Transcript AP Biology (An Introduction)

AP Biology
(An Introduction)
Mr. Boswell
Room 208
CUSTOMARY INTRODUCTION
TO
COLLEGE BIOLOGY
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INTRODUCTION TO
21ST CENTURY SCIENCE
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Molecular Biology Revolution
 Have you heard about it?
 Increase life span
 Increase quality of life
 Compare to The Internet
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Alba – GFP bunny
 Expired in 2002
 “Transgenic art”
 AP Lab #6
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Human Genome Project
 Completed in 2003
 Joint Genome Institute (Walnut Creek, CA)
 Sequenced entire human genome (DNA)
 Cost $2.7 billion
 2004, Celera (J. Craig Venter) = $300,000,000 (11%)
 2010, Illumina (San Diego, CA) = $14,500 (0.0005%)
 2013, $1,000 or less (estimate)
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“We are now part of an early radical
biological revolution that will dwarf the
industrial revolution.”
-- Julian Savulescu (Oxford University)
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Futurama
 Last year – Juan Enriquez video
 Now it is outdated
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st
21 Century Therapies
 Gleevec – Chronic Myelogenous Leukemia
 1 pill a day
 Sprycel & Tasigna
 BrCa-1 and BrCa-2 gene tests for breast and ovarian
cancer
 In 2010, Oncept DNA Vaccine
 Canine Oral Melanoma
 Transdermal application
 June 2010, “siRNA ‘Cure’ for Ebola?” (Geisbert et al.)
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Venter Institute
August 2009 – 1st Genetically Engineered
Organism
Altered Yeast genome  bacterium
May 2010 – Four bottles (ACTG) + signals = Fully
functional Mycoplasma mycoides genome
Not just engineering bacteria, but creating
them
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http://2011.igem.org/Main_Page
http://ung.igem.org/Team_List?year=2011
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Tracheal Replacement
 Lab made organ implanted for first time
 Trachial Cancer patient
 Not tissue derived from patient, entirely
foreign materials
 Made in London, UK  Stockholm,
Sweden
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What does this mean?
 2008 Plastic Surgeons performed 10.2 Million
procedures
 Corrections, deletions, augmentations, & enhancements
 What will happen when you can design organs, limbs,
...?
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Hugh Herr
"When you go into my closet, there are many,
many pairs of legs. I have a running pair, I
have a bionic walking pair, limbs that are
waterproof," he says. "I have various legs to
climb mountains and to sense steep ice walls,
other feet that wedge into small rock fissures
[and] others that stand on small rock edges
the width of a coin.”
“My biological body will degrade in time…,
but the artificial part of my body will improve
over time since I can upgrade.”
http://www.npr.org/2011/08/10/137552538/the-doubleamputee-who-designs-better-limbs
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iPSCs (Induced Pluripotent Stem Cells)
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Engineering Humans
 Engineering Children
 Already determine gender & eliminate some diseases
 What amount of intelligence will your child have?
 Will you give them the 577R genotype in the ACTN3
gene?
 84% of Africans have it, 49% of Eurasians have it
 What about Olympic athletes?
 Engineering Adults
 Hear ultrasound frequencies
 Telescopic vision
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INTRODUCTION TO AP BIOLOGY
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Exit Interview Comments
 “…take the class only if you enjoy biology or the
sciences.”
 “If he/she doesn’t wish to go into the field of science,
I’d highly dissuade them from taking the course.”
 “If a student is only taking a course to have it on her
transcript then she will have a horrible time.”

“…you must learn a ton of information in a short
period of time.”
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Page 2
 “AP Biology is nothing like honors Biology.”
 “…the teacher should have removed students from the
class who were not up to the standards of the course.”
 “Some people played on the computer or did not pay
attention in class. Why are they still here?”
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2010 AP Biology Results
 Pass Rate = 90%
 “5”s = 52%
 “5” + “4” = 77%
 Students = 64
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Why this class is difficult…
1. Biology knowledge base is deficient
 How many years ago did you take Honors Biology?
2. Honors Biology ≠ AP Biology
3. 55 Chapters (1,230 pages)
4. 3 credits vs. 8 credits
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Why this class not difficult…
1. Clear expectations
 Vocabulary & Objectives
2. Information is readily available
3. Course Materials sourced from 3 Biology textbooks
4. Course materials are easily accessible
5. Few complicated concepts
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What is a College Level Course?
 Student-Driven Learning
 Role of teacher is to highlight some important points
 Will NOT cover every concept in class
 “students are expected to work independently outside
the class”
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Q1
Biochemistry
Cells
Energetics
Classical Genetics
Molecular Genetics
DNA Technology & Genomics
Q3
Animal & Human Physiology
Ecology
Evolution
Free-Response Questions
CHAPTERS 21-25 & 42-55 [18]
CHAPTERS 1 – 20 [20]
Q2
Q4
Labs 1-6
Classification
Plant Physiology
Basic Systems
Review for AP Exam
CHAPTERS 26-40 [14]
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Class Discussions
 You WILL be called on to attempt an answer
 I want to hear what you have to say
 Make all questions and comments relevant to the
content discussion
 If your question is off topic, write it down and ask it later
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INTRODUCTION TO MR. BOSWELL
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Background
 Undergrad: Philosophy & Biochemistry
 Masters: Medical Economics & Epidemiology
 HHMI (Howard Hughes Medical Institute) Cohort
 Inaugural Fellow (2008) @ University of Florida
 Translational Medicine Institute (2011) @ UF
 AP Summer Institute (2007, 2008, & 2009)
 Nova SE, BCPS, and Stanford University
 AP Annual Conference (2008) in Seattle, WA
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Schedule
PERIOD
COURSE
1
AP Biology
2
AP Biology
3
AP Biology
4
Honors Biology I
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Assignments
 Diagnostic Test due by 2:00 am Tonight !!!
 Biology: Diagnostic Test – (45 minutes)
 http://www.quia.com/quiz/3231852.html
 Student Information Survey
 http://www.quia.com/sv/540447.html
 Any questions on the Student Survey, email me @ bb@ap-
bio.com
 Due by 2:00 am Tonight !!
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Assignment (Page 2)
 http://www.ap-bio.com
 Student Handbook 2011: Printout, Read, & then Sign
 Due Wednesday 8/24/11
 Statement of Understanding (Page 4)
 Lab Safety Contract (Page 4)
 Academic Integrity (Honor Code) (Page 5)
 AP Exam Exception (Page 6)
 Homework / Summer Project
 Due in class Wednesday 8/24/11
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Assignment (Page 3)
 If you have not gotten emails from Mr. Boswell, make
sure you add name to email list
 Chapters 2 & 3 tomorrow
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