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ONE STEP IN THE FIGHT AGAINST CANCER Sustainable Third Quality Party Assurance Auditing Pruning Patented Extraction Technologies Elite Plantation Sites © Chatham Biotec Ltd. 2005 2000 Ryan Smith starts small harvesting operation in Gaspe, Quebec. Harvest 17,000 lbs green weight for local NB processor. © Chatham Biotec Ltd. 2005 2001 Nepugt Work A contract begins EcoisTech on signed the formed development with to a NS for plantations develop processor harvesting for with 200,000 nursery operations lb quotes green in weight. from Madrin, Quebec, Subsequently, NB based andanother at discussions Listuguj 100,000 Reserve with lbRon Smith at contract Cross of Canadian Point. is signed with Forest a Quebec Service (CFS) processor. on elite This plantations. allows Ryan to become the largest private harvesting contractor in Canada. Total annual harvesting of 300,000 pounds green biomass. © Chatham Biotec Ltd. 2005 2002 Joint venture signed Contract Drying and signed processing with with large facilities US Collaborative agreement with Naturol technologies to processor established for at 24Marine million Extract lbs of CFS valued at dollars develop extraction of processed Ltd. in Shippagan green NB. signed with newlybiomass. formed taxanes from green Chatham Biotec Ltd. for biomass. rights to elite Canada exclusive Total annual harvest of 1.5 yew plantation million pounds research of green and commercial development which biomass. will produce biomass 2 ½ times cheaper than wild biomass and be the lowest priced supply in world markets. © Chatham Biotec Ltd. 2005 2003 Research Contract signed and exclusive with Quebec processing processor Supply Refinedcontract extract plant signed custom with built to rights to supply developed processed for liguid/liguid biomass for plant Quebec supply intermediate marketing board for US forGMP API separation start up. technology for paclitaxel green contract biomass supplier. in Gaspe. refinement. Contract signed with US processor for long term supply of processed biomass with yearly supply of 2- 4 million lbs. Long term processed biomass supply contract signed with large international drug company for processed wild and plantation biomass equivalent to 6 million lbs per year of green biomass. © Chatham Biotec Ltd. 2005 Total annual harvest of 3 million pounds of green biomass 2004 Establishment of worlds first Biomass processing facility commercial yew plantation upgraded to Canada handle 20-50 using elite plants. million lbs per year green biomass withseedlings wood separation Over 80, 000 technology. from elite selection were planted in 7 acres. On site quality control lab expanded with 3 HPLC and Plantation site selected for extraction testing equipment ideal growing climate and is at Shippigan facilities. fully automated. © Chatham Biotec Ltd. 2005 Expansion into Ontario and Nova Scotia. Total of 30 buying stations brought over 10 million Granted in permission to pounds greenlands Canada yew prune onofcrown biomass. in both provinces. All product pruned from Ontario crown land was audited by third parties. 10 cents per pound donated to local charities for all Ontario crown land biomass. © Chatham Biotec Ltd. 2005 2004 Research buying Establish contractstations signed in with Michigan, USA. Ontario research to yew seedlings Plant 100,000 Elitegroup Canada develop sustainable at Zelenka nurseries harvesting located in Grand of wild biomass. Haven, MI. © Chatham Biotec Ltd. 2005 Begin pruning and processing Canada yew biomass in Quebec. Processing facilities will be located near Quebec City. Commercial paclitaxel refinement perfected to become competitive with other suppliers, solid/solid paclitaxel separation technology. © Chatham Biotec Ltd. 2005 Contracts signed with large industrial landowners in NB for wild biomass harvesting rights. Wild harvesting auditing expanded to all areas, product certification proceeding. Begin a data base of all sites pruned to create a computerized inventory of Canada yew. Increase production by 2 times for a total of 20 million pounds of green Canada yew biomass. © Chatham Biotec Ltd. 2005 © Chatham Biotec Ltd. 2005