Transcript Reflections

Fin whale thoracic aorta
25µm
100µm
Collagen - red
VSMC - brown
Collagen - yellow
VSMC - brown
Gosline, JM & Chadwick, RE. J. Exp. Biol. 199, 985-997 (1996).
Thoracic aorta
Rat
Fin whale
Thoracic
aorta
Whale and Rat Einc/strain plot
Fin whale
Rat
10 6
10 5
10 4
4w
6w
8w
12w
20w
52w
10 3
10 3
0
0.1
0.2
0.3
0.4
10 1
0
0.5
1.0
1.5
Strain
J. Exp. Biol. 199, 985-997 (1996)
Cardiovasc. Res. 9, 669-678 (1975)
Human aorta
Common iliac artery
Femoral artery
Rabbit aorta (freeze-fracture SEM)
Collagen (freeze-fracture SEM)
Endothelium
An idea of scale
Structure function relationships in arteries
Einc = k1∆Pr/h.r/∆r
Chemical
composition
Material
Stiffness (Y)
Structure
Functional
Stiffness (E)
= k3PWV2
Ep = k2∆P.r/∆r
= Einc.h/R
Geometry (h/r)
Occlusive
disease/hyp.
)1/2
Zc = k3(Ep
≈ ∆P/∆Q
Elastic reservoir
(Impedance, Z)
Pulse wave
reflection
Peripheral
resistance, R
Smooth muscle
tone
Heart work