Transcript Antibiotics Oversimplified

Gram Negative
Gram Positive
Two Drug Bugs
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Enterobactor
Bacteroides
Salmonella
MRSA
Shigella
Strep
Oral Anaerobes
Fragilis – Gut
Melanogenicus –
Respiratory
Anaerobes
Staph
MRSE
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Penicillin
(Pen G, Pen VK)
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Enterobactor
Bacteroides
Salmonella
MRSA
Shigella
Strep
Oral Anaerobes
Anaerobes
Staph
MRSE
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Synthetic Penicillins
Augmentin / Unasyn
(w/ beta lactamase inhibitor)
Ampicillin / Amoxicillin
Beta
Lactamase
Serratia
Aerobes
H. Flu
Pseudomonas
Acinetobactor
Klebsiella
Salmonella
E. Coli
Shigella
Citrobactor
Beta
Lactamase
Strep
Enterobactor
Bacteroides
Oral Anaerobes
Anaerobes
Staph
MRSA
MRSE
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Synthetic Penicillins
Nafcillin /
Methicillin//Dicloxacillin
Ampicillin / Amoxicillin
Aerobes
Serratia
H. Flu
Pseudomonas
Acinetobactor
Klebsiella
Salmonella
E. Coli
Shigella
Citrobactor
Beta
Lactamase
Strep
Enterobactor
Bacteroides
Oral Anaerobes
Anaerobes
Staph
MRSA
MRSE
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Anti-Pseudomonal Penicillins
Zosyn / Timentin
Piperacillin
Penicillin
(Pen G, Pen VK)
(w/ beta lactamase inhibitor)
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Enterobactor
Bacteroides
Beta
Lactamase
Salmonella
Shigella
Proteus
Mirabilis
Strep
Oral Anaerobes
Staph
MRSA
MRSE
Clostridium
Difficile
Anaerobes
Spotty lines mean spotty coverage, look up individual coverages for
SPACE bugs other than Pseudomonas
VRE
Gram Negative
First Generation Cephalosporins
Gram Positive
Cephalexin, cefazolin, cefadroxil
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Salmonella
MRSA
Shigella
Strep
Enterobactor
Bacteroides
Oral Anaerobes
Anaerobes
Staph
MRSE
Clostridium
Difficile
VRE
Gram Negative
Second Generation Cephalosporins
Gram Positive
Cephalexin, cefazolin,
Cefuroxime,
Cefotetan,cefadroxil
cefoxitin
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Salmonella
MRSA
Shigella
Strep
Enterobactor
Staph
MRSE
Cefoxitin and Cefotetan only
Bacteroides
Oral Anaerobes
Anaerobes
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Third Generation Cephalosporins
Cephalexin, Cefotaxime,
Ceftriaxone,
cefazolin, cefadroxil
Cefdinir
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Salmonella
MRSA
Shigella
Strep
Enterobactor
Staph
MRSE
Ceftazidime
Bacteroides
Oral Anaerobes
Anaerobes
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Fourth Generation Cephalosporins
Cephalexin,
Cefipime
(Maxipime)
cefazolin, cefadroxil
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Salmonella
MRSA
Shigella
Strep
Enterobactor
Bacteroides
Oral Anaerobes
Anaerobes
Staph
MRSE
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Carbapenems
Meropenem, Imipenem, Ertapenem
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Salmonella
MRSA
Shigella
Strep
Enterobactor
Staph
MRSE
Ertapenem= No Pseudomonas
Bacteroides
Oral Anaerobes
Anaerobes
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Monobactams
Aztreonam
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Salmonella
MRSA
Shigella
Strep
Enterobactor
Bacteroides
Oral Anaerobes
Anaerobes
Staph
MRSE
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Aminoglycosides
Gentamicin, Tobramycin, Amikacin
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Salmonella
MRSA
Shigella
Strep
Enterobactor
Bacteroides
Oral Anaerobes
Anaerobes
Staph
MRSE
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Carbapenems
Meropenem, Imipenem, Ertapenem
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Salmonella
MRSA
Shigella
Strep
Enterobactor
Staph
MRSE
Ertapenem= No Pseudomonas
Bacteroides
Oral Anaerobes
Anaerobes
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Simple Fluroquinolones
Cephalexin, cefazolin,
Ciprofloxacin,
Ofloxacin,cefadroxil
Norfloxacin
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Salmonella
MRSA
Shigella
Strep
Enterobactor
Staph
MRSE
VRE
Ciproflxoci9n best FQ for Pseudomonas
Bacteroides
Oral Anaerobes
Clostridium
Difficile
Anaerobes
Fluroquinolones also cover atypicals like Chlamydia, Legionella and Mycoplasma
Gram Negative
Gram Positive
Simple Fluroquinolones
Cephalexin, cefazolin,
Ciprofloxacin,
Ofloxacin,cefadroxil
Norfloxacin
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Salmonella
MRSA
Shigella
Strep
Enterobactor
Staph
MRSE
VRE
Ciproflxoci9n best FQ for Pseudomonas
Bacteroides
Oral Anaerobes
Clostridium
Difficile
Anaerobes
Fluroquinolones also cover atypicals like Chlamydia, Legionella and Mycoplasma
Gram Negative
Gram Positive
“Respiratory” Fluroquinolones
Cephalexin,
Levofloxacincefazolin, cefadroxil
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Salmonella
MRSA
Shigella
Strep
Enterobactor
Staph
MRSE
VRE
**
Bacteroides
Oral Anaerobes
Clostridium
Difficile
Anaerobes
Fluroquinolones also cover atypicals like Chlamydia, Legionella and Mycoplasma
** Resistance develops quickly
Gram Negative
“Broad Spectrum” Fluroquinolones
Gram Positive
Cephalexin,
Moxifloxacincefazolin, cefadroxil
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Salmonella
MRSA
Shigella
Strep
Enterobactor
Bacteroides
Oral Anaerobes
Staph
MRSE
VRE
Clostridium
Difficile
Anaerobes
Fluroquinolones also cover atypicals like Chlamydia, Legionella and Mycoplasma
** Resistance develops quickly
Gram Negative
Gram Positive
Macrolides
Cephalexin, cefazolin,
Eythromycin,
Clarithromycin,
cefadroxil
Azithromycin
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Salmonella
MRSA
Shigella
Strep
Enterobactor
Bacteroides
Oral Anaerobes
Staph
MRSE
Clostridium
Difficile
Macrolides also cover atypicals like Chlamydia, Legionella and Mycoplasma,
Toxoplasmosis
VRE
Gram Negative
Gram Positive
Ketolides
Cephalexin,
Telithromyicin
cefazolin, cefadroxil
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Salmonella
MRSA
Shigella
Strep
Enterobactor
Bacteroides
Oral Anaerobes
Staph
MRSE
Clostridium
Difficile
Macrolides also cover atypicals like Chlamydia, Legionella and Mycoplasma,
Toxoplasmosis
VRE
Gram Negative
Gram Positive
Tetracyclines
Cephalexin, cefazolin,
Tetracycline,
Doxycycline,
cefadroxil
Minocycline
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Salmonella
Shigella
Citrobactor
Strep
Enterobactor
CA- MRSA
StaphMRSA MRSE
VRE
Moderate Activity against anerobes
Bacteroides
Lots of Resistance!!
Oral Anaerobes
Clostridium
Difficile
Tetracyclines also cover atypicals like Chlamydia, Legionella and Mycoplasma,
Gram Negative
Gram Positive
Tigecycline
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Salmonella
MRSA
Shigella
Strep
Enterobactor
Bacteroides
Oral Anaerobes
Staph
MRSE
Clostridium
Difficile
Tigecylcine also covers atypicals like Chlamydia, Legionella and Mycoplasma,
VRE
Gram Negative
Gram Positive
Trimethoprim / Sulfa
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Salmonella
CA- MRSA
Strep Staph MRSA MRSE
Shigella
Citrobactor
Enterobactor
Klebsiella/E coli resistance increasing
Bacteroides
Oral Anaerobes
First Line drug for Community Acquired MRSA
Also covers Pneumocystis Carinii
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Vancomycin
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Enterobactor
Bacteroides
Salmonella
Shigella
CA- MRSA
Strep Staph MRSA MRSE
Oral Anaerobes
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Clindamycin
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Enterobactor
Bacteroides
Salmonella
Shigella
CA- MRSA
Strep Staph MRSA MRSE
Oral Anaerobes
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Metronidazole
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Enterobactor
Bacteroides
Salmonella
Shigella
CA- MRSA
Strep Staph MRSA MRSE
Oral Anaerobes
Also Covers Trichomonas
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Daptomycin
Linezolid
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Enterobactor
Bacteroides
Salmonella
Shigella
CA- MRSA
Strep Staph MRSA MRSE
Oral Anaerobes
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Enterobactor
Bacteroides
Salmonella
MRSA
Shigella
Strep
Oral Anaerobes
Anaerobes
Staph
MRSE
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Enterobactor
Bacteroides
Salmonella
MRSA
Shigella
Strep
Oral Anaerobes
Anaerobes
Staph
MRSE
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Enterobactor
Bacteroides
Salmonella
MRSA
Shigella
Strep
Oral Anaerobes
Anaerobes
Staph
MRSE
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Enterobactor
Bacteroides
Salmonella
MRSA
Shigella
Strep
Oral Anaerobes
Anaerobes
Staph
MRSE
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Enterobactor
Bacteroides
Salmonella
MRSA
Shigella
Strep
Oral Anaerobes
Anaerobes
Staph
MRSE
Clostridium
Difficile
VRE
Gram Negative
Gram Positive
Aerobes
Serratia
H. Flu
Pseudomonas
Klebsiella
Acinetobactor
E. Coli
Citrobactor
Enterobactor
Bacteroides
Salmonella
MRSA
Shigella
Strep
Oral Anaerobes
Anaerobes
Staph
MRSE
Clostridium
Difficile
VRE