Transcript Metabolic Testing – How to Use Testing to Treat a Wide

Metabolic Testing – How to Use Testing to Treat a
Wide Variety of Diseases
Dr. Mark Schauss – Lab Interpretation LLC
How I Choose Lab Tests
• People ask me about how I go about
determining whether a test is valuable or
not.
• Above all, it must have clinical relevance.
– If Aunt Martha comes in complaining of
fatigue and the test I use doesn’t address
this issue, there is no reason to run it.
• If the results change the way the patient is
treated, then it may be valuable.
– This is utilizing the concept of biochemical
individuality
How to Choose Lab Tests
• Does the test and the use of the results
have scientific backing.
– In the case of Fatty Acids, targeting
changes based on those results with
specific fatty acids have not been shown
to be effective.
• Ordering the fewest number of tests to get
the maximum benefit.
• Preserving patient cash while increasing
clinical success.
How I Choose Lab Tests
• Measuring an item in the blood or within a
cell and applying a reference range to it may
not reveal anything about the functionality of
said item.
• Say two people do a test to measure the
amount of magnesium in their cells.
• The reference range is 10 – 50 with a mid
point of 30.
• Both people get a 30 yet person A is
magnesium deficient and person B is not.
• How is this possible?
How I Choose Lab Tests
• When we do a functional test, we can look at
the level of Ethanololamine in a Plasma Amino
Acid test.
• It is a strong marker for the presence of a
functional magnesium deficiency as well as
giving us clues as to the production of
acetylcholine.
• If person A shows up for a number of functional
magnesium deficiencies than maybe the level of
magnesium present in the sample of their cells
may not be adequate due to genetic or
environmental reasons.
How I Choose Lab Tests
• Person B may not need as much
magnesium to function as efficiently
compared to Person A.
• In order to get the best clinical outcomes,
I look at the test in a true functional way.
• A problem I see with some labs is the
agendizing of interpretations.
• They begin with a premise and will stick with
that in spite of a preponderance of evidence
to the contrary.
How I Choose Lab Tests
• The problem arises when a lab takes a position on
the meaning of a variable and will not change the
stance.
• p-Hydroxybenzoate, measured in urine organic acid
tests, is used as a marker for paraben exposure.
• Ye, X., A. Bishop, et al. (2006). "Parabens as Urinary Biomarkers of
Exposure in Humans." Environmental Health Perspectives 114(12): 18431846.
•
Pugazhendhi, D., G. Pope, et al. (2005). "Oestrogenic activity of p-hydroxybenozic acid
(common metabolite of paraben esters) and methylparaben in human breast cancer cell
lines." Journal of Applied Toxicology 25: 301-309.
• Yet a number of labs sidestep the evidence and
stick by their definition as strictly a marker for
dysbiosis which may or may not be accurate.
How I Choose Lab Tests
• Some labs go so far as to interpret data in a
way that has already been shown to be false
yet hold steady because of their dogmatic
views.
• Citramalate, Tartarate and Arabinose have been
claimed to be markers for yeast yet there is
powerful evidence to the contrary.
• There is a lab that continues to make the claim
leading to countless people being treated with
anti-fungals when there may be no need.
• Interpreting lab data is not an emotional issue, it
must stay strictly scientific.
How I Choose Lab Tests
• So why do children with autism improve using antifungals if yeast is not so prevalent?
• Many children with autism have upregulated Phase
I detoxification pathways and down regulated
Phase II.
• The intermediary chemicals created in Phase I are
more neurologically toxic than the original chemical,
especially with petrochemical solvents.
• Anti-fungal drugs down regulate Phase I which
allows Phase II to catch up.
• This is also why they do so poorly after removing
the drugs.
• Improving Phase II through the use of amino acids
such as Glycine will help upregulate Phase II.
How I Choose Lab Tests
• Lab competence is critical.
• I typically visit the lab, talk to their lab
directors and talk to practitioners about their
experiences.
• In an interview in Lab Interpretation LLC’s
CD series, Laboratory Medical Update, I
talked to Mark Newman, Assistant Lab
Director for ZRT Labs about this issue.
• In my opinion, lab competency is one of the
most important problems in our industry.
How I Choose Lab Tests
• I have seen lab results that made me
believe that the lab used a random number
generator to come up with the results.
• If the results cannot be trusted, what good is
the interpretation?
• I will be starting a lab competency program
this fall and will have a signup sheet for
anyone interested in being involved and
being kept abreast of the results.
Why Another Lecture About Lab Tests
• Albert Einstein once said when told his final exam
he had given his students was the same as last
years
• “True, but this year the answers are different.”
• In laboratory testing, we learn new things from new
research every day.
• We find new ways of testing, new results we can
interpret and better techniques of testing things we
already know about.
• We also find new meanings about results causing
paradigm shifts in treatment protocols.
Important Tidbits of Information
• An example of a new interpretation for a pair of
well known test variables.
• Vanilmandelic acid is the main metabolite of
catecholamines and Homovannilic acid is the
main dopamine metabolite are both urinary
metabolites .
• Vanilmandelate is related to phenylalanine and
homovanillate to tyrosine.
• A few labs use these two to recommend the
appropriate amino acid complex as well as the
use of these two amino acids alone.
• This may be contraindicated because of newer
research that has come to light.
Important Tidbits of Information
• According to research, both of these variables
being elevated in urine have been correlated to
environmental toxins such as heavy metals and
petrochemical solvents and pesticides.
• de Burbure, C., J. Buchet, et al. (2006). "Renal and Neurologic Effects of
Cadmium, Lead, Mercury, and Arsenic in Children: Evidence of Early Effects and
Multiple Interactions at Environmental Exposure Levels." Environmental Health
Persepectives 114(4): 584-590.
• Extremely elevated levels of these two metabolites
may be indicative of tumor growth and possibly the
onset of a myocardial injury.
• Toxins are implicated in a number of cancers so
here may be one of the early warning flags before
the disease presents itself.
Reference Ranges
• Labs typically run a number of tests on a
wide variety of people in order to determine
the reference range for a result.
• The range is where 95% of the test subjects
results are.
• In some cases the reference range is
overwritten by the medical director in order
to propose a new definition of healthy.
• There are significant problems with these
two scenarios.
Reference Ranges
• In the case of the 95%, there is a problem
when the population is not healthy.
• This is the case with Ultra-Sensitive Thyroid
Stimulating Hormone (TSH).
• The typical lab range is .5 – 5.5 uIU/mL.
• Unfortunately, an estimated 25-30% (it could
be higher) of the population is hypothyroid
and fall into this range.
• Research has suggested that the proper
reference range for TSH should be 1.1 – 2.5.
• This is the range we use in the LabAssist™
Reports.
Reference Ranges
• In the other scenario, medical bias comes into play.
• In a number of labs I have seen, the reference
range for Total Cholesterol is 0 – 199 mg/dL.
• According to Bernard Statland, MD PhD, a world
renowed clinical pathologist states in his book
Clinical Decision Levels for Lab Tests, when
discussing a Cholesterol of 90 mg/dL or below
“Values below this level are often associated with
severe liver insufficiency.”
• So a person is in the reference range can be
deathly ill as often times the prognosis for people at
that level is “poor”.
Reference Ranges
• The journal Circulation has an editorial that pointed
out the risks for many diseases goes up when Total
Cholesterol is below 160 mg/dL.
– Hulley, S., J. Walsh, et al. (1992). "Health Policy on Blood
Cholesterol: Time to Change Directions." Circulation
86(4): 1026-1029.
• The pressure put upon the editorial staff of
Circulation by the pharmaceutical industry was
immense for obvious reasons.
• Within the alternative supplement industry, there is
a great deal of marketing money put into to the
lowering of cholesterol paradigm despite evidence
that it may not be beneficial in the prevention of
coronary heart disease.
Toxicity Issues
• In 2005 the CDC did a survey across America
where the average citizen had the presence of 148
chemicals in their blood. The report is 475 pages
long.
– Third National Report of Human Exposure to Environmental
Chemicals, Centers for Disease Control and Prevention 2005.
www.cdc.gov/exposurereport/pdf/thirdreport.pdf
• One line in the report struck me for different
reasons than it might strike others.
• Under Public Health Uses of the Report it states “To
establish reference ranges that can be used by
physicians and scientists to determine whether a
person or group has an unusually high exposure.”
Toxicity Issues
• As we know with laboratory testing, often
times reference ranges are skewed due to
an abnormal population. Case in point TSH
levels.
• This report makes it so that it will be used to
allow for an “acceptable level” of toxicity for
each of you and your patients.
• Some chemicals have an effect at low levels
only.
• Polymorphisms in genes coding for
metabolizing enzymes contribute to
interindividual variability and may vary by
more than 50-fold in humans (Guengerich et
al. 1991).
Toxicity Issues
• What is a poison for you may not be for me.
• According to research done by the EPA on
Bisphenol A (BPA), they only looked at the
changes to the weight of rat brains to
determine toxicity levels.
• Some studies found changes in rodents'
reproductive organs and brains at doses as
low as 0.002 mg per kilogram of body weight
per day.
• is just one-25,000th the dose that the EPA
said was the lowest exposure having an
observable adverse effect.
Toxicity Issues
• Newer research into the subtle effects of
BPA on hormone levels indicates that far
lower doses can have profound effects on
the development of human fetuses and on
adult health, especially women.
• While I believe there is an enormous benefit
in testing people for hormone levels, I
believe it is more important to test for
endocrine disrupting chemicals that can
affect hormone balance.
Toxicity Issues
• If the findings that chemicals like Bisphenol A (BPA)
are found in the drinking water, house dust, and
ambient air are true and at tiny levels they can
affect estrogen receptors think of the types of
cancers our children will have.
• In the 1950’s a woman’s lifetime risk of breast
cancer was 1 in 22.
• Today it is 1 in 7.
• It is not a genetic epidemic, it is environmental, it is
due to endocrine disruption.
• BPA is worth $100 million an hour.
• Banning it will take enormous guts.
• Becoming good detoxifiers forever is therefore
critical.
Toxicity Issues
• If you have a person that has done a saliva
hormone test and noticed that their cortisol levels
do not go down through the day as expected the
mechanism may be toxic in nature.
• In a study published in EHP February 2008, Gump
et al showed that lead levels, even low ones below
10 μg/dL can alter corticosteroid levels and interfere
with heightened reactivity to acute stress.
• Gump, B., P. Stewart, et al. (2008). "Low-level prenatal and postnatal blood
lead exposure and adrenocortical responses to acute stress in children."
Environmental Health Perspectives 116(2): 249-55.
• The higher lead levels in big cities like New York
may explain the higher stress readings of
inhabitants.
Toxicity, Is It In Us?
• When the topic of toxicity is discussed, we
should no longer wonder whether our patient
is toxic or not, but whether they are good
excretors of toxins.
• This is especially true when dealing with
petrochemical solvents as well as heavy
metals.
• Other toxins like the byproducts of bacterial,
parasitic and viral metabolism should also
be monitored.
• The toxicity of stress is another issue that
should be looked at holistically.
Toxicity Is It In Us?
• Detoxification should be thought of as a
three-step process.
• First step is to identify the toxins (never
assume there is only one) and begin an
individualized detoxification protocol.
• This is where you determine the patient’s
ability to naturally detoxify, support whatever
phase of detoxification is efficient (if any)
and bolster the phase that is inefficient in an
individualized manner.
Toxicity Is It In Us?
• The second step, the part I feel is most
important is to identify the source of the toxicity.
• If phthalates are the problem, look into the
sources like cosmetics, air fresheners,
perfumes and colognes, microwaving of
plastics, dental retainers, etc…
• If it is stress, look into their lifestyles, behaviors,
home life, and their past.
• Have them do an inventory of their environment
to see where the toxins are and have them work
on eliminating them.
Toxicity Is It In Us?
• The third step may be the hardest to convey.
• We no longer live in a world where “living
clean” makes you free of toxic exposure.
• Eating organic, making sure you avoid
toxicity in your home and work area is
important but it does not keep you safe.
• We live in a toxic world.
• Because of this concept, we need to
become efficient excretors of toxins for life.
Toxicity Is It In Us?
• People need to have tools to become efficient
excretors and they need to do this on a daily
basis.
• All of us, need to practice this on ourselves
before we practice it on our patients.
• Educating the patient that this is a life long
change that they need to commit to is critical to
their ability to achieve victory over this toxic
world.
• Turning ones face to the onslaught of toxins
and denying it is an invitation to disease,
morbidity and eventually mortality.
Toxicity Testing
• When dealing with endocrine disruption
disorders ranging from diabetes to
hypothyroidism there are two essential tests
to run.
• An Environmental Pollutants Biomarker test
and a Whole Blood Elements.
• Both are available through LabAssist.
• The first is run by US Biotek and the second
through Doctor’s Data.
Toxicity Testing
• Finding out the excretion pattern in
individuals with solvent toxicity is critical in
determining exposure and subsequently,
detoxification protocols.
• Finding out heavy metal levels as well as
trace mineral competency is also highly
beneficial in treating the causative factors in
endocrine disruption.
Toxicity
• A normal mammalian response to toxicity is
to lower metabolism.
• The increased incidence of depressed basal
temperatures in patients can be directly
related to the increased levels of toxicity.
• In a number of cases we have noticed a
distinct improvement in basal temperature
through proper detoxification.
Important Tidbits of Information
• When comparing lab results from one test to
another, timing is everything.
• In the case of Cholesterol, readings tend to
be higher in the fall and winter than the
spring and summer.
• The difference can be as much as 20%.
• If you wanted to produce a study on the
effect of your drug or supplement on
cholesterol levels, when would you start the
study and when would you follow up the
test?
Important Tidbits of Information
• If the person has had a traumatic episode
recently such as surgery, accident, death in
the family, do not run an organic acid in
urine test.
• The results of this test would be highly
skewed and may not accurately reflect the
persons true metabolic state.
• A 1-2 month rest period is suggested to let
the system “settle down”.
Important Tidbits of Information
• If a child is traumatized because of a blood
draw, the results will be skewed and will not
be reflective of their true metabolic state.
• Liver enzymes, electrolytes and hematology
will all be negatively affected by a traumatic
blood draw.
• An amino acid plasma test needs a 12-14
hour fast prior to the test for accuracy.
• A comprehensive blood chemistry needs 8
hours.
• Urinary Organic Acids need dietary
restrictions to be accurate.
Aging
• One of the most important issues in today’s
society is aging.
• With our aging population, a lot of people
want to know how to slow down the process.
• Here is what we do know:
– Aging is about oxidation
• The use of anti-oxidants do not seem to
slow down the aging process all that
much.
Aging
• You can cut back the speed at which
you age by cutting back on the amount
of food you eat drastically.
– Numerous studies suggest that it is
the quantity of food that is the key.
When you eat very little the cells last
longer. Or is that the real
mechanism???
Aging
• The real key to living longer is reigning in
inflammation.
• In an excellent, but hard read, Professor
Caleb E. Finch wrote the book – The Biology
of Human Longevity: Inflammation, Nutrition,
and Aging in the Evolution of Lifespans,
2007 Academic Press discusses the issue.
• Does the longevity research into low-calorie
diets only mean that the low intake is the
sole anti-aging driver?
• Another possibility is that when you restrict
your diet, you avoid inflammatory foods.
Aging
• The LEAP MRT Food Sensitivity test is a good way
to find out what foods increase the inflammatory
response.
• By avoiding these foods, you can drastically reduce
inflammation which is beneficial not just in slowing
down the aging process but in a myriad of
inflammatory diseases ranging from coronary heart
disease, migraines, arthritis, irritable bowel
syndrome, and any neurodegenerative disease.
• We know that inflammation can also affect the
mitochondria so any time we can reduce
inflammation we protect the mitochondria.
Aging, Oxidation and Inflammation
• We know that chronic infections cause
oxidative stress.
• Wen, J., P. Yachelini, et al. (2006). "Increased oxidative stress is
correlated with mitochondrial dysfunction in chagasic patients."
Free Radical Biology and Medicine 41(2): 270-6.
• Monitoring the patient using a
Comprehensive Blood Chemistry is highly
beneficial.
• The pattern in the differential of White Blood
Cells is helpful in determining the type of
infection.
• The test should always include Uric Acid
which isn’t typically included.
Uric Acid
• Uric Acid is one of the bodies natural
antioxidants.
• Increased levels are typically caused by the
bodies need for antioxidant help.
• It is known to scavenge peroxynitrate.
• Multiple sclerosis patients have low Uric
Acid and high peroxynitrate.
• Lower serum Uric Acid levels in MS patients
may represent a primary, constitutive loss of
protection against Nitric Oxide.
• Stimulating xanathine oxidase through the
use of molybdenum may be beneficial.
Inflammation and Infection
• Neutrophils are typically indicative of a bacterial
infection but an increase of the absolute numbers
can occur with inflammation.
• Eosinophils are typically seen in allergic responses
but also in infestations of parasites.
• Basophils are rarely seen but when they are
elevated it is indicative of an allergic response and
correlates to elevated histamine in the blood.
• Monocytes, the largest of the white blood cells are
phagocytic as they are viewed as scavengers but
they also produce the antiviral agent interferon.
Inflammation and Infection
• Lymphocytes are a primary defense against
viruses but they are also seen in the early
and late stages of inflammation.
• Looking at the pattern of these cells both in
percentages of the total and in absolute
numbers can give you a very accurate
picture of what is going on immunologically.
• With LabAssist™ we have already preprogrammed many of these patterns.
• Through that we have even been able to
reveal a case of Psittacosis.
Infertility and Pregnancy
• At no time in human history has infertility
reached such epidemic proportions.
• The blame clearly has to lie at the feet of our
toxic environment.
• According to the Center for Disease
Control’s National Survey of Family Growth
the fastest growing segment of the
population with “impaired fecundity
(infertility) is women under the age of 25.”
Infertility and Pregnancy
• In the 1970’s, Danish researcher Niels
Skakkebaek of the Copehagen University
Hospital showed links between testicular
cancer in adults and abnormalities in genital
development.
• At 3 months, baby boys experience a surge
of testosterone.
• In a study of 65 infants published in 2006,
they discovered that the higher the level of
phthalates, the greater the evidence of antiandrogenic hormonal activity.
Infertility and Pregnancy
• Ana Soto of Tufts University School of
Medicine was studying the effect of estrogen
on a breast cancer cell line.
• Much to her chagrin, the cancer cells were
proliferating like crazy as if a bottle of
estradiol had been dumped in them.
• Turns out, the tubes storing a component of
the medium growing the cells had
nonylphenol to improve impact resistance.
• The chemical, injected into rats, made the
epithelial lining of the uterus proliferate – a
sign of its being an estrogen.
Infertility and Pregnancy
• I believe that for all people, male or female, it is
imperative to do an Environmental Pollutants
Biomarker test.
• Phthalates, xylene, toluene, benzene, styrene, and
dimethylbenzene are all developmentally toxic.
• Phthalates can damage male DNA in sperm.
• It can also cause shortening of pregnancies by up
to two weeks and according to research full-term
babies have markedly higher cognitive scores later
in life (Larroque, et al, The Lancet, Vol 371, pg
823).
• Urinary markers of phthalates are vastly superior to
serum.
–
Hogberg, J., A. Hanberg, et al. (2008). "Phthalate diesters and their metabolites in human
breast milk, blood or serum, and urine as biomarkers of exposure in vunerable populations."
Environmental Health Perspectives 116(3): 334-9.
Infertility and Pregnancy
• For women, I would highly suggest doing two
additional tests aside from the EPP.
• A Whole Blood Elements test from DDI would be #1
as quite often women trying unsuccessfully to have
a child are very mineral deficient.
• Also, any toxic heavy metal load could decrease
the chances for a healthy pregnancy.
• In the March 2008 EHP journal, researchers led by
Leasure, et al, showed that gestational lead
exposure produced permanent male-specific effects
including an increase in obesity as well as motor
deficit, and altered dopamine.
• The responses were dose-dependent.
Infertility and Pregnancy
• Secondarily, a Plasma Amino Acid test often times
show broad deficiencies in both essential and
conditionally essential amino acids.
• With women, there have been some issues with
increased tryptophan and elevated serotonin
(especially with 5-HTP) and an increase in
miscarriages, dysmenorrhea and tubal spasms.
• With males, it may improve sperm viability.
• In a study by Schacter in 1973, 4 grams of arginine
was used on 178 men and 111 had significant
improvement, 21 moderate and only 25 showed no
improvement in sperm motility and sperm counts.
Infertility and Pregnancy
• A urine iodine challenge may be another
important test to do for pregnant women.
• In the autism pesticide study (Roberts, et al,
2007 EHP), iodine deficiency may be the
mechanism by which the incidence of autism
rose to exposed mothers.
• Since many environmental toxins affect the
thyroid and the lack of iodine can adversely
affect the fetus, this is another very
important test to run.
Autism
• Urinary porphyrin testing is the latest rage.
• It is theoretically useful if the specimen is handled
correctly.
• There in lies the rub.
– Porphyrin’s are highly light and air sensitive.
– Pee into a bucket with a fluorescent light and half
the analyte is gone.
– Shaking instead of gently rocking the specimen
can cause depletion of the porphyrin analyte.
• There is a very high incidence of false negatives with
this test.
• Even with proper handling, the false negative rate
reduces clinical utility.
Autism
• Urine heavy metal challenge tests are also
commonly used with children with autism.
• It’s clinical utility is questionable.
• The risk of developing side-effects due to the
use of a chelating substance is substantial.
• It does not indicate the burden and/or the
disruption of biochemical pathways due to
mercury or other heavy metals.
• A hair elements test, using the counting method
developed by Dr. Andrew Cutler and spelled out
in his books Hair Test Interpretation and
Amalgam Illness (available at
www.noamalgam.com) is safer and superior.
Autism
• According to the data from the DAN website,
chelation therapy has a very high positive
outcome with a low negative and relatively
low no effect rate.
• http://www.autism.com/treatable/form34qr.htm
• Out of 803 cases reported the positive
response rate was 74% with negative results
being at 3% and no response being the
lowest of all treatments at 23%.
Autism
• I see a high percentage of autistic children,
especially boys with high urinary phthalate levels.
• They also often times have other solvents such as
xylene, toluene, styrene, and benzene.
• Detoxifying these ubiquitous chemicals seems to
lower many of the common traits such as stimming,
head banging and hand flapping.
• This may be due to the upregulation of Phase II
detoxification from the detoxification protocols
reported in the LabAssist Interpretive Reports.
Autism
• A Plasma, Blood Spot or Urine Amino Acid
test would be beneficial in assessing these
important builders of neurotransmitters.
• LabAssistTM has developed a method to
customize the My Aminoplex based on a
Plasma or Blood Spot Amino Acid test.
• We see a number of children with autism
with dramatically abnormal amino acid
profiles.
• Taurine is typically low and autistic children
benefit greatly from its supplementation.
Asthma
• In numerous studies, pollution has been a
driving force in the increase of asthma cases,
especially pediatric.
• Many of the variables found in the
Environmental Pollutants Biomarker test from
US Biotek, have been shown to increase
asthma rates.
• Diesel fuel driven trucks and cars release
benzene, which is known to cause inflammatory
responses in the lungs as well as reduce
oxygen carried by red blood cells.
• Inner city children, exposed to petrochemicals
have some of the highest rates of asthma.
– Wu, F. and T. Takaro (2007). "Childhood asthma and
environmental interventions." Environmental Health
Perspectives 113(6): 971-5.
Asthma
• The driving force behind the dramatic
increases in asthma cannot be explained by a
genetic component.
• The evidence is clear.
• Environmental pollution is the reason for the
increases.
• Xylene can irritate the lungs.
• Toluene can cause a disruption of the
hypothalamus which has been linked to an
increase in asthmatic attacks.
– Moron, L., J. Pascual, et al. (2004). "Toluene alters appetite, NPY, and galanin
immunostaining in the rat hypothalamus." Journal of Neurotoxicology and
Teratology 26(2): 195-200.
– Nagata, S, Role of anterior hypothalamus on asthma, International Congress
Series Volume 1287, April 2006, Pages 256-259 Psychosomatic Medicine Proceedings of the 18th World Congress on Psychosomatic Medicine, held in
Kobe, Japan, between 21 and 26 August 2005
Asthma
• Phthalates, found in air fresheners, new car
smell and many plastics have been
implicated in asthma.
– Bornehag, C., J. Sundell, et al. (2004). "The Association between
Asthma and Allergic Symptoms in Children an Phthalates in House
Dust: A Nested Case-Control Study." Environmental Health
Persepectives 112(14): 1393-1397.
– Kolarik, B., K. Naydenov, et al. (2008). "The association between
phthalates in dust and allergic diseases among Bulgarian children."
Environmental Health Perspectives 116(1): 98-103.
• Assessing urinary output of these solvents
and following the recommended protocols
may be helpful in working with asthmatics.
Asthma
• Air pollution and stress interact to create a
predictive clinical outcome in asthma.
– Chen, E., H. Schreier, et al. (2008). "Chronic traffic-related air pollution
and stress interact to predict biologic and clinical outcomes in asthma."
Environmental Health Perspectives 116(7): 970-5.
• In my preaching to the choir statement of the
day, asthma is not a deficiency of steroids.
• It is clearly related in many cases to an
increase of pollution and toxicity in both
children and adults, especially women.
Asthma
• Adult onset asthma is often linked to
hypothyroidism.
• The Nurses’ Health Study done at Harvard
found that women taking postmenopausal
hormones were 50% more likely to develop
adult-onset asthma due to higher estrogen.
• This may explain why girls have much higher
rates of asthma than boys.
• Often times, asthmatics will have abnormal
electrolyte and thyroid panels.
• Using a balanced electrolyte like Peltier often
times improves breathing but should not be
thought of as a treatment for acute episodes.
• A comprehensive blood chemistry is essential in
the treatment of asthma.
Type II Diabetes
• With any diabetic, running a comprehensive
blood chemistry should be a given.
• Monitoring blood sugar, triglycerides,
cholesterol with LDL and HDL are critical to
any dietary intervention.
• Electrolyte depletion, particularly sodium,
potassium, magnesium, calcium,
bicarbonates and chlorides are often seen
and need to be addressed if deficient.
• Some of the markers for oxidation like uric
acid are also seen along with elevated
fibrinogen.
Type II Diabetes
• Here is the pattern often seen with people
with Type II diabetes:
– Elevated: Alkaline Phosphatase,
Basophils, Cholesterol, Creatinine,
Fibrinogen, Glucose, GGT, Hemoglobin
A1c, LDL, Triglycerides, BUN, and Uric
Acid
– Decreased: Albumin, CO2, Calcium,
Chloride, HDL, Iron, Phosphorus,
Potassium, and Sodium.
Type II Diabetes
• Plasma amino acids can also help with a
support protocol for people with diabetes.
• Cysteine and Taurine are beneficial in
preventing kidney failure.
• Taurine is helpful in counteracting oxidative
stress commonly found in diabetics.
• It should be used with caution as it can
lower blood sugar due to its action of
potentiating insulin.
• GABA is thought to increase insulin’s effect
and the use of 2-4 grams can significantly
decrease blood sugar.
Type II Diabetes
• An Environmental Pollutants Biomarker test
is also very helpful if the person has been
exposed to high levels of a number of toxins.
• Phthalates have been shown to affect insulin
resistance.
– Stahlhut, R., E. Wijngaarden, et al. (2007). "Concentrations of
Urinary Phthalate Metabolites Are Associated with Increased
Waist Circumference and Insulin Resistance in Adult U.S.
Males." Environmental Health Perspectives 115(6): 876-82.
• Chemicals like toluene, xylene, benzene and
styrene have been implicated in a wide array
of endocrine disruption and blood sugar
regulation.
Type II Diabetes
• Urinary Organic Acids are a tertiary test to use
because it can help identify the following problems
known to occur in diabetics:
– Excessive Fatty Acid Oxidation
– Carnitine Deficiencies
– Keto-acidosis
– Disordered Gluconeogenesis
– Excessive Oxidative Stress
– Intestinal Dysbiosis
– B-Complex Competency
– Liver Detox Dysfunction
– Poor Energy Production
Type II Diabetes
• As with most disorders, inflammation is a
key component in the progression and/or
control of diabetes.
• Diet is critical.
• Assessing the foods that can trigger
inflammatory reactions is important in
helping your patient achieve optimal help.
• This is another good reason to utilize the
LEAP MRT blood test.
Type II Diabetes
• The LEAP MRT test is beneficial in order to
isolate those foods, regardless of their affect
on blood sugar, that might induce an
inflammatory response.
• Reducing this response will improve the
quality of life of the diabetic since many of
them have numerous other symptoms like
arthritis.
• Drugs used to treat arthritis like anikinra
(Kinemet) have been shown to help regulate
blood sugar because of their effect on the
cytokine IL-1 (interleukin-1).
Type II Diabetes
• The immune system produces cytokines in response
to inflammation in the body. The cytokine, Interleuken1 (IL-1) shows up in areas of inflammation, like in the
joints or other places in the body. Anakinra blocks the
production of interleukin-1. That's why it's used to
treat arthritis.
• In diabetes, interleukin-1-beta is produced in the
pancreas. High glucose levels appear to trigger the
release of interleukin-1-beta. This not only reduces
the function of beta cells in the pancreas, but can
cause beta cells to self-destruct.
• This is why using LEAP MRT with diabetics may be
highly beneficial.
Further Information
• I will be doing one and two-day seminars
here in Colorado and around the country
starting this fall through next spring.
• It will be covering 25 different disorders and
the appropriate tests that would give the
best clinical results.
• The course will also review actual cases.
• If you are interested, please see us this
weekend at our booth to get on the list.
Contact Information
Dr. Mark Schauss, DB
Lab Interpretation LLC
18124 Wedge Parkway,
Ste 432
Reno, NV 89511
775-851-3337
[email protected]
www.labinterpretation.com
www.MarkSchauss.com
www.ToxicWorldBook.com