Transcript Main presentation heading in one or two lines

Fostering Translational Research in Women’s Health
Lucilla Poston
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WOMEN’S HEALTH - A LOCAL PROBLEM
South London; LAMBETH, LEWISHAM & SOUTHWARK
● Infant mortality in Lambeth and
Southwark amongst highest in
England
A Government Priority.
• Darzi Next Stage Review.
● Lambeth- highest rate in England • Healthcare Commission Review
of Maternity Services.
of teenage pregnancy (83.1
births/1000).
• National Service Framework for
Children, Young People and
Maternity and Maternity Matters.
● Women’s health – voted high
• Public Service Agreement (PSA)
priority by Primary Care
targets
• Teenage Pregnancy Strategy.
● More than 12000 deliveries/year
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WOMEN’S HEALTH GSTFT, KCH & KCL
AHSC BOARD
CAG EXECUTIVE
MANAGEMENT BOARD
Clinical Head; Academic Lead; Teaching Lead;
Deputies & Executive Administrator
CAG Executive; Heads of Research; Heads of
Clinical Groups;
SERVICE DELIVERY
UNITS
RESEARCH
DELIVERY UNITS
Pre-preg Health
Antenatal Care – Low risk
& high risk
Stem cell Biology
Intra-partum care
Reproductive
medicine and genetics
Abnormal
Maternal and fetal
pregnancy outcome
health
PCTs Implementation
Pregnancy &
childbirth
Reproductive
medicine
in community
RESEARCH METHODS
Complex intervention
Epidemiology, Statistics and
Bioinformatics
Social services perspectives
Clinical Trials
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Neonatology
Ambulatory Gynae
Gynae – general, Gynaeoncology, urogynaecology, menopause
Fetal & Neonatal
Health
Safety and quality
Postnatal & Community
Care
Basic Science
Assisted conception
PCT’s
TEACHING:
Training Clinical Academics,
Nursing/Midwifery, MBBS;
Sch. Biomed Health Sciences
BSc, MSc; PGR
Animal
Models
Experimental
Animals
Basic Science
Clinical
Trials
Clinical Studies
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Service
Evaluation
Preterm Labour
Problem
Solution
25 preterm babies die a week
More survive but with disability.
60 % linked to preterm labour
which is a complex syndrome
Better science.
Improve prediction.
Develop novel and effective
preventative & tocolytic therapies.
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Preterm Labour Research Strategy
Basic Science
• Uterine muscle biology
Ca2+signalling, ion channels,
uterine smooth muscle
excitability
• Onset of labour
Inflammatory mediators,
Mechanical strain
• Identification of novel tocolytics
Development, and animal studies
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Clinical
• Predicting preterm delivery
Fetal fibronectin - development
of new bedside quantitative device
IL-6 test
IGFBP-1 test
• Clinical trials of treatments
RCT of abdominal cerclage
RCT of progesterone
KCNQ channel complexes – targets for tocolysis?
2007-2009
Novel, functional
KCNQ channels
discovered in
pregnant mouse
and human
myometrium
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2008-2010
KCNQ channels
activators tested
in animal model
of preterm
labour
2011-2015
Clinical studies
and trials
of pregnant
women
in preterm
labour
2016
Evaluation in
clinical
practice
Maternal and
neonatal
outcome
improved
Blood Pressure Measurement
Device development
Mercury replacement
Automated
Calibration
errors
Aneroid
Inaccurate
in some
populations
Device validation
Preeclampsia
Only 3 commercially
available home
monitoring devices
confirmed accurate.
No Hospital devices
accurate.
New devices developed
with commercial partner.
Development of
calibration devices
for primary care
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Clinical Trials
Community and
hospital based
studies of new devices
Microlife Device
Low resource
device
with WHO
Preimplantation Diagnosis
of Genetic Disease
Basic Science
Clinical Studies
Development of single
cell genetic screening
Case series
(> 300 cycles)
PGD
FISH (X-Linked)
PCR
(single gene
disorders)
PGH
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DNA
amplification
X-linked disorders
and
Single gene disorders
Cystic fibrosis
Huntingdon’s
Spinal muscular atrophy
Epidermolysis bullosa
Clinical Evaluation
Evaluation of clinical
Service; impact on
families.
Genetic Counselling
Dissemination to
other clinical
centres
The Problems of Obesity in Pregnancy
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Obesity in Pregnancy
Animal models
Clinical Studies
Clinical Trials
Mouse and Rat
Obese Pregnant Women
Multicentre
RCT
Development of
interventions
2700 women from
London,
Manchester, Glasgow
and Newcastle
Maternal
Gestational Diabetes
Dysfunctional labour
Diet
Exercise
Offspring
Obese
Hyperphagic
Hypertensive
Insulin resistant
Pilot Study
UPBEAT
Uk Pregnancies Better Eating and Activity Trial
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The Women’s Health Translational Research Team
Professor Peter Braude
Dr Susan Bewley
Professor Linda Cardozo
Dr Clive Coen
Professor Clive Coen
Dr Lucy Chappell
Professor Kypros Nicolaides
Dr Tarek El-Toukhy
Professor Debra Bick
Dr Nick Kametas
Professor Lucilla Poston.
Dr Con Kelleher
Professor Janice Rymer
Dr Yacoub Khalaf
Professor Jane Sandall
Dr Pippa Kyle
Professor Andrew Shennan
Dr Kumar Kunde
Ms Nina Khazaezadeh
Dr Kevin O’Byrne
Dr Eugene Oteng-Ntim
Dr Shanti Raju
Dr Rachel Tribe
Dr Raj Varma
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