Transcript Leukocytes

‫بسم هللا الرحمن الرحيم‬
Leukocytes
•Leukopenia
•Leukocytosis
Leukopenia
(Agranulocytosis)
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Myeloid stem cell suppression
Ineffective granulopoisis
Heriditary disorders, kostmann syn.
Immune destruction
Spleenic sequestration
Peripheral destruction
Leukocytosis
Normal Lymph node
Lymphadenitis
• Acute nonspecific
• Chronic non specific
lym.
lym.
– Follicular hyperplasia
– Sinus histiocytosis
– Paracortical hyperplasis
Neoplastic proliferation of
leukocytes
–Lymphomas
–Leukemias
–Plasmacell dyskerasia
–Langerhans cell histiocytosis
Lymphoproliferative disorders
• Lymphomas
• Leukemias
• Plasma cell dyscrasia
Myeloid Neoplasms
• Acute Leukemias
• Chronic Leukemias
• Myelodysplastic disorders
• Myeloproliferative disorders
Lymphomas
• Hodgkins lymphoma (HD)
• Non Hodgkins lymphoma
(NHL)
Hodgkin's Lymphoma
Non Hodgkin's lymphoma
Leukemia
Classification
• Acute Aml , ALL
• Chronic CML , CLL
Myeloblast
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Lymphoblast
Chromatin
Fine
Clamp
Nucleoli
3–5
1- 2
Granules
Variable
Non
PA
+
Tdt
%5
% 95
Sudan Black
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Mpo
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-
A.M.L
A.L.L
Myelo dysplastic
syndromes
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Refractory anemia
R.A with ring sideroblast
R.A with excess blast
Chronic myelomonocytic leukemia
RAED in trans Formation
CMML in trans Formation
Chronic myeloproliferative
disorders
• CML
• P.V
• MMM
• E.T
disease
Chronic lymphoproliferative
disorders
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CLL
PLL
NHL
HCL
Plasma Cell neoplasms
• Multiple myeloma
• Solitary plasmacytoma
Waldenstorm macroglobulinemia
• Heavy chain diseases
• Primary Amiloidosis
• Monoclonal Gamma pathy U.S
Histiocytoses
Langerhans H / HistiocytosisX
• Eosinophilic granuloma
• Acute disseminated H.
((Letterer – Siwe synd))
• Hand schuller chrisrian disease
Morphologic aspects
• HLA – DR
• CDa
• Birbeck (HX) granules