PhD Theses: • DEA Theses: • Publications/PDI/year: • Citations/PDI/year: DATA BBG 2,0 9,0 2,5 21,0 (1995-2004) (1995-2004) (ISI 1990-1999) (ISI 1990-1999) DATA Catalunya (all areas) • Citations/article/year: 1,7 (1994-1998) DATA USA (Chemical Engineering source: NRC 1990-94) • Citations/PDI/year: 23,44 (rank #1 U of Minnesota) 20,78 (rank #2 Stanford U) • Publications/PDI/year: 4,6 (rank #1 U of Minnesota) 2,5 (rank #13 SUNY, Buffalo) 1,7 (rank #72 U of Tulsa) Applied Biotechnology Innovation Centre ACKNOWLEDGEMENTS Our work is financed by: • INNOCUOUS (Immunostrips for TCA detection) • MICROPROTEIN (Patterning and arraying) • HEALTHY AIMS (Fuel cells) • CIDEM and our Clients • URV, DURSI, MECD