Transcript Synthetic colloid solution therapy

Hazem Abd El-Salam
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Colloid solutions are solutions containing
high molecular weight substances { >30
000 dalton}
Colloids are used for volume resuscitation
in shocked patients.
Colloid solutions are either blood derived
or synthetic colloids.
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Blood derived colloids are:
Human albumin(5%,25%).
plasma protein fraction(5%).
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Synthetic colloids are:
Dextrose starches.
Gelatins.
hydroxyethyle starch.
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They are D-glucose polymers linked by
alpha bonds into linear macromolecules
prepared from sucrose.
Their half life is 12 hours.
Types are:
Dextran 70(M.W 70 000)
Dextran 40(M.W. 40 000)
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Interfere with blood typing.
Antiplatelet effect.
Antigenic effect with anaphylactoid and
anaphylactic reactions.
Affect renal functions and can be associated
with renal failure.
Gelatins are either:
Succinylated gelatin.
Polygelines (higher ca+ and k+ content)
 Their M.W. 30 000-35 000 dalton.
 Their half life is 4-5 hours.
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Histamine mediated allergic reaction.
Advantages of gelatins
Does not interfere with blood grouping.
 Does not affect renal function.
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Synthetic colloids resemble glycogen
structurally,synthesized from amylopectin.
 Heta starch(e.g.hestril):M.W.450 000,half life
48 h0urs.
 Pentastarch:M.W.200 000,half life less than
24 hours.
 Hextend:M.W. is higher ,half life is longer.
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All hydroxyethyle starches do not affect
coagulation study.
are not antigenic but can cause anaphylactoid
reactions.
less expensive than human albumin.
Colloides are formulated in either: 
 0.9% sodium chloride:
Has higher incidence of mental 
changes,abdominal discomfort,and gastric
mucosa hypoperfusion.
 Lactated ringer:
may lead to hypercoagulable state. 
 D5w.
Normosol solution:
which consists of
electrolytes that are
present in plasma.
Hypertonic saline:
rapid plasma volume
expansions.
to make a summary
colloid solutions are solutions containing high
molecular weight substances.
Can be used in resuscitation of shocked patints.
They are either blood derived or synthetic colloids.
Synthetic colloids are dextrose starches,Gelatins and
etherified starch.
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Thank you