Transcript Nakano-200400707-

Trend of PCB Use in Japan
Total 58,000t
12000
10000
8000
使用量(t)
Amount
of PCB use (t)
6000
4000
2000
54
55
56
57
58
59
1960
61
62
63
64
1965
66
67
68
69
1970
71
72
0
year
PCB product use in Japan
(t)
製品別使用量(1969-1971)
1969-1971
15,000
10,000
5,000
0
KC300
KC400
KC-300 400
Ar-1242 1248
KC500
KC600
500 600
1254 1260
D10CB
N9CBs
30
KC600
KC500
10
0
KC600
製品別使用量(1969-1971)
50
5
40
0
KC500
25
10
0
Japan
D10CB
15,000
N9CBs
0
KC400
O8CBs
KC300
H7CBs
KC400
H6CBs
50
P5CBs
10
T4CBs
D10CB
N9CBs
O8CBs
(t)
T3CBs
D10CB
N9CBs
O8CBs
H7CBs
H6CBs
P5CBs
T4CBs
T3CBs
D2CBs
M1CBs
KC300
D2CBs
MCBｓ
D10CB
N9CBs
20
O8CBs
30
O8CBs
H7CBs
H6CBs
P5CBs
T4CBs
T3CBs
D2CBs
M1CBs
30
H7CBs
H6CBs
P5CBs
T4CBs
T3CBs
D2CBs
M1CBs
30
H7CBs
H6CBs
P5CBs
T4CBs
T3CBs
20
D2CBs
M1CBs
50
KC300
40
20
Japan
0
10,000
5,000
0
40
KC600
KC400
20
10
Homologue pattern
reflects product use
60
50
40
KC500
30
20
日本
15
10
Daily variation of PCDD/Fs
and PCBs in ambient air
20
15
8-1
8-2
8-3
8-4
8-5
8-6
8-7
8-8
8-9
8-10
8-11
8-12
8-14
8-15
8-16
8-17
8-18
8-20
8-21
8-22
8-23
8-24
8-25
8-26
8-27
8-28
8-30
8-31
3　concentration (pg/m )
Daily variation of Dioxin Concentration
50
45
Hi-vol.
40
PCDF
PCDD
35
30
25
Low-vol.
（PCDD+PCDF)
10
5
0
Time trend of PCB levels
in ambient air
(log scale)
33
(ng/m
(pg/m ))
1000
Ambient air
100
10
1
0.1
0.01
1970
1975
1980
1985
1990
1995
2000
2005
33
Time
trend
of
PCBs
concentration
in
ambient
air
(ng/m
Time trend of PCBs concentration in ambient air (pg/m ))
1954
1955
1956
1957
1958
1959
1960
1961
1962
1963
1964
1965
1966
1967
1968
1969
1970
1971
1972
1973
1974
1975
1976
1977
1978
1979
1980
1981
1982
1983
1984
1985
1986
1987
1988
1989
1990
1991
1992
1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
PCB 使用量(t)
12000
10000
PCB (t)
8000
6000
4000
2000
0
year
PCB 濃度(ng/m3)
PCB levels
and
Homologue profiles
in
Environmental samples
C o n c e n tra tio n (p g /ｇ -ｄ ｒｙ )
10000
1000
10
1
0 .1
M e d ia n
M ax
100
M in
25%
Sediment
0.05-800ng/g-dry
1000
100
10
S e d im e n t
25%
M in
10000
M e d ia n
75%
100000
M ax
M in
0 .0 1
PCB levels (2002, 環境省)
1
B io t a
Biota
0.1-800ng/g-wet
HCHs
PCBs
HCB
25%
HCHs
HCB
75%
DDTs
h eptach lor
en d rin
M e d ia n
PCBs
h ep tach lo r
0 .1
d ieldrin
10
en d rin
1
ch lo rd an e
aldrin
M ax
d ieldrin
C o n c e n tra tio n (p g / ｌ )
HCHs
h ep tach lor
10000
DDTs
1000000
100
ch lo rd an e
A tm o s p h e re
Air
1000
ald rin
0 .0 1
C o n c e n tra tio n (p g /ｇ )
HCB
PCBs
M in
HCHs
HCB
25%
en drin
10000
h eptach lo r
75%
PCBs
100000
d ieldrin
M ax
en drin
75%
d ield rin
M e d ia n
DDTs
1000
DDTs
0 .1
ch lo rd an e
1
ch lo rd an e
10
ald rin
100
ald rin
C o n c e n tra tio n (p g /m 3 )
0.01-1ng/m3
100000
0.1-10ng/L
W a te r
Water
1000000
0.01-1ng/m3
0 .1
0.1-10ng/L
1
Water
W a te r
0 .0 1
HCB
0.01-10ng/g
10000
75%
M e d ia n
DDTs
h ep tach lo r
B io t a
1
Biota
PCB
0.05-800ng/g-dry
d ieldrin
10
M in
ch lo rd an e
100
25%
PCBs
1000
HCHs
HCB
M ax
ald rin
HCHs
HCB
h eptach lo r
100000
S e d im e n t
Sediment
0 .1
C o n c e n tra tio n (p g /ｇ )
M in
PCBs
ch lo rd an e
1
en drin
25%
100
10
d ield rin
75%
DDTs
1000
M ax
M e d ia n
ald rin
C o n c e n tra tio n (p g /ｇ -ｄ ｒｙ )
100000
en d rin
1000000
1000000
10000
HCHs
HCB
M in
A tm o s p h e re
0 .0 1
PCBs
10
25%
h eptach lor
75%
aldrin
100
en d rin
M e d ia n
0 .1
Air
DDTs
M ax
1000
d ieldrin
1
10000
ch lo rd an e
ch lo rd an e
M in
HCHs
PCBs
HCB
10
en drin
25%
ald rin
100
d ieldrin
75%
M e d ia n
DDTs
C o n c e n tra tio n (p g /m 3 )
M ax
1000
0.01-1ng/L
100000
h ep tach lor
10000
C o n c e n tra tio n (p g / ｌ )
0.1-5ng/m3
0.01-1ng/g
0.1-800ng/g-wet
HCB & PCB levels (2002, 環境省)
PCBの同族体分布
（平均組成）
40
20
10
0
NoCBs
Sediment
OcCBs
30
NoCBs
OcCBs
HpCBs
30
HpCBs
0
HxCBs
0
HxCBs
10
PeCBs
10
PeCBs
20
TeCBs
20
TeCBs
NoCBs
OcCBs
HpCBs
HxCBs
PeCBs
TeCBs
0
TrCBs
0
TrCBs
10
TrCBs
10
DiCBs
20
DiCBs
Water
MoCBs
NoCBs
OcCBs
20
DiCBs
40
MoCBs
NoCBs
OcCBs
HpCBs
HxCBs
PeCBs
TeCBs
TrCBs
DiCBs
Air
MoCBs
NoCBs
OcCBs
30
HpCBs
HxCBs
PeCBs
TeCBs
TrCBs
DiCBs
30
HpCBs
HxCBs
PeCBs
底質
TeCBs
Sediment
TrCBs
水質
DiCBs
Water
MoCBs
大気
MoCBs
Air
MoCBs
40
40
30
Fish
Fish
魚
40
Shellfish
Shellfish
貝類
50
Bird
30
20
Bird
10
0
鳥
30
20
10
0
DeCB
Bir d
NoCB
50
OcCB
ng/g-lipid
HpCB
0
HxCB
Water
PeCB
40
TeCB
0
abundance(%)
10
TrCB
NoCBs
OcCBs
20
DiCB
NoCBs
OcCBs
HpCBs
HxCBs
PeCBs
TeCBs
TrCBs
Air
MCB
NoCBs
OcCBs
30
HpCBs
HxCBs
PeCBs
TeCBs
TrCBs
DiCBs
MoCBs
30
HpCBs
HxCBs
PeCBs
TeCBs
Bird
TrCBs
40
DiCBs
Water
DiCBs
MoCBs
Air
MoCBs
40
50
45
40
35
30
25
20
15
10
5
0
Human blood
20
10
Breast milk
70
60
50
40
30
20
10
0
20
10
0
De10CB
40
N9CB
50
O8CB
龍野市Air
Room
air
Hp7CB
De10CB
N9CB
O8CB
Hp7CB
10
Hx6CB
10
Hx6CB
20
Pe5CB
20
Pe5CB
30
Te4CB
30
Te4CB
40
Tr3CB
40
Di2CB
60
Tr3CB
0
M1CB
50
%
50
Di2CB
30
%
De10CB
N9CB
O8CB
Hp7CB
Hx6CB
Pe5CB
Te4CB
龍野市庁舎シーリング材
Sealant
（Low-Cl)
M1CB
De10CB
N9CB
O8CB
Hp7CB
Hx6CB
Pe5CB
60
Te4CB
Tr3CB
Di2CB
M1CB
%
60
Tr3CB
Di2CB
M1CB
%
Homologue profiles of PCB in sealant and air
伊丹市庁舎シーリング材
Sealant
（High-Cl)
0
Room
air
伊丹市Air
60
50
40
30
20
10
0
30
25
20
15
Insulator
10
5
0
capacitor
45
40
KC600
Ship paint
5
0
D10CBs
10
D10CBs
15
N9CBs
20
N9CBs
25
O8CBs
30
O8CBs
35
H7CBs
KC600
H7CBs
H6CBs
P5CBs
D10CBs
N9CBs
O8CBs
H7CBs
H6CBs
P5CBs
T4CBs
T3CBs
KC500
50
45
40
35
30
25
20
15
10
5
0
H6CBs
KC400
D2CBs
Source estimation
P5CBs
35
T4CBs
0
T4CBs
Sediment A
T3CBs
40
T3CBs
底質(KC300由来)
45
40
35
30
25
20
15
10
5
0
D2CBs
60
capacitor
M1CBs
20
M1CBs
KC300
D2CBs
KC400
N.C.P.
D10CBs
50
M1CBs
10
D10CBs
KC300
D10CBs
20
N9CBs
0
N9CBs
10
N9CBs
30
O8CBs
H7CBs
H6CBs
30
O8CBs
H7CBs
H6CBs
P5CBs
T4CBs
T3CBs
D2CBs
M1CBs
40
O8CBs
H7CBs
45
40
P5CBs
T4CBs
T3CBs
D2CBs
M1CBs
50
H6CBs
50
P5CBs
T4CBs
T3CBs
D2CBs
M1CBs
60
KC500
Insulator
底質(KC600由来)
Sediment B
PCBの異性体分析
GC/MS-SIM chromatogram of TrCB (HT8-PCB)
Intensity
T3CB
PCB product
4000000
0
12
13
14
15
16
17
18
Retention Time (min)
19
20
21
22
23
#37
#35
#38
#39
#36
#22
#21
#20
#33
#26
#25
#31
#28
#23
#34
#29
#32
#16
#18
#17
#24
#27
#30
#19
Calculated Retention Time
Intensity
13C-T3CB
13C-TrCB
0
12
13
14
15
16
17
18
Retention Time (min)
19
Matsumura et al, J. Env. Chem. (2002)
20
21
22
23
GC/MS-SIM chromatogram of PeCB (HT8-PCB)
Intensity
P5CB
800000
PCB product
400000
0
20
22
24
26
28
30
Retention Time (min)
32
34
36
38
#104
#96
#103
#100
#94
#102
#93
#98
#95
#88
#91
#121
#92
#84
#89
#90
#101
#113
#99
#112
#119
#83
#108
#86
#117
#97
#125
#116
#87
#115
#111
#85
#120
#110
#82
#124
#109
#107
#123
#106
#118
#114
#122
#105
#127
#126
Calculated Retention Time
Intensity
13C-P5CB
50000
13C-PeCB
0
20
22
24
26
28
30
Retention Time (min)
32
Matsumura et al, J. Env. Chem. (2002)
34
36
38
Congener profiles of PCBs
in environmental samples
50
KC300-600
40
30
20
10
0
#11 (3,3’)
60
Sediment
50
#35 (3,3’,4)
40
30
20
10
0
50
Water
40
30
20
10
0
80
70
60
50
40
30
20
10
0
Congener profiles of PCBs(Di-, Tri-) in environmental samples
#37
#35
#33/#20
#31/#28
#25
#26
#16/#32
#18/#17
#15
#12/#13
#11
#8/#5
Air (gas phase)
#4
40
35
30
25
20
15
10
5
0
Rain
Congener profiles of TrCB,TeCB
in human
and
combustion sample (A)
_19
_30
_18
_17
_32
_16
_31
_28
_22
_35
_37
_53
_51
_45
_52_69
_43_49
_48_47
_44
_64
_74
_70
_66
_79
_78
_81
_77
_19
_30
_18
_17
_32
_16
_31
_28
_22
_35
_37
_53
_51
_45
_52_69
_43_49
_48_47
_44
_64
_74
_70
_66
_79
_78
_81
_77
_19
_30
_18
_17
_32
_16
_31
_28
_22
_35
_37
_53
_51
_45
_52_69
_43_49
_48_47
_44
_64
_74
_70
_66
_79
_78
_81
_77
8
6
KC400
70
60
50
40
30
20
10
0
4
3
PCB product
4
2
0
PCB product
医療廃棄物
Combustion
Combustion
5
母乳
Breast milk
2
1
0
Breast milk
PCB congeners predominant in human samples (TrCB, TeCB)
Congener profiles of TrCB,TeCB
in combustion sample (B)
(stack gas)
Compound View
Page 1
DqData : C:\Documents and Settings\hyogo\My Documents\0404PCB•ˆ—•ƒf•[ƒ^•ˆ—•\DiokData\PCBN38Along-new\0404PCBN38Along-003
Injection : PCBGas-GeomeltTO-Exhaust
T3CB / Average
129564
#47
TrCB
Intensity
24-24
0
12
14
16
18
#51
T4CB / Average
172261
20
22
Retention Time (min)
24
#68
26
30
32
TeCB
24-35
Intensity
24-26
28
0
12
14
16
18
20
22
Retention Time (min)
24
26
28
30
32
Congener profiles of PCBs
in environmental
and
human samples
Isomer
Isomerdistribution
distribution（HxCB）
（HxCB）
PCB
PCBproduct
product
Intensity
HW1013+KC3-600
124328
0
18
19
20
21
22
Retention Time (min)
23
24
sediment
sediment
Intensity
01Sed-55
32392
0
18
19
20
21
22
23
24
Retention Time (min)
sea　sea　water
water
Intensity
Portisland7/19-6L
5128
992
18
19
20
21
22
23
human
humanmilk
milk
Intensity
MM-44
47792
0
18
19
20
21
22
23
24
adipose
adiposetissue
tissue
o-neck-fat
162432
Intensity
24
0
18
19
20
#153
#153(2,2',4,4',5,5'-)
(2,2',4,4',5,5'-)
21
22
23
24
#138(2,2',3,4,4',5'-)
#138(2,2',3,4,4',5'-)
Congener profiles of PCBs(Hexa-) in environmental and human samples
Isomer
Isomerdistribution
distribution（HpCB）
（HpCB）
PCB
PCBproduct
product
Intensity
HW1013+KC3-600
74056
0
20.0
20.5
21.0
21.5
22.0
22.5
23.0
23.5
Retention Time (min)
24.0
24.5
25.0 25.5
sediment
sediment
Intensity
01Sed-55
8744
960
20.0
20.5
21.0
21.5
22.0
22.5
23.0
23.5
24.0
24.5
25.0 25.5
Retention Time (min)
sea　sea　water
water
Intensity
Portisland7/19-6L
2080
984
20.0
20.5
21.0
21.5
22.0
22.5
23.0
23.5
24.0
24.5
human
humanmilk
milk
MM-44
Intensity
25.0 25.5
16312
944
20.0
20.5
21.0
21.5
22.0
22.5
23.0
23.5
24.0
24.5
25.0 25.5
Retention Time (min)
adipose
adiposetissue
tissue
Intensity
o-neck-fat
42888
0
20.0
20.5
21.0
21.5
#187
#187
22.0
22.5
23.0
23.5
Retention Time (min)
#180
#180
24.0
24.5
25.0 25.5
#170
#170
Congener profiles of PCBs(Hepta-) in environmental and human samples
#28
＃28
Tri-CBs
24-4
＃31
Tetra-CBs
245-4
＃74
#74
＃80
Penta-CBs
#99
#118
245-34 ＃118
＃99
245-24
Hexa-CBs
＃153
245-234
#153
245-245
＃163/
＃164
Hepta-CBs
#187
＃187
245-2356
#138
＃138
245-2345
＃180
#180
＃170
Chromatogram of PCB in human blood （3~7Cl）
Hirai et al, (2003) Organohalogen compounds
0.4
0.35
0.3
0.25
0.2
0.15
0.1
0.05
0
#188
#188
0.3
0.2
0.1
0
#179
#176
#186
#178
#175
#187,
#182
#183
#185
#174,
#181
#177
#171
#173
#192,
#172
#180,
#193
#191
#170,
#190
#189
#179
#176
#186
#178
#175
#187,
#182
#183
#185
#174,
#181
#177
#171
#173
#192,
#172
#180,
#193
#191
#170,
#190
#189
#179
#176
#186
#178
#175
#187, #182
#183
#185
#174, #181
#177
#171
#173
#189
#180
#170, #190
#191
#180, #193
KC300-600
#174
#192, #172
#184
Mussel
#184
Sea Water
#184
#188
Intensity
0.6
0.4
0.2
0
#170
Isomer distribution (P7CB, Port Island in June,2001)
4000
KC300-600
2000
0
0.001
Sea Water
0
0.02
0.015
0.01
0.005
0
#202
#201
#199
#196 #203
#195
#205
#194
#195
#196,
#203
#199
#198
#200
#197
#201
Mussel
#202
Intensity
0.002
#194
Isomer distribution (O8CB, Port Island in June, 2001)
Congener profiles of PCBs
in environmental
and
human samples
PCB 製品 ー> 環境（大気、水質、底
質） ー> 生物（貝、魚、鳥） ー> ヒト
PCB 製品
ヒト
#74 < #66
245-4
24-34
#74 > #66
245-4
24-34
#99 < #101
245-24 245-25
#99 > #101
245-24 245-25
#146 < #149
245-235 245-236
#146 > #149
245-235 245-236
Congener profiles of PCBs
in human samples
(pooled blood)
Levels of the predominant PCB congeners in human blood
(n=24)
Congeners Mean±2S.D. Existence Ratio*
245-245
245-2345
245-234
245-2356
245-34
245-24
245-4
245-235
2345-234
2345-34
(BZ#)
(ng /g-lipid)
(%)
#153
#180
#138
#187
#118
#163,164
#99
#74
#146
#170
#156
Sum
28.0±28.0
14.9±16.6
10.4±9.2
8.3±8.5
6.9±5.9
6.4±6.2
4.7±4.2
4.6±2.6
4.1±3.7
3.8±4.1
2.8±3.0
22.3
11.8
8.3
6.6
5.5
5.1
3.8
3.6
3.3
3.0
2.3
75.6
* Mean is compare to total PCBs level
Hirai et al, (2003) Organohalogen compounds
cumulative
(%)
22.3
34.1
42.4
49.0
54.5
59.6
63.4
67.0
70.3
73.3
75.6
human milk/adipose tissue
#74
(2,4,4',5-)
#99
(2,2',4,4',5-)
#153
(2,2',4,4',5,5'-)
# 7 4 (4 -2 4 5 )
# 1 5 3 (2 4 5 -2 4 5 )
#138
(2,2',3,4,4',5'-)
# 9 9 (2 4 -2 4 5 )
# 1 3 8 (2 3 4 -2 4 5 )
#187
(2,2',3,4',5,5',6-)
#118
(2,3',4,4',5-)
# 1 1 8 (3 4 -2 4 5 )
# 1 8 7 (2 3 5 6 -2 4 5 )
PCB congeners predominant in human samples
PCB waste stock
transformer and capacitor : 370,000
stabilizer for Flu. lamp
: 2,400,000
non carbon paper
: 644,000 kg
waste sludge
: 117,000 kg
waste
: 105,000,000 kg
other equipments
: 33,000
waste PCB etc
:
PCB waste stock
transformer and capacitor : 370,000
stabilizer for Flu. lamp
: 2,400,000
non carbon paper
: 644,000 kg
waste sludge
: 117,000 kg
waste
: 105,000,000 kg
other equipments
: 33,000
waste PCB etc
:
PCB waste stock
transformer and capacitor : 370,000
stabilizer for Flu. lamp
: 2,400,000
non carbon paper
: 644,000 kg
waste sludge
: 117,000 kg
waste
: 105,000,000 kg
other equipments
: 33,000
waste PCB etc
:
Congener profiles of PCB
in human sample
#153
#138
#118
#74
#180
#99
1973
#187
PCB congener composition in human breast milk
#153
2000
#74
#99
#118
#138
#187
#180
PCB congener composition in human breast milk
#153
Salmon
#101
#138
#118
#66
#187
#180
PCB congener composition in salmon
#153
Breast milk
#74
#99
#118
#138
#187
#180
PCB congener composition in human breast milk