Transcript PET in Head and Neck Cancer

Nuclear Molecular Imaging and
Therapy of Cancer
Richard L. Wahl, M.D.
Division of Nuclear Medicine
Johns Hopkins Medical Institutes
Baltimore, MD
Results
d18
Treated (35 uCi/mouse)
Untreated
Results
In Vivo Raji Cell Growth
2,000,000,000
1,800,000,000
Tumor Luminescence
(photons/cm2-sec)
1,600,000,000
1,400,000,000
1,200,000,000
Control
1,000,000,000
Ritux (4 ug)
800,000,000
Bi-Ritux (35 uCi/mouse)
600,000,000
400,000,000
200,000,000
0
0
2
4
6
8
10
12
14
Day post i.v. tumor administration
16
18
20