Transcript PowerPoint-presentatie

an UMC Utrecht spin-off
Early detection of delirium
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A PATIENT
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THE PATIENT
100.000+ times each year in NL
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DELIRIUM HAS IMPACT
• Impact on the healthcare system
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longer hospitalisation
increased admission to nursing homes
more often dementia
increased mortality
• Very costly
• $ 100+ billion in the USA
• similar to diabetes
• A growing problem
• aging populations
• rising surgical standards
• older age surgery
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DELIRIUM IS VERY COMMON
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EARLY DETECTION = KEY TO RECOVERY
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DRASTICALLY IMPROVED DETECTION
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PROLIRA MAKES DETECTION EASY
• World’s first biomarker-based device (slowing of brain activity)
for routine delirium detection
• as fast as checklist, ≤ 2 min
• objective, safe, sensitive & specific
“thermometer” for delirium
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CLINICAL RESEARCH DEVICE
UMC Utrecht et al.
Current situation: 7 components, 1 hour process
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Off the shelf EEG signal
capturing device
Headband that indicates the right
position for the electrodes
3 reusable electrodes with customized
cable are manually placed in headband
Manually applied conductive, sticky gel
to connect the electrodes to the head
Set up takes 5-10 minutes
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Laptop stores EEG signals
Signal processing and interpretation takes
place offline
Manual noise reduction
Manual algorithm for delirium recognition
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AVAILABLE IN 2017
Prolira’s Delirium Monitor
Future situation: 2 components, 2 minute process
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Reusable device with automated
signal processing and noise
reduction
Display shows number on
delirium scale
Set up takes 10 - 20 seconds
Disposable ”peel-stick” patch
Patch contains 3 pre-gelled electrodes
at right position
Patch contains necessary electronics
artist impression
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Class IIa
510(k)
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Financials
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7/18/2015
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FINANCIAL ROADMAP
1 year
1 year
2 years
Mixed sources
Early commitment from investors wanted!
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START-UP FINANCIALS
• Own investment
• Prize money
• Subsidies/grants
• Loans
• VC
easiest to plan, shows commitment
pitches (Utrecht Ureka, Venture Challenge)
write & apply: self or consultant , ‘lottery’
BP & solid financial plan, security
total sum, dilution, network, experience
tips: prioritize, keep burn rate low, payment agreements
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REALISED
• okt 2014: UMC Utrecht Ureka finalist
Boston
• nov 2014: ESICM Research grant for Dr Arjen Slooter
• jan 2015: Rabo Pre-seed loan
• feb 2015: NL STW take-off Phase 1 subsidy
• mar 2015: EU H2020 SME Phase 1 subsidy
ir Annemarie
Willems
CCO
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Dr Arjen
Slooter
Principal
Investigator
Dr ir Rutger
van Merkerk
CEO
€ 3.000
€ 20.000
€ 50.000
€ 40.000
€ 50.000
Dr Philip
Zeman
Lead
Engineer
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IN THE PIPELINE
• NL STW take off Phase 2 loan (€ 250.000)
• EU Horizon 2020 Phase 2 subsidy (max. € 2,5 million)
• Rabo Herman Wijffels innovation award (€ 5.000 of 30.000)
• Interest from business angel and manufacturer in participation
• Strategic investment from multinational?
• Serious interest from various investors
Join Prolira! Let’s reach a substantial part of the
€ 1.4 billion delirium monitoring market by 2020
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CONTACT
Rutger van Merkerk
[email protected]
Tel. 06 4776 2936
Annemarie Willems
[email protected]
Tel. 06 2297 8972
Padualaan 8
3584 CH Utrecht
The Netherlands
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