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A Current Update on U.S. Risk Capital Markets Ivar Sorensen, Managing Partner, The M&A Group, LLC Total Annual U.S. Venture Capital Investment ($ Millions) $120,000.0 $100,000.0 $80,000.0 $60,000.0 $40,000.0 $20,000.0 $0.0 1995 1997 1999 2001 2003 2005 2007 2009 2011 2013P Source: PricewaterhouseCoopers/National Venture Capital Association MoneyTree™ Report, Data: Thomson Reuters 2 Annual U.S. VC Investment ($ Millions) $14,000 $12,000 U.S. VC Average Investment Size ($ Millions) $12.0 $10.0 $10,000 $8,000 $6,000 $4,000 $8.0 $6.0 $4.0 $2,000 $0 $2.0 $0.0 2002 2004 Seed Seed Early Stage Early Stage Expansion Stage Expansion Stage Later Stage Later Stage 2006 2008 2010 2012 Source: PricewaterhouseCoopers/National Venture Capital Association MoneyTree™ Report, Data: Thomson Reuters 3 Annual U.S. VC Investment ($ Millions) $30,000.0 U.S. VC Average Investment Size ($ Millions) $10.0 $9.5 $25,000.0 $9.0 $8.5 $20,000.0 $8.0 $15,000.0 $7.5 $7.0 $10,000.0 $6.5 $6.0 $5,000.0 $5.5 $0.0 $5.0 2002 2004 2006 2008 2010 2012 2002 2004 2006 2008 2010 Total Investment Less Medical Device s & Equipment Total Investment Less Medical Device s & Equipment Medical Device s & Equipment Medical Device s & Equipment 2012 Source: PricewaterhouseCoopers/National Venture Capital Association MoneyTree™ Report, Data: Thomson Reuters 4 Total Global VC Funding by Sub Segment ($ Millions) $1,000 $900 $800 $700 $600 $500 $400 $300 Medical Therapeutics $200 Medical / Health Products $100 Medical Diagnostics $0 2010 2010 2010 2010 2011 2011 2011 2011 2012 2012 2012 2012 2013 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Source: PricewaterhouseCoopers Capital Crunch May 2013 5 VC investments have consistently underperformed most every other asset class since 2001 250 200 150 100 50 0 1Q 2Q 3Q 4Q 1Q 2Q 3Q 4Q 1Q 2Q 3Q 4Q 1Q 2Q 3Q 4Q 1Q 2Q 3Q 4Q 1Q 2Q 3Q 4Q 1Q 2Q 3Q 4Q 1Q 2Q 3Q 4Q 1Q 2Q 3Q 4Q 1Q 2Q 3Q 4Q 1Q 2Q 3Q 4Q 1Q 2Q 3Q 2001 2002 2003 PE 2004 2005 VC 2006 S&P 500 2007 2008 Debt 2009 2010 Real Estate 2011 2012 Source: PitchBook 6 The performance of VC Funds has consistently lagged other alternative fund types over the last decade 20% 18% 16% 14% 12% 10% 8% 6% 4% 2% 0% 1-year 3-year All PE Funds VC Funds 5-year Debt Funds 10-year Fund-of-Funds Source: PitchBook 7 More than a quarter of all VC funds raised since 2001 currently have a negative IRR 20% 15% 10% 5% 0% 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 -5% -10% -15% IRR 25th Percentile IRR Median IRR 75th Percentile Source: PitchBook 8 • VC investment spending has been fairly consistent since 2003 • Total investments made and average investment size increase as companies move up the development curve • Investment in medical devices & equipment, both in total amount invested and average investment size, mainly track the total VC market • Global VC funds have underperformed most every other asset classes for the past decade • Poor performance = fewer investment dollars 9 The best opportunities are still being funded Critical Unmet Need Disruptive Therapeutic Technology Proven Management Team 10 Target Buyer Transaction Vessix Vascular, Inc., a pre-revenue medical device company, was acquired by Boston Scientific in November 20012 for $125M plus milestone payments up to $300M by 2017. Vessix has a catheter based radio frequency device for the treatment of uncontrolled hypertension. Its device has CE certification, but not FDA approved. Vessix expecting to commercialize its product in Europe in 2013. Cameron Health, Inc., an early-stage medical device company, was acquired by Boston Scientific in June 2012 for an initial price of $150M plus $150M upon FDA approval and up to an additional $1,050M based on six-year revenue targets. Cameron has a CE certified (2009) device for a subcutaneous implantable cardioverter defibrillator. The device is commercially available in Europe and FDA approval is expected in 2013. Visiogen Inc., an optical device company founded in 2001, raised $40M in April 2009 to fund a US FDA phase III study for its intraocular lens for use with cataract and refractive patients and to launch commercial operations in Europe for its CE certified device. The company was sold five months later for $400M to Abbot Laboratories. Spinal Modulation, an early-stage neurostimulation medical device company, raised $40 million in June 2013 from St. Jude Medical, Inc. in exchange for an exclusive option to acquire the company for as much as $300 million plus incentives. Spinal Modulation’s neurostimulation pain management therapy is CE certified, but not FDA approved. 11 Full Cycle Funding Plan • Open capital structure • Seek later stage funding sources day 1 • Engage strategic partners sooner, not later Diagnostics and IT Related • Less capital needed = less financial upside • Alternative capital sources including: – Grants – Angels – FFFs – User Groups 12 Ivar Sorensen: p 612.375.1190 [email protected] Address: 3565 IDS Center 80 South Eighth Street Minneapolis, Minnesota 55402 www.m-a-group.com M&A Group, LLC 3565 IDS Center 80 South Eighth Street Minneapolis, MN 55402 USA m-a-group.com Member FINRA and SIPC 13