XXXIV Nordic Congress in Clinical Chemistry

SePtember 16 –19, 2014 At SvenSkA mäSSAn in GöteborG

Final Programme

www.nfkk2014.se

Nordisk Forening for Klinisk Kemi

S K K L F

Sveriges klinisk kemiska laboratorieingenjörers förening C: 88 M: 0 Y: 57 K: 36

Contents

Welcome ........................... 1 Committees ........................ 2 Scientific Program, Overview ..... 4 Scientific Program, Day by Day ... 7 Posters list ........................ 13 Author index ..................... 18 Guidelines for Speakers ......... 24 Social Program ................... 26 Congress Information ........... 27 General Information ............. 28 Our Exhibitors .................... 34 City Map ......................... 36

Dear nCCC Delegates

It is a pleasure and a privilege to welcome you to Gothenburg, Sweden, for the XXXIVth Nordic Congress in Clinical Chemistry on September 16 –19, 2014. A major aim of the NCCC 2014 is to gather all professions in the clinical labs in the Nordic countries, to meet, discuss and share knowledge. Another aim is to broaden our perspective with the overall theme of ”Future opportunities in clinical chemistry”. This includes exciting examples of how the laboratory with its expertise among physicians, biomedical scientists, chemists and laboratory engineers can develop further as a diagnostic partner. The meeting will also cover the use of new biomarkers in risk assessment and diagnosis, novel areas of biomarker discovery, including glycoproteomics, tissue-specific inflammation and an interesting example of using biomarker patterns in multivariate analysis. We will also learn about emerging laboratory techniques, including Next Generation Sequencing and single molecule detection.

We wish to extend a cordial welcome to Gothenburg to all of you, and we hope that, during this meeting and especially at the spectacular Glitter & Glamour banquet on the 18th of September, you will meet old friends, make new friends and establish important future connections with colleagues throughout the Nordic countries. On behalf of the organizing committee I wish you all VERY WELCOME to Gothenburg!

Ola Hammarsten

President, XXXIV Nordic Congress in Clinical Chemistry

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Committees

Organising Committee

Ola Hammarsten,

Chairman of the Scientific Committee for The XXXIVth Nordic Congress in Clinical Chemistry, MD, PhD, Professor, Senior Consultant, Clinical Chemistry, Sahlgrenska University Hospital

Birgitta Kallberg,

Head of Unit Clinical Chemistry, Sahlgrenska University Hospital/Mölndal

Camilla Brantsing,

Biomedical Scientist, Section leader at Clinical molecular research, Clinical Chemistry, Sahlgrenska University Hospital

Therese Lorentzon Gräbel,

Head Secretary, Clinical Chemistry, Sahlgrenska University Hospital

Scientific Committee

Ola Hammarsten

, Chairman of the Scientific Committee for The XXXIVth Nordic Congress in Clinical Chemistry, MD, PhD, Professor, Senior Consultant, Clinical Chemistry, Sahlgrenska University Hospital

Jorge Asin Cayuela

, MD, PhD, Associate Professor, Clinical Chemistry, Sahlgrenska University Hospital

Julia Asp

, PhD, Associate Professor, Clinical Chemistry, Sahlgrenska University Hospital

Anders Elmgren

, MD, PhD, Clinical Chemistry, Sahlgrenska University Hospital

Linda Fogelstrand

, MD, PhD, Clinical Chemistry, Sahlgrenska University Hospital

Stefan Jacobsson

, MD, Senior Consultant Clinical Chemistry, Sahlgrenska University Hospital

Anne-Marie Johannesson

, POCT Coordinator, Biomedical Scientist, Clinical Chemistry, Sahlgrenska University Hospital

Helene Johansson

, President, The Swedish Institute of Biomedical Laboratory Science, Regional Quality coordinator for haematologi cal diagnostics in Västra Götaland, Clinical Chemistry, Sahlgrenska University Hospital

Göran Larson

, MD, PhD, Professor, Senior Lecturer, Clinical Chemistry, Sahlgrenska University Hospital

Anders Larsson

, MD, PhD, Professor and Consultant, Clinical Chemistry, Akademiska Hospital, Uppsala

Anders Lindahl

, MD, PhD, Professor, Clinical Chemistry, Sahlgrenska University Hospital

Christian Löwbeer

, MD, PhD, Clinical Chemistry, Aleris Medilab

Mats Ohlson

, PhD, Clinical Chemistry, Sahlgrenska University Hospital, President of The Swedish Association of Clinical Biochemists

Lars Palmqvist

, MD, PhD, Associate Professor, Senior Consultant, Clinical Chemistry, Sahlgrenska University Hospital

Anne Ricksten

, PhD, Associate Professor, Clinical Chemistry, Sahlgrenska University Hospital

Henrik Zetterberg

, MD, PhD Professor of Neurochemistry, Senior Consultant in Clinical Chemistry, Sahlgrenska University Hospital

Conference Organisation

Conference organisation, registration and abstract management, sponsoring and exhibition.

Congress secretariat

Delegate service, housing, social programme MCI – Gothenburg Office Mail: [email protected] Phone: +46 (31) 780 30 30 www.mci-group.com

Congress venue

The Swedish Exhibition & Congress Centre (Svenska Mässan) Mässans Gata 2, Gothenburg, Sweden 3

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Scientific Program overview

Tuesday, September 16

11:00 13:20 13:30 15:15 Registration Opening Ceremony Afternoon Session:

Food, metabolomics and health

Welcome Reception in the exhibition hall Room: F3 F3

Wednesday, September 17

08:00–08:45 09:00 09:45 10:15 10:15 10:15 12:00 12:30–13:15 12:30–13:15 14:00 14:45 15:15 15:15 15:15 16:00 16:45 Breakfast seminar:

Beckman Coulter AB

Morning Plenary session:

Future biomarkers in acute coronary syndromes

Coffee and exhibition in the exhibition and poster area Biomarkers for future risk of cardiovascular disease Laboratory Point Of Care Testing – current and future challenges Novel laboratory technology – the single molecule era Lunch – Exhibition and lunch seminars Abbott Scandinavia AB Siemens Healthcare Diagnostics Afternoon Plenary session:

Surface-based single-liposome sensing for diagnostics and drug screening applications

Coffee and exhibition in the exhibition and poster area Novel diagnostic biomarkers in cardiology The Astrup Prize Next Generation Sequencing (NGS) in clinical diagnosis SKKLF Annual Meeting SSKF Annual Meeting Possibility for companies to arrange a social sponsor activity F1 F3 F1 F2 F3 F1 F2 F3 F1 F2 F3 Norden sköld F3

Thursday, September 18

08:00–08:45 08:00–08:45 09:00 09:45 10:15 10:15 10:15 12:00 12:30–13:15 12:30–13:15 14:00 14:45 15:15 15:15 15:15 16:45 19:30 Breakfast seminar:

HemoCue

Breakfast seminar:

Thermo Fisher Scientific

Morning Plenary session:

Vitamin B12 deficiency New trends in biomarkers and diagnostic strategies

Coffee and exhibition in the exhibition and poster area Rare disorders of erythrocytes. The dysregulation of iron and ferritin homeostasis Biomarkers in diagnosis of neurodegenerative diseases The future clinical laboratory as a diagnostic partner Lunch – Exhibition and lunch seminars Roche Diagnostics AB Sysmex Sverige Afternoon Plenary session:

Blood based biomarkers for Alzheimer’s disease – from case control to endophenotype discovery and from small to large, potentially huge, replication

Coffee and exhibition in the exhibition and poster area Laboratory diagnostics of myeloproliferative neoplasms The Eldjarn Prize Organization of the future clinical laboratory SFKK Annual Meeting Banquet “Glitter and Glamoure” in Estrad Restaurant F1 F2 F3 F1 F2 F3 F1 F2 F3 F1 Room: F2 F1 F3

Friday, September 19

09:00 09:45 10:15 10:15 10:15 12:00 Morning Plenary session:

Application of massively parallel sequencing (MPS) for clinical analyses: challenges and opportunities

Coffee and exhibition in the exhibition and poster area Clinical laboratory education today and tomorrow Future use of cancer biomarkers Biomarkers of kidney disease Poster Prize winning ceremony and Closing Remarks F3 F1 F2 F3 F3

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ARCHITECT

STAT

HIGH SENSITIVE TROPONIN-I ASSAY

Redefi ning Precision to Increase Confi dence in Decision Making for Chest Pain in the Acute Setting Hear more at our

Lunch Symposium

Wednesday, September 17

th

, 12.30-13.15, Room F1 or come to the Abbott Booth

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www.abbott.com

ADD-00003721 ADD-00003721_ARCH_hsTnI_Advert_Nordic-Congress_uk.indd 1 14.08.2014 08:36:41

Scientific Program, day by day

Tuesday, September 16

07:00 11:00 13:20– 13:30 13:30– 15:00 15:15 Exhibition building up and moving in 07:00–10:00 Registration Opening Ceremony Room: F3

Opening of the XXXI V Nordic Congress in Clinical Chemistry by the President Ola Hammarsten

Afternoon session: Food, metabolomics and health

Chair: Ola Hammarsten

Room: F3

Metabolites and antioxidants from dietary sources or produced endogenously are becoming an important field of study to find new biomarkers for disease. This session will discuss recent developments in the study of the human metabolome, inflammation and the role of antioxidants in health and disease 13:30 –14:00 Clinical Metabolomics: the next stage of clinical biochemistry? (101)

Jan Borén, Sweden

14:00–14:30 Can we tell infection from tissue damage as a cause of inflammation? A strategy using clinical chemistry and patten recognition methods (102)

Agnes Wold, Sweden

14:30–15:00 Antioxidants – the dark side (103)

Per Lindahl, Sweden

Welcome Reception in the exhibition hall

The reception is hosted by the City of Göteborg and the Region of Västra Götaland.

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Wednesday, September 17

08:00– 08:45 09:00 Breakfast seminar: Beckman Coulter AB Room: F1

Beckman Coulter’s Innovative Approach to Automating Clinical Molecular Diagnostics

Speaker: Brendan McKeown, PhD, Senior Molecular Applications Specialist, UK

Morning Plenary session Room: F3

Chair: Ola Hammarsten

Future biomarkers in acute coronary syndromes (201)

Bertil Lindahl, Sweden

Coffee and exhibition in the exhibition and poster area 09:45 10:15 Room F1: Biomarkers for future risk of cardiovascular disease

Our ability to use biomarkers to predict the development of cardiovascular disease in a healthy person, as a foundation for primary prevention, is currently less than perfect. This session will discuss approaches to finding new bio markers that may be used for pri mary and secondary prevention

Chairs: Ola Hammarsten and Christian Löwbeer

10:15–10:45

Endocrine and metabolic risk factors for cardio metabolic disease (202)

Olle Melander, Sweden

10:45–11:15

Novel and estab lished kidney disease biomarkers in the prediction of cardio vascular disease (203)

Johan Ärnlöv, Sweden

11:15–11:45

(204) Risk prediction of cardiovascular disease by high sensitive cardiac troponin assays

Per Venge, Sweden

11:45–12:00

United States

Integrated Targeted Quantitation Method for Insulin and its Therapeutic Analogs (205)

Ravindra Chaudhari,

12:00 Parallel Sessions Room F2: Laboratory Point Of Care Testing – current and future challenges

Small and locally available laboratory equipment gives the physician convenient and immediate access to test results. However, as the tests are often performed by untrained personnel, the test quality is often a problem. This session will discuss the current and future challenges in the quality control of Point Of Care Testing

Chair: Anne-Charlotte Wicktorsson

10:15–10:25

Introduction

10:25–10:55

(206)

Sweden

Patient safety – the value of SKUP evaluations of point of care instruments

Elisabeth Eriksson Boija,

10:55–11:25

phase (207) Quality assurance of the pre- and post analytical

Sverre Sandberg, Norway.

11:25–11:55

Accreditation of Point Of Care Testing, POCT, at Sahlgrenska University Hospital according to ISO 22870:2006 (208)

Birgitta Kallberg, Sweden

11:55–12:00 Summary Lunch – Exhibition and lunch seminars Room F3: Novel laboratory technology – the single molecule era

Nanotechnology and other techniques now allow reliable single molecule detection that can be implemented in routine analysis. This session will cover the challenges and opportunities that this novel technology will bring to clinical laboratories

Chairs: Julia Asp and Göran Larson

10:15–10:45

Analyzing biology cell by cell and molecule by molecule (209)

Ulf Landegren and Masood Kamali-Moghaddam

10:45–11:15

High throughput single cell expression profiling and characterization of circulating tumor cells (210)

Mikael Kubista, Sweden

11:15–11:40

(211) A translational equine approach towards development of human biomarkers of early osteoarthritis

Anders Lindahl, Sweden

11:40–11:50

Establishment of a GC-MS/ MS methodology for comprehensive sex steroid profiling in mouse serum (212)

Maria Nilsson, Sweden

11:50–12:00

Development and appli cation of an LC-MS method with high resolution accurate masses detection (HRAM) with ExactivePlus mass spectrometer and online sample preparation (213)

Valérie Thibert, France

12:30– 13:15 12:30– 13:15 14:00 Lunch seminars: Abbott Scandinavia AB Room: F1

Chairperson: Dave Ambruster, Director, Global Scientific Affairs, Abbott Diagnostics

Real life experiences of new assays. HbA1c multicentre study- what do the results tell us

Speaker: Johannes Lotz, Institute for Laboratory Medicine, University Hospital Mainz, Germany

Our experience with High Sensitive Troponin

Speakers: Clare Ford, The Royal Wolverhampton NHS Trust, New Cross Hospital, UK

Siemens Healthcare Diagnostics Room: F2

Elf in Liver Fibrosis

Speaker: Professor W M C Rosenberg MA, MBBS, DPhil, FRCP, UCL Institute for Liver & Digestive Health, University College, UK

Afternoon Plenary session Room: F3

Chair: Göran Larson

Surface-based single-liposome sensing for diagnostics and drug screening applications (214)

Fredrik Höök, Sweden

Coffee and exhibition in the exhibition and poster area 14:45 15:15 Room F1: Novel diagnostic bio markers in cardiology

A large proportion of patients seeking health care have cardiac disease that can often be treated effectively if correctly diagnosed. This session will discuss novel diagnostic biomarkers in acute cardiac care

Chairs: Ola Hammarsten and Christian Löwbeer

15:15–15:45

(215) Copeptin-Marker of Acute Myocardial Infarction

Martin Möckel, Germany

15:45–16:15

PEA multiplex technology – New tools for clinical proteomics (216)

Agneta Siegbahn, Sweden

16:15–16:30

Analytical Evaluation of the ARCHITECT STAT High Sensitive Troponin-I Assay (217)

Lieselotte Lennartz, Germany

16:30–16:45

Highly Multi plexed Proteomic Analysis as a translational tool: Implications for useful biomarker discovery and early clinical development (218)

Stephen Williams, United States

16:00 16:45 Parallel Sessions

A Multi-Center

Room F2: Prize

Siemens.

Rasmussen Denmark

activation

Denmark

The Astrup

The Astrup Prize is awarded to contemporary Nordic research work related to the field of clinical chemistry.

The Prize is sponsored by The winners of the Astrup prizes will be announced at the Congress Banquet

Chair: Lars Melholt

15:15–15:35

mannose receptor

Sidsel Rødgaard-Hansen,

15:35–15:55 15:55–16:15

The soluble Comparing the diagnostic accuracies of CSF A and PET Flor betapir

Niklas Mattson, Sweden

Detection of polymerized C1-inh in plasma of HAE patients – possible role in contact

Daniel Elenius Madsen,

Room F3: Next Generation Sequen cing (NGS) in clinical diagnosis

Next Generation Sequencing has revolutionised gene sequencing by allowing the simultaneous analysis of multiple genes, and has been opti mised to such an extent that it is now possible to apply it to clinical diagnoses. In this session we will present some examples of how NGS has contributed to the identification of new gene defects linked to hereditary human diseases

Chair: Jorge Asin Cayuela and Anne Ricksten

15:15–15:40

Next generation sequencing in the identification of new pathogenic mechanisms for mitochondrial disorders (219)

Henna Tyynismaa, Finland

15:40–16:05

Next Generation Sequencing in Inherited Cardiovascular Diseases (220)

Lorenzo Monserrat, Spain

16:05–16:30

Genomic analysis of Neurodegenerative Disease (221)

John Hardy, United Kingdom

16:30–16:45

Pilot study for the detection of mutations associated with lysosomal diseases using Next Generation Sequencing (222)

Julia Lindgren, Sweden

16:45–17:00

The use of design programs from Sequenom when diagnosing familial hypercholesterolemia (223)

Peter Benedek, Sweden

SKKLF Annual Meeting Room: Nordenskiöld SSKF Annual Meeting Room: F2 Possibility for companies to arrange a social sponsor activity

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Thursday, September 18

08:00– 08:45 08:00– 08:45 09:00 09:45 Breakfast seminars: Thermo Fisher Scientific Room: F1

Copetin – a marker of risk stratification and for early rule out in patients with suspected ACS

Speaker: Dr. Joern Ole Vollert, MD., Medical Director, Thermo Fisher Scientific

The latest news in molecular allergology

Speaker: Robert Moverare, Principal Scientist, Thermo Fisher Scientific

HemoCue Room: F2

Improved workflow for efficient emergency healthcare

Speaker: Younis Khalid, Chief Physician, Head of Section, Children’s ER, Drottning Silvias child- and youth hospital

Morning Plenary session Room: F3

Chair: Stefan Jacobsson

Vitamin B12 deficiency. New trends in biomarkers and diagnostic strategies (301)

Ebba Nexø, Denmark

Coffee and exhibition in the exhibition and poster area 10:15 Parallel Sessions Room F1: Rare disorders of erythrocytes. The dys regulation of iron and ferritin homeostasis

Dysregulation of the fine-tuned systemic and/or local iron homeostasis is emerging as an under lying cause of haematological and neurodegen erative diseases. Various forms of hereditary hemochromatosis with low hepcidin expression and iron-refractory iron deficiency anaemia with high hepcidin expression are attributed to muta tions affecting the hepcidin-mediated control of the regulation of ferroportin. This session will give an overview of the molecular mechanisms behind rare hereditary disorders of the red blood cell. The aim is to achieve a better understanding of how to use the different available diagnostic tools

Chairs: Linda Fogelstrand and Stefan Jacobsson

10:15–10:45

Hereditary hemochromatosis and ferroportin disease (302)

Sandro Altamura, Germany

10:45–11:15

(303) Neurological disorders of iron homeostasis: neurodegeneration with brain iron accumulation (NBIA) and neuroferritinopathies

Paolo Arosio, Italy

11:15–11:45

Why do we make mistakes in the morphological interpretation of blood slides and how can we improve? (304)

John Burthem, United Kingdom

11:45–12:00

Bloodhound Technology™ – Returning to the roots of Hematology (305)

Mark Fellmann, Switzerland

Room F2: Biomarkers in diagnosis of neurodegenerative diseases

Neurodegenerative disorders constitute a pleiotropic group of diseases that are often hard to distinguish from one another, without knowledge of the under lying pathology, as they often present with similar symptoms. This session will focus on the research frontier of the use of novel biomarkers in the diagnosis of neurodegenerative disorders

Chair: Henrik Zetterberg

10:15–10:45

CSF and plasma biomarkers for Alzheimer’s disease – use for diagnostics and theragnostics (306)

Kaj Blennow, Sweden

10:45–11:15

(307)

Denmark

Emergening molecular diagnostics tools for Alzheimer’s (AD) and other neurodegenerative diseases

Niels H. H. Heegaard,

11:15–11:45

Single Molecule Arrays (Simoa) for Ultrasensitive, Multiplexed Detection of Proteins and Nucleic Acids (308)

David Hanlon, United States

Room F3: The future clinical l aboratory as a diagnostic partner

The expansion of our knowledge of disease mechanisms and novel biomarkers is expected to increase the interaction between experts in the clinical laboratory and physicians. This session will discuss what will be expected from the laboratoryas a diagnostic partner in future medicine

Chair: Per Simonsson and Birgitta Kallberg

10:15–10:40

(309)

Sweden

The Cinderellas of health care

Mirja Mindemark,

10:40–11:05

The future clinical laboratory as diagnostic partner (310)

Martina Jürs, Denmark

11:05-11:30

Do you read me? – Radio check for clinical chemists. (311)

Per Simonsson, Sweden

12:00 Lunch – Exhibition and lunch seminars

12:30– 13:15 12:30– 13:15 14:00 14:45 Lunch seminars: Roche Diagnostics AB Room: F1

Panel discussion: True value of labs within the healthcare system

Speakers: Tor-Arne Hagve, Physician Medical biochemistry, Laboratory Medical Centre, Akershus, Oslo.

Göran Larson Professor, Head of Core Facilities Sahlgrenska Akademin. Robert Sinclair MD, Ph.D, DTM&H, Senior Medical Advisor, Dept. of Health Care Region Västra Götaland. Srinivas Uppugunduri Professor, Head of Dept. of Clinical Chemistry, Östergötland. Kasper Iversen Ph.D, MD, Cardiologist Head Physician, Kardiologisk afdeling, Herlev. Magnus Göransson General Manager, Roche Diagnostics, Sweden.

Sysmex Sverige Room: F2

Better staining. Better diagnostic morphology. Three Ways

Speaker: Henricus Jansen, Marketing Diagnostic Concepts & Lab Solutions, Sysmex Europe

Afternoon Plenary session Room: F3

Chair: Henrik Zetterberg

Blood based biomarkers for Alzheimer’s disease – from case control to endophenotype discovery and from small to large, potentially huge, replication (312)

Simon Lovestone, United Kingdom

Coffee and exhibition in the exhibition and poster area 15:15 Parallel Sessions Room F1: Laboratory diagnostics of myelo proliferative neoplasms

Our understanding of the molecular changes that lead to the development of different myelo proliferative neoplasms (MPN) has developed rapidly, through the discovery of activating mutations in several genes responsible for the regulation of cell differentiation and proliferation (e.g. the JAK2 gene but also, very recently, the CALR gene). This has led to new diagnostic and therapeutic opportunities but also to new challenges. This session will give a background and update of the laboratory diagnostic of MPN and suggestions on how to integrate new genetic findings in diagnostic algorithms

Chairs: Linda Fogelstrand and Lars Palmqvist

15:15–15:45

cancer? (313) Perspectives on chronic inflamma tion in essential thrombocythemia, polycythemia vera, and myelofibrosis: is chronic inflammation a trigger and driver of clonal evolution and develop ment of accelerated atherosclerosis and second

Hans Hasselbalch, Denmark

15:45–16:15

Laboratory Diagnostics of Myelo proliferative Neoplasms (314)

Susanne Schnittger, Germany

16:15–16:30

Frequency of CALR mutations and correlation with laboratory findings and clinical outcome in Essential Thrombocythaemia and Primary Myelofibrosis patients (315)

Julia Asp, Sweden

16:30–16:45

(316) European JAK2V617F interlaboratory quality control study carried out by the MPN&MPNR- EURONET (COST ACTION BM0902)

Niels Pallisgaard, Denmark

Room F2: The Eldjarn Prize

The Lorentz Eldjarn Prize Competition is financed by a Fund established by Professor Lorentz Eldjarn and his wife Torunn in 2009, to reward the best article published in Scand J Clin Lab Invest during the five years preceding the prize year. The Prize Committee has nominated three articles based on the scientific quality of the studies and the clarity of the presentations. The recipients of the prize will be announced at the Congress banquet

Chair: Jens P Berg

15:15–15:40

Vitamin D and PTH – seasonal and age-related variations (317)

Monika Christensen, Norway

15:40–16:05

Biomarkers of alcohol use and related health risks (318)

Onni Niemelä, Finland

16:05–16:30

Soluble CD163 – a biomarker of macrophage activation in disease (319)

Holger Jon Møller, Denmark

Room F3: Organisation of the future clinical laboratory

As laboratory medicine has converged during the past decade, it now possible to merge several aspects of the clinical laboratory. This merger will need different IT solutions for different platforms. This session will discuss opportunities and potential problems in this process

Chairs: Birgitta Kallberg and Anders Lindahl

15:15–15:35

Sweden

Opportuni ties and pitfalls when integrating laboratory disciplines (320)

Andreas Matussek,

15:35–15:55

The future of Lab Medicine seen through the eyes of a Niche Supplier (321)

Jørgen Viktil, Norway

15:55–16:15

Clinical Chemistry towards the future-where to go? (322)

Anders Lindahl, Sweden

16:15–16:30

Panel discussion

16:45–17:00 SFKK Annual Meeting Room: F1 19:30 Banquet “Glitter and Glamour” Estrad Restaurant, Mässans gata 5. Entrance 5

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Friday, September 19

09:00 Morning Plenary session Room: F3

Chair: Anne Ricksten

Application of massively parallel sequencing (MPS) for clinical analyses: challenges and opportunities (401)

Ulf Gyllensten, Sweden

09:45 Coffee and exhibition in the exhibition and poster area 10:15 Parallel Sessions Room F1: Clinical laboratory education today and tomorrow

The different professions within laboratory medicine complement each other. The education programs are under development and revision. Future laboratory medicine will be dynamic with new biomarkers and techniques. This session will illustrate the situation within the Nordic countries

Chairs: Mats Ohlson and Camilla Hesse

10:15–10:30

(402) Collaborative Design of Educational Model for Clinical Biochemists in Swedish Laboratory Medicine – “The Swedish Model”

Tom M Pettersson, Sweden

10:30–10:40

Training of Clinical Biochemists in Finland (403)

Päivi Laitinen, Finland

10:40–10:55

(404) Biomedical laboratory science, present and future aspects on the education

Camilla Hesse, Sweden

10:55–11:05

Clinical laboratory education today and tomorrow – the Swedish physician’s perspective (405)

Christian Löwbeer, Sweden

11:05–11:20

Specialist training in the Nordic Countries and the Danish model (406)

Nete Hornung, Denmark

11:20–11:30

Panel discussion

Room F2: Future use of cancer biomarkers

Our knowledge of how cancer develops and evolves into stable tissue has recently been rewritten. In addition, several cancer biomarkers are now used for screening and to guide personalised treatment. This session will give an overview of our new vistas in cancer biology and provide examples of future cancer biomarkers that will aid in the diagnosis and treatment of cancer

Chairs: Julia Asp and Anne Ricksten

10:15–10:45

Do you think (cancer) medicine is modern? The need for a new cancer paradigm (407)

Ingemar Ernberg, Sweden

10:45–11:15

Combined assessment of six Tumor Markers for the Diagnosis and Histological Diagnosis of Lung Cancer (408)

Rafael Molina, Spain

11:15–11:45

cancer (409) Biomarkers increase survival in ovarian

Karin Sundfeldt, Sweden

11:45–12:00

Cobalamin Predicts a Poor Survival for Cancer Patients – a Population-based Cohort Study (410)

Johan Frederik Berg Arendt, Denmark

Elevated plasma

Room F3: disease

Sweden

Biomarkers of kidney

How to estimate kidney function has been debated for decades. Recently, ways to standardise the measurement of cystatin C have been presented, and new better formulae for both creatinine and cystatin C-based estimations of the GFR have been developed. This session will discuss how kidney function should be measured. In addition, novel methods for the measurement of carbohydrate urine markers and how cardiac markers might be affected by kidney function will be discussed

Chairs: Ola Hammarsten and Anders Larsson

10:15–10:45

Biomarkers of Kidney Disease (411)

Anders Grubb, Sweden

10:45–11:15

Simple protocol for preparation and nLC-MS/MS charac terization of proteoglycan linkage region glycopeptides of human plasma, urine and cerebrospinal fluid samples (412)

Göran Larson, Sweden

11:15–11:25

more closely associated with mortality than creatinine-based GFR in un selected patients seeking health care (413)

Johanna Helmersson-Karlqvist,

11:15–11:35

Cystatin C-based GFR is Troponin I levels are less dependent on glomerular filtration rate compared to Troponin T and other cardiac biomarkers (414)

Christian Bjurman, Sweden

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12:00 Poster Prize winning cermony and Closing Remarks Room: F3

Posters list

Biomarkers in heart disease

P01 Lipoprotein(a), total/HDL-cholesterol ratio, ApoB/ApoA ratio as risk factors for atherogenesis in patients with coronary artery disease

Danica Labudovic, Sonja Alabakovska, Katerina Tosheska Trajkovska, Jasna Bogdanska, Silvana Jovanova

P02 P03 P04 P05 P06 P07 P07:2 High Sensitive Troponin in patients with Erectile Dysfunction

Gianvico Melzi D’eril, Raffaele Pezzilli, Clara A. L. Damele, Rossana Stefanelli, Giovanni M. Colpi, Massimiliano M. Corsi Romanelli, Alessandra Barassi

Acute pancreatitis and myocardial damage

GianVico Melzi d’Eril, Raffaele Pezzilli, Giovanni M. Colpi, Massimiliano M. Corsi Romanelli, Alessandra Barassi

Quality assurance measurement of the cholesterol markers apolipoproteins A1 and B; Going against the grain

Joannis Kinalis, Eva Fahlen, Erika Langenstam, Erika Karabasic

Evaluation of the Alere NT-proBNP test for point of care testing

Banafsheh Seyyed Khezri, Lena Carlsson, Anders Larsson

Serial Troponin T testing based on stored samples in the clinical laboratory

Oscar Oliva Torstensson, Carina Gustafsson, Birgitta Gren, Jan Friden, Ola Hammarsten

Implementation of cardiac biomarkers in ambulatory emergency medicine department

Vaike Viia

Estimation of the possible economic effects of a sequential testing strategy with NT-proBNP before echocardiography in primary care

Banafsheh Seyyed Khezri, Johanna Helmersson-Karlqvist, Anders Larsson

Novel techniques

P08 An invitro assay to measure cell sensitivity to ionizing radiation

Sherin Mathew, Pegah Johansson, Ola Hammarsten

P09 P10 P11 P012 An improved high performance liquid chromatography-fluorescence detection method for the analysis of Pimozide in human plasma samples

Alessandra Barassi, Francesca Ghilardi, Alessandra Flaminio, Roberta Marotta, GianVico Melzi d'Eril

Validation of a new OptiScanner™ 5000 system for an intermittent glucose monitoring

Alessandra Barassi, Michele Umbrello, Clara A. L. Damele, Francesca Ghilardi, Rossana Stefanelli, Gaetano Iapichino, GianVico Melzi d'Eril

Preparation and in vitro evaluation of doxorubicin-loaded Fe 3 O 4 magnetic nanoparticles modified with biocompatible copolymers

Abolfazl Akbarzadeh

Amyloidosis diagnosis by mass spectrometry

Jakob C. Albrethsen, Morten Salomo, Anders H. Johnsen

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Biomarkers in neurodegenerative disease

P13 Plasma levels of apolipoprotein E and risk of dementia in the general population

Katrine Laura Rasmussen, Anne Tybjærg-Hansen, Børge G. Nordestgaard, Ruth Frikke-Schmidt

P14 P15 Blood biomarkers for brain injury in concussed professional ice hockey players

Pashtun Shahim, Gisela Malmgård, David H. Wilson, Jeffrey Randall, Birgitta Kallberg, Yelverton Tegner, Kaj Blennow, Henrik Zetterberg

Biomarker-determined Alzheimer prevalence in patients undergoing surgery due to hip fracture

Maria Lönnquist, Birgitta Kallberg, Kaj Blennow, Henrik Zetterberg, Bengt Nellgård

Laboratory as a diagnostic partner

P16 Critical results for community based patients and audit of a two tier biochemical phone list

Jeffrey Barron, Geoff Smith

P017 P018 P019 P20 P21 P22 P23 P24 HbA1c as the diagnostic criterion for diabetes reduces incidence and prevalence of DM2 by 25% but strongly depending on analytical quality

Ivan Brandslund, Aneta A. Nielsen, Per H. Petersen, Anders Green, Cramer K. Christensen, Henry Christensen

Ensuring faster patient treatment by reducing turn-around-time for laboratory results

Carsten Thomsen, Claus Brasen, Christian U. Maegaard, Nina Mogensen, Ivan Brandslund

Vitamin D in patients with pancreatic diseases

Gianvico Melzi D’eril, Alessandra Barassi, Raffaele Pezzilli

Vitamin D and Erectile Dysfunction

Alessandra Barassi, Raffaele Pezzilli, Clara A. L. Damele, Rossana Stefanelli, Giovanni M. Colpi, Massimiliano M. Corsi Romanelli, GianVico Melzi d’Eril

Assessing the mitochondrial iron metabolism in hereditary hemochromatosis

Sonia Distante, Ragnhild Skinnes, Kari Høie, Lars Mørkrid, Lars Eide

The Role of Early Evaluation of Porphyrins in Diagnosis of Acute Porphyria

Galina Zemtsovskaja, Agnes Ivanov, Marika Pikta

Can Morning Serum Cortisol Ranges and Action Limits be Harmonised?

Robert Wardrop, Narelle Hadlow

An Alpha-Thalassemia Case in Estonia

Marika Pikta, Galina Zemtsovskaja, Iige Viigimaa, Jelena Jerjomina

P25 Use of Pyrosequencing for the Detection of Several Polymorphisms Associated with Lactase Persistence

Catherine Herrera, Gunnhild Kravdahl, Malene Nilsen

Biomarker development

P26 Effect of fasting on plasma levels of 7-alpha-hydroxy-4-cholesten-3-one – a marker for bile acid synthesis in humans

Magnus Axelson, Kerstin Brismar

P27 P28 P29 P30 Detection of antinuclear antibodies – a comparison of indirect immunefluorescence on HEp-2 cells and fluoroenzymeimmunoassay (EliA CTD screen, Thermo Fisher)

Lone Nørgård Troelsen, Søren Jacobsen, Lina Pedersen

Measuring gamma-H2AX as a biomarker for DNA damage after ionizing radiation treatment in cancer patients

Pegah Johansson, Aida Muslimovic, Ragnar Hultborn, Erik Fernström, Ola Hammarsten

Novel Circulating isoforms of hepcidin

Morten Moe, Tor-Arne Hagve, Ingrid M. Hardang

Early diagnosis and calculating the risk of ovarian cancer in women by combining the results of two biomarkers HE4 & CA125

Aaso Raoofi, Adam Molner, Fereshteh Pourlotfi, Tatyana Danylchenko

Hematology

P31 Assessment of a diagnostic algorithm to classify von Willebrand disease

Karin Littmann, Maria Berndtsson, Eva-Marie Norberg, Jovan Antovic

P32 P33 P34 P35 P36 P37 P38 P39 Trypan Blue accurately defines the viability of CFU-GM cells in Cord Blood Units

Sofia U. Frändberg, Eva Anghem, Inger Ögärd, Lars Palmqvist

Exploring the heterogeneity of the hematopoietic stem cell pool: A simultaneous staining protocol for the Side population, Aldehyde dehydrogenase and CD34 in Cord Blood

Sofia U. Frändberg, Susann Li, Cecilia Boreström, Lars Palmqvist

Are hemoglobin variants eluting in “variant window” on Bio-Rad Variant Turbo 2.0 affecting the HbA1c results?

Britta Landin, Lena Fredriksson

The usefulness of the “Imm Gran?” flag reported on by the Sysmex XE-5000

Heidi Eilertsen, Tor-Arne Hagve

Hypersegmentation in a routin laboratory– a common finding or not?

Anna Maj Ericsson, Helena Orre-Ekdahl, Stefan Jacobsson

Evaluation of ‘CellaVision Advanced RBC application’; new software for reporting erythrocyte morphology

Eva Grönlund, Margit Döry, Agnetha Evers, Soheir Beshara

Interference of Monoclonal Antibody Therapies with Serum Protein Electrophoresis Analysis

Claus Brasen, Jakub Krejcik, Torben Plesner

Whole exome sequencing of sorted leukemic cells as a complementing method in genetic characterization of acute myeloid leukemia

Erik Malmberg, Sara Ståhlman, Sofie J. Alm, Tore Samuelsson, Lars Palmqvist, Linda Fogelstrand

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Point of care testing

P40 Evaluation of HemoCue WBC DIFF system versus Sysmex XE in blood samples from pediatric patients

Anette Friis Larsen, Ole Halfdan Larsen, Anne Dorthe Møller, Søren Ladefoged, Tore Hardlei

P41 P41:2 P42 P43 P44 Harmonizing POCT and Central Core Laboratory analyzers

Anne-Charlotte Wicktorsson, Maria Thornemo

Assuring quality in point-of-care testing at the Sahlgrenska University Hospital

Anne-Marie Johannesson, Ingrid Uttberg, Maria Thornemo

Centralized vs. decentralized blood collection: A comparison of quality indicators for the preanalytical phase

Erik K. Amundsen, Solrun Fransen, Gro Siri B. Lillesund, Tonje V. Larsen, Karin Toska

Like Herding Cats – Information Technology Facilitates Management of Point of Care Testing Systems

Nicole Carney, Robert Dodds, Katrina Moreau, Gregory Sharp

Evaluation of three different CRP Point of Care Testing instruments

Slavena Mandic, Marie Palmblad, Laura Goobar Larsson

Laboratory education

P45 Clinical chemistry practice in Republic of Macedonia

Jasna Bogdanska, Danica Labudovic

Novel company technology

P46 Keeping Bacteria Under Control to Minimize Impact on Assays and Maximize Analyzer Uptime

Stephane Mabic, Maryse Gauthey Baraou, Johan Thorell

Other

P47 P48 P49 P50 P51 P52 Integrated EQA

Jonna Pelanti, Samuli Niiranen

Method comparison of three automated 25-hydroxy vitamin D enzyme immunoassays to liquid chromatography tandem mass spectroscopy (LCMS/MS) and against each other

Nada Rakovan, Trine Lauritzen, Per O. Nordstrøm, Øyvind Skadberg

Automated alarm to detect antigen excess in serum free immunoglobulin light chain kappa and lambda assays – Experience from routine application

Karin Toska, Erik K. Amundsen, Petter Urdal, Olav Klingenberg

Haemolysis in underfilled venipuncture testtubes

Birgitta Gren

Reproducibility problem in an ELISA assay method – fibroblast growth factor 23 (FGF-23) as an example

Henrik Alfthan, Helene Markkanen, Esa Hämäläinen

Efficient extraction of human DNA from stool samples and detection of genetic and epigenetic alterations specific for colorectal neoplasia

Aleksandra Mandic Havelka, Annelie Strålfors, Lars-Olof Hansson, Ulrik Lindfors, Gösta Eggertsen

P53 P54 P55 P56 P57 P58 P59 P60 P61 P62 P63 P64 P65 PAPP-A2. Median values in normal pregnancy in first trimester and association to Small-For-Gestational-Age infants

Young Bae Hansen, Vibeke Myrhøj, Finn S. Jørgensen, Claus Oxvig, Steen Sørensen

Comparison of two methods for determination of coagulation factor VIII activity

Susanne Samuelsson

Evaluation of Technopath Controls on the ARCHITECT Family of Instruments

Jessie Shih, Didier Brault, Antonio Croce, Lieselotte Lennartz, Matthias Orth

Comparison of the results of immunoglobulin (IgA,IgG,IgM), IgG subclasses and specific antibodies of patients with frequent sinopulmonary problems

Elo Saue

Clinical chemical monitoring of PFIC-patients treated with a new surgical method

Karin Littmann, Cecilia Gälman, Paolo Parini, Björn Fishler, Antal Nemeth, Eva Beijer, Maria Magnusson, Ronald Oude-Elferink, Gösta Eggertsen

Hidden asymptomatic CDG cases may be mistaken for excessive alcohol consumption

Anders Helander, Jaak Jaeken, Gert Matthijs, Gösta Eggertsen

Up-regulation of Liver Enriched Transcription Factors (HNF4a and HNF6) and Liver Specific MicroRNA (MiR-122) by Inhibition of Let-7b in Mesenchymal Stem Cells

Nosratollah Zarghami, Effat Alizadeh, Abolfazl Akbarzadeh, Mohamadreza Baghaban Eslaminejad, Kazem Nejati-Koshki

Kidney stone analysis by FTIR

Morten Moe, Marianne Moe, Gunnhild Kravdal

Sigma metrics used to assess analytical quality of clinical chemistry assays: Importance of the allowable total error (TEa) target

Dave Armbruster, Sten A. Westgard

Inhibitory Effects of β -Cyclodextrin-Helenalin Complexes on H-TERT Gene Expression in the T47D Breast Cancer Cell Line – Results of Real Time Quantitative PCR

Faraz Zarghami, Abolfazl Akbarzadeh

Effect of rest time prior to blood sampling on common biochemical parameter – results from thyreotropin

Ida B. Andersen, Claus L. Brasen, Lene Nohr-Jensen, Dorthe E. Nielsen, Jonna S. Madsen

Serum 25-hydroxyvitamin D below 75 nmol/L observed in 75% of healthy Swedish audults during 75% of the year

Göran Oleröd, Eva Klingberg, Jan Konar, Max Petzold , Ola Hammarsten

Effect of apixaban on common coagulation analyses

Inger Fagerberg Blixter and Equalis

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Author index

A Aggerholm, Anni Akbarzadeh, Abolfazl Alabakovska, Sonja Albrethsen, Jakob C.

Alfthan, Henrik Alizadeh, Effat Alm Johansson, Sofie Almås, Bjørg Altamura, Sandro Amundsen Koldberg, Erik Andersen Boegh, Ida Andersen Tolstrup, Morten Andréasson, Björn Andrikovics, Hajnalka Angelin, Bo Anghem, Eva Antovic, Jovan Antwi, Kwasi Arendt, Johan Frederik Berg Armbruster, Dave Ärnlöv, Johan Asin Cayuela, Jorge Asp, Julia Axelson, Magnus Ayala, Rosa B Baghaban Eslaminejad, Mohamadreza Barassi, Alessandra Barron, Jeffrey Bauer, Timothy

316, P316 P11, P59, P62 P01 P12 P51 P59 P39 317 302 P42, P49 P63 316, P316 315, P315 316, P316 223, P223 P32 P31 205, P205 410, P410 P61 203,413, P413 222, P222 315, P315, 316, P316 P26 316, P316 P59 P02, P03, P09, P10, P19, P20 P16 218, P218

Beijer, Eva Bellosillo, Beatriz Benedek, Peter Bergo, Martin O.

Berndtsson, Maria Beshara, Soheir Bjurman, Christian Blennow, Kaj Bogdanska, Jasna Borén, Jan Boreström, Cecilia Boudry, Pascal Brandslund, Ivan Brasen Lohmann, Claus Brasen, Claus Brault, Didier Brismar, Kerstin Brody, Ed Bryon, Jane Burthem, John

P57 316, P316 223, P223 103 P31 P37 414, P414 306, P14, P15 P01,P45 101 P33 217, P217 P17, P18 P63 P18, P38 P55 P26 218, P218 316, P316 304

C Carlsson, Lena Carney, Nicole Cassinat, Bruno Chaudhari, Ravindra Christensen Kjeldahl, Cramer Christensen, Henry Christensen, Monika H.E.

Colpi, Giovanni M Corsi Romanelli, Massimiliano M Coudoré, François Croce, Antonio

P05 P43 316, P316 205, P205 P17 P17 317 P02, P03, P20 P02, P03, P20 213, P213 P55

D Damele, Clara Anna Linda Danylchenko, Tatyana Dicker, Frank Distante, Sonia Dodds, Robert Duvefelt, Kristina Döry, Margit E Eggertsen, Gösta Eide, Lars Eilertsen, Heidi Ericsson, Anna Maj Eriksson Boija, Elisabet Eriksson, Mats Ernberg, Ingemar Estan, Nuria Evers, Agnetha F Fagerberg Blixter, Inger Fahlen, Eva Farkas Körmendiné, Dóra Fellmann, Mark Fernström, Erik Finazzi, Dario Fishler, Björn Flaminio, Alessandra Fogelstrand, Linda Fransen, Solrun Fredriksson, Lena Friden, Jan Friis Larsen, Anette Frikke-Schmidt, Ruth Frändberg, Sofia Ulrika Fu, Michael

P65 P04 410, P410 305, P305 P28 303 P57 P09 P39 P42 P34 P06 P40 P13 P32, P33 414, P414 P02, P10, P20 P30 316, P316 P21 P43 223, P223 P37 P52, P57, P58 P21 P35 P36 206 223, P223 407 217, P217 P37

G Gauthey Baraou, Maryse Ghilardi, Francesca Girodon, François Gomez Toledo, Alejandro Goobar Larsson, Laura Green, Anders Gren, Birgitta Grubb, Anders Grönlund, Eva Gustafsson, Carina Gyllensten, Ulf Gälman, Cecilia H Hadlow, Narelle Hagve, Tor-Arne Hammarsten, Ola Hanlon, David Hansen, Young Bae Hansson, Lars-Olof Hansson, Ulrika Hardang, Ingrid M Hardlei, Tore Hardy, John Hasselbalch, Hans Hasselbalch, Hans Karl Heegaard, Niels Helander, Anders Helmersson-Karlqvist, Johanna Hermouet, Sylvie Herrera, Catherine Hesse, Camilla Høie, Kari Hornung, Nete Hultborn, Ragnar

P46 P09, P10 316, P316 412, P412 P44 P17 P06, P50 411 P37 P06 401 P57 P23 P29,P35 414, P414, P06, P08, P28, P64 308 P53 P52 315, P315 P29 P40 221 313 316, P316 307 P58 413, P413, P07:2 316, P316 P25 404 P21 406 P28 19

20

Hustad, Steinar Hämäläinen, Esa Höök, Fredrik I Iapichino, Gaetano Ivanov, Agnes J Jacobsen, Søren Jacobsson, Stefan Jaeken, Jaak Jerjomina, Jelena Johannesson, Anne-Marie Johansson, Pegah Johansson, Peter Johnsen, Anders H.

Jørgensen, Finn Stener Jovanova, Silvana Jürs, Martina K Kallberg, Birgitta Karabasic, Erika Kere, Juha Kiernan, Urban Kinalis, Joannis Kjær, Lasse Kjellström, Birgitta Klingberg, Eva Klingenberg, Olav Konar, Jan Krastins, Bryan Kravdahl, Gunnhild Krejcik, Jakub Krintus, Magdalena Kristensen Kielsgaard, Thomas Kubista, Mikael Köller, Ursula

317 P51 214 P10 P22 P27 P36 P58 P24 P41:2 P08, P28 315, P315 P12 P53 P01 310 208, P14, P15 P04 223, P223 205, P205 P04 316, P316 222, P222 P64 P49 P64 205, P205 P25, P60 P38 217, P217 316, P316 210 217, P217

L Labudovic, Danica Ladefoged, Søren Laitinen, Päivi Landegren, Ulf Landin, Britta Langenstam, Erika Larsen Versvik, Tonje Larsen, Ole Halfdan Larson, Göran Larsson, Anders Lauritzen, Trine Leber, Amanda Lefèvre, Guillaume Leibundgut Oppliger, Elisabeth Lemonnier, Alban Lennartsson, Ann-Britt Lennartz, Lieselotte Lewandowski, Krzysztof Li, Susann Lien, Ernst A.

Lillesund Birkeland, Gro Siri Lindahl, Anders Lindahl, Bertil Lindahl, Per Linde, Malin Lindfors, Ulrik Lindgren, Julia Lippert, Eric Littmann, Karin Lodé, Laurence Lopez, Mary Lotz, Johannes Lovestone, Simon Lönnquist, Maria Löwbeer, Christian M Mabic, Stephane Madsen Skov, Jonna Maegaard, Christian Ulrik

P01, P45 P40 403 209 P34 P04 P42 P40 412, P412 413, P413, P05, P07:2 P48 205, P205 217, P217 316, P316 213, P213 305, P305 217, P217,P55 316, P316 P33 317 P42 211, P211,322 201 103 223, P223 P52 222, P222 316, P316 P31,P57 316, P316 205, P205 217, P217 312 P15 405 P46 P63 P18

Magnusson, Maria Malmberg, Erik Malmgård, Gisela Mandic Havelka, Aleksandra Mandic, Slavena Markkanen, Helene Marotta, Roberta Marusic, Maruska Mathew, Sherin Matthijs, Gert Matussek, Andreas Mehler, Bob Melander, Olle Melzi D'eril, Gianvico Mindemark, Mirja Moe, Marianne Moe, Morten Mogensen, Nina Molina, Rafael Møller, Anne Dorthe Møller, Holger Jon Molner, Adam Monserrat, Lorenzo Moreau, Katrina Mørkrid, Lars Muslimovic, Aida Myrhøj, Vibeke Månsson, Jan-Eric Möckel, Martin N Naguib, Dina Nejati-Koshki, Kazem Nellgård, Bengt Nemeth, Antal Nexø, Ebba Niederkofler, Eric Nielsen Elkjaer, Dorthe Nielsen, Aneta Alexandra Niemelä, Onni Niiranen, Samuli Nilsen, Malene

P57 P39 P14 P52 P44 P51 P09 316, P316 P08 P58 320 218, P218 202 P02, P03, P09, P10, P19, P20 309 P60 P29,P60 P18 408 P40 319 P30 220 P43 P21 P28 P53 222, P222 215 316, P316 P59 P15 P57 301,410, P410 205, P205 P63 P17 318 P47 P25

Nilsson, Åsa Nilsson, Jonas Nilsson, Maria Noborn, Fredrik Nohr-Jensen, Lene Nomdedéu, Josep Norberg, Eva-Marie Nordestgaard, Børge G Nordstrøm, Per Olov Norlén, Anna-Karin Nybo, Mads O Ohlsson, Claes Oleröd, Göran Oliva Torstensson, Oscar Orre-Ekdahl, Helena Orth, Matthias Oude-Elferink, Ronald Oxvig, Claus P Pallisgaard, Niels Palmblad, Marie Palmqvist, Lars Pancrazzi, Alessandro Paolo, Arosio Parini, Paolo Pedersen, Lars Pedersen, Lina Pelanti, Jonna Percy, Melanie Peterman, Scott Petersen Hyltoft, Per Pettersson, Tom Petzold, Max Pezzilli, Raffaele Pikta, Marika Plebani, Mario Plesner, Torben Pourlotfi, Fereshteh Prakash, Amol

222, P222 412, P412 212, P212 412, P412 P63 316, P316 P31 P13 P48 212, P212 217, P217 212, P212 P64 P06 P36 P55 P57 P53 316, P316 P44 315, P315, P32, P33, P39 316, P316 303 P57 410, P410 P27 P47 316, P316 205, P205 P17 402 414, P414, P64 P02, P03, P19, P20 P22, P24 217, P217 P38 P30 205, P205 21

22

R Rakovan, Nada Randall, Jeffrey Raoofi, Aaso Rasmussen, Katrine Laura Ryberg, Henrik S Salomo, Morten Samuelson, Emma Samuelsson, Susanne Samuelsson, Tore Sandberg, Sverre Saue, Elo Sayin, Volkan Schnittger, Susanne Schroeder, Tara Schwarz, Jiri Seyyed Khezri, Banafsheh Shahim, Pashtun Sharp, Gregory Shih, Jessie Siegbahn, Agneta Simonsson, Per Singer, Britta Skadberg, Øyvind Skinnes, Ragnhild Smith, Geoff Sørensen Toft, Henrik Sørensen, Steen Ståhlman, Sara Stefanelli, Rossana Sterling, David Strålfors, Annelie Sundfeldt, Karin T Tegner, Yelverton Thibert, Valérie Thomsen, Carsten Thorell, Johan

P48 P14 P30 P13 212, P212 P12 222, P222, 316, P316 P54 P39 207 P56 103 314 205, P205 316, P316 P05, P07:2 P14 P43 217, P217, P55 216 311 218, P218 217, P217, P48 P21 P16 410, P410 P53 P39 P02,P10,P20 218, P218 P52 409 P14 213, P213 P18 P46

Thornemo, Maria Tivesten, Åsa Tosheska Trajkovska, Katerina Toska, Karin Troelsen, Lone Nørgård Tubbs, Kemmons Tybjærg-Hansen, Anne Tyynismaa, Henna U Umbrello, Michele Urdal, Petter Uttberg, Ingrid V Vandenput, Liesbeth Venge, Per Viia, Vaike Viigimaa, Iige Viktil, Jørgen Vorland, Marta W Wardrop, Robert Wasslavik, Carina Westgard, Sten Anders Wicktorsson, Anne-Charlotte Williams, Stephen Wilson, David H Wold, Agnes Z Zarghami, Faraz Zarghami, Nosratollah Zemtsovskaja, Galina Zetterberg, Henrik Ä Ärnlöv, Johan Ö Ögärd, Inger

P41, P41:2 212, P212 P01 P42,P49 P27 205, P205 P13 219 P10 P49 P41:2 212, P212 204 P07 P24 321 316, P316 P23 315, P315 P61 P41 218, P218 P14 102 P62 P59 P22,P24 P14,P15 P32

Roche Diagnostics Seminars

Program

Wednesday, September 17

8:30-9:00 (Booth)

The value of NT-proBNP in the monitoring and treatment of heart failure patients

Åke johansson M.D. Specialist Allmänmedicin Askim Vårdcentral Göteborg 9:45-10:15 (Booth)

The value of NT-proBNP in the monitoring and treatment of heart failure patients

Åke johansson M.D. Specialist Allmänmedicin Askim Vårdcentral Göteborg 11:30-12:00 (Booth) 12:30-13:00 (Booth) 14:45-15:15 (Booth)

Evaluation of the CoaguChek XS for analysis of PK(INR) taken by capillary sampling

Maria Tornemo M.D.Ph.D., Annika Björk Leg. BMA Klinisk Kemi Sahlgrenska Universitetsjukhuset

Evaluation of the CoaguChek XS for analysis of PK(INR) taken by capillary sampling

Maria Tornemo M.D.Ph.D., Annika Björk Leg. BMA Klinisk Kemi Sahlgrenska Universitetsjukhuset

High-sensitivity troponin T provides faster and better care for chest pain

Dina Melki M.D., Ph.D. Avd för Kardiologi Karolinska Universitetssjukhuset

Thursday, September 18

8:30-9:00 (Booth)

New hematology instruments from Roche - cobas m511 (Bloodhound technology)

Mark Fellmann Ph.D., Int Produktchef Hematologi Roche 9:45-10:15 (Booth)

New hematology instruments from Roche - cobas m511 (Bloodhound technology)

Mark Fellmann Ph.D., Int Produktchef Hematologi Roche 10:15-11:30 (Conference program)

The future clinical laboratory as diagnostic partner

Mirja Mindemark, PhD, Senior Account Manager, Roche Diagnostics Scandinavia AB 12:30-13:15 (F1)

Lunchseminarium, Paneldebatt med fokus på hur sjukvården kan dra mer nytta av laboratoriemedicin

14:45-15:15 (Booth)

S100B; Biomarker in new guidelines for traumatic brain injury

Eric elin, M.D., Ph.D.-doktorand Avd. för Neurokirurgi Karolinska Universitetssjukhuset

Friday, September 19

9:45-10:15 (Booth)

S100B; Biomarker in new guidelines for traumatic brain injury

Eric elin, M.D., Ph.D.-doktorand Avd. för Neurokirurgi Karolinska Universitetssjukhuset

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Guidelines for Speakers

The Speakers Preview Room is located outside Room 1. Speakers are kindly requested to provide their PC-formatted USB keys (PowerPoint presentations) to the staff in the Speakers room, preferably the day before, or at least 2 hours prior to the presentation.

The lecture room is equipped with data projection equipment. File format: Microsoft Power Point or Adobe Acrobat formatted for Windows (PC). Preferred Resolution: XGA (1024 x 768)

Technical staff will be available in the Conference room as follows:

Tuesday 16th 11.00–15.30

Wednesday–Thursday 17th & 18th 07.30–16.30

Friday 19th 08.00–11.30

!

Prepare your presentation in good time.

If you have film sequences in your presentation be sure that they function when you have transferred them into the NFKK computer system. In respect to Your fellow Oral Presenters be at the first row seats 15 minutes prior to the start of Your session and announce Your presence to the Chairman of Your session.

WE ARE SHARING OUR KNOWLEDGE – JOIN US!

“Better staining. Better diagnostic morphology. Three Ways.”

Thursday 18 September 12:30 – 13:15, Meetingroom F2 Come visit us at booth #14 and win an iPod nano * !

We pride ourselves on being a knowledge-based company and enjoy sharing our know-how. So you can truly make the most of our products, technology and services. And, perhaps, even better serve your customers.

This year at the XXXIV Nordic Congress in Clinical Chemistry, Gothenburg, Sweden, we are holding a lunch symposium – given by one of our experts within Laboratory Solutions.

So why not take some time out from your busy schedule to brush up on some of our latest insights and enjoy a tasty lunch? We think you’ll appreciate it …

“Better staining. Better diagnostic morphology. Three Ways.” Thursday 18 September 12:30 – 13:15, Meetingroom F2

We look forward to seeing you there. Of course there will be time for a Q&A session afterwards.

Sysmex Sverige Shaping the Advancement of Healthcare

www.sysmex.se

SYSME_14416_Advert_RAL_BFM_SP_10_EN_A5_Nordic_RZneu.indd 1 13.08.14 17:01

Social Program

Welcome Reception Tuesday, September 16th, 15:15

Immediately after the last session this day a Welcome Reception will be held in the exhibition area. The reception is hosted by the City of Göteborg and the Region of Västra Götaland.

Participation is included in the congress fee but must be reserved in advance through the online registration system to obtain a ticket.

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Glitter and Glamour Banquet Thursday, September 18th, 19:30

Estrad Restaurant, Mässans gata 5. Entrance 5

Come and join colleagues and new friends!

The Congress Banquet with the theme, “Glitter & Glamour” will be held in the Estrad Restaurant, one of the restaurants in the Congress Centre. We will start with a drink at “Bryggan” located on the first floor, directly above our entrance. We then proceed along the “red carpet” to the Estrad Restaurant where a delicious three course dinner will be served. During this evening, the winners of the Astrup prizes and the recipients of the Eldjarn prizes will be announced. The “Glitter Girls” Jamladies will entertain us followed by a Dj and dancing.

Participation is not included in the congress fee.

Price SEK 700.

Jamladies are three well experienced artists who will give your evening that little extra when it comes to glitter and glamour. With fancy costumes, beautiful voices and a warm and charming appeal Jamladies will create a show you will never forget.

Congress information

Abstracts

All abstracts will be available in an abstract database on the web site

www.nfkk2014.se

You can search for abstracts in several different ways; browse author index and session programme indices (orals and posters) or free text search.

Badge

Participants will receive their name badges at the conference registration desk. Since only registered participants will be permitted to attend the scientific sessions, the exhibition and poster areas, you are kindly requested to wear your badge when entering the congress venue. Please note that admission to scientific sessions is strictly restricted to participants wearing their badges. Exhibitors without a full congress registration are not entitled to attend the scientific sessions. Lost badges can be replaced at the registration desk. However, a handling fee will be charged.

Cloak room

There is an unattended cloak room in the exhibition are.

Coffee breaks and luncheon

Refreshments will be served free of charge in the exhibition area.

Congress Web site

In time for the congress we will rearrange www.nfkk2014.se to focus on the information you need when you are on site. The site will also be optimised for portable units to fit nicely on your smartphone or tablet. The Daily News is produced by our editorial on site, follow it on our big screen or on nfkk2014.org

On site Registration

Registration Desk Opening Hours Tuesday 16th................................................11.00–15.30

Wednesday–Thursday 17th & 18th...........07.30–16.30

Friday 19th...................................................08.00–12.00

On-site registration is accepted but participation in the social events at that time may be severely limited.

Exhibition Opening Hours

Tuesday 16th................................................11.00–18.00 (Welcome reception 15.15–18.00) Wednesday 17th.........................................09.30–16.30 Thursday 18th.............................................09.30–16.30 Friday 19th...................................................09.30–12.00

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General information

Credit cards

Commonly accepted credit cards in hotels, restaurants and shops and at the conference registration desk are American Express, Diners Club, Visa, Master Card and Euro card. Restaurants and shops generally display signs indicating what cards they accept.

Currency

The local currency is the Krona (pl. kronor). 1 krona = 100 öre. Approximate exchange rate: 1 EUR = 9.15 SEK. Most banks, the manned ones, can exchange foreign currency. Credit cards are widely accepted in Sweden and the exchange rate is usually better than for cash or travellers cheques. It is advisable to find out what the commission is before proceeding with the transaction.

Electricity

Sweden uses 230-volt AC, 50Hz current. Visitors will need an adaptor for electric appliances, whereas North Americans need a transformer.

Emergency numbers

For all emergencies, please dial 112.

Internet

There is WIFI access in the exhibition area. Use the net work NCCC2014 and login NCCC2014 to go on line.

Insurance

Neither the Conference Organisers or the Conference Secretariat accept any liability for personal injuries sustained, or for loss or damage to property belonging to conference participants, either during or as a result of the conference.

Language

The official conference language is English. There will be no simultaneous translation.

Swedish is the official language in Sweden. English is common in hotels and tourist places and is also spoken by most Swedes.

Public transportation

Gothenburg has a very modern and efficient public transportation network which includes an elaborate tramway system, buses, and ferries. The city has over 200 trams, covering 11 different routes, all of which connect to other forms of transport. Gothenburg also bills itself as having “the world’s most modern public transportation system”, with electronic signs at all tram, bus, and ferry stops telling passengers exactly when the next one is coming and notifying riders of any traffic snarls in the system. The information posted on the trams and stops is in Swedish only, so you should have a good idea of how the trip should go before starting. www.vasttrafik.se/en

From Landvetter Airport to the Congress Centre

Gothenburg-Landvetter Airport – main international airport – is located 20 km to the east of Gothenburg. Airport buses are running frequently between Gothenburg and the airport. Take the airport bus (SEK 90 = approx. EUR 9) or taxi to Korsvägen (SEK 450 = approx. EUR 50) – opposite The Swedish Exhibition Centre´s main entrance.

From City Airport (Säve Airport) to the Congress Centre

Gothenburg City Airport is located 8 km to the north of Gothenburg. Buses run every 20 minutes between the airport and Gothenburg Central Station. Stop at Nils Ericssonsplatsen/ Central Station. Change to tram (see below). The trip takes 35 minutes. A taxi fare between the airport and the City Centre is approximately SEK 400 (around EUR 45).

From Gothenburg Train Central Station by tram

Take tram No. 4, 13 or 14. From nearby Brunnsparken, you can take tram No. 4 or 5. The trams stop at Korsvägen, just opposite Svenska Mässan and Gothenburg Convention Centre.

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Tram

Gothenburg has the largest tram network in Europe. Taking the tram is one of the nicest ways of getting around in Gothenburg. The city has 204 trams which operate 11 routes, as well as buses and archipelago ferries. The Älvsnabben ferry provides services along the harbour. The journeys are included in the same public transport ticket. The easiest way is to buy tickets in advance from Tidpunkten or Pressbyrån shops. The Gothenburg’s City Pass, available from all tobacconists allows unlim ited use of the city’s excellent tram and bus system. You can also buy your ticket directly on the bus or tram.

Shopping

Department stores and most shops are open from:

Monday–Friday....................................... 09:30–18:00 Saturday.........................................09:30–13:00/16:00 Sunday (department stores)....................12:00–16:00

In Sweden, many convenience stores (“närbutiker”) are open 07:00–23:00 in major cities, such as Stockholm, Gothenburg and Malmö.

Taxis

The concierge of your hotel can call a taxi for you, or you may want to call the following taxi companies: “Taxi Göteborg”: +46 (0)31 650 000 or “Taxikedjan” +46 (0)911-922 66. Gothenburg’s taxis are one way of getting around in the city, although the meter ticks away alarmingly when you are stuck in the rush hour traffic. You can share the front seat with the driver if you wish. There is an initial charge when starting the journey. There is a slightly higher rate per kilometre if leaving the city limits. If you pay by credit card, it is necessary to inform the driver in advance.

note!

There are a lot of so called “Svart taxis” in Gothenburg. That means a person driving an ordinary car without a taxi license. Usually they come up to you asking you if you would like a “Svart taxi”. We do not recommend you to take these taxis.

Smoking policy

No smoking will be permitted at any time inside the conference venue. Smoking is banned on public transport, in stores, restaurants and pubs. Hotels offer special rooms for non smokers. Please indicate your request on the registration form, when you make your hotel reservation.

Time zone

Sweden is one hour ahead of Greenwich Mean Time (GMT).

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Tourist information

For tourist information about Gothenburg, Sweden, please visit the website: www.goteborg.com.

VAT

The standard VAT rate in Sweden is 25%. Everybody who visits Sweden as a tourist and who is not a resident of an EU country is eligible for the VAT reimbursement (More information at www.globalrefund.com). Note that value added tax in Sweden is almost always included in the price that is indicated in shops. Visitors from outside the European Union are able to reclaim the VAT on goods purchased, either at the airport or at the border. Look for the tax-free sign in shops and please remember to ask for the VAT reclaim form at the time of the purchase. Global Refund Sverige has around 15’000 affiliated shops and department stores. Minimum purchase is 200 SEK. When purchasing the goods, a Global Refund Cheque is issued and your items are sealed. The Global Refund Cheque can be cashed upon departure from the EU at any exit point – ports, ferry terminals, airports, border crossings, etc. The cheque is valid during the month of purchase and during the 3 following months. For additional information, please contact: Global Refund Sverige E-mail: [email protected]

Venue

Svenska Mässan (The Swedish Exhibition & Congress Centre) in Gothenburg Visitor´s addresse: Mässans Gata 2, Entrance 2.

Today’s well-being is tomorrow’s greatest resource.

Siemens answers are creating an impact on human health that will last generations.

siemens.se/healthcare

The healthier people are today, the better the world will be tomorrow. That’s because long, healthy lives make it possible for people to give their best. And build a happier world for today’s generations and genera tions to come. That’s why Siemens works to advance human health, with answers that last. We’re helping clinicians and hospitals expand access to care while cutting costs, so they can better care for a growing world. We’re creating innovations that will have a lasting impact, so an aging population can continue to be a healthy one. We believe that, like every precious resource on earth, human health should be cherished, sustained. Not just for today, but for the promise of a better tomorrow.

Answers for life.

Today’s well-being is tomorrow’s greatest resource.

Siemens answers are creating an impact on human health that will last generations.

siemens.se/healthcare

The healthier people are today, the better the world will be tomorrow. That’s because long, healthy lives make it possible for people to give their best. And build a happier world for today’s generations and genera tions to come. That’s why Siemens works to advance human health, with answers that last. We’re helping clinicians and hospitals expand access to care while cutting costs, so they can better care for a growing world. We’re creating innovations that will have a lasting impact, so an aging population can continue to be a healthy one. We believe that, like every precious resource on earth, human health should be cherished, sustained. Not just for today, but for the promise of a better tomorrow.

Answers for life.

34

our exhibitors

Exhibitor

Abbott Scandinavia AB ACC NordiC AB Alere AB AH diagnostics Beckman Coulter AB Bio-Medical Lab Supplies Ltd Bio-Rad Laboratories AB BioMerieux Sweden AB Biotech-IgG AB

Stand No

12 23 32 22 10 5 3 27 25

Exhibitor

CALPRO AS CellaVision CompuGroup Medical Lab AB Dako DiaSorin AB DiaSystem Scandinavia AB Electra-Box Diagnostica AB Euro Diagnostica AB Fiomi Diagnostics AB

Stand No

26 6 4 24 7 40 8 29 33

Entrance 1

Room Nordenskiöld F1 F2 F3 TECH p o s t e r s TECH buffét p o s t e r s TECH buffét Nordic BioSit daily news Registration LGC 37

Room Nordenskiöld F1 F2 F3

Exhibitor

GATC Biotech AB

Stand No

17 Haemo Medtec Aps HemoCue IDS Nordic A/S Lab-Tech & Skafte Medlab 38 15 20 1 LGC 37 Merck Millipore 21 Nordic BioSite Nordic Haemostasis AB Roche Diagnostics 30 41 13

Exhibitor

Scantec Nordic AB SERO AS Siemens Healthcare Diagnostics Software Point Sysmex Sverige 19 9 2 14 Thermo Fisher Scientific 11 Tieto Sweden Healthcare & Welfare 28 Timedico A/S Triolab AB

Stand No

39 18 34 daily news Registration LGC 37

Entrance 2

Nordic BioSit TECH p o s t e r s TECH buffét p o s t e r s TECH buffét 35

Operan Kajskjul 8 Lilla Bommen Central Station

Göteborg city

Ullevi Scandic Hotel Opalen Avenyn The Swedish Exhibition & Congress Centre Götaplatsen Museum of Modern Art Villa Fridolin Korsvägen Hotel Gothia Universeum

Operan Kajskjul 8 Lilla Bommen Central Station

Göteborg city

Ullevi Scandic Hotel Opalen Avenyn The Swedish Exhibition & Congress Centre Götaplatsen Museum of Modern Art Villa Fridolin Korsvägen Hotel Gothia Universeum

thanks to our Sponsors and exhibitors

PL AT I N U M SP O NSOR S:

WE ARE SHARING OUR KNOWLEDGE – JOIN US!

GO L D SP O NSOR S:

“Better staining. Better diagnostic morphology. Three Ways.”

Thursday 18 September 12:30 – 13:15, Meetingroom F2

E X H I BI TOR S:

ACC NordiC AB, Alere AB, AH diagnostics, Bio-Medical Lab Supplies Ltd, Bio-Rad Laboratories AB, BioMerieux Sweden AB, Biotech-IgG AB, CALPRO AS, CellaVision, CompuGroup Medical Lab AB, Dako, DiaSorin AB, DiaSystem Scandinavia AB, Electra-Box Diagnostica AB, Euro Diagnostica AB, Fiomi Diagnostics AB, GATC,

Come visit us

Nordic Biosite, Nordic Haemostasis AB, Scantec Nordic AB, SERO AS, Software Point,

at booth #14 and win an iPod nano

*

!

We pride ourselves on being a knowledge-based company and enjoy sharing our know-how. So you can truly make the most of our products, technology and services. And, perhaps, even better serve your customers.

This year at the XXXIV Nordic Congress in Clinical Chemistry, Gothenburg, Sweden, we are holding a lunch symposium – given by one of our experts within Laboratory Solutions.

So why not take some time out from your busy schedule to brush up on some of our latest insights and enjoy a tasty lunch? We think you’ll appreciate it …

“Better staining. Better diagnostic morphology. Three Ways.” Thursday 18 September 12:30 – 13:15, Meetingroom F2

We look forward to seeing you there. Of course there will be time for a Q&A session afterwards.

Sysmex Sverige Shaping the Advancement of Healthcare

www.sysmex.se

SYSME_14416_Advert_RAL_BFM_SP_10_EN_A5_Nordic_RZneu.indd 1 13.08.14 17:01