Transcript Isotonix Advantage Presentation

®
The Isotonix Advantage
Mark Lange, Ph.D.
Director, Quality Control
Market America
OVERVIEW
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Understanding Your Digestive System
Transporting Nutrients into Cells
The Isotonix Delivery System
Isotonix Advantage #1,2,3…..
STOMACH
Secretes 5 substances mainly:
 Water – diluent
Hydrochloric acid
 Chloride ions
HCl = pH 1.0 – 2.8
 Hydrogen ions
 Pepsin – proteolytic enzyme (proteins)
 Intrinsic factor – vitamin B-12 binding
protein released by parietal cells
Isotonix Advantage #1
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Nutrients are not exposed to acidic
environment of stomach, where
they would otherwise degrade.
Customer money is not wasted.
Isotonix Advantage #2
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Reduced delivery time.
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Example: B vitamins for energy
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Minutes to uptake – not hours
SMALL INTESTINE
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ACIDIC FOOD SOLUTION stimulates
pancreas to release numerous digestive
enzymes in a sodium bicarbonate
solution
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NEUTRALIZATION pH of food solution
changed from acidic to nearly neutral
SMALL INTESTINE
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BILE is a product of the liver, collected
in the gall bladder, and secreted onto
the food solution.
Contains surfactants that disperse fat.
Lipases act on triglycerides, releasing
fatty acids.
Isotonix Advantage #3
Carbon dioxide created by the
effervescent reaction reduces the
thickness and viscosity of the mucus
layer of the intestinal tract, promoting
absorption into the cells.
Pharm. Res. 1998, vol 15, pp 925-930. “Mechanistic studies on
effervescent-induced permeability enhancement.”
FOLDS
IN THE SMALL INTESTINE
Villi
Mucosa
Sub Mucosa
The Cell Membrane
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Cell Membrane Barriers
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Lipid bi-layers are impermeable to most
essential molecules and ions.
Oxygen, Water, & Carbon Dioxide can
freely pass.
Many nutrients cannot freely pass.
Movement through
Differences in Concentration
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Diffusion is moving molecules from a
region of higher concentration to a
region of lower concentration.
Simple Diffusion
Higher concentrations
move nutrients into cells
Membrane
(lipid bilayer)
Isotonix Advantage #4
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Favorable concentration gradient
for absorption of some nutrients.
Example: Calcium/Magnesium
Nutrients are delivered to the small
intestine in a concentrated solution.
Facilitated Diffusion
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Takes place through channels
embedded in the membrane.
Example: Fructose moved into cell by
facilitated diffusion.
Active Transport
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Pumping of molecules or ions through a
membrane into a region of higher
concentration. It requires a transmembrane protein and energy input.
Example: Amino Acids, ATP, Sodium,
Potassium moved into cell by Active
Transport.
SMALL INTESTINE
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Absorption of nutrients occurs throughout
entire length of small intestine (90 – 95%
efficient)
Calcium absorption occurs as late as ileocecal juncture (appendix)  transport into
cells via calcium channels
Under neutral pH, intrinsic factor binds to
vitamin B-12 to form a complex
SMALL INTESTINE
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Intrinsic factor/vitamin B-12 complex
binds to receptors (specialized docking
structures) on intestinal membranes
Last 1/3rd of small intestine is main
absorptive site
COLON
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Most nutrients will have been absorbed by the
time they reach the large intestine —an
additional 3-5% possible.
Major functions of colon:
 Site of bacterial cell growth and residence
 An estimated 300-400 species or strains of
bacteria continue digestion of waste products
 Regulates water in body
 Some vitamins produced in low amounts by
bacteria and absorbed
COLON
Bacteria adjust the pH of the colon into the
acidic range – prevents overgrowth of
harmful bacteria.
Continued growth of friendly bacteria help
maintain healthy balance.
What does “isotonic” mean?
ISO = SAME
TONIC = Tension or Pressure
An Isotonic Cell is a Happy Cell.
Cells act like little bags of
salty water…..
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The movement of water in and out of a
cell is called “Osmosis.”
Cells want the same concentration of
dissolved particles (salt) on both sides
of the membrane.
ISOTONIC
(NORMAL)
HYPOTONIC
(WATER GOING
IN)
HYPERTONIC
(WATER GOING
OUT)
Isotonix Advantage #5
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Isotonic solutions are the optimal
delivery system.
Isotonix products work with – not
against – normal body physiology.
Composition of
Isotonix Delivery System
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Active ingredients: vitamins, minerals,
oligomeric proanthocyanidins (OPC),
flavonoids, coenzyme Q10, etc.
Base ingredients: fructose, glucose,
citric acid, malic acid, calcium sulfate,
maltodextrin, silica, potassium
bicarbonate
Composition of
Isotonix Delivery System
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Glucose and fructose:
 Sweet-tasting simple sugars
 Add significant osmotic pressure
 Caloric value (~ 8 cal/serving)
 Fructose: principle sugar in formula scores
20 out of 100 on glycemic index (i.e.,
relatively low value)
Composition of
Isotonix Delivery System
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Citric acid and malic acid:
 Adjust pH to acid range (about 3.5 – 5.0)
 Adjust taste to “citrus” flavor
 Minor osmotic pressure adjustment
Composition of
Isotonix Delivery System
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Calcium sulfate:
 Desiccant (takes up moisture in powder) /
free-flow agent
 Minor osmotic pressure adjustment
 Minor nutritive value
Composition of
Isotonix Delivery System
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Maltodextrin:
 Glucose polymer has minor caloric value
 Powder — bulking agent
 Prevents citric acid from reacting with
potassium bicarbonate and water
 Thickening and suspending agent in
solution
Composition of
Isotonix Delivery System
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Potassium bicarbonate:
 Potassium and bicarbonate ions have
significant osmotic pressure
 Helps adjust and buffer pH
 Release of CO2 stirs liquid
Isotonix Advantage #6
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Isotonix offers an alternative to pills.
Survey shows 40% of American adults
have experienced difficulty swallowing
pills
The survey of 679 adults (513 ages 18-64, 166 age 65 and older) was funded by the US
affiliate of Germany's Schwarz Pharma.
Isotonix Advantage #7
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People with stomach and esophageal
challenges benefit from Isotonix delivery.
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Acid reflux sufferers
Bariatric patients
Hiatal Hernia (stomach protrudes up through
diaphragm)
People who have trouble swallowing
Elderly (reduced acid production)
Conclusion
Isotonix® product line offers customers
a wide selection of nutrient
combinations with the advantages of
isotonic delivery.
Isotonix® is the logical choice of those
seeking fast and optimal nutrient
uptake.