Transcript Title of article

Characteristics and Visual Outcome of
Patients With Retinal Vasculitis
Ku JH, Ali A, Suhler EB, Choi D, Rosenbaum JT. Characteristics and
visual outcome of patients with retinal vasculitis. Arch Ophthalmol.
Published online June 11, 2012. doi:10.1001/archophthalmol.2012.1596.
Copyright restrictions may apply
Introduction
•
Purpose
– To examine the characteristics and visual outcome in 207 patients with
retinal vasculitis.
– To examine factors predictive of visual outcome in this population.
Copyright restrictions may apply
Methods
•
Study Design
– Retrospective medical record review.
•
Study Population
– 207 cases of retinal vasculitis identified from 1390 patients attending
the uveitis clinic at Oregon Health & Science University between 1985
and 2010.
Copyright restrictions may apply
Methods
•
Data Analysis
– Frequencies of variables tabulated for descriptive analysis.
– Kaplan-Meier method applied to compute proportions of visual acuity
improvement as a function of follow-up time.
– Cox proportional hazards model with shared-frailty controls for withinindividual correlation.
Copyright restrictions may apply
Results
• 75 eyes (36.9%) had visual acuity of 20/25 or better at baseline.
• 33.6% of eyes with visual acuity worse than 20/25 at baseline experienced
visual acuity improvement of at least 2 lines on the Snellen chart during
follow-up, and some continued to improve more than 9 years after the
initial evaluation.
• Positive prognostic factors: nonwhite race, worse visual acuity at baseline,
ocular infection.
• Negative prognostic factor: primary retinal vasculitis.
Copyright restrictions may apply
Results
Characteristics of 207 Patients
With Retinal Vasculitis
Copyright restrictions may apply
Results
Average LogMAR Change per
Year in 203 Eyes With Retinal
Vasculitis
Copyright restrictions may apply
Results
Kaplan-Meier curve
demonstrating the
cumulative proportion
of eyes that had visual
acuity improvement of
≥2 lines on the Snellen
chart as a function of
follow-up time in 203
eyes in 114 patients
with retinal vasculitis
who had visual acuity
recorded at ≥2 points.
Tick marks represent
cases lost to follow-up;
dotted lines, 95% CIs
for survival proportions.
Copyright restrictions may apply
Comment
•
This is the first case series to examine visual outcome of retinal vasculitis
in a population from North America.
•
Limitations
– Heterogeneity of retinal vasculitis.
– Accuracy and consistency of data less than from a prospective study.
– Patients had varying lengths of follow-up.
– Data largely represent a northwestern US population.
– Cases may be more severe than seen in primary clinics.
Copyright restrictions may apply
Comment
•
Work Under Way
– Identifying subsets of retinal vasculitis and the prognosis of
each subset.
– Prognostic importance of associated physical and angiographic
findings.
Copyright restrictions may apply
Contact Information
•
If you have questions, please contact the corresponding author:
– Jennifer H. Ku, MPH, Casey Eye Institute, Oregon Health & Science
University, 3181 Sam Jackson Park Rd SW, Portland, OR 97239
([email protected]).
Funding/Support
•
This work was supported by Research to Prevent Blindness, a core grant
from the National Eye Institute, and funds from the Stan and Madelle
Rosenfeld Family Trust, the William and Mary Bauman Foundation, and the
William C. Kuzell Foundation.
Copyright restrictions may apply