Transcript Enabling Roadmap Research: Core Facilities and Infrastructure

Overview of Core Facilities and
Their Infrastructure
Nancy D. Denslow, Ph.D.
Association of Biomolecular Resource Facilities
Executive Board Member
www.abrf.org
ABRF
Mission: The Association of Biomolecular Resource
Facilities is an international society dedicated to
advancing core and research biotechnology laboratories
through research, communication, and education.
Membership:
Core Facilities (Academic, Industry, Government)
Service Providers – Independent Research Institutes
Academic researchers (not in core facilities)
www.abrf.org
ABRF
Mission: The Association of Biomolecular Resource
Facilities is an international society dedicated to
advancing core and research biotechnology laboratories
through research, communication, and education.
Membership:
Core Facilities (Academia, Industry, Government)
Service Providers – Independent Research Institutes
Academic researchers (not in core facilities)
www.abrf.org
Current Biotechnology Core Facilities
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Proteomics
- Protein identification
- Post-transl. modifications
- Protein sequencing
- Protein profiling
Peptide Synthesis
Protein Production & Purific.
DNA Technologies
- DNA sequencing
- Fragment Analysis
Nucleic Acids
- Oligonucleotide synthesis
- Q-PCR
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www.abrf.org
Microarrays
- Commercial arrays
- Spotted arrays
Hybridoma
Cell based technologies
- Laser dissection
- Cell arrays
- EM
Molecular Interactions
- BIAcore
- Microcalorimetry
- Analytical
Ultracentrifugation
Core Laboratories: Total Staff & Degree Breakdown
15%
15%
12
28%
20%
Average Total Staff
Ph.D.
10
20% non4yr.
15%
non4yr.
Ph.D.
33%
Ph.D.
6%
BS/MS
non4yr.
Ph.D.
BS/MS
44%
65%
BS/MS
61%
Ph.D.
8
BS/MS
65%
57%
19%
6
non4yr.
BS/MS
37%
4
2
0
www.abrf.org
ABRF survey-2003
Core support varies by institute
• 100% institutional support
• Partial subsidy
• No subsidy
www.abrf.org
Cost Recovery From User Fees
60
50
40
100%
% 30
50-95%
<50%
20
10
0
Academic
Res. Inst.
GOV
ABRF survey-2003
Industrial and CRO labs not included. Industrial labs were internally subsidized and CRO labs rely exclusively on user fees.
www.abrf.org
Cost Recovery Formula
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Depends on core level of support
Should include funds for
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Salaries
Instrument depreciation
Instrument service contracts
Consumables
Percentage for instrument failures
Development of new methods
Staff development and training
www.abrf.org
Core Lab
• Standard service provider
• New methods development
• Research based/Discovery driven
Academic Core Lab
• Advancement of technology
• Specific research needs
• Student training
www.abrf.org
New Instrument Acquisition
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Direct institutional funding
Savings from instrument depreciation costs
NIH/NSF/DOD grants
NIH-NSF co-funding grants
Leasing instrument
www.abrf.org
Instrumentation acquisition by grants
NIH
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NSF
5-10 NIH funded
investigators
Documented need for
instrument
Biomedical research focus
Documented expertise
1 yr waiting time
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Broad based research
group
Educational component
Documented need
Non-biomedical research
Institutional commitment
for cost sharing
6 months waiting time
NIH-NSF Co-funding of Major Instrumentation
www.abrf.org
Innovative Science – New Directions
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Discovery driven research
Hypothesis driven research
Interdisciplinary collaboration
Computational biology
Cross-platform data sharing
Systems biology approach
www.abrf.org
New Interdisciplinary Research
Role of Core Facilities
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Understand technology to acquire proper equipment
Purchasing of shared instrumentation
Training staff in new methodology
Educational role – teaching members of
interdisciplinary team the common language
• Interaction with bioinformatics specialists
• Seed money to get project going
• Faculty vision
www.abrf.org
Role of scientists in core labs
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Project success will depend on staff
Are staff recognized as scientist colleagues?
Are staff given credit for developing the project?
Are staff in “professional” career tracks?
Are staff properly compensated?
www.abrf.org
Role for Professional Societies
• Support scientists in core facilities
• Introduce new technologies in a non-intimidating
atmosphere.
• Serve as a resource for troubleshooting,
instrument satisfaction, technology evaluation
• Provide well characterized test samples on an
annual basis
• Networking
• Professional advancement of members –
“professional” career tracks for core staff
www.abrf.org
Learn more about ABRF
• Visit our web site: www.abrf.org
• Attend our annual conference:
• Obtain latest study results from research
groups
• Read and submit manuscripts to the Journal
of Biomolecular Techniques (JBT)
• Join our web-based discussion forum
www.abrf.org