Transcript Slide 1

Impact of Autologous Platelet Rich Plasma
Transfusion On Clinical Outcomes in
Descending Thoracic Abdominal Aortic
Aneurysm Repair
S. Zhou, MD, A. Estrera, MD, T. LI, MD, C. Ignacio, MD, S.
Panthayi, MD, H. Safi, MD, R. Sheinbaum, MD
Cardiothoracic and Vascular Anesthesia
Department of Anesthesiology
The University of Texas Medical School at Houston
Autologous Platelet Rich
Plasma
Harvesting
Platelet Rich Plasma
WB
Collected by harvesting 15-20 ml/kg
whole blood prior to CPB
Fractionating off the PRP component.
The goal was a yield of 10-15 ml/kg of
aPRP.
RBC
aPRP
Purpose
aPRP was used to reestablish
hemostasis and significantly reduce
intra-operative transfusions
 Investigate the effect of aPRP
transfusion on the clinical outcome
of patients undergoing TAAA repair.
Materials and Methods
 Retrospectively reviewed 535 cases of
TAAA repair
 Ages 18-80,
 From Feb. 2003 to July 2008.
 182 patients received aPRP harvest and
353 patients did not.
Patient Demographics
Demographics and surgical characteristic between two
groups were similar.
Intra-Operative Blood
Transfusion
Intra-Operative blood transfusions were significantly
reduced in the aPRP cohort .
Intra-Operative Blood
Transfusion
Results
 In the PRP group
24/182 (13.2%) received no
transfusions
134/182(73.6%) received no
platelet transfusion
69/182(37.9%) required 4 or less
units of PRBC transfusion
Morbidity
Time To Extubation
The aPRP group also required reduced ventilator time and were extubated earlier
Conclusions
 Use of PRP in thoracic and
thoracoabdominal aortic aneurysm repair
resulted in reduced blood product
utilization translating into improved
morbidity and mortality.
 Prospective randomized studies are
required.