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ISGO: The International Structural Genomics Organization
Goals of ISGO
•Develop standards and policies for structural genomics
•Sponsor international meetings and workshops
•Promote cooperation in structural genomics, including between
public and private efforts
•Promote deposition of coordinates, raw data, and other information
ISGO 2000-2001
Led by John Moult, Chris Sander, John Norvell, Barbara Skene
•Workshops on international cooperation
•Hinxton (April, 2000) and Airlie House (April, 2001)
•Task Forces
•Task Force on Deposition, Archiving, and Curation of the Primary
Information (Helen Berman and Geoff Barton, chairs)
•Task Force on Mechanisms for Publication and Recording of Methods
and Results (Guy Dodson, chair)
•Task force on Intellectual Property (John Norvell, Barbara Skene, chairs)
•Task Force on Numerical Criteria in Structural Genomics (Randy Read,
chair)
•Task Force on Target Tracking (Steve Bryant, chair)
•Workshops on in vitro expression systems (Shigeyuki Yokoyama)
ISGO 2000-2001
Agreed Principles and Procedures
Coordination of International Programs in Structural Genomics
“The goal is to encourage harmonious cooperation among a broad range of public and
private sector institutions in the international effort to characterize macromolecular
structures in living organisms on a pan-genomic scale”
Key Principles
•Free exchange of data and materials
•Deposition of coordinates and other mandatory data in the PDB immediately on
completion of structure determination
•Public release in a short time (always less than 6 months)
•Open exchange of target information
ISGO 2000-2001
Additional recommendations
•Short peer-reviewed papers to ensure quality (Proteins, Structure Function and
Genetics; Acta Cryst. D in place now)
•Quality is not to be sacrificed in the interests of quantity
•Structure depositions will be accompanied by experimental data
•Access to material such as clones, cell lines, and protein samples encouraged
•Exchange of protocols and materials encouraged (Clearinghouse recommended)
•Promote the free access and exchange of scientific information among scientists
engaged in basic research.
• Harmonize patent law.
•Strengthen the utility requirement for patentability. (Community is concerned about the
implications of the granting of patents based solely on the submission of three-dimensional structural
co-ordinates, without any identified non-trivial utility.)
ISGO Today
•Open membership
•[email protected] mailing list
•Web site:
•http://www.isgo.org
•An executive committee
•Continuing members: Shigeyuki Yokoyama, Udo Heinemann, Tom Terwilliger
•New members: Seiki Kuramitsu, Ian Wilson, David Stuart
•An Advisory Board
•Gaetano Montelione , Guy Dodson, Chris Sander, Dino Moras, Joel Sussman,
Wayne Hendrickson, John Norvell, Barbara Skene, Norihisa Hara
•Active Task forces
•Task Force on Deposition, Archiving, and Curation of the Primary
Information (Helen Berman, chair)
•Task Force on Mechanisms for Publication and Recording of Methods
and Results (Guy Dodson, chair)
•Task force on Intellectual Property (John Norvell, Barbara Skene, chairs)
ISGO and the Structural Genomics Community
Sponsored International Conference on Structural Genomics in Berlin, Oct 1013, 2002 (Udo Heinemann, organizer)
Sponsored workshops for collaborative efforts and sharing of technology
•in vitro expression workshops (2001-2002, Shigeyuki Yokoyama)
•Collaboration in high-throughput crystallography (March 2002, Tom Terwilliger)
•Automation of X-ray Structure Determination of Macromolecules (Oct, 2002, Uwe
Mueller)
Run pre-conference ISGO session on structural genomics policies (Oct, 2002)
Sponsoring next International Conference on Structural Genomics (USA,
2004/2005 (Gaetano Montelione & Tom Terwilliger have volunteered to
organize)
Suggested ISGO statement on
patentability of protein structures
“ISGO strongly supports the position that a
high level of utility should be required for
patenting of protein structures”
NOTE: ISGO continues to expect that most structures will be
immediately deposited and released, as agreed at Airlie House.
Continued work of Task Forces
Task Force on Deposition, Archiving, and Curation of the Primary Information.
(Helen Berman, chair)
Development of data dictionary for deposition of all relevant experimental data
(cloning, protein production, crystallography, NMR)
Development of target tracking web site and structural genomics pipeline for
deposition to PDB
Task Force on Mechanisms for Publication and Recording of Methods and
Results (Guy Dodson, chair)
Negotiate with journals to create a smooth pathway for publishing short structure
reports
(Identify what should be in short articles)
Task force on Intellectual Property (John Norvell and Barbara Skene)
Discussion and drafting of proposed policies on patenting and structural
genomics