Transcript Slide 1

LETCHUMI THANNIMALAY
SENIOR RESEARCHER
SIRIM BERHAD
GHS Review Conference for
Southeast Asia
22nd May 2013
One World Hotel, Kuala Lumpur
Health Hazards
Acute Toxicity
Skin corrosion/irritation
Serious eye damage / eye
irritation
Trachea
Skin / Respiratory sensitization
Lung
Germ cell mutagenicity
Heart
Carcinogenicity
Reproductive toxicity
Liver
Gall bladder
Specific target organ toxicity
Kidney
(Single exposure)
Specific target organ toxicity
(Repeated exposure)
Aspiration hazard
Oesophagus
Lung
Spleen
Stomach
Kidney
•
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Tobacco
•Tobacco Smoke
Classification of detergent for skin
irritation/corrosion
Does the mixture as
a whole have
data/information to
evaluate skin
corrosion/irritation?
Yes
Does the mixture contain one or
more corrosive ingredients for
which additive applies and where
the sum of concentrations of
ingredients classified as: Skin
Category 1 ≥ 5%?
Category 1
Yes
Danger
N
o
Classification Not Possible
Does the mixture contain one or more corrosive
or irritant ingredients for which additive applies
and where the sum of concentrations of
ingredients classified as:
Skin Category 1 ≥ 1% but < 5%; or
Category 2
Yes
Skin Category 2 ≥10%; or
Warning
(10 x Skin Category 1) + Skin Category 2
≥10%?
No
Classification Not Possible
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Classification of detergent for eye
damage/ irritation
Mixture:
Does the mixture as a
whole or its
ingredients have eye
damage/irritation
data?
Yes
Does the mixture contain one
or more corrosive or irritant
ingredients for which additive
applies and where the sum of
concentrations of ingredients
classified as:
Category 1
Yes
Danger
Eye Category 1 ≥ 3% ; or
Skin Category 1 + Eye
Category 1: ≥3%?
N
o
Classification Not Possible
Does the mixture contain one or more
corrosive or irritant ingredients for which
additivity applies, and where the sum of
concentrations of ingredients classified
as:
(eye or skin Category 1≥ 1% but < 3% or
Category 2A
Yes
(eye Category 2/2A ≥ 10% or
((10 x eye Category 1) + eye Category 2A/2B≥
10%
(Skin Category 1 + eye Category 1≥ 1% but <
3%, or
(10 x (Skin Category 1 + eye Category 1) + eye
Category 2A/B ≥ 10%
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Warning
GHS Toolkit
☺GHS
Toolkit was developed to facilitate
the classification and labelling of
chemical mixtures for 16 physical
hazards, 10 health hazards and three
environmental hazards.
☺Contains 700 pure chemicals which
were classified according to GHS.
☺Able to classify products/mixtures that
contain large number of
ingredients/chemicals such as
detergent.
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GHS TOOLKIT
☺GHS
Toolkit was developed
according to Malaysia building
block (DOSH-CLASS regulation).
☺The toolkit can predict the
classification for the mixtures if
the ingredients are available.
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GHS Toolkit
Results of Classification for Laundry
Detergent
MANUAL CLASSIFICATIONS AND RESULTS FROM THE
TOOLKIT
FOR HEALTH HAZARD
ADVANTAGES
OFAND
TOOLKIT
ENVIRONMENTAL HAZARD
☺Classification
of mixture will be based
on the available test data for the raw
materials of the mixture using
concentration limits or summation
method or additivity formula for the
ingredients in the mixture.
☺Manual classifications are time
consuming with a higher tendency to
make mistakes.
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Validation of the GHS TOOLKIT
 Using local detergent product that
contains about 10 ingredients.
 Experimental data were
conducted (if available) for health
and environmental hazards.
 Manual classification were also
conducted for the detergent
product.
 The results from the GHS Toolkit
were compared with Experimental
data and manual classification
data.
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Validation of the GHS Toolkit Using Randomly
Selected Mixtures for Health and Environmental
Hazard
Validation for inhalation toxicity
100‐(∑C unknown if > 10%)
ATEmix
=
Ci
∑ ATEi
ｎ
(100-50% ) / ATE mix = (2/5.03) +(48/6.6)
ATE mix = 50/((2/5.03) +(48/6.6))= 6.5 mg/l
classified as Category 3 for acute toxicity inhalation of vapours.
(Category 3 is in between 2 mg/l and 10 mg/l as shown in Table 1 in Appendix 4).
Validation for mutagenicity
Validation for Mutagenicity
If the mixture has more than 1% of mutagenic Category 2 raw
materials then the mixture is classified as Category 2. Although the
raw material in the mixture, lead chromate, only consists of 2%
mutagen, the whole mixture is considered as mutagen.
Validation for Aquatic Toxicity (chronic
toxicity)
Validation of the GHS toolkit for aquatic toxicity was conducted using
the mixture that contains 4,4’ Methylenedianiline 2% (category 3),
disodium tetraborate anhydrous 74.5% (not classified), chloroaniline
0.5% (category 1) and methylstyrene 23% (category 2).
Summation method was used to classify aquatic toxicity (chronic).
Step 1 Chronic 1 x M > 25% (M=1 because LC50= 0.46)
(category 1 has 0.5% chemicals)
0.5% x 1 not more than 25% so it is not classified as
Category 1
Step 2 (M x 10x Chronic 1) + Chronic 2 > 25%
(1 x 10 x 0.5) + 23% = 28% > 25% (the mixture is
classified as Category 2)
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