Transcript Toxicology Update

Toxicology Update
Tracie Phillips, Ph.D. & Roberta Grant, Ph.D.
Toxicology Division
Texas Commission on Environmental Quality
Environmental Trade Fair 2015
Objectives
• New Toxicology Database:
• Database Introduction
• Database Prototype
• Database Testing
• Updates to Odor Values:
• Odor Regulation
• Odor Changes
• Odor Timeline
NEW
A new beginning
THE NEW TOXICOLOGY
DATABASE
What is the new
database?
Housed within the
TAMIS database
One stop shop:
• ESL List
• AMCV List
• Supporting
documents
Why are we changing?
•
•
•
•
Reduce errors
Proper database structure
More information/detail
Dynamic
Manual
Spreadsheets
1000s of
Chemicals
Errors &
Frustration
What will be different?
1. No more “Published List” spreadsheets
What will be different?
2. Information will be dynamic
New
Info
Updates
Database
What will be different?
3. ESL requests
Database =
Real Time
New ESL
Request
• Consult the database 1st
• No verification for
existing values
• At least a 2-week turnaround
• Each value documented
• Should be received early in the
permitting process
What will be different?
4. All associated documentation will be
linked:
•
•
•
•
DSDs
Fact sheets
Public comments
Interim documentation
What will be different?
5. Screening level reports
Reports
Toxicology Reports
ESL
AMCV
Effects Screening Levels
Summary
Values Used in
Permitting Only
Detail
All Values (Health &
Welfare)
Air Monitoring
Comparison Values
What will be different?
6. More detail will be available:
•
Each value will be dated
ShortShortterm ESL- term ESLHealth
Health
(ug/m3)
(ppb)
Date
Derived
Status
--
10/1/2003
Interim
54
3/1/2011
Final
6/28/2010
Interim
Substance
CASNo.
Phase
antimony
7440-36-0
PM10
5
benzene
71-43-2
--
170
cyclohexene
110-83-8
--
600
180
Interim
Source
NIOSH,
TLV, OSHA
-NIOSH,
TLV, OSHA,
FRG-MAK
Used for
ShortShortAir
term ESL- term ESL Permitting
Odor
Odor
Review
(ug/m3)
(ppb)
Date
Derived
Status
Odor
Source
Used for
Air
Permitting
Review
YES
--
--
--
--
--
--
YES
8700
2700
10/17/2007
Final
--
--
--
10000
3000
6/28/2010
Interim
Amoore
YES
What will be different?
7. Source codes
Odor
Interim
Long-term
Short-term
What will be different?
8. List will be
searchable by:
•
•
Date
Substance:
•
•
•
CAS#
Identified synonyms
Substance type:
•
•
Alcohols
Surrogates
What will be different?
9. Use of surrogates:
•
Promotes consistency
Parent
Children
Chemical
A
Chemical
X
Chemical
Z
What will be different?
10. Identified synonyms
Phenylethylene
Styrene
Styrene
Monomer
Vinyl
benzene
What is the timeline?
(2)
External
User
Testing:
(1)
Internal
User
Testing:
Date TBD
Date TBD
(3)
Transition
& Beta
Testing:
Date TBD
(4) Full Production – No More Published List:
Date TBD
Time for a conceptual demonstration
PROTOTYPE DEMO
**For example purposes only, the following is not a true
representation of the final product
TAMIS Welcome Screen
Login Screen
Report Selection Screen –
Wizard Mode
Date Selection Screen
Report Parameter Criteria
Screen
File Delimiter Selection Screen
Report Generation Screen
Report Output in Excel
Short-term
ESL
(ug/m3)
Short-term
ESL
(ppb)
Date
Derived
Status
Chemical
Basis
54
3/1/2011
Final
Health
71-43-2
170
MUST MEET
NAAQS
benzene resin
71-43-2
CONTACT
TOXICOLOGY
ethylene
hydrogen fluoride
and soluble
inorganic
fluorides, for
permit reviews in
agricultural
areas with cattle,
as HF
hydrogen fluoride
and soluble
inorganic
fluorides, for
permit reviews in
agricultural
areas, as HF
hydrogen fluoride
and soluble
inorganic
fluorides, as HF
glycols,
polyethylene,
mono-(1,1,3,3tetramethylbutyl
phenyl) ether
glycols,
polyethylene,
mono-(1,1,3,3tetramethylbutyl
phenyl) ether
glycols,
polypropylene,
2,3-epoxypropyl
ether (DER 736
Epxoy Resin)
glycols,
polypropylene,
2,3-epoxypropyl
ether (DER 736
Epxoy Resin)
71-85-1
1400
1200
4/15/2008
Final
Odor
7664-39-3
3
3.7 (24 h)
9/15/2003
Final
7664-39-3
3
3.7 (24 h)
1/23/2013
Substance
CASNo.
benzene
71-43-2
benzene polymer
Phase
Long-term
ESL
(ug/m3)
Long-term
ESL
(ppb)
Date
Derived
Status
Chemical
Basis
4.5
1.4
2/1/2011
Final
34
30
4/15/2008
animal
0.75
0.91
Final
vegetation
0.6
7664-39-3
PM10
18
22
5/23/2007
Final
Health
9036-19-5
PM10
50
--
1/23/2013
Interim
Health
9036-19-5
VAPOR
600
--
5/23/2007
Interim
Health
9072-62-2
PM10
50
--
1/23/2013
Interim
Odor
9072-62-2
VAPOR
1000
--
5/23/2007
Interim
Odor
Interim
Source
DSD
Health
2/1/2011
http:/…
http:/…
http:/…
http:/…
Final
Health
4/15/2008
http:/…
http:/…
http:/…
http:/…
9/15/2003
Final
animal
9/15/2003
http:/…
http:/…
http:/…
http:/…
0.75
1/23/2013
Final
vegetation
1/23/2013
http:/…
http:/…
http:/…
http:/…
8.7
11
5/23/2007
Final
Health
5/23/2007
http:/…
http:/…
http:/…
http:/…
5
--
1/23/2013
Interim
Health
1/23/2013
http:/…
http:/…
http:/…
http:/…
Leonardos
60
--
5/23/2007
Interim
Health
Nader
5
--
1/23/2013
Interim
Health
1/23/2013
100
--
5/23/2007
Interim
Health
5/23/2007
PEL
NESCAUM
Leonardos
Interim
Source
Public
Fact Sheet comments Appendices
DSD derived
date
Odor Source
TLV-TD
5/23/2007
Testers Wanted!
TESTING
THE
DATABASE
External Testing
If you would like to participate, send an
e-mail to:
• Tracie Phillips: [email protected]
-or• Toxicology Division: [email protected]
NEW
A needed change
PROPOSED CHANGES TO
THE DERIVATION OF
ODOR-BASED VALUES
Why do we regulate
odors?
Odor is a leading cause of citizen complaints
The Texas Clean Air Act
Intent is regulation of odor to prevent
nuisance conditions, not odor detection
Why are we changing?
Derivation with
the intention of
preventing odor
nuisance
conditions
Large differences
in reported odor
threshold values
Consistency – all
odor values
derived at one
time
What will be different?
Source Data
Chemical
Classification
Derivation
• Available and reliable studies
• Historical data
• Study bias considerations
• Malodorous chemicals
• Generic/surrogation, if needed
• Identify all potential values
• Data integration to determine final
value
What is the timeline?
Odor White
Paper
Toxicity Factor
Guidelines
Update
https://www.tceq.texas.gov/toxicology
Odor Values
Finalized
Roberta Grant, Ph.D.
512-239-4115
[email protected]
Tracie Phillips, Ph.D.
512-239-2269
[email protected]