Transcript Contractile Proteins - Mrs. DeNicola's Science Corner

Contractile Proteins
Meghan Costello and Olivia
Wallden
What is their function?
-Contractile proteins are the force
generators of muscle contraction
-They are part of what makes up our muscle
fibers, along with regulatory and structural
proteins
-The types of contractile proteins that are in
muscle fibers are actin, which is part of
thin filament, and myosin, which is part of
thick filament
Role in Living Things
Myosin and Actin Cross Bridges
SHAPE
The non-globular shape of the contractile proteins is what
allows them to function. Because they are are long strands
of proteins, it is easier for them to slide back and forth contracting.
How proteins are made
Actin
-Thin filament
-Relatively small protein
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-If mutated or absent,
the movement of the
human would either be
limited or none. Actin is essential to all
muscle movement.
Organisms that have a similar
protein to actin
-Crab-eating macaque-WAS protein-like at
92%
-Rhesus monkey-WASP associated with
actin at 92%
-(Predicted) Gorilla-WASP associated with
actin at 93%
-(Predicted) Chimpanzee-WASP associated
with actin at 92%
-(Predicted) Bolivian Squirrel MonkeyWASP associated with actin at 91%
Hypertrophic Cardiomyopathy
Symptoms
-Chest pain
-Dizziness
-Fainting
-Fatigue
-Sensation of feeling the heart beat
-Shortness of breath
-Some see no symptoms
Resources
http://class.fst.ohio-state.edu/FST822/lecturesab/Muscl.htm
http://en.wikipedia.org/wiki/Actin#Actomyosin_filaments
http://science.nasa.gov/science-news/science-at-nasa/2004/10dec_muscles/
https://docs.google.com/viewer?a=v&q=cache:xuhfM4By7gMJ:faculty.rcc.edu/o
lin/docs/AMY2A/Lec18v2.ppt+&hl=en&gl=us&pid=bl&srcid=ADGEESiPuS7L
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http://www.sciencemuseum.org.uk/WhoAmI/FindOutMore/Yourbody/Whatdoyo
urcellsdo/Howdocellsmakeproteins/Howareproteinsmade.aspx
http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=83516
http://www.ncbi.nlm.nih.gov/protein/Q1A5X7.1
http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001243/