Transcript George F. White M.D - Scioto County Medical Society

George F. White M.D
Retired Otolaryngology
Student of Wine
Presents:
WINE AND HEALTH
A comparison of antiquity and modern concepts
Disclaimer #1
Unfortunately,I have not received funding from
any winery or pharmaceutical firm for this
presentation
Opus One Winery
Disclaimer #2
Any comments regarding religious concepts are
based on historical articles and are not intended to
represent any personal views on cosmology
Disclaimer # 3
When using the term “myth” the following
definition by Dr. Robert Oden, Ph.D. (former
Hotchkiss Head Master and President of
Kenyon College) is applied:
Disclaimer # 3 Cont.
• A myth is a story in narration form with a
beginning, middle, and end.
• A myth is traditional and social creation within a
religious or otherwise distinctive society.
• A myth deals with a being who is supernatural and
the deeds are impossible for an ordinary human.
Origins of Wine
I. Noah Hypothesis
• Genesis 1:11 “Every kind of plant that bears
seed”
Origins of Wine
•Genesis 10:20 “Now Noah, a man of the soil,
was the first to plant a vineyard”
Origins of Wine
II.
Gilgamesh Epic- Search for immortality,
Utnapishtim, Mt. Nisir
Gilgamesh meets Siduri-Goddess of Wine
Origin of Wine
III. Jamshid of the Pishdadian Dynasty
• Jamshid’s wife (one of many) and
migraine
Origin of Wine
IV. Greek God Zeus and his flood.
Oresthens planted the first vineyard
Domestication of Wine
NEOLITHIC TIMES
Wild Grapes- Diocecious Domestic Grapes-Hermaphroditic
Domestication of Wine
St Emilion
Rhone Valley Hermitage
The Ancients and Wine
Book of Sirach 31:27
“Wine means life for a man if he is
moderate in drinking…it was made to
make men glad”
Zind Humbrecht
Robert Mondavi
The Ancients and Wine
Dionysos and Hephaistos 550 BC
The Ancients and Wine
HOMER
Wounds of Philoctetes (Troy) healed with wine
by Podaleirius (son of Asclepius)
The Ancients and Wine
INDIA
Vedic Period (2500 BC) – Gupta Classical (530 AD)
Soma-(God of Liquid Pleasure)
Rigg-Veda (sacred text) makes the blind see
and the lame walk
Ayurveda- (Medical text) happiness and good
digestion, antidote to fatigue, sorrow , shock,
anesthetic
Sushruta- (ancient physician) used it as an
anesthetic
Madya-(wine) classical era; for fatigue,
depression and TB if mixed with goat’s milk
SOMA
The Ancients and Wine
CHINA
Wine and black cat liver-malaria
Wine and flesh of pit viper- colic, worms,
hemorrhoids, flatulence
The Ancients and Wine
HIPPOCRATES
“Father of Medicine”
Cooling fever, diuretic, antiseptic and to help
convalescence, jaundice and digestion, menstrual
pain
The Ancients and Wine
CATO/PLINY
Gastric, urologic ailments; snakebite,
constipation; calms the soul, nourishes the
blood
EARLY CHRISTIANITY
• Feast of Cana
• Sacrament of the Eucharist
EARLY CHRISTIANITY
• St Paul
• Timothy 5:23
“Stop drinking only water but have a little wine
for the sake of your stomach and your frequent
illnesses”
Pre Modern
AVICENNA
(982-1037)
Wine is the best friend of wise people
Pre Modern
MAIMONIDES
(Jewish)
Spain, Egypt 12th Century
Wine cures many illnesses, keeps the body healthy
Pre
Modern
SALERNO MEDICAL SCHOOL
Wine raises the tonus, makes the mind lively, hearing sharp
and favors with good health
RENAISSANCE
ENLIGHTENMENT
DR. BENJAMIN RUSH-Signer of the Declaration of
Independence
Classification
Order-Rhamnales
Includes IVY ,VA Creeper
Family-Vitaceae
Genus-Vitis
Species-Vinifera
– Wild-VV Silvestris
– VV Sativa
Structure of a Grape
The polyphenols, resveratrol, catechins,
quercetin, oligomeric procyanidin and
other antioxidants are produced in the
skin.
Modern Era
MID-20th CENTURY DENIAL
Prohibition
1970’s NIH suppressed Framingham Heart study
that showed moderate drinkers had 50% fewer
deaths from coronary disease than non-drinkers
Modern Era
MID-20th CENTURY DENIAL
Total Mortality Rate Compared to
Alcohol Consumption
Ten-Year 12
10
Mortality 8
6
Rate (per 4
2
1000)
0
Source:
Klatsky, 1981.
Annuals of
Internal
Medicine
0
1-2
3-5
Drinks Per Day
6+
Heart Disease Rates in 18 Western Countries
Heart
Disease
Mortality
Per
1000
Men
Source:
St. Leger,
The Lancet
May 12, 1979
Wine Consumption (4 Oz Glasses/Day)
Modern Era
Late 20th Century Denial
French Paradox
•Dr. Samuel Black 1819
•Dr. Serge Renaud, Bordeaux University
•60 minutes 1991- Morley Safer
•Dr. Klatsky-Kaiser Study
Cheese Restaurant
(Bordeaux)
Modern Era
Late 20th Century Denial
French Paradox
• 1999 British Heart Foundation
• Rate of Death CHD:
• 115/100,000 USA
• 83/100,000 France
• 2004 WHO-Similar Study
Cellar Master, (Rhone Valley)
Formula
A simplified concept of how antioxidants work
1.Cell + +oxygen
= “free radicals”
2.Free Radicals
antioxidants
= Good Health
+ 02 =+
=
Internet Al
Hanoi Jane
Modern Era
MECHANISM OF ACTION
Science of Wine
1. Antioxidants
ininhibit
wine prevent
the oxidation
of
4. 2.
* The
polyphenols
Endothelin
I.
This
The alcohol itself increases HDL concentration
LDL which
prevents
the macrophages
from
compound
damages
the
endothelium
and
which is anti inflammatory, thus decreases the
fillingvasoconstriction-the
up
with cholesterol,
thus
reducing
produces
primary
events
3.Wine
decreases
platelet
stickiness
risk of atherosclerosis
atherosclerosis.
for atherosclerosis
Results of Studies
CARDIOVASCULAR
.
 Helps prevent cardiofibrosis.
 Dilates small blood vessels, prevents clotting
and plaque formation, increases HDL, reduces the
risk of stroke and MI.
Moderate consumption of red wine reduces risk
factors by 30%-50%.
Results of Findings
DIABETES II
Reduces risk by 33%-56%, and does not interfere
with medication, increases insulin sensitivity
“Red wine protects diabetic patients from
meal-induced oxidative stress and thrombosis,
a pleasant approach to the prevention of
cardiovascular disease in diabetes.”
Results of Findings
DEMENTIA
Moderate drinkers have lower risk of developing
dementia and perform better on cognitive tests than
non-drinkers.
Results of Findings
CANCER
Quercetin inhibits growth of cancer and
leukemia cells. It potentiates chemotherapy.
28% lower risks for kidney cancer
Prostate cancer in mice using resveratrol had 87% lower rate
Lung cancer- 22 % less chance
Take a deep breathe this
will not hurt.
Results of Findings
ORTHOPEDICS
Hip fractures reduced 39% in elderly. The wine
increases estrogen which is protective.
Conclusions
THE ANCIENTS WERE CORRECT:
• Wine in moderation is good for the health
• Exercise
• Diet discretion
• Excess of alcohol is not healthy
• Better yet, select your parents wisely
Grape Harvester
BarrellTasting
Conclusions
WHICH WINES ARE MOST HEALTHY:
Cabernet Sauvignon
Syrah
Pinot Noir
:
Ultraviolet Effect
WINE WITH FOOD IS BETTER
Appropriate Wine Drinking
George, Mark, Sandy
Greenbrier
Inappropriate Wine Drinking
3 Bottle Club
? Medical Staff
The End
I end with the beginning from Sirach
Wine means life for a man if
he is moderate in drinking”