Transcript www.ishlt.org

THE REGISTRY OF THE
INTERNATIONAL SOCIETY
FOR HEART AND LUNG
TRANSPLANTATION:
TWENTIETH ANNUAL
REPORT
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Major Contributors to the ISHLT Transplant Registry
Australia and New Zealand Cardiothoracic Organ Transplant Registry (ANZCOTR):
Australia
New Zealand
Eurotransplant (ET):
Austria
Germany
Belgium
Netherlands
Slovenia
Scandiatransplant:
Denmark
Norway
Finland
Sweden
United Kingdom Transplant Services Authority (UKTSSA):
United Kingdom
Ireland
United Network for Organ Sharing (UNOS):
United States
70 individual centers from Canada, Central/South America, Europe and
Asia reporting transplants since 1995
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
ACKNOWLEDGMENTS:
We wish to extend our sincere thanks
to the many thoracic transplant
surgeons, physicians and data
coordinators in transplant programs
throughout the world whose timely
and accurate submission of data has
made these analyses possible.
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
ISHLT International Heart and Lung Transplant
Registry Mission Statement
The ISHLT International Heart and Lung Transplant
Registry was created to advance the state of knowledge
and patient care regarding therapies for the failing heart
and lung. This mission is accomplished by maintaining a
repository of the worldwide thoracic organ transplant
experience and by fostering related outcomes research in
order to:
1. Create new knowledge related to advanced heart and
lung failure and transplantation;
2. Serve as a resource for healthcare providers seeking
information regarding patient care;
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
ISHLT International Heart and Lung
Transplant Registry Mission Statement
(cont’d)
3. Provide benchmark aggregate date for use by individual
centers to assess their center-specific practices and
outcomes;
4. Serve as a resource for governmental agencies
worldwide when formulating public policy regarding
thoracic organ transplantation;
5. Serve as a resource for patient-related organizations and
pharmaceutical companies regarding disease-specific
therapies and transplant outcomes
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Goals of Registry
1. Increase the number of studies using Registry data
2. Increase the number of non-US reporting centers
3. Develop sources of external funding
4. Optimize the value and image of the Registry to the
Society, its members, and the external research
community
5. Identify patient-related organizations and pharmaceutical
companies and make them aware of the Registry as a
resource
6. Restructure the data fields into a tiered system and
increase the number of required fields
7. Increase the number of reporting agreements with nonUS government regulatory agencies
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
REGISTRY STEERING COMMITTEE
Marshall Hertz – Medical Director
Elbert Trulock – Associate Dir. for Lung Transpl.
David O. Taylor – Associate Dir. for Heart Transpl.
Mark Boucek – Associate Dir. for Pediatric Transpl.
Mario Deng – MCSD Database Medical Director
Amanda Rowe – ISHLT Executive Director
Berkeley Keck – Assoc. Dir. for Database Management
Leah Edwards – Associate Dir. for Data Analysis
ISHLT
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J Heart Lung Transplant 2004; 23: 789-95
General Registry Statistics
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
REGISTRY DATABASE:
Number of Transplants Reported
ORGAN
Transplants Reported
Through 6/30/2003
Heart
66,353
Heart-Lung
3,049
Lung
17,128
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
REGISTRY DATABASE:
Number of Centers Reporting Transplants
Centers
Centers
Reporting
Reporting
Transplants
Transplants in
between 1/2002
1994
and 6/2003
Organ
Centers
Ever
Reporting
Data
Heart
333
252
200
Heart-Lung
132
63
44
Lung
201
119
111
ISHLT
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J Heart Lung Transplant 2004; 23: 789-95
REGISTRY DATABASE:
Number of Centers Reporting Heart Transplants
250
200
150
100
Year of Transplant
ISHLT
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2002
2001
2000
1999
1998
1997
1996
1995
1994
1993
1992
1991
1990
1989
1988
1987
1986
1985
1984
1983
1982
0
1981
50
1980
# of Centers Reporting
300
REGISTRY DATABASE:
Number of Centers Reporting Lung Transplants
100
50
0
19
87
19
88
19
89
19
90
19
91
19
92
19
93
19
94
19
95
19
96
19
97
19
98
19
99
20
00
20
01
20
02
# of Centers Reporting
150
Year of Transplant
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
REGISTRY DATABASE:
Number of Centers Reporting Heart-Lung Transplants
60
50
40
30
20
10
0
19
85
19
86
19
87
19
88
19
89
19
90
19
91
19
92
19
93
19
94
19
95
19
96
19
97
19
98
19
99
20
00
20
01
20
02
# of Centers Reporting
70
Year of Transplant
ISHLT
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APPENDIX
ISHLT
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J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
x
x
St. Vincent
x
x
The Prince Charles Hospital
x
x
Royal Children’s Hospital
x
x
The Alfred Hospital
x
x
Royal Perth Hospital
x
x
University of Vienna
x
x
Innsbruck University Hospital
x
x
University Klinik fur Chirurgie (Graz)
x
x
x
x
COUNTRY/Center
ARGENTINA
Fundacion Favaloro
AUSTRALIA
AUSTRIA
BELGIUM
Erasme Univ. Hospital (Brussels)
(Cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
Univ. Hospital Gasthuisberg (Leuven)
x
x
University Hospital Antwerp
x
x
University Hospital Gent
x
x
Centre Hospitalier Universitaire de
Liege, CHU Sart-Tilman
x
x
Royal Victoria Hospital
x
x
Montreal Heart Institute
x
x
The Toronto General Hospital
x
x
Hospital Notre-Dame
x
x
Quebec Heart Institute - Laval Hospital
x
x
Ottawa Heart Institute
x
Univ. of Alberta Hospitals/ Walter C.
Mackenzie Health Sciences
(Cont’d)
x
COUNTRY/Center
BELGIUM (cont’d)
CANADA
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
x
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
St. Paul
x
x
Vancouver General Hospital
x
x
The Hospital for Sick Children
x
x
Hospital DIPRECA
x
x
Clinica Las Condes
x
x
Skejby University Hospital
x
x
Rigshospitalet, National University
Hospital
x
x
Helsinki University Central Hospital
x
x
Children's Hospital, Univ. of Helsinki
x
x
COUNTRY/Center
CANADA (cont’d)
CHILE
DENMARK
FINLAND
(Cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
COUNTRY/Center
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
FRANCE
Hopital Cardiolgique (Lille)
x
Hopital La Pitie - Salpetriere
x
Hopices Civils Hopital Universitaires
de Strasbourg
x
GERMANY
Organisationsbuero des K.F.H.
(Homburg/Saar)
x
Technischen Universitaet Dresden
x
x
German Heart Institute (Berlin)
x
x
Universitat Hamburg
x
x
Universitaetsklinik (Koeln)
x
x
University of Leipzig - Heart Center
x
Kerckoff-Klinik der Max-PlanckGesellschaft zur Forderung der
Wissenschaften e.V. (Bad Nauheim)
x
ISHLT
2004
(Cont’d)
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
Klinikum der Universitaet (Heidelberg)
x
x
Herz-und Diabetesentrum Nordrhein
-Westfalen (Bad Oeynhausen)
x
x
Chirurgische Universitaetsklinik/
Univ. Rostock (Freiburg Im Breisgau)
x
x
Essen University Medical School
x
x
I. Med. Klinik J. Gutenberg (Mainz)
x
x
der Heinrich-Heine-Universitat
Dusseldorf
x
x
Klinikum GroBhadern, LudwigMaximilians-Universitat Munchen
x
x
Chirurgische Universitatsklinik
Heidelberg
x
x
COUNTRY/Center
GERMANY (cont’d)
(Cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
Medizinische Hochschule Hannover
x
x
Universitatsklinik Gottingen
x
x
Klinikum der RheinischWestfalischen Technischen
Hochschule Aachen
x
x
Fulda Medical Center
x
x
Klinikum der J. W. Goethe
University (Frankfurt am Main)
x
x
Klinikum Der Christian-AlbrechtsUniverstat zu Kiel
x
x
Transplantations-Zentrum (Frankfurt)
x
x
Friedrich Schiller Universitaet (Jena)
x
x
COUNTRY/Center
GERMANY (cont’d)
(Cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
COUNTRY/Center
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
x
x
x
x
x
x
x
x
x
x
GERMANY (cont’d)
Medizinische Einrichtupgen der
Universiteat , Nurenberg
GREECE
Onassis Cardiac Surgery Center
IRELAND
Mater Hospital
ISRAEL
Sheba Medical Center
ITALY
Policlinico S. Orsola - Universita
degli Studi
Ospedali Riuniti
x
(Cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
COUNTRY/Center
TXs Performed 1/2002-6/2003
and Reported to ISHLT
JAPAN
Tohoku University, IDAC Hospital
x
Osaka University Hospital
x
x
National Cardiovascular Center
x
x
Heart-Lung Institute, University
Hospital Utrecht
x
x
Thoraxcenter - University Hospital
Rotterdam
x
x
University Hospital Groningen
x
x
x
x
x
x
NETHERLANDS
NEW ZEALAND
Green Lane Hospital
NORWAY
Rikshospitalet - National Hospital of
Norway
(Cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
x
x
University Hospital of Lund
x
x
Sahlgrenska University Hospital
x
x
COUNTRY/Center
SLOVENIA
University Medical Center Ljubljana
SWEDEN
SWITZERLAND
Bern University Hospital
x
University Hospital Zurich
x
Univ Clinic for CardioThoracic Surgery
Basel
x
UNITED KINGDOM
Great Ormand Street Hospital for Children
x
x
University of Glasgow/Glasgow Royal
Infirmary
x
x
Northern General Hospital
x
x
ISHLT
(Cont’d)
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
The Freeman Hospital
x
x
Harefield Hosp
x
x
Wythenshawe Hospital
x
x
Queen Elizabeth Hospital
x
x
Papworth Hospital
x
x
University of Alabama Hospital
x
x
Baptist Medical Center, Little Rock
x
x
Arkansas Children’s Hospital
x
x
The University Hospital of Arkansas
x
x
University Medical Center,
University of AZ
x
x
COUNTRY/Center
UNITED KINGDOM (cont’d)
UNITED STATES
(Cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
Children’s Hospital Los Angeles
x
x
Cedars Sinai Medical Center
x
x
Loma Linda Univ. Medical Center
x
x
California Pacific Medical Center
x
x
UCSD Medical Center
x
x
University of CA San Francisco
Medical Center
x
x
Sutter Memorial Hospital
x
x
Sharp Memorial Hospital
x
x
Stanford University Medical Center
x
x
St Vincent Medical Center
x
x
UCLA Medical Center
x
x
COUNTRY/Center
UNITED STATES (cont’d)
(Cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
USC University Hospital
x
x
The Children’s Hospital, Denver
x
x
University Hospital, Denver
x
x
Hartford Hospital
x
x
Yale New Haven Hospital
x
x
COUNTRY/Center
UNITED STATES (cont’d)
Children’s National Medical Center
x
Washington Hospital Center
x
x
All Children’s Hospital
x
x
Jackson Memorial Hospital
x
x
St Luke’s Hospital, Jacksonville
x
Tampa General Hospital
x
x
Tallahassee Memorial Hospital
x
x
(Cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
Shands Hospital at University of
Florida
x
x
Children’s Healthcare of Atlanta
x
x
Emory University Hospital
x
x
St. Joseph Hospital of Atlanta
x
x
St. Francis Medical Center, Honolulu
x
x
Univ. of Iowa Hospital and Clinics
x
x
Children’s Memorial Hospital
x
x
Loyola University Medical Center
x
x
OSF St. Francis Medical Center
x
x
St. John’s Hospital
x
COUNTRY/Center
UNITED STATES (cont’d)
(Cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
Univ. of Chicago Medical Center
x
x
University of Illinois Hospital
x
x
Clarian Health-Methodist/IU/Riley
x
x
Lutheran Hospital of Ft. Wayne
x
x
St. Vincent Hosp. and Health Care Ctr
x
x
Via Christi Regional Medical Center
x
x
Jewish Hospital
x
x
COUNTRY/Center
UNITED STATES (cont’d)
Kosair Children’s Hospital
x
Univ. of Kentucky Medical Center
x
x
Ochsner Foundation Hospital
x
x
Tulane University Medical Center
x
x
Willis Knighton Medical Center
x
x
(Cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
Children's Hospital, Boston
x
x
Massachusetts General Hospital
x
x
New England Medical Center
x
x
Brigham and Women’s Hospital
x
x
UMass Memorial Medical Center
x
Johns Hopkins Hospital
x
x
Univ. of Maryland Medical System
x
x
Children’s Hospital of Michigan
x
x
Henry Ford Hospital
x
x
Univ. of Michigan Medical Center
x
x
Abbott Northwestern Hospital
x
x
St. Mary’s Hospital (Mayo Clinic)
x
x
Fairview University Medical Center
(Cont’d)
x
x
COUNTRY/Center
UNITED STATES (cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
Barnes-Jewish Hospital
x
x
Cardinal Glennon Children’s Hospital
x
x
St. Louis Children’s Hospital
x
x
St. Luke’s Hospital of Kansas City
x
x
St. Louis University Hospital
x
x
Univ. of Missouri Hospital and Clinic
x
x
University of MS Medical Center
x
x
NC Baptist Hospital
x
x
Carolinas Medical Center
x
x
Duke University Medical Center
x
x
UNC Hospitals
x
x
Bryan LGH Medical Center East
x
x
Newark Beth Israel Medical Center
(Cont’d)
x
x
COUNTRY/Center
UNITED STATES (cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
Robert Wood Johnson Univ. Hosp
x
x
Presbyterian Hospital, Albuquerque
x
x
Albany Medical Center Hospital
x
x
The Presbyterian Hospital in NY City
x
x
Strong Memorial Hospital
x
x
Montefiore Medical Center
x
x
Mt. Sinai Medical Center
x
x
New York University Medical Center
x
Westchester County Medical Center
x
x
Cleveland Clinic Foundation
x
x
COUNTRY/Center
UNITED STATES (cont’d)
Children’s Hospital Dayton
x
Children's Hospital Medical Center,
Cincinnati
x
x
Medical College Hospital, Toledo
x
x
(Cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
Ohio State University Hospital
x
x
Univ. of Cincinnati Medical Center
x
x
University Hospital of Cleveland
x
x
Integris Baptist Medical Center
x
x
St. Francis Hospital, Tulsa
x
x
Providence Portland Medical Center
x
x
Oregon Health Sciences Univ. Hosp
x
x
Allegheny General Hospital
x
x
Children’s Hospital of Pittsburgh
x
x
Children’s Hospital of Philadelphia
x
x
Penn State Milton S Hershey Med Ctr
x
x
Hahnemann University Hospital Tenet
x
x
Univ of Pittsburgh Medical Center
(Cont’d)
x
x
COUNTRY/Center
UNITED STATES (cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
Temple University Hospital
x
x
The Hospital of the University of PA
x
x
Cardiovascular Center of PR
x
x
Medical University of SC
x
x
Baptist Memorial Hosp, Memphis
x
x
St. Thomas Hospital
x
x
Vanderbilt University Medical Center
x
x
Brooke Army Medical Center
x
University Hospital, San Antonio
x
x
Children’s Medical Center of Dallas
x
x
Seton Medical Center
x
x
Columbia Hosp at Medical City Dallas
x
x
St Luke’s Episcopal Hospital
(Cont’d)
x
x
COUNTRY/Center
UNITED STATES (cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
Methodist Specialty & Transplant Hospital
x
x
University of Texas Medical Branch
x
x
The Methodist Hospital, Houston
x
x
Christus Santa Rosa Medical Center
x
x
St Paul University Hospital
x
x
COUNTRY/Center
UNITED STATES (cont’d)
Texas Children’s Hospital Dallas
x
Baylor University Medical Center
x
x
LDS Hospital
x
x
University of Utah Medical Center
x
x
Primary Children’s Medical Center
x
x
Inova Fairfax Hospital
x
x
Henrico Doctors Hospital
x
x
MCV Hospitals
x
x
(Cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Centers Reporting to the ISHLT Transplant Registry
TXs Performed in 2001
and Reported to ISHLT
TXs Performed 1/2002-6/2003
and Reported to ISHLT
McGuire VA Medical Center
x
x
Sentara Norfolk General Hospital
x
x
University of Virginia HSC
x
x
Children’s Hosp Medical Ctr, Seattle
x
x
Sacred Heart Medical Center
x
x
Univ. of Washington Medical Center
x
x
Children’s Hospital of Wisconsin
x
x
Froedtert Memorial Lutheran Hospital
x
x
St Luke’s Medical Center
x
x
Univ. of Wisconsin Hosp. and Clinics
x
x
COUNTRY/Center
UNITED STATES (cont’d)
(Cont’d)
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Data Currently Available on the ISHLT Web Site:
http://www.ishlt.org
1. Quarterly reports of recent continent-specific statistics are
available for general public:
• Transplant counts
• Tabulation of recipient, transplant and donor demographics
• Survival rates stratified by demographics
2. Quarterly reports for center-specific data are available for each
center through the secure section of the ISHLT web site.
• If your center does not currently have access to the secure site,
contact the Help Desk at [email protected] to obtain an ID and
password
3. Registry Report slides will be available for download from the ISHLT
web site Summer 2004.
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95
Requesting Data from the ISHLT Registry
Data request form is available on the ISHLT web site:
http://www.ishlt.org
PROCESS FOR SUBMITTING A DATA REQUEST:
•Complete form and send to Amanda Rowe
•Request will be reviewed by the appropriate Registry staff
•If approved, the request will be processed and programmed.
•Results are usually provided within 2 weeks of being received by
analytical staff.
TYPES OF DATA AND ANALYSES:
•Datasets (patients and centers will not be identified)
•Simple descriptive statistics
•Multivariate analyses -- may require more extensive review
ISHLT
2004
J Heart Lung Transplant 2004; 23: 789-95