Karolinska Institutet – a medical university

Innovation

Innovation: what does it mean?

    From the Latin

innovare

“to renew and change” To create better and more effective products, processes, technologies and ideas It usually denotes a significant positive change, in contrast to “normal improvements” According to many definitions, the product, process or service must be commercialised for it to count as an innovation Name Surname 2 May 2020

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The knowledge triangle

   Interaction between research, education and innovation Important driving forces for a knowledge-based society The goal is to make Sweden more competitive Education Research Innovation Name Surname 2 May 2020

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Obstacles to the utilisation of ideas in the healthcare sector

   Vocational education with weak links to industry Constant exposure to problems feeds innovation Few know how their ideas are best implemented © Anders Norderman 2 May 2020

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Name Surname

Research + industry = the future

   The gap between research and industry must be bridged Significant changes in healthcare Knowledge and technology transfer, where the utilisation of research is important Name Surname © Pierre Zoetterman 2 May 2020

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The teachers’ exemption

   In Sweden, university employees have the right to own their patentable ideas and research results In private industry, the ideas are owned by the employers The right to inventions and research results can usually be transferred in agreements Name Surname 2 May 2020

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The growth of KI’s innovation system

The system is initiated when Swedish universities are allowed to own holding companies

1995 1996

Karolinska Institutet Innovations AB established Karolinska Institutet Science Park AB is established

2000 2004

Unit for Bioentrepreneurship is established Innovation Office established

2010 2011

Investment company Karolinska Development AB initial public offering Name Surname 2 May 2020

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Today’s innovation system

Name Surname Karolinska Institutet The Innovation Office The Unit for Bio entrepreneurship Karolinska Institutet Holding AB Karolinska Institutet Innovations AB Karolinska Development AB Actar AB Karolinska Institutet Science Park AB Incubator 2 May 2020

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The innovation system’s mission

 To put knowledge to use in the best interests of society.

Name Surname © Lasse Skog 2 May 2020

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The innovation system puts ideas to use in the best interests of society

Partners/ External expertise Innovations ystem Name Surname 2 May 2020

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The overall objective of the innovation system

    

To inspire

new ideas

To identify

ideas with development potential and make them useable

To commersialise

users innovations and get them out to the market and to

To establish

partnership between industry and academy Six entities, each with its own field of expertise:  Unit for Bioentrepreneurship  The Innovation Office  Karolinska Institutet Science Park AB  Karolinska Institutet Innovations AB  Karolinska Development AB  Actar AB Name Surname 2 May 2020

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Karolinska Institutet’s Innovation Office

     Portal to Karolinska Institutet’s innovation system Has separate government financing Offers free, impartial advice and guidance Arranges inspiration and information activities Facilitates interaction between the academic and private sectors Name Surname 2 May 2020

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Unit for Bioentrepreneurship

   KI’s unit for academic education and research in entrepreneurship and innovation Offers a two year international Master’s programme in bioentrepreneurship Holds courses in entrepreneurship for all students and researchers at KI Name Surname © Camilla Svensk 2 May 2020

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Karolinska Institutet Innovations AB

   Supports researchers in the conversion of their ideas into marketable medical products Offers project management, coaching, financing, patenting and business development Has created some 40 start-up companies and made about 30 licence deals Name Surname a 2 May 2020

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Karolinska Institutet Science Park AB

   KI’s own science park with 60 life-science businesses, from start-ups to mature companies Offers office and laboratory space Offers professional networking, symposia and support Name Surname © Pierre Zoetterman 2 May 2020

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Karolinska Development AB

     Investment company specialising in the life sciences Business concept is to select, develop and commercialise drug discovery and med tech innovations Deal flow agreements with Karolinska Institutet Innovations AB Listed on the NASDAQ OMX Stockholm exchange in 2011 Portfolio comprises 36 projects, 14 of which are in the clinical development phase Name Surname © XSpray 2 May 2020

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Actar AB

   Produces and evaluates drug candidates for new target proteins Unique expertise and infrastructure in analysis, screening and medical chemistry Wholly-owned subsidiary of Karolinska Development AB Name Surname 2 May 2020

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The innovation system helps to:

       Assess the idea’s commercial potential Apply for protection (e.g. patents) Offer expertise, market analyses and networks Start and develop companies Finance early company development via e.g.

 Grant applications (e.g. Vinnova)  Seek out private venture capital Provide premises, infrastructure and venture capital Secure licence deals Name Surname 2 May 2020

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The innovation system commercialises the research idea

    If the researcher wants to continue researching full-time, help is offered with the following:  Project management  Patenting, licensing and negotiations  Company formation and business development All overheads for the commercialisation process are covered by the system The intellectual property rights for the invention are transferred from the researcher Future profits are shared Name Surname 2 May 2020

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The innovation system helps researchers run companies

 Entrepreneurial researchers are offered:  Coaching and mentorship programmes  Infrastructure and premises  Seminar series and courses  Broad network of research colleagues  Opportunities to make early contact with investment companies © Pierre Zoetterman 2 May 2020

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Name Surname

Strategic alliances

  KI’s innovation system promotes above all high-class translational research Translational research shortens the pathway from discovery to utilisation Name Surname © Marcus Erixson 2 May 2020

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Collaboration with small and medium-sized enterprises (SMEs)

    SMEs are the backbone of the biotech industry The SME sector is an important employer The Stockholm-Uppsala region has a large number of SMEs SMEs are a priority group for KI’s innovation system Name Surname © Lasse Skog 2 May 2020

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Two good examples Kunskapslotsen (The knowledge pilot)

A joint project set up by KI and KTH to create a sustainable and effective contact platform between the universities and the SME sector

Doctoral students in companies

25 of KI’s doctoral students spent a month each at a company in 2011 Name Surname 2 May 2020

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Entrepreneurial training for all groups

KI students External students Doctoral students KI’s innovation system Clinically active employees Postdocs Researchers Name Surname 2 May 2020

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Master’s programme in bioentrepreneurship

   Two-year international programme that prepares tomorrow’s corporate leaders Focuses on the management and development of life science companies in order to meet the needs of tomorrow’s life science sector Combines business acumen with natural science and medicine © Camilla Svensk 2 May 2020

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Name Surname

Courses in bioentrepreneurship

   Elective courses at Master’s and doctoral level Can be combined with other studies Examples:  “From science to business – Concepts in biotechnology”  “From idea to service business – Transforming health care”  “Effective advocacy within boards and committees”  “Health care and business management for future medical doctors” Name Surname 2 May 2020

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Entrepreneurial training in partnership

   Collaboration with KTH, the Stockholm School of Economics, Stockholm University and the University College of Arts, Crafts and Design through the Stockholm School of Entrepreneurship 160 visiting lecturers, mentors and coaches take part in the training programme every year Gives a broad perspective and interdisciplinary learning Name Surname © Camilla Svensk 2 May 2020

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Business involvement in education

   Students work in project form (1 to 20 weeks) to solve a genuine problem at a company Solutions are sought in the fields of:  Business development  Market analysis  Healthcare management issues Representatives of industry hold talks on campus about their own (and the company’s) experiences Name Surname 2 May 2020

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Inspiration activities

   Ideas competitions Workshops and seminars  “Meet an innovator”, intellectual property rights  “The business plan as innovation tool” Inspiration material, e.g. “Toolbox for entrepreneurs” Name Surname 2 May 2020

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Bioentrepreneurship research at KI

   Multidisciplinary research opportunities Focus on the interface between industry, academic research and clinic Projects led by senior researcher fellows, doctoral students and Master’s students Transferring research Intellectual property in science UBE Academic knowledge creation Growth drivers and barriers Name Surname 2 May 2020

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