Transcript Seattle (Englisch) - Hochtontherapie nach Dr. May

H. U. MAY:
Facts and hypotheses concerning the causal or
symptomatic therapeutic use of currents in
oncology - direct and indirect effects upon cells,
tissues and the whole organism.
The possibilities to optimize the efficacy of currents
by variation or fixation of their parameters in
dependence on the intended therapeutic purpose.
Introduction
concerning the history
of therapeutic use of currents
for the treatment of tumor patients
Already in the middle of the 18th century the two
German physicists HAUSEN & WINKLER tried with
their electrical machine, based on friction, to treat
tumors.
After the spreading of the inventions of GALVANI
(1737 - 1798) and VOLTA (1745 - 1827) since the
19th century electricity has been used more
frequently to treat tumor patients.
Not only symptomatic treatments for pain relief but
even mainly causal treatments consisting in trials to
destroy the tumors were usual.
In standard dictionaries and encyclopedias from
the second part of the 19th century and the first
decades of the 20th century you can find very
much more general information and special
description of the
electrolytic destruction of tumors
by direct currents
under the catchword “electrotherapy” than in the
second part of the 20th century and today.
Until today the galvanic current as the primarily preferred current
in the causal treatment of tumor patients is used in various
clinics and hospitals, for instance in Austria according the
recommendations of PEKAR given in his 3 books about the
percutaneous galvanotherapy in cases of tumors, published
since 1988, basing on experiences since 1977.
Also in Sweden NORDENSTRÖM used direct currents (DC) for
the treatment of tumors, basing on his theory of “biologically
closed electric circuits” (1983). The DC method requires needles
to be placed inside the tumor. It is an invasive method. I know,
that in Germany, Denmark, Italy and China in special hospitals
this invasive DC method is in use, however in Germany without
public advertising.
Just before the 1st world war VERAGUTH & SEYDERHELM
(1913 and 1914, Zürich and Straßburg) found the tendency of
various direct and alternating currents, applied as whole body
treatments in a “4 cell bath”, to reduce the number of white blood
cells in leukemia patients.
The histories of RIFE’s work in the United States and
independently from him of LAKHOVSKY’s work in France
concerning cancer treatment using alternating electrical fields of
various frequencies are well described in the
“RIFE Report”, written by Barry LYNES and published 1987,
and
in LAKHOVSKY’s “Secret of life”, published the first time 1929.
“Tone frequency currents”,
a not very precise term introduced by KOEPPEN 1935 in his
paper “Tone frequency currents in medicine”, has been changed
1944 by the German physiologist GILDEMEISTER in Leipzig
into the term “middle frequency currents” (MF), defined
by the frequency range between 1 kHz and ca. 100 kHz.
GILDEMEISTER and his pupil SCHWARZ, furthermore WYSS in
Zürich, investigated the very interesting and special
advantageous physiological properties of these MF currents,
however
more from the standpoint of physiology as a theoretical field of
medicine than with a practical therapeutic view.
Consequently, they did not take into account any thoughts
concerning the effects of MF upon tumors.
Without any knowledge about the publications
concerning MF currents
published mainly in journals of physiology
the electronic engineer Doctor NEMEC
from Austria in the late 40s up to 1952 used
MF currents between 4000 and 4100 Hz
for his invention of “interferential current”,
realized by the company NEMECTRON as the
“Nemectrodyn” machine.
Dr. Hanna FRESENIUS, a female general
practitioner in Steinau in Hessen (Germany) was
one of the first medical doctors, who experienced
the wide range of indications of the new
equipment including pain relief in cancer patients.
Additionally she observed in the majority of the
patients not only pain relief but additionally a
general increase of their condition, of their quality
of life, in some of the patients even an inhibition
of tumor growth or a shrinking of the tumor.
After several years of successful treatments of
cancer patients with these interferential currents
other medical doctors, competitors which were
not familiar with the new treatment, suggested a
damning of the new electrotherapeutic method
in cancer patients by the regionally responsible
professional instance.
Dr. Hanna FRESENIUS was not agree. She
moved with her practice to Bavaria and pursued
successfully to treat cancer patients but more
secretly.
Convinced by the beneficial effects of interferential currents in
cancer patients Dr.Hanna FRESENIUS initiated animal
experiments together with the University of Freiburg. She fed
two groups of rats with the carcinogeneous “butter yellow”
(dimethylaminoazobenzol). One group was treated nearly
everyday with interferential current.
Only the animals of the other group developed liver tumors.
In this time I was
as a neurologist, physiologist and pharmacologist with long experiences in
biomedical engineering and biocybernetics in the University of Karlsruhe
a member of the medical-scientific research and development
department of Nemectron in Karlsruhe, responsible for all
theoretical and practical medical questions.
With monetary, technical and scientific support by
Nemectron and with prepared rats from
Prof. Ferdinand SCHMIDT
(Institute for Preventive Oncology of the University Heidelberg-Mannheim)
Hanna FRESENIUS started new series in rats suffering
from chemically induced subcutaneous tumors.
When the tumors were detected early enough and the
diameter of the tumor was not larger than 8 to 10 mm,
the treatments with interferential current (carrier
frequencies around 4000 Hz) leaded to a shrinking and
finally to a disappearance of the tumors:
Larger tumors did not disappear. They sustained to
grow, partially up to the size of apples, and the
tumors seemed to cause intensive itch sensations.
The rats injured the skin in the region of the
subcutaneous tumor and finally the tumor itself.
The initially solid tumor had changed to a cyst filled
with a fluid. The cyst opened by the teeth of the rat
collapsed, was infected, and the rat died within hours
or few days.
These kinds of animal experiments could not be continued because of a
new law concerning the use of animals for scientific research.
Therefore, with financial support by the German Ministry
for Research and Technology in the laboratories of
Nemectron and 4 institutes of the medical faculties of
various universities and scientific centers (Freiburg, Aachen,
German Cancer Research Center Heidelberg, German Nuclear Research Center
investigations concerning the influences of middle
frequency currents were carried out with normal and
various tumor cells.
Karlsruhe)
In 2 doctor dissertations (M. NOSZVAI-NAGY, Karlsruhe,
1993/94, W. PETROW, Aachen, 1988), in lectures and
papers on a symposium in Karlsruhe, 1990, and a
German Cancer Congress in Hamburg 1994 the results
were presented.
The most important results were:
1. Some kinds of tumor cells in vitro can be killed
during the application of middle frequency currents
(with frequencies in the lower MF range, mainly
4000 Hz); they suddenly disappear by destruction
of their cell membrane. Abnormal large cells appea
to be more sensitive. However, not all types of the
tumor cells had the same sensitivity.
2. MF currents can facilitate the growth of normal
fibroblasts in dependence on the strength of the
electric field.
3. MF currents can influence the adenylcyclase
resulting in changes of the intracellular cAMP
formation, that means MF currents can have
hormone-like effects. This corresponds with the
results of other authors.
4. MF currents can cause an increase of the number
and the size of mitochondria.
5. Alternating electric fields within the MF range
facilitate and consequently accelerate the diffusion
along the lines of the electric fields – in the two
opposite directions. This result was predictable due
to physical, electrochemical and statistical
considerations.
The cell culture research program supported by the
German government unfortunately could not be
continued because of monetary restrictions.
Additional psychological problems between the
supervisory board and the leading management of
Nemectron caused repetitive changes within the top
management team.
Finally the owner of Nemectron, the margrave of
Baden, had to sale his company.
After few years the ownership changed again.
My own experiences with interferential current (MF between 4000
and 4100 Hz) as a neurologist – not an oncologist – in tumor
patients were different. Some examples:
Tumor
Result
Astrocytoma
No success
Glioblastoma
No success
Chordoma
Stop of the growth of the tumor for
many years, but not destruction
Patient was found dead in his bed in
the morning after a long evening of a
festival during his vacation in Spain.
Tumor
Result
Melanoma with metastases
in the central nervous system,
earlier and larger in the spinal
cord resulting in paraplegia,
later and smaller in the medulla
oblongata causing dizziness
and circulatory disturbances
Slowing of growth
Not treatable
In general: Significant pain relief,
reduction of the analgesic drugs,
enhancement of the quality of life,
6 months prolongation of the
survival time, life at home with his
family instead of an immediate death
under high dosages of narcotics at the
intensive care station of the
Dermatological department of the
University of Köln
Tumor
Result
The same patient suffered since
his early childhood from multiple
benignant tumors of the fatty
tissue, lipomas, disseminated to
the whole body, rump and limbs.
All the lipomas disappeared within
few weeks after the begin of the
daily electrical treatments.
1981 THIESS & DIETRICH in Heilbronn and
1994 KUKLINSKI in Rostock
also reported conspicuous beneficial however finally not healing
effects in tumor patients treated with interferential currents.
In KUKLINSKI’s study a group of 37 patients received interferential current
(IFC) treatment twice per day. Modulation frequency was scanned between 0.5 and 150 Hz.
Results:
Partial remissions were observed in patients with superficial cutaneous
metastases or ulcerative mammary carcinomas (n=3).
Tumor progression was lowered in 2 patients with pancreatic carcinomas.
Responses of tumors of the pulmonary and bowel tracts were generally poor.
In many cases, a considerable reduction of inconveniencies associated with
the disease was noted (e.g. reduction of pain, rapid improvement of physical
condition, etc.)
Conclusion: In order to improve the response of malignant tumors,
particularly of deep-lying tumors, hitherto existing parameters
and strategies of IFC-treatment seem to require revision.
Taking into account the fact that
in cell culture experiments and in patients
the desired effects of MF currents
seemed to be dependent
on the type of the tumor,
the question arose:
Is the sensitivity
of the special type of tumor cells
dependent on the frequency of the MF current?
This was the origin of my idea to use
the modulation of the frequency
in a mathematically continual way
over a wide range
in accordance with the technical and legitimate possibilities,
avoiding arbitrary irregular and to large steps
and
to minimize the differences
between
the theoretically optimum frequency
and
the really generated frequency.
Additionally,
the electrical, neurophysiologic and
psychophysical possibilities
concerning the intensities of the applied
frequency-dependent currents should be
optimized.
The
distance to local and systemic tolerance limits
should be as large as possible to
maximize the therapeutic width.
Since 2000 my idea of
simultaneous modulation
of
frequency and amplitude (SimulFAM®)
adaptable to
the individual and local
frequency-dependent threshold of sensation
is realized and available until now
in Europe and Asia as
HiToP®,
High Tone Power Therapy (MAY, 2002 and 2004).
The manufacturer is the company gbo, “Gerätebau
Odenwald”, in Rimbach, manufacturing and
distributing too still traditional low-frequency and
interferential electrotherapy units of Siemens.
The frequency is modulated in quarter tone steps
between 4096 and 32768 Hz.
With 73 frequencies (“tones” in the high tone and
low ultrasound ranges) 3 octaves are covered.
The maximum distance to a theoretically optimum
frequency or to a frequency in an harmonic relation
to this optimum frequency is 1/8 tone step.
Facts and hypotheses
concerning
the causal or symptomatic therapeutic
use of currents in oncology –
direct and indirect effects upon
cells, tissues and the whole organism
Causal therapeutic use
Facts:
Some facts as results of experimental studies
are already itemized in the
introduction under number 1 – 5.
Hypotheses
regarding inhibitory effects of un-modulated, amplitudemodulated and simultaneously frequency- and amplitudemodulated middle frequency currents upon tumor growth
Direct effects of currents upon transformed cells
Changes and renormalizations of pathological processes in
tumor cells, caused by stimulatory and multi-facilitatory
(electro-biochemical, non-stimulatory) effects
induced by electrically triggered molecular conformation
changes within the cell membrane, that means a kind of
simulation of hormone effects, resulting in the (normalization
of) formation of intracellular second messengers, for
example cyclic AMP
induced by capacitively coupled effects
through the cell membrane into the intracellular space
(cytosol),
through the outer mitochondrial membrane into the
intermembrane space and
through the inner mitochondrial membrane into the
mitochondrial matrix,
for instance
multi-facilitatory effects upon the metabolism:
facilitation of diffusion processes
facilitation of enzymatically mediated processes of
the intracellular metabolism
facilitation of enzymatically mediated processes of the
intracellular metabolism, basing on
the increase of the kinetic energy of molecules involved in
metabolic processes, lowering the differences to the required
activation energy,
the increase of the probability of the events of the important
accidental meetings between enzyme and substrate,
the increase of the probability of the events of the important
accidental meetings between enzyme and substrate in the
correct position
(according to DAFFORN & KOSHLAND:
A. DAFFORN & D. E. KOSHLAND jr., Biochem. Biophys. Res. Commun. 52, 780, (1973) )
direct influences upon the transport mechanisms of
protons and electrons within the inner membrane of
the mitochondria
preference of the aerobic metabolic pathways
instead of the anaerobic glycolysis
induced by direct influence upon the
intercellular communication ("cleaning effect" concerning ion
channels including gap junctions), resulting in
partial or total recovery of the disturbed
electrical and chemical communication between tumor cells
mutually and between tumor cells and the cells in the adjacent
tissue
(one step to a redifferentiation)
partial or total recovery of the disturbed
metabolic cooperation between tumor cells mutually and
between tumor cells and the cells in the adjacent tissue
(a second step to a redifferentiation)
partial or total recovery of the disturbed
functional coordination between tumor cells mutually and
between tumor cells and the cells in the adjacent tissue
(a third step to a redifferentiation)
partial or total recovery of the disturbed probably
electrically mediated
control of the target of the normal
topographic-anatomical and histological
structure of the referred body region
(last step and desired main goal of redifferentiation)
Over-stress of the pathologically changed
metabolism of the tumor cell,
caused by frequently generated depolarization
and the required repolarisation
(stimulatory effect, possible with suprathreshold intensities only)
Indirect effects
Primary effects:
Activation of cells of the immune system
by means of sustained depolarization (non-stimulatory effect)
of the involved cells of the immune system, causing an increase
of cell division rates of normal cells which are able to increase
their mitotic activity if such increase is required,
by means of cyclic AMP formation
(non-stimulatory multi-facilitatory and stimulatory effect)
within the involved cells of the immune system,
by facilitation of intercellular communication (non-stimulatory
multi-facilitatory effect)
by an increase
of generation of natural killer cells (NKC),
observed by KUKLINSKI as a result of
stimulatory effects, probably possible with
non-stimulating currents too.
Enhancement of the efficacy of the activity of the
cells of the immune system
in the neighborhood of the tumor by means of the
equilibration effect upon concentration differences
normalizing the pH values.
Due to the preference of the anaerobic metabolism in
tumor cells with an increase of lactic acid production
the pH is lowered in the extracellular space within the
tumor and in it’s neighborhood; the lowered pH is
impairing the function of the cells of the immune
system.
Partial or total recovery of the disturbed communication
between the “asocial” cells of the tumor takes place by means
of the electrochemical shaking effect.
Stimulation of the sympathetic nervous system (by stimulatory effects)
o
release of transmitters (mainly nor-epinephrine)
from the varicosities of the sympathetic nerve endings
o
reduction of inflammatory tissue changes
in the neighborhood of the tumor
o
activation of receptors within the cell membranes involved in
the tumor growth inhibiting processes
Secondary effects:
The activation of cells of the immune
system could result in the following
secondary effects:
Increase of phagocytosis
Increase of the release of mediators
acting as inhibitors of tumor growth
or even as tumor cell destroying agents
(for instance tumor necrosis factor)
Symptomatic therapeutic use
The symptomatic therapeutic use concerns mainly
1. pain relief
2. edema reduction
3. prevention of venous thromboses
4. reduction of the required dosage of pain relieving
and other drugs with reduction of their side effects
5. inhibition of cachexia by b-mimetic effects
6. general enhancement of the quality of life
The possibilities to optimize the efficacy of currents
by variation or fixation of their parameters in dependence
on the intended therapeutic purpose
Pain relief
Five pain relieving effects are available:
1. Distribution and thinning of mediators of pain and inflammation
2. “Real nerve block” by reversible sustained partial depolarization,
“plateau effect”
3. ”Pseudo block” associated with “tea”, transient excitatory activity
4. Counter-irritation (GAMMON & STARR, 1941)
and b -endorphin release
5. In cases of painful swellings indirect causal pain relief
by edema reduction
The following parameters should be preferred:
1. High intensities during blocks with higher fixed frequencies
(max. 32768 Hz)
or SimulFAM along the threshold curve, SimulFAMi
2. Maximum tolerable intensity with higher fixed frequencies
(max. 32768 Hz)
3. High intensity with higher fixed frequencies (max. 32768 Hz)
4. SimulFAMX with crossing of the threshold curve, frequency
of modulation: 100 Hz
5. SimulFAMX with crossing of the threshold curve, frequency
of modulation: 10 Hz
2. Edema reduction (in general) and
prevention of venous thromboses
a. caused by stimulation of sympathetic fibers
b. (in lower legs an feet) caused by
activation of the “muscle pump”
c. caused by reversible sustained partial depolarization of the
smooth muscles of the lymphatic vessels and the blood
vessels, “plateau effect”
The following parameters should be preferred:
a. SimulFAMX with crossing of the threshold curve,
frequency of modulation 10 Hz
b. SimulFAMX with crossing of the threshold curve,
frequency of modulation 0.3 Hz
c. High intensity with higher fixed frequencies (max. 32768Hz)
3. - 5.
The therapeutically desired effects
mentioned above concerning
reduction of drugs and their side effects,
inhibition of cachexia and
general enhancement of the quality of life
are present in all cases of parameter selection.
They do not require special parameters.
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Extremely comfortable trancutaneous electrical stimulation of nerves –
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MAY, H. U.:
High Tone Frequency Power Therapy with HiToP® in general and particularly
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MAY, H. U.:
High Tone Power Therapy
Scientific development to optimise the physical, physiological and therapeutic
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Paper presented at the
6th Annual International Congress of Egyptian Society of Back Pain, Cairo,
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MAY, H. U., & A. HANSJÜRGENS:
Elektrische Differentialtherapie1
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1) Electric Differential Therapy (in general),
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Karlsruhe, Nemectron 1988
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21. Deutscher Krebskongreß, Hamburg, 7.-11. März 1994
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Supplement to Journal of Cancer Research and Clinical Oncology Vol. 120,
05.09.04 (1994)
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Fizjoterapia Polska (Polish Journal of Physiotherapy) 2, 118 – 121 (2002)