Transcript Document

LifePak® Nano
Workshop
North America
Leadership Conference
March 3, 2006
This material has been prepared by Pharmanex to be used in
conjunction with general educational events and activities only.
Alterations or modifications of this presentation without the express
approval of Pharmanex is prohibited.
The Opportunity Simplified
One unique
technology
teamed with
Two proprietary
products drive
One exclusive
sponsoring story
Carsten R Smidt,
Ph.D., FACN
Vice President,
Global Research & Development
Pharmanex
Beijing Clinical Center
Shanghai R&D Center
Huzhou Mfr. Plant
Provo, Utah Headquarters &
Pharmanex Research Institute
over 125 Scientists
Prof. Lester Packer
The Power of
Nanotechnology
Nano-Switch
Nanotube Wires
What is Nanotechnology?
1. Size: 1 -100 nanometers
–
Most molecules are 1 to 100 nm in size
2. Function at the Molecular Level
–
Nanotechnology achieves new
functionalities by molecular
rearrangements
Reasons for Limited Absorption
• Poor intestinal solubility
• Requires fat for dissolution (e.g.,
Lipocarotenes)
• Aggregation into large particles
– not easily digested and absorbed
The Nanotechnology Difference
Pharmanex patent-pending & proprietary process
nano-carbohydrate
shell
Coenzyme Q10
+
=
nano-CoQ10
Small nano-nutrients are easily dispersed and absorbed
*These statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
NanoCoQ10™
The Nanotechnology Difference
CoQ10
Absorptionby
byHuman
Human Intestinal
CoQ10
Absorption
IntestinalCells
Cells
300.0
300.0
250.0
250.0
5-fold increase in absorption!
pmol/mg protein
protein
pmol/mg
200.0
200.0
150.0
150.0
100.0
100.0
50.0
50.0
0.0
0.0
AA
BB
C
C
D
D
NanoCoQ
Nano 10
Intestinal Lumen
Mucosa Cell
(Intestinal Wall Cell)
nano-CoQ10
CoQ10
Nano-Carbohydrate Shell
Nano-CoQ10
Carotenoids?
Nano-Carotenoids
lifepak® nano Study
60+ Antioxidants
Ongoing placebo-controlled clinical study
40000
A n tio x id a n t S c o re
35000
lifepak nano
?
30000
25000
Placebo
20000
15000
0
2
4
6
T im e (w e e k s )
8
10
Highly Effective
Minerals
Red Wine
Polyphenols
New
Vitamin E
Nano-CoQ10
NanoCarotenoids
lifepak nano: 8 Formulas in 1
Complete, Balanced and Convenient
Multi
Vitamin
Mineral
>
Antioxidant
Formula
Metabolism
Anti
Aging
Formula
Immune
Nutrient
Formula
Glucose
Formula
Bone
Formula
CardioVascular
Formula
The New Dimension!
• For All Adults
(age 18-121)
• Proprietary Science
• Broadest Health
Benefits
www.lifepaknano.com
• Ph.D. Exercise Physiology
Oregon State University
• M.S. Nutrition Science Oregon
State University
• Society for Free Radical Biology
and Medicine
– Young Investigator Award
• Lester Packer
– Young Investigator Award
• Linus Pauling Institute
Angela Mastaloudis, PhD
Associate Senior Scientist
R&D, Pharmanex
– Graduate Fellowship
lifepak nano
• New, broader-spectrum nano-carotenoid
formula:
– alpha-carotene
– beta-carotene
– lycopene
– lutein
– zeaxanthin (new): Eye health benefits*
– astaxanthin (new): Inflammatory balance*
• as found in 5-10 fruits & vegetables per day
*These statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Pharmanex Nanotechnology
• To increase intestinal uptake of poorly
absorbed fat-soluble nutrients:
– Carotenoids (lycopene, alpha+beta-carotenes,
zeaxanthin, astaxanthin)
– Coenzyme Q10
= Better Bioavailability*
= Increased Scanner
Scores*
*These statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Purpose
• How much more and how much faster
does lifepak nano increase scanner
scores than a placebo?
OR
PLACEBO
Study Design I
Supplementation
• 52 Subjects were recruited and randomly assigned
to groups
• Twice a day, with breakfast and with dinner,
subjects took:
– lifepak nano
or
– Placebo
• Study length: 18 weeks
Study Design II
BioPhotonic Scanner
• Subjects were scanned a total of 15 times!
Diet
• We encouraged to continue with their typical diet
for the entire study
Results
• 42 out of 52 subjects completed the 18 week study
Scanner Scores Increase with lifepak nano
45%
Scanner Score Increase (Counts)
20,000
Increase!
*p<0.05 between groups
41%
17,500
Increase!
37%
15,000
Increase!
*
*
*
*
*
12,500
30%
Increase!
10,000
19%
7,500
*
*
*
Increase!
*
5,000
2,500
0
0
1
2
3
4
6
Weeks
8
10
13
15
18
Scanner Scores Increase with lifepak nano
LifePak Nano
Placebo
45,000
*p<0.05 compared to wk 0 #p<0.05 compared to placebo
Scanner Score (Counts)
40,000
#,
#,
35,000
#,
#,
30,000
*
#,NSE
*
#,
* Global
*
#,
*
#,
*
*
#,
*
*
Convention
25,000
20,000
15,000
10,000
0
1
2
3
4
6
Weeks
8
10
13
15
18
Scanner Scores Increase with lifepak nano
LifePak Nano
Placebo
45,000
*p<0.05 compared to wk 0 #p<0.05 compared to placebo
Scanner Score (Counts)
40,000
#,
#,
35,000
#,
#,
30,000
*
#,
#,
*
*
#,
*
#,
*
*
#,
*
*
*
25,000
20,000
15,000
10,000
0
1
2
3
4
6
Weeks
8
10
13
15
18
Summary
• Lifepak nano increased scanner scores as
fast as two weeks
• Scanner scores increased in all 20 subjects
taking lifepak nano
• Lifepak nano increased scanner scores
18,000 units more than placebo in 18
weeks
• Even after 18 weeks scanner scores were
still increasing in the lifepak nano group
Better
Bioavailability*
=
Faster and Higher
Increases in
Scanner Scores*
*These statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
The Power of
Nanotechnology
Visit our PRODUCT SHOWCASE!
Key Business Takeaways
• Nanotechnology increases absorption of poorly
absorbed nutrients*
• First in industry to apply nanotechnology to a
multivitamin supplement*
• Proprietary and patent-pending
• Guaranteed to increase SCS*
• Clinically proven ~ 18,000 increase
• Do You NANO?
*These statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
www.lifepaknano.com
More Information
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