Transcript Clinical Translational Research Center Operations Committee

Clinical Translational Research Center:
Funding for New Projects
Eric Kleerup
Version 2/17/12
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Clinical Translational Research
Center
Operations Committee
Eric Kleerup, Chair
John Adams
Tony Butch
Lin Chang
Michael Irwin
Ron Mitsuyasu
Isidro Salusky
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New Model for UCLA CTRC
3-Bed Inpatient
CTRC (RRMC)
36 bed-days per
month
Inpatient scatter
support
High-risk
outpatient visits
23-Hour
Outpatient
CTRC (CHS)
M-F
1 weekend/month
Dietitian & Kitchen
Community Nurse
(48 hours/month)
Clinical Translational Research
Laboratory
Hospital Sleep Center
Continuous Inpatient Unit at
Harbor-UCLA
Harbor-UCLA Special Dietary
Kitchen
Community (CERP)
Nursing, specimen processing,
phlebotomy, dietary, currier,
participant transportation
Future continuous inpatient units
at
NPI, VA and/or SM-UCLA
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Group 1 Resources:
CTRC Nursing and Nutrition
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Research Nursing support (CHS 23-Hour Unit) hourly nursing based
on intensity of subject contact
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Supplemental Research Nursing support (RRMC 6W Inpatient
unit)hourly nursing based on intensity of subject contact. Routine (1:4)
nursing is included in the Hospital overnight rate
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Nutrition (Research Nutritionist and meals)
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Metabolic diets of different levels of complexity including controlled
feeding studies
Anthropometry measures, bioelectrical impedance analysis, resting
energy expenditure by indirect calorimetry, and CPX testing
Collection, analysis, coding and reporting of dietary intake data
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Group 2 Resources:
Inpatient Overnight Stays
(RRMC)
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Three dedicated beds on 6 West
Includes basic nursing care
Current Hospital charge $1557.62/night
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Group 3 Resources: Patient
Care Supplied Outside the
CTRC
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Clinical Translational Research Lab
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Department of Pathology
Adjacent to CTRC
Currently 150 common tests for research
Will source suppliers including the Hospital lab for other tests
Not for inpatient (RRMC) stays
Other Ancillary Services purchased from the Hospital
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Inpatient clinical labs, Radiology, Cardiac, PFT etc.
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Group 4 Resources:
Other Costs
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CTRC Other Costs
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Extensive/off site training of personnel needed for protocol
Non-CTRC Other Costs
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Pharmacy dispensing and set-up
Parking
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Model for Transition: Non-Profit
Grants Funded 9/1/12-12/31/15
CTSI Grant Year
PI Charges
6/1/11-2/29/12
0%
3/1/12-2/28/13
5%
3/1/13-2/28/14
10%
3/1/14-2/28/15
15%
3/1/15-2/29/16
20%
3/1/16-beyond
50%
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CTRC Subsidy Plan:
Grants Funded after 1/1/16
CTRC
Subsidy
Limits
Group 1: CTRC Labor
(Nursing and dietary)
50%
$50,000
10% direct cost PI grant
Group 2: Inpatient
Hospital Stays
50%
$50,000
20% direct cost PI grant
Group 3: Clinical
Translational
Research Lab &
Hospital Ancillary
50%
$6,000
10% direct cost PI grant
Group 4: NIH “Other
Costs” Category
0%
$0
Prior GCRC
Limits
$30,000-60,000
Median $3,000
IQR $1,050-6,000
Max $21,500
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Model for Transition: New
Grants Funded 9/1/12-12/31/15
Duration of Grant
Funding Start Date
5 Year
4 Year
3 Year
2 Year
1 Year
9/1/12- 12/31/12
23%
16%
11%
9%
6%
1/1/13- 12/31/13
31%
27%
19%
14%
11%
1/1/14- 12/31/14
39%
36%
32%
23%
16%
1/1/15- 12/31/15
46%
45%
43%
39%
29%
1/1/16-continuing
50%
50%
50%
50%
50%
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Model for Transition:
Grants Funded Before 9/1/12
Grant End Date
6/1/11-12/31/11
PI Cost from
6/1/11End of Grant
0%
CTRC
Transition
Funding
50%
CTRC
Standard
Funding
50%
1/1/12-12/31/12
1%
49%
50%
1/1/13-12/31/13
4%
46%
50%
1/1/14-12/31/14
7%
43%
50%
1/1/15-12/31/15
9%
41%
50%
1/1/16-12/31/16
13%
37%
50%
1/1/17-8/31/17
19%
31%
50%
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Additional Subsidies
New Investigators–20%
NIH definition, as PI or Co-PI on parent grant
CTSI Translational Research Cluster grants–10%
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Funding Limits:
Per Project
Resource Type
Limit as Percent of
Direct Costs
Absolute $ Limit per
Calendar Year
Group 1 (CTRC Labor)
10%
$50,000
Group 2 (Inpatient Stay)
20%
$50,000
Group 3 (CTRL and
Hospital Ancillary)
10%
$6,000
Group 4 (NIH “Other
Costs”)
0%
$0
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Direct Cost Limits
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Percent of project limits doubled for Oppenheimer seed grants
and CTSI Research Education, Training and Career Development
Program (CTSI-ED), R21 (exploratory/developmental) and R03 (if
pilot)
K23 grants may use both salary and research support
components to calculate limits
Program project grants and Clinical Trials consortium grants use
the portion of direct costs attributed to the particular project.
Sub-contracts use the UCLA specific portion
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Annual Review
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Utilization/Activity
Changes in plan, protocol, expectations
Reports from OSMB/DSMB and IRB renewal
Review from Nursing and other service providers
Review from Investigator regarding problems/difficulties
Recognition of support in publications
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