Transcript www.ishlt.org

THE REGISTRY OF THE
INTERNATIONAL SOCIETY
FOR HEART AND LUNG
TRANSPLANTATION:
TWENTIETH ANNUAL
REPORT
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Major Contributors to the ISHLT Transplant Registry
Eurotransplant (ET):
Austria
Germany
Slovenia
Belgium
Netherlands
Scandiatransplant:
Denmark
Norway
Finland
Sweden
United Kingdom Transplant Services Authority (UKTSSA):
United Kingdom
Ireland
United Network for Organ Sharing (UNOS):
United States
74 Individual centers from Canada, Central/South America,
Europe, Asia, and Australia/Oceania reporting transplants
since 1995
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
ACKNOWLEDGMENTS:
We wish to extend our sincere thanks
to the many thoracic transplant
surgeons, physicians and data
coordinators in transplant programs
throughout the world whose timely
and accurate submission of data has
made these analyses possible.
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
ISHLT International Heart and Lung Transplant
Registry Mission Statement
The ISHLT International Heart and Lung Transplant
Registry was created to advance the state of knowledge
and patient care regarding therapies for the failing heart
and lung. This mission is accomplished by maintaining a
repository of the worldwide thoracic organ transplant
experience and by fostering related outcomes research in
order to:
1. Create new knowledge related to advanced heart and
lung failure and transplantation;
2. Serve as a resource for healthcare providers seeking
information regarding patient care;
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
ISHLT International Heart and Lung
Transplant Registry Mission Statement
(cont’d)
3. Provide benchmark aggregate date for use by individual
centers to assess their center-specific practices and
outcomes;
4. Serve as a resource for governmental agencies
worldwide when formulating public policy regarding
thoracic organ transplantation;
5. Serve as a resource for patient-related organizations and
pharmaceutical companies regarding disease-specific
therapies and transplant outcomes
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Goals of Registry
1. Increase the number of publications/studies using
Registry data
2. Increase the number of non-US reporting centers
3. Optimize the data quality and integrity
4. Improve the process of receiving, processing and
fulfilling data and analysis requests
5. Develop sources of external funding
6. Develop a formal publication policy regarding the use of
Registry data
7. Increase the number of centers reporting data online
8. Redefine and improve the working relationship with
UNOS Registry staff
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Goals of Registry
(cont’d)
9.
Optimize the value and image of the Registry to the
Society, its members, and the external research
community
10. Identify patient-related organizations and pharmaceutical
companies and make them aware of the Registry as a
resource
11. Restructure the data fields into a tiered system and
increased the number of required fields
12. Increase the number of reporting agreements with nonUS government regulatory agencies (i.e, Swiss
Transplant, France Transplant, etc.)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
REGISTRY STEERING COMMITTEE
Marshall Hertz – Medical Director
Elbert Trulock – Associate Director for Lung Transplantation
David O. Taylor – Associate Director for Heart Transplantation
Mark Boucek – Associate Director for Pediatric Transplantation
Paul Mohacsi – Associate Director for Non-US Centers
Amanda Rowe – ISHLT Executive Director
Berkeley Keck – Associate Director for Database Management
Leah Bennett Edwards – Associate Director for Data Analysis
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
General Registry Statistics
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
REGISTRY DATABASE:
Number of Transplants Performed
ORGAN
Transplants Reported
Through 6/30/2002
Heart
62,851
Heart-Lung
2,955
Lung
15,199
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
REGISTRY DATABASE:
Number of Centers Reporting Transplants
Centers
Centers
Reporting
Reporting
Transplants
Transplants in
between 1/2001
1993
and 6/2002
Organ
Centers
Ever
Reporting
Data
Heart
330
231
202
Heart-Lung
129
60
41
Lung
183
102
105
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
REGISTRY DATABASE:
Number of Centers Reporting Heart Transplants
200
150
100
50
Year of Transplant
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
2001
2000
1999
1998
1997
1996
1995
1994
1993
1992
1991
1990
1989
1988
1987
1986
1985
1984
1983
1982
1981
0
1980
# of Centers Reporting
250
REGISTRY DATABASE:
Number of Centers Reporting Lung Transplants
100
75
50
25
ISHLT
Year of Transplant
2003
J Heart Lung Transplant 2003; 22: 610-72.
01
20
00
20
99
19
98
19
97
19
96
19
95
19
94
19
93
19
92
19
91
19
90
19
89
19
88
19
87
0
19
# of Centers Reporting
125
REGISTRY DATABASE:
Number of Centers Reporting Heart-Lung Transplants
60
50
40
30
20
10
0
19
85
19
86
19
87
19
88
19
89
19
90
19
91
19
92
19
93
19
94
19
95
19
96
19
97
19
98
19
99
20
00
20
01
# of Centers Reporting
70
Year of Transplant
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
APPENDIX
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
x
x
St. Vincent
x
x
The Prince Charles Hospital
x
x
COUNTRY/Center
ARGENTINA
Fundacion Favaloro
AUSTRALIA
The Alfred Hospital
x
Royal Perth Hospital
x
x
University of Vienna
x
x
Innsbruck University Hospital
x
x
University Klinik fur Chirurgie (Graz)
x
x
Erasme Univ. Hospital (Brussels)
x
x
Univ. Hospital Gasthuisberg (Leuven)
(Cont’d)
x
x
AUSTRIA
BELGIUM
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
University Hospital Antwerp
x
x
OLV Hospital (Aalst)
x
x
University Hospital Gent
x
x
Centre Hospitalier Universitaire de
Liege, CHU Sart-Tilman
x
x
Royal Victoria Hospital
x
x
Montreal Heart Institute
x
x
The Toronto General Hospital
x
x
Quebec Heart Institute - Laval
Hospital
x
x
Ottawa Heart Institute
x
x
x
x
COUNTRY/Center
BELGIUM (cont’d)
CANADA
Univ. of Alberta Hospitals/ Walter C.
Mackenzie Health Sciences
(Cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
St. Paul
x
x
Vancouver General Hospital
x
x
The Hospital for Sick Children
x
x
x
x
COUNTRY/Center
CANADA (cont’d)
CHILE
Hospital DIPRECA
Clinica Las Condes
x
DENMARK
Skejby University Hospital
x
x
Rigshospitalet, National University
Hospital
x
x
Helsinki University Central Hospital
x
x
Children's Hospital, Univ. of Helsinki
x
x
FINLAND
(Cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
Hopital Cardiolgique (Lille)
x
x
Hopital La Pitie
x
x
x
x
Martin-Luther Universitaet Halle
x
x
Technischen Universitaet Dresden
x
x
German Heart Institute (Berlin)
x
x
Universitat Hamburg
x
x
Universitaetsklinik (Koeln)
x
x
University of Leipzig - Heart Center
x
x
Kerckoff-Klinik der Max-PlanckGesellschaft zur Forderung der
Wissenschaften e.V. (Bad Nauheim)
x
x
COUNTRY/Center
FRANCE
GERMANY
Organisationsbuero des K.F.H.
(Homburg/Saar)
(Cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
Klinikum der Universitaet (Heidelberg)
x
x
Herz-und Diabetesentrum Nordrhein
-Westfalen (Bad Oeynhausen)
x
x
Chirurgische Universitaetsklinik/
Univ. Rostock (Freiburg Im Breisgau)
x
x
Essen University Medical School
x
x
I. Med. Klinik J. Gutenberg (Mainz)
x
x
der Heinrich-Heine-Universitat
Dusseldorf
x
x
Klinikum GroBhadern, LudwigMaximilians-Universitat Munchen
x
x
Klinikum der Universitat
Kaiserslautern
x
Chirurgische Universitatsklinik
Heidelberg
(Cont’d)
x
COUNTRY/Center
GERMANY (cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
x
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
Medizinische Hochschule Hannover
x
x
Universitatsklinik Gottingen
x
x
Klinikum der RheinischWestfalischen Technischen
Hochschule Aachen
x
x
Fulda Medical Center
x
x
Klinikum der J. W. Goethe
University (Frankfurt am Main)
x
x
Klinikum Der Christian-AlbrechtsUniverstat zu Kiel
x
x
Transplantations-Zentrum (Frankfurt)
x
x
Friedrich Schiller Universitaet (Jena)
x
x
Klinikum Karlsburg
x
Klinik fuer Herzchirurgie Karlsruhe
(Cont’d)
x
COUNTRY/Center
GERMANY (cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
x
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
Medizinische Einrichtupgen der
Universiteat , Nurenberg
x
x
Chirurgische Univ. Klinik/Julius
Maxmillians Universitaet (Wurzburg)
x
COUNTRY/Center
GERMANY (cont’d)
GREECE
Onassis Cardiac Surgery Center
x
x
x
x
Sheba Medical Center
x
x
Hadassah University Hospital
x
IRELAND
Mater Hospital
ISRAEL
ITALY
Policlinico S. Orsola - Universita
degli Studi
(Cont’d)
ISHLT
x
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
Tohoku University, IDAC Hospital
x
x
Osaka University Hospital
x
x
National Cardiovascular Center
x
x
Heart-Lung Institute, University
Hospital Utrecht
x
x
Thoraxcenter - University Hospital
Rotterdam
x
x
University Hospital Groningen
x
x
x
x
x
x
COUNTRY/Center
JAPAN
NETHERLANDS
NEW ZEALAND
Green Lane Hospital
NORWAY
Rikshospitalet - National Hospital of
Norway
(Cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
COUNTRY/Center
TXs Performed 1/2001-6/2002
and Reported to ISHLT
SINGAPORE
National Heart Centre
x
SLOVENIA
University Medical Center Ljubljana
x
x
University Hospital of Lund
x
x
Sahlgrenska University Hospital
x
x
x
x
Great Ormand Street Hospital for
Children
x
x
University of Glasgow/Glasgow
Royal Infirmary
x
x
Northern General Hospital
x
x
SWEDEN
SWITZERLAND
Bern University Hospital
UNITED KINGDOM
ISHLT
(Cont’d)
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
The Freeman Hospital
x
x
Harefield Hosp
x
x
Wythenshawe Hospital
x
x
St. George's Hospital
x
Queen Elizabeth Hospital
x
x
Papworth Hospital
x
x
University of Alabama Hospital
x
x
Baptist Medical Center, Little Rock
x
x
Arkansas Children’s Hospital
x
x
The University Hospital of Arkansas
x
x
University Medical Center,
University of AZ
x
x
COUNTRY/Center
UNITED KINGDOM (cont’d)
UNITED STATES
(Cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
Children’s Hospital Los Angeles
x
x
Cedars Sinai Medical Center
x
x
Loma Linda Univ. Medical Center
x
x
California Pacific Medical Center
x
x
UCSD Medical Center
x
x
University of CA San Francisco
Medical Center
x
x
Sutter Memorial Hospital
x
x
Sharp Memorial Hospital
x
x
UC Davis Medical Center
x
Stanford University Medical Center
x
x
St Vincent Medical Center
x
x
UCLA Medical Center
x
x
COUNTRY/Center
UNITED STATES (cont’d)
(Cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
USC University Hospital
x
x
The Children’s Hospital, Denver
x
x
University Hospital, Denver
x
x
Hartford Hospital
x
x
Yale New Haven Hospital
x
x
Children’s National Medical Center
x
Washington Hospital Center
x
x
All Children’s Hospital
x
x
Jackson Memorial Hospital
x
x
COUNTRY/Center
UNITED STATES (cont’d)
St Luke’s Hospital, Jacksonville
x
Tampa General Hospital
x
x
Tallahassee Memorial Hospital
x
x
(Cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
Shands Hospital at University of
Florida
x
x
Egleston Children’s Hospital
x
x
Emory University Hospital
x
x
St. Joseph Hospital of Atlanta
x
x
St. Francis Medical Center, Honolulu
x
x
Univ. of Iowa Hospital and Clinics
x
x
Children’s Memorial Hospital
x
x
Loyola University Medical Center
x
x
Northwestern Memorial Hospital
x
Rush Pres St Luke’s Medical Center
x
x
OSF St. Francis Medical Center
x
x
St. John’s Hospital
x
COUNTRY/Center
UNITED STATES (cont’d)
(Cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
Univ. of Chicago Medical Center
x
x
University of Illinois Hospital
x
x
Clarian Health-Methodist/IU/Riley
x
x
Indiana University Medical Center
x
x
Lutheran Hospital of Ft. Wayne
x
x
St. Vincent Hosp. and Health Care Ctr
x
x
Via Christi Regional Medical Center
x
x
Jewish Hospital
x
x
Kosair Children’s Hospital
x
Univ. of Kentucky Medical Center
x
x
Ochsner Foundation Hospital
x
x
Tulane University Medical Center
x
x
Willis Knighton Medical Center
(Cont’d)
x
x
COUNTRY/Center
UNITED STATES (cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
Children's Hospital, Boston
x
x
Massachusetts General Hospital
x
x
New England Medical Center
x
x
Brigham and Women’s Hospital
x
x
COUNTRY/Center
UNITED STATES (cont’d)
UMass Memorial Medical Center
x
Johns Hopkins Hospital
x
x
Univ. of Maryland Medical System
x
x
Children’s Hospital of Michigan
x
x
Henry Ford Hospital
x
x
Univ. of Michigan Medical Center
x
x
Abbott Northwestern Hospital
x
x
St. Mary’s Hospital, Rochester
x
x
Fairview University Medical Center
(Cont’d)
x
x
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
Barnes-Jewish Hospital
x
x
Cardinal Glennon Children’s Hospital
x
x
St. Louis Children’s Hospital
x
x
St. Luke’s Hospital of Kansas City
x
x
St. Louis University Hospital
x
x
Univ. of Missouri Hospital and Clinic
x
x
University of MS Medical Center
x
x
NC Baptist Hospital
x
x
Carolinas Medical Center
x
x
Duke University Medical Center
x
x
UNC Hospitals
x
x
Bryan LGH Medical Center East
x
x
Newark Beth Israel Medical Center
(Cont’d)
x
x
COUNTRY/Center
UNITED STATES (cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
Robert Wood Johnson Univ. Hosp
x
x
Presbyterian Hospital, Albuquerque
x
x
Albany Medical Center Hospital
x
x
The Presbyterian Hospital in NY City
x
x
COUNTRY/Center
UNITED STATES (cont’d)
Strong Memorial Hospital
x
Montefiore Medical Center
x
Mt. Sinai Medical Center
x
x
New York University Medical Center
x
Westchester County Medical Center
x
Cleveland Clinic Foundation
x
x
Children's Hospital Medical Center,
Cincinnati
x
x
Medical College Hospital, Toledo
x
x
(Cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
Ohio State University Hospital
x
x
Univ. of Cincinnati Medical Center
x
x
University Hospital of Cleveland
x
x
Integris Baptist Medical Center
x
x
St. Francis Hospital, Tulsa
x
x
Providence Portland Medical Center
x
x
Oregon Health Sciences Univ. Hosp
x
x
Allegheny General Hospital
x
x
Children’s Hospital of Pittsburgh
x
x
Children’s Hospital of Philadelphia
x
x
Penn State Milton S Hershey Med Ctr
x
x
Hahnemann University Hospital Tenet
x
x
Univ of Pittsburgh Medical Center
(Cont’d)
x
x
COUNTRY/Center
UNITED STATES (cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
Temple University Hospital
x
x
The Hospital of the University of PA
x
x
Cardiovascular Center of PR
x
x
Medical University of SC
x
x
Baptist Memorial Hosp, Memphis
x
x
St. Thomas Hospital
x
x
Vanderbilt University Medical Center
x
x
Brooke Army Medical Center
x
x
University Hospital, San Antonio
x
x
Children’s Medical Center of Dallas
x
x
Seton Medical Center
x
x
Columbia Hosp at Medical City Dallas
x
x
St Luke’s Episcopal Hospital
(Cont’d)
x
x
COUNTRY/Center
UNITED STATES (cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
Methodist Specialty & Transplant
Hospital
x
x
University of Texas Medical Branch
x
x
The Methodist Hospital, Houston
x
x
Christus Santa Rosa Medical Center
x
x
St Paul University Hospital
x
x
Baylor University Medical Center
x
x
LDS Hospital
x
x
University of Utah Medical Center
x
x
Primary Children’s Medical Center
x
x
Inova Fairfax Hospital
x
x
Henrico Doctors Hospital
x
x
MCV Hospitals
x
x
COUNTRY/Center
UNITED STATES (cont’d)
(Cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2000
and Reported to ISHLT
TXs Performed 1/2001-6/2002
and Reported to ISHLT
McGuire VA Medical Center
x
x
Sentara Norfolk General Hospital
x
x
University of Virginia HSC
x
x
Children’s Hosp Medical Ctr, Seattle
x
x
Sacred Heart Medical Center
x
x
Univ. of Washington Medical Center
x
x
Children’s Hospital of Wisconsin
x
x
Froedtert Memorial Lutheran Hospital
x
x
St Luke’s Medical Center
x
x
Univ. of Wisconsin Hosp. and Clinics
x
x
COUNTRY/Center
UNITED STATES (cont’d)
(Cont’d)
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Data Currently Available on the ISHLT Web Site:
http://www.ishlt.org
1. Quarterly reports of recent continent-specific statistics are
available for general public:
• Transplant counts
• Tabulation of recipient, transplant and donor demographics
• Survival rates stratified by demographics
2. Quarterly reports for center-specific data are available for each
center through the secure section of the ISHLT web site.
• If your center does not currently have access to the secure site,
contact Linda Butler to obtain an ID and password
3. Registry Report slides will be available for download from the ISHLT
web site on July 1.
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.
Requesting Data from the ISHLT Registry
Data request form is available on the ISHLT web site:
http://www.ishlt.org
PROCESS FOR SUBMITTING A DATA REQUEST:
•Complete form and send to Amanda Rowe
•Request will be reviewed by the appropriate Registry staff
•If approved, request will be processed and programmed.
•Results are usually sent out within 2 weeks of being received by
analytical staff.
DATA/ANALYSES:
•Datasets (patients and centers will not be identified)
•Simple descriptive statistics
•Multivariate analyses -- may require more extensive review
ISHLT
2003
J Heart Lung Transplant 2003; 22: 610-72.