Transcript Ragweed pollen load and sensitisation in Hungary

Investigation of allergic
sensitisation in areas of Hungary
with different level of
ragweed pollution
Páldy A1 Bobvos J1., Nékám K2., Bitay Zs3., Csajbók V4., Kelemen A5.,
Major T6.
1 National
Institute of Environmental Health, 2Hospital of Brothers of Mercy,
Budapest, 3Bács-Kiskun County Dispensary Kecskemét,
4Józsa András Hospital, Nyíregyháza, Szabolcs-Szatmár Bereg County
5Heves
County Dispnesary Eger, 6HRCh Hospital of Cardio-pulmonary patients Mosdós
Aim
 To investigate the pattern of sensitisation of
allergic patients in areas with different level of
ragweed pollution
 Sampling sites and patients:

Kecskemét, Nyíregyháza, Eger



50-50 adult allergic patients
Mosdós: 22 allergic patients
Study: questionnaire survey
 Specific IgE measurement by using a
common panel
Examined
allergens in
children and
adult
population with
symptoms of
allergy,
Hungary, 2006
Cladosporium herbarum
Cladosporium herbarum
Alternaria alternata
Alternaria alternata
Hámszövet keverék
mix of cutaneous tissue
Macska hámszövet
cat cutaneous tissue
Kutya hámszövet
dog cutaneous tissue
Kutya szőr
dog hair
Macska szőr
cat hair
Házipor keverék (H1, D1, D2, I6)
mix of housedust
Csótány
cocroach
Dermatophagoides pteronyssinus (poratka) Dermatophagoides pteronyssinus (poratka)
Dermatophagoiedes farinae (liszt atka)
Dermatophagoiedes farinae (liszt atka)
Lepidoglyphus destructor
Lepidoglyphus destructor
Tyrophagus putresentiae
Tyrophagus putresentiae
Fű keverék (G2,G3,G5,G6,G8,G10,G12,G13,G14,G15,G16)
grass mix
Csenkesz faj
Fescue (Festuca)
Kukorica
maize
Gyom keverék (W6, W9, W10, W12, W20) weed mix
Lándzsás útifű
plantain (Plantago)
Fehér libatop
Goose-foot family(chenopodiaceae)
Aranyvessző
golden rod
nagy csalán
nettle family (Urticaceae)
Fekete üröm
Mugwort (Artemisia)
Szőrös disznóparéj
Amaranth (Amaranthus)
Juh sóska
Sorrel (Rumex)
Közönséges falgyom
Common pellitory (Parietaria erecta)
Ürömlevelű parlagfű
ragweed (Ambrosia)
Fa keverék (T1, T2,T 3, T4, T7, T11, T12, T14)
mix of trees)
Juhar
Maple (Acer)
Hamvas éger
Alder (Alnus)
Nyírfa
Birch (Betula)
Mogyoró
Hazel (Corylus)
Platán
Plane (Platanus)
Fűz
Willow (Salix)
Magas kőris
Ash (Fraxinus)
Élelmiszer keverék (F1,F2,F4,F5,F8, F75, F76,F77,F78,F79,F81)
mix of food)
Tojásfehérje
egg white
Tehéntej
cow milk
Búzaliszt
flour of corn
Rozs
rye
Tojássárgája
egg yellow
Kazein (marha)
caseine
Élelmiszer keverék (F13, F14, F16, F17, F26,mix
F45,
of F48,
food)F83)
Földimogyoró
peanut
Szójabab
soybeen
Dió
nut
Mogyoró
hazel nut
Szezámmag
sesam seed
Mustár
mustard
Latex
Latex
Results

Evaluation of the questionnaire

Description of sensitisation

Demonstration of the association of
ragweed sensitisation and answers to the
questions
Distribution of answers to the
questionnaire I.
60
50
40
Do you have
allergic symptoms
30
Feather
20
Breast-fed
Ever smoked
count
10
Mold
0
Number of sample
1
2
3
4
Sampling site: M - E - K - NY
In Eger and Kecskemét the rate of breast fed patients was higher
In Eger and Nyíregyháza the rate of complaints due to feather allergy was high
The rate of smokers and rate of mould in flats was the highest in Kecskemét
Distribution of answers to the
questionnaire II.
60
Dust allergy
50
Pollen allergy
40
Food allergy
Allergic skin
30
symptoms
Pet allergy
20
Drog allergy
Insect bite
count
10
Number of
0
sample
1
2
3
4
Sampling site: M - E - K - NY
The leading complaints are housedust mite and pollen allergy – highest in Eger,
Allergic skin symptoms and pet allergy – highest in Kecskemét.
Distribution of polysensitisation acc.
to the questionnaire
60
Multiple allergy
50
7
40
6
5
30
4
20
3
2
Count
10
1
0
0
1
2
3
4
Sampling site: M - E - K - NY
Rate of polysensitized patients -highest in Eger, lowest in Nyiregyhaza
Animal hair allergy
70
60
50
40
30
Cow
Pig
20
Poultry
Sum
10
Cat
0
Dog
1
2
3
4
Sampling site: M - E - K - NY
Cow hair allergy was reported in Mosdós and Kecskemét
Rate of patients reporting dog hair allergy is high in each site
Type of house and allergic complains
100
60
Type of house
50
40
90
Other
80
Housing
70
Insect bite
60
Drug allergy
50
Pet allergy
40
Allergic
30
skin symptoms
20
Food allergy
10
Pollen allergy
district (H)
Block
30
of flats (B)
Attached
20
house (A)
count
10
hause (F)
0
Missing
1
2
3
Sum
Family
0
4
2
3
4
Type of house: F - A - B - H
Sampling site: M - E - K - NY
In Mosdós, majority of patients
live in family houses,
In Eger and Nyíregyháza the
majority of them live in housing
district (panel building).
Dust allergy
1
The type of house does not affect the allergic
complaints. House dust mite allergy is the most
frequent in block houses, drug allergy and skin
symptoms – in family houses, pet hair – in panel
buildings.
Allergic symptoms and breast feeding
100
100.0
90
90.0
80
80.0
70
70.0
Insect bite
60
60.0
Drog allergy
50
50.0
Pet allergy
40
40.0
Allergic
30.0
skin symptoms
20.0
Food allergy
10.0
Pollen allergy
30
Count
20
Yes
10
0
No
0
1
2
3
4
5
Multiple allergy
Multiallergic symptoms are
less frequent among non
breast fed patients.
6
7
Mean
Breast fed
0.0
Dust allergy
0
1
Breast fed
Rate of pollen and mite alleric
symptoms are less frequent among
breast fed patients.
Percentage of sensitisation in the total sample
Ash
Goose-foot
Birch
Corn wheet
Maple
Plantago
Urtica
Mugworth
Maize
Hazel
housedust mite
grass
flour mite
Golden rod
Willlow
Plane
Amaranth
Rye
Cocroach
Mustard
Alternaria alternata
Ash
Sorrrel
Dog hair
Latex
Sesam seed
Cat cutaneous tissue
Hazel
cow milk
Cladosporium herbarum
dog cutaneous tissue
cat hair
egg white
goose feather
pea nut
nut
soybeen
casein
egg yellow
X
X
X
X
X
X
X
X
X
X
X
X
x
0,0
5,0
10,0
15,0
20,0
25,0
30,0
Ragweed
Common pellitory
Fescue (Festuca)
35,0
40,0
The most frequently detectable outdoor allergen
IgEs by sites
Alder
Willow
Plane
Hazel
Birch
Ash
Maple
Ragweed
Commo n pellito ry
Eger
Sorrel
Amaran th
Nyíegyháza
Mugwo rth
Mosdós
Kecskemét
Urtica
Golden rod
Goose feet
Plantago
Maize
Fescue
Alternaria
0,0
20,0
40,0
60,0
80,0
The most frequently detectable food allergen and animal
IgE levels (%) by sites
latex
mustard
sesa m seed
rye
corn whee t
flour mite
dust mite
cocroach
goose feather
Eger
Nyíegyháza
Mosdós
Kecskemét
dog hair
dog cuta neou s tissue
cat cutaneous tissu e
0,0
10,0
20,0
30,0
40,0
50,0
60,0
70,0 %
Frequency of sensitisation in Eger
Cat cutaneous tissue
Rye
Sesam seed
Willow
Sorrel
Golden rod
Hazel
Am aranth
Dog hair
Alternaria
Flour m ite
Housedust m ite
Mustard
RAGWEED
Plane
Mugw ort
Goose feather
Birch
Goosefoot
Maize
Cocroach
Maple
Urtica
Plantago
Fescue
Ash
Com m on pellitory
Corn flour
0,0
10,0
20,0
30,0
40,0
50,0
60,0
%
70,0
Frequency of sensitization in Kecskemét
Am aranth
Sesam seed
Rye
Plane
Birch
Urtica
Mustard
Hazel
Ash
Latex
Fescue
Maple
Sorrel
Alder
Willow
Mugw ort
Corn flour
Golden rod
RAGWEED
%
0,0
10,0
20,0
30,0
40,0
50,0
60,0
Frequency of sensitisation in Nyíregyháza
Rye
Ash
Flour m ite
Cat cutaneous tissue
Sesam seed
Cocroach
Corn flour
Plane
Sorrrel
Am aranth
Golden ros
Housedust m ite
Dog hair
Alternaria
Mustaed
Willow
Hazel
Mugw ort
Plantago
Maize
RAGWEED
Fescue
Birch
Maple
Goose feather
Alder
Goosefoot
Urtica
Com m on pellitory
%
0,0
10,0
20,0
30,0
40,0
50,0
60,0
Frequency of sensitisation in Mosdós
Willow
Sorrel
Urtica
Rye
Com m on pellitory
Alternaria
Latex
Goosefoot
Flour m ite
Cat cutaneous tissue
Ash
Plane
Am aranth
Golden rod
Plantago
Maple
Mugw ort
Maize
Dog hair
Hazel
Alder
Housedust m ite
Birch
Fescue
RAGWEED
0,0
10,0
20,0
30,0
40,0
50,0
60,0
70,0
%
80,0
Prevalence of pollen and dust mite allergy
complaints in relation to ragweed sensitised patients
30
100
90
80
70
20
60
50
40
10
30
Dust allergy
20
No
0
Yes
1
2
3
4
Sampling site: M - E - K - NY
In Eger and Kecskemét complaints do
not correlate with ragweed IgE positivity
N of W1
N of W1
Pollen allergy
Yes
10
0
No
1
2
3
4
Sampling site: M - E - K - NY
In general 33% of patients have IgE
against house dust mite - in more than
50% in Nyíregyháza.
Detectable anti - ragweed IgE in breast fed
and smoking patients
30
30
20
20
10
10
No
0
Yes
1
2
3
4
Sampling site: M - E - K - NY
In Kecskemét and in Nyíregyháza rate of
ragweed IgE pozitivity is higher among
non breast fed patients.
Ever smoking
N of W1
N of W1
Breast-fed
No
0
Yes
1
2
3
4
Sampling site: M - E - K - NY
In Kecskemét rate of smoking
patients is higher among ragweed
positive patients
The project was founded by:
National
Research and Development Program socio-health research
NKFP -1B/022/04. 2005-2006