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Biodesign at ASU 1 Design Imperatives • ASU Must Embrace its Cultural, Socioeconomic, and Physical Setting • ASU Must Become a Force, and Not Only a Place • ASU as Entrepreneur • Pasteur’s Principle • A Focus on the Individual • Intellectual Fusion • Social Embeddedness • Global Engagement 2 Arizona Biodesign Institute bio.de.sign: the creative linkage of fundamental science and technology based solutions to confront specific human challenges. 3 To advance innovations improving quality of life through use-inspired, biosystems research and effective, multidisciplinary partnerships. 4 • • • • • Collaboration Communication Integration Use-inspired Translation 5 Pasteur’s Quadrant Research not Inspired by Considerations of Use Research Inspired by a Quest for Fundamental Understanding Research is not Inspired by a Quest for Fundamental Understanding I. Pure Basic Research IV. Research Inspired by Considerations of Use II. Use Inspired Basic Research III. Purely Applied Research 6 Nanotechnology Biotechnology Biologics & Pharmaceuticals Nano-scale Biosystems & Devices Information Technology Neural Interface & Rehabilitation Therapies Genomics & Bioinformatics 7 Institute Director George Poste Leading Scientist • • • • DVM and Ph.D. Virology > 350 publications Fellow of the Royal Society Honorary Doctorate in Science CTO and President R&D SmithKline Beecham • Brought 29 drugs to market • Introduced genomics as discovery tool to pharmaceutical industry Policy Expert • NAS working group on non-proliferation of Bioweapons • Chair DoD Task Force on Bioterrrorism • Honorary Doctorate in Law 8 Research & Design Centers • Focused on defined problems of major importance • Networked to multiple departments, colleges, and external institutions • Structured to be flexible and adaptive 9 Biologics and Pharmaceuticals • Production of Vaccines from Applied Crop Science Charles Arntzen, Director • Protein and Peptide Pharmaceuticals Colleen Brophy, Director 10 Nano-scale Biosystems and Devices Bio-Optical Nanotechnologies Neal Woodbury, Director Single Molecule Biophysics Stuart Lindsay, Director Applied NanoBioscience Frederic Zenhausern, Director 11 Neural Interface and Rehabilitation Therapies Neural Interface and Brain Control Jiping He, Director Rehabilitation Neuroscience/ Rehabilitation Engineering James Abbas, Ranu Jung, Directors 12 Genomics and Bioinformatics • Evolutionary Functional Genomics Sudhir Kumar, Director • Experimental Genomics Jeff Touchman, Director 13 Arizona Biodesign Institute Phase 1 - 170,000 sq. ft. State-of-the-art: research only; for biosciences, IT, nanotech labs Communication & Collaborative: open architecture, shared interdisciplinary labs Flexible: reconfigurable project-based space Serve as a Hub: prime location, access 14 Phase I - 170,000 sq. ft. 15 Phase I Phase II Phase III 16 17 ASU School of Life Sciences Expanding: 75-100 faculty over the next 5 years Enhancing Intellectual Fusion: Reorganizing for agility and creating a more horizontally integrated structure • • • • • Biology Microbiology Plant Biology Clinical Laboratory Sciences Program Molecular Biosciences/Biotechnology Program 18 ASU School of Life Sciences Laboratories and Facilities • DNA Laboratory • Goldwater Environmental Laboratory • W.M. Keck BioImaging Laboratory • Electron Microscopy Facility • ASU Lichen Herbarium • Vascular Plant Herbarium Research Support • Life Sciences Computer Support Cluster • Life Sciences Visualization Lab Outreach • Ask a Biologist • Ecology Explorers 19 NSF IGERT in Musculoskeletal and Neural Adaptation in Form and Function • 13 co-investigators – BME, Physics, Anthropology, Exercise Science, Math, Bio – SSERC, PRISM, Institute of Human Origins • In partnership with Barrows Neurological Institute, Good Samaritan Medical Center, Mayo Clinic, Scottsdale Medical Imaging 20 NSF IGERT in Optical BioMolecular Devices Biomimetics Cellular and molecular biology Biology of light-mediated processes Light-interactive materials Invention and engineering of new materials, processes and devices Biomedical Technology Biomolecular Devices Light Activated Processes Molecular Machines Novel Materials Molecular Electronics 21 • CAP LTER is one of only 2 urban sites in NSF’s network of 24 LTER sites • 60 faculty members, 90 grad students, 15 postdocs, 67 undergrads, 85 K-12 teachers, and over 40 community partners are engaged in this research • Original $4.2 million in funding has been leveraged to $18.5 million 22 ASU Center for the Study of Law, Science & Technology Executive Director: Gary Marchant, Ph.D. • Oldest and largest academic center in the nation studying the law’s interaction with science and technology • Established in 1984 • 17 Faculty Fellows with expertise in law, science and technology – focus on legal and policy issues relating to genomic technologies, intellectual property, privacy, bioethics, GM foods, digital copyright, e-commerce, antitrust, environmental regulation, public health, forensic sciences, scientific evidence, nanotechnology, telecommunications, human behavior, and family law. 23 Research Investment Strategy Bioscience & Biotechnolo gy (301) Nanoscience & Technology (301) Stress/ Neuroendrocrine Environment Earth / Space Science Social Science & Public Policy Humanities Arts Education (301) International Digital Library Arts, Media & Engineering (AME) CRESMET Arizona Biodesign Institute Institute for Comp/Info S&E Astrobiology Health and Disability Policy Competitive Grants Program Biogeochemistry American Indian Health Initiative Law, Science & Technology Planetary Missions Prevention Intervention Wireless Nanotechnology Center (WINTECH) Nanoelectronics Embedded Systems (CEINT) Homeland Security Institute Animal Care Manufacturing (301) Rapidly Urbanizing Regions / Environments School of Life Sciences Bioengineering Information Science & Technology (301) CSSER / CSSS Supply Chain Integration Morrison Institute ITAC Religion and Conflict Museum Project Supercomputer 24 Technopolis Mission: Encourage innovation in Greater Phoenix by providing local entrepreneurs with the entrepreneurial education and hands-on business development assistance necessary to convert their ideas into commercially viable businesses. • Entrepreneurial education • Product development assistance • Business infrastructure development and management assistance • Proof-of-concept capital formation • Revenue development assistance 25 Arizona Technology Enterprises Technology bundling with other institutions Contingencybased Outlicensing firms Partner with Corporate spinouts Utilize Web-based IP Exchanges (Yetz.com) Utilize University website Arizona Technology Enterprises, LLC Create University based start-ups General solicitations to market players Utilize Industry specific consultants & brokers Leverage Industry relationships Leverage clients of VC funds, investment banks & lawfirms 26