Transcript Slide 1

Justin Charton, MD, Preston H. Blomquist, MD, Nalini K. Aggarwal, MD, James P. McCulley, MD
University of Texas Southwestern Department of Ophthalmology
** Dr. McCulley is an consultant for Alcon Labs

Cataract surgery technique and technology are evolving rapidly. New lens
technologies allow us the ability to give patients a greater degree of spectacle
independence.

Toric intraocular lens allow for intra-operative correction of astigmatism and multifocal
lens allow for the correction of near vision in addition to distance vision.

These new technologies are rapidly being assimilated and are an important
component of today’s comprehensive practice.

Each lens platform represents a different surgical technique to which the surgeon
must adapt.

It is important to remember these technologies when considering current resident
education. Use of these lens platforms during training will better equip residents for
transition to their own practice.

A total of 17 eyes of 11 patients with more than 1.0 diopters of corneal astigmatism had placement
of an Alcon AcrylSof Toric IOL. Preoperatively, informed consent was obtained, and the patients
received a complete ophthalmic exam including slit lamp exam, applanation tonometry, slit lamp
exam, best corrected visual acuity, keratometry and A-scan (IOLMaster), topography (Humphrey
Atlas Eclipse), and dilated fundus exam. Patients with extensive retinal pathology, corneal
surface abnormalities, and irregular astigmatism were excluded.

The AcrylSof Toric online calculator was used for determination of correct lens platform. The
AcrylSof is supplied as a T3 (1.5 D), T4 (2.25 D), and T5 (3.00 D) lens. The steep and flat
keratometry readings were placed into the calculator, and 0.4 D of surgically induced astigmatism
was used. The placement of the main incision was varied to give the most desirable anticipated
residual astigmatism. All incisions were 3.0 mm wounds. Lens spherical power was determined
using IOL Master measurements in the SRK/T formula. The targeted spherical outcome was
plano to -0.50 diopters.

The preoperative corneal markings were made with the patients sitting upright to negate any
possible cyclotorsion in the supine position. An intraoperative toric axis marker was used for
determination of actual axis placement. The surgeries were performed by senior residents who
were completing their surgical chief rotation, and were completed using the divide and conquer
technique. After injection, all IOLs were rotated 15-25 degrees from intended axis and the
viscoelastic was then removed from posterior to the lens. The IOLs were then rotated to their final
position to coincide with corneal axis markings.

The multifocal group consisted of a total of 8 eyes of 6 patients who requested correction of both
near and distance vision. These patients had placement of the Alcon AcrySof ReSTOR SN6AD3
intraocular lens. Preoperatively, informed consent was obtained, and the patients received a
complete ophthalmic exam including slit lamp exam, applanation tonometry, slit lamp exam, best
corrected visual acuity, keratometry and A-scan (IOLMaster), topography (Humphrey Atlas
Eclipse), and dilated fundus exam. Patients with extensive retinal pathology, corneal surface
abnormalities, irregular astigmatism, and astigmatism greater then +0.75 diopters were excluded.

Lens spherical power was determined using IOL Master measurements in the SRK/T formula with
a target refraction of plano to +0.25 diopters.

The surgeries were performed by senior residents who were completing their surgical chief
rotation, and were completed using the divide and conquer technique. The IOLs were only placed
if cases had a continuous curvilinear capsular rhexis. All patients in both groups were followed up
at 1 day, 1 week, 1 month, and 6 month intervals. Only cases that retained follow-up through the
1 month appointment were included in the study.

All residents were given a questionnaire after completion of their surgical chief rotation. They
were asked to respond to various questions and rate their responses with 1 being the lowest and
5 the highest. A total of 5 residents had completed the rotation at completion of this poster.

The mean age of toric patients was 66.4 years with the range being 48 to 70 years.
The gender breakdown was 70.6% female / 29.4% male for the toric platform.

In the toric group, 76.5% of patients achieved an uncorrected visual acuity (VA) of
20/25 or better, and 94.1% of patients achieved an uncorrected VA of 20/30 or better.
A total of 1 patient (5.9%) achieved uncorrected VA of 20/40 which is thought to be
due to tear film abnormalities post-op. A total of 88.2% of patients had best corrected
VA of 20/20 with 100% of patients having BCVA of 20/25 or better.

The residual postoperative cylinder for all toric patients was 0.41 +/- 0.34. The
residual cylinder was 0.25 +/- 0.29, 0.6 +/- 0.38, and 0.34 +/- 0.27 for the T3, T4, and
T5 platforms respectively. Two patients in the T4 group had residual astigmatism of
+1.0 D for unknown reasons. These IOLs were on correct axis at dilated exam.

All toric lens had gross assessment of final alignment at 1 month follow-up with all
but one IOL being stable in their alignment. One T5 lens was noted to have rotated
13 degrees s/p YAG capsulotomy.

The mean age of the multifocal group was 63.5 years with the range being 53 to 73
years of age. The gender breakdown was 50% female / 50% male for this group.

In the study, 87.5% of multifocal patients achieved an distance UCVA of 20/25 or
better. One patient (12.5%) achieved an UCVA of 20/30. This was due to an
unexpected myopic outcome. For near vision 87.5% of patients achieved
uncorrected near VA of J1 with one patient having uncorrected vision of J4.

The mean pre-op cylinder for the multifocal group was 0.46 +/- 0.32.
Toric Intraocular Lens
Measurements
N
Mean age
Pre-op refractive
cylinder
IOLMaster cylinder
Topographic
Cylinder
Axial Length
Mean IOL
spherical power
SN60T3
4
66.75 +/- 12.5
2.25 +/- 0.46
1.57 +/- 0.24
1.31 +/- 0.16
23.37 +/- 1.06
19.5 +/- 3.49
SN60T4
5
63.4 +/- 5.13
0.75 +/- 0.83
1.44 +/- 0.19
1.35 +/- 0.31
24.61 +/- 0.89
18.4 +/- 4.42
SN60T5
8
68.13 +/- 5.36
1.96 +/- 0.37
2.75 +/- 1.07
2.47 +/- 1.34
23.67 +/- 1.30
20.0 +/- 3.15
Outcomes
Mean residual cylinder
(refractive)
UCVA
20/20 – 20/25
UCVA
20/30
UCVA
< 20/30
BCVA
20/20 – 20/25
SN60T3
0.25 +/- 0.29
2 (50%)
2 (50%)
--
4 (100%)
SN60T4
0.6 +/- 0.38
4 (80%)
1 (20%)
--
5 (100%)
SN60T5
0.34 +/- 0.27
7 (87.5%)
--
1 (12.5%)
8 (100%)
Multifocal Intraocular Lens
Measurements
SN6AD3
N
Mean age
IOLMaster cylinder
Topographic Cylinder
Axial Length
Mean IOL spherical
power
8
63.5 +/- 6.26
0.46 +/- 0.32
0.51 +/- 0.46
23.94 +/- 0.37
19.06 +/- 1.86
Outcomes
SN6AD3
UCVA
20/20 – 20/25
UCVA
20/30
UCVA
< 20/30
BCVA
20/20 – 20/25
BUCVA
Near vision J1
BUCVA
< J1
7 (87.5%)
1 (12.5%)
0
8 (100%)
7 (87.5%)
1 (12.5%)
Results
Post rotation survey
Rating from 1 (lowest) to 5 (highest)
Knowledge with the pre-op workup needed for the multifocal IOLs.
4.8
Knowledge with the pre-op workup needed for the toric IOLs.
4.8
Knowledge of the surgical techniques needed for multifocal IOLs.
4.8
Knowledge of the surgical techniques needed for the toric IOLs.
4.8
To what degree will (multifocal/toric) IOLs impact your practice.
4.4
Will the resident personally utilize these IOLs in post residency practice?
4.4
Did this experience better prepare you for using the (multifocal/toric) IOLs in
practice?
4.8
To what degree do you feel these lenses will provide spectacle independence for
patients?
4.4
** Total of 5 Residents

The use of toric IOLs allows the surgeon to provide correction of astigmatism intra-op
with the use of a lens platform. This provides the surgeon with more options for
treating astigmatism.

The toric group of patients in our study compared favorably to prior studies with
76.5% of patients having a uncorrected visual acuity of 20/25 or better, and 100% of
patients achieved a BCVA of 20/20.

The residual refractive error was 0.25, 0.60, 0.34 for the T3, T4, and T5 lenses
respectively. The T4 group is skewed higher due to two patients with +1.0 D of
residual astigmatism for unknown reasons.

In the multifocal group, results were also similar to prior studies. A total of 87.5% of
patients achieved a distance UCVA of 20/25 or greater with 100% achieving distance
BCVA of 20/25 or better. The only patient to have a UCVA of worse than 20/25 was
due to an unexpected myopic outcome. All but one patient achieved near UCVA of
J1.

The survey indicates that residents strongly feel that these lenses will be utilized
frequently in their practice and experience with these lenses will better prepare them
for future practice.

The opportunity to learn the pre-op, intra-op, and post-op management associated
with these new technologies help prepare the residents for their future practices.
Also, valuable experience is gained by residents in counseling patients about their
personal goals and subsequent operative options.

Premium IOLs are an important component of today’s comprehensive ophthalmology
practice, and residents can be taught to use these IOLs during their training with
outcomes comparable to other published studies.
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