Norquay Technology Inc.
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Transcript Norquay Technology Inc.
Norquay Technology Inc.
Moving forward,
in
Fine & Specialty Chemicals
P.O. Box 468
Chester, PA 19016 USA
phone:
fax:
+1(610) 874-4330
+1(610) 874-3575
www.NorquayTech.com
today’s discussion
Overview
Custom Synthesis
Seven (7) Day Guarantee
Equipment
Product Lines
Contact Information
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2
Roach’s Shipyard,
old Chester Harbor, 1859-1885
Chester Waterfront ca 1875
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The
Chester plant
1927-1961
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Norquay Technology
Chester plant
1927-1961
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Norquay Overview
Founded
Focus
Niche Markets
High Value-added
Kilo-Lab:
Low Volume
Commercial Scale
1987: Philadelphia, PA
Products
Sales
Custom Synthesis:
Product Line:
Export:
$15.00 - $42,000/kg
10 grams to 20 kg
50 kg to 85+tpy
100-1,500 gal
50%
50%
30%:
Europe, South America, Japan & Asia
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Seamless Scale-up
Laboratory,
Kilo-lab,
Pilot Plant
Commercial Quantities
Compound pricing studies, Economic Model
Confidentiality Agreements
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Equipment
Kilo Lab:
( 5-12-22-30-50 liter)
Plant Reactors:
jacketed, condensers & instrumentation
Hastelloy –C-276:
316 Stainless Steel:
Glass Lined:
20-100-350 gal
500-1,500 gal
100-500-750-1,000 gal
Vacuum Distillation:
50 liter to 100-500-1,500 gal
<1.0 torr
10 – 25 theoretical plates
Filter-Drying:
Drying:
shelf, double-cone & rotary (316 s/s)
Utilities:
Analytical:
-78° to 170o C (future to 220o C)
to Contents
air & moisture sensitive
HPLC, GC, NMR, UV, L-a-b color, Karl Fischer, etc.
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Products
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Products
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NORQUAY: Seven (7) Day Guarantee
Formal Response
“Yes” or “No” within Seven (7) Days
Project Defined, unequivocally
Chemical Name, CAS Number
Scope
Volume, Timing, Stage GATE Process
How is Success measured?
Outline Open Issues
(Step 3)
TSCA LVE or REACh for Europe
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NORQUAY: Seven (7) Day Guarantee
Customer Clarifying Questions
Key Parameters, measure of SUCCESS
Analytical Methods- Need development?
Alignment between customer “ Use Test” & QC Methods
Timing
Quote to first lab sample <?>
Qualification (3 lots?)
Steps to commercial scale?
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NQ: Product Lines
To Contents
؏ Substituted Benzophenones
؏ Phenylhydrazines & Indoles
؏ Cyanoacetates
؏ Heterocycles
؏ Metallocenes, cp-ligands
؏ HPLC/Process Surfactants: Sulfonates
؏ Chlorendate Esters
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Benzophenones
1.
2.
3.
4.
5.
6.
7.
8.
9.
9.
13 .
14 .
15 .
16 .
17 .
18 .
19 .
2,42,2',4,4'2222,2'2,2'2,2'2,2'4,4'2,2'bis (2,4bis (224,4'4,4'4,4'2,444-
substituents
Dihydroxy
Tetrahydroxy
Hydroxy
-4-allyloxy
Hydroxy
-4-methoxy
Hydroxy
-4-methoxy
Dihydroxy -4,4'-dimethoxy
Dihydroxy
-4-methoxy
Dihydroxy -4,4'-dimethoxy
Tetrahydroxy
Dihydroxy -4,4'-dimethoxy
Dihydroxy
phenyl)
Hydroxy-4-methoxyphenyl)
Hydroxy
-4-octyloxy
Difluoro
Dimethoxy
Dimethyl
Dimethyl
Fluoro
Morpholino
to Contents
benzophenone
sulfonic acid
benzophenone
benzophenone
benzophenone
benzophenone
benzophenone -5-sulfonic Acid
benzophenone
benzophenone
benzophenone -5,5'-disulfonic Acid Na Salt
benzophenone
benzophenone
methanone
methanone
benzophenone
benzophenone
benzophenone
benzophenone
benzophenone
benzophenone
benzophenone
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CAS #
131-56-6
131-55-5
2549-87-3
131-57-7
4065-45-6
131-54-4
131-53-3
76656-36-5
1341-54-4
1341-54-4
1843-05-6
345-92-6
90-96-0
611-97-2
1140-14-3
345-83-5
24758-49-4
to Products
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O
O
H3C
O
O
OH
Benzophenones
CH3
F
O
F
O
CH2
O
O
O
OH
O
F
OH
OH
O
CH3
H3C
O
CH3
H3C
HO
O
OH
H3C
H3C
OH
HO
O
OH
H3C
O
OH
O
H3C
O
SO 3H
O
OH
O
OH
O
O
OH
OH
OH
O
O
O
CH3
N
OH
O
H3C
OC8H17
O
O
-
+
SO 3 Na
to Contents
-
CH3
+
SO 3 Na
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13
PRODUCT OVERVIEW
Primary Use
Solubility
(g Product / 100ml Solvent)
(30°C)
Helisorb-1
Helisorb-10
(2,2’,4,4’-Tetrahydroxybenzophenone)
(Benzophenone-1)
Water: Insoluble
Methanol: 32.0
Ethanol: 32.0
Bath Preparations
• Cosmetics
Water: .10
Shampoos
ToiletBlushes
Water
Methanol: 50.0
Nail Polish / Enamel Ethanol: 40.0
Fragrances
• Paints
Perfumes
• Plastics
Shampoos
Skin Products
HO
• Plastics / Paints
O
OH
O
% TRANSMITTANCE
• Cosmetics
OH
OH
O
280
300
320
340
360
380
400
UV-C
% TRANSMITTANCE
O
% TRANSMITTANCE
OH
2
/
3
3
0
n
m
UV-B
UV-A
60%
40%
20%
240
260
280
300
320
340
360
380
400
WAVELENGTH
λ max: 285/320nm
UV-C
100%
Water: 28.0
Methanol: 40.0
Ethanol:
O
OH
OH 35.0
9
80%
0%
OCH3
UV-B
UV-A
80%
60%
40%
20%
0%
OCH3
O
-
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260
CH3
5,5’-disulfonic acid sodium salt)
H3C
240
100%
Helisorb-4
(Benzophenone-4)
Helisorb-11DS
(2,2’-Dihydroxy-4,4’-dimethoxybenzophenone2-Hydroxy-4-methoxybenzophenone-
• Plastics
20%
WAVELENGTH
λ max:
OH
O
O
40%
2
• Cosmetics
Bath Preparations
Bath Preparations
Water: 5.0
Fragrances, Cologne
Hair Cosmetics
Methanol: 2.0
Hair Care
Blushes
Shampoos
Ethanol: 1.0
Skin Care
Skin
Products
• Paints
60%
OH
• Cosmetics
Water: Insoluble
Bath Preparations
Water: Insoluble
Colognes / Perfumes Methanol: <1.0
Methanol: 6.0
Nail Polish
OH
O
OH 6.0
Sunscreens
Ethanol:
Nail
Enamels
Ethanol: <1.0
• Paints
• Plastics
• Plastics
• Films
• Cosmetics
UV-A
80%
0%
2-Hydroxy-4-methoxybenzophenone
(Benzophenone-6)
5-sulfonic acid
(Benzophenone-9)
UV-B
OH
Helisorb-3
Helisorb-11
(2,2’-Dihydroxy-4,4’-dimethoxybenzophenone)
(Benzophenone-3)
H3C
UV-C
100%
2,4-Dihydroxybenzophenone
(Benzophenone-2)
10mg/l
20mg/l
40mg/l
UV Spectrum
SO3H
+
SO 3 Na
O
-
+
SO 3 Na
CH3
240
260
280
300
320
340
WAVELENGTH
λ max: 285/320nm
360
380
400
Br
Br
H2N
HCl
NH
HN
HCl
H3C
H2N
HCl
1.
2.
3.
4.
5.
6.
7.
8.
9.
10 .
11 .
12 .
13 .
14 .
15 .
24242,43,53,41,12244234-
Cl
NH
Substitution
NH2
Cl
Phenylhydrazines
Phenyl hydrazine
Bromo
Bromo
Chloro
Chloro
Di chloro
Di chloro
Di methyl
Di
Ethyl
Fluoro
Fluoro
Methoxy
phenyl
phenyl
phenyl
phenyl
phenyl
phenyl
phenyl
phenyl
phenyl
phenyl
phenyl
phenyl
Tolyl
Tolyl
Tolyl
hydrazine
hydrazine
hydrazine
hydrazine
hydrazine
hydrazine
hydrazine
hydrazine
hydrazine
hydrazine
hydrazine
hydrazine
hydrazine
hydrazine
hydrazine
NH2
Cl
NH2
N HCl
HCl
NH
CAS #
HCl
HCl
HCl
HCl
HCl
HCl
HCl
HCl
HCl
HCl
HCl
HCl
HCl
HCl
HCl
50709-33-6
To Contents
NH
NH2
HCl
HCl
Cl
41931-18-4
41052-75-9
H3C
CH3
1073-70-7
NH
5446-18-4
63352-99-8
NH2
HCl
F
NH NH2
HCl
60481-51-8
530-47-2
19398-06-2
F
2924-15-4
823-85-8
NH
NH
NH2
HCl
19501-58-7
CH3
635-26-7
637-04-7
637-60-5
H3C
H3C
NH
O
CH3
NH
NH2
HN
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HCl
NH
NH2
NH2
HCl
NH2
HCl 15
NH2
HCl
O
NC
CH3
O
Specialty Cyanoacetates
CH3
O
NC
H3C
O
NC
O
CH3
O
NC
O
NC
CH3
O-R
O
NC
O
CH3
O
NC
O
O
NC
O
CH3
for:
Specialty Adhesives
NC
Medical devices
Disposable Components
NC
O
to Contents
CH3
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CH3
O
O
CH3
O
O
O
O
CH3
CH3
O
NC
CH3
CH3
O
NC
O
O
CH3
O-CH3
O
to Products
CH3
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Specialty Cyanoacetates
1 . n2 . n3 . n4 . n5.
6.
7.
8 . 29 . "210 . "211 . "2-
to Contents
substituent
Propyl
Hexyl
Octyl
Decyl
Isopropyl
Isobutyl
Isoamyl
Octyl
Methoxyethyl"
Methoxyisopropyl"
Ethoxyethyl"
cyanoacetate
cyanoacetate
cyanoacetate
cyanoacetate
cyanoacetate
cyanoacetate
cyanoacetate
cyanoacetate
cyanoacetate
cyanoacetate
cyanoacetate
cyanoacetate
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CAS
14447-15-5
13361-53-0
15666-97-4
17686-43-0
13361-30-3
13361-31-4
60180-49-6
52688-08-1
10258-54-5
32804-79-8
32804-77-6
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Heterocycles
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18
N
SH
O
Heterocycles
O-CH3
H3C-O
O-CH3
H3C-O
O
Chemical Name
5,6-dimethoxy indanone
2,5-Dimethyl benzothiazole
5-Fluoro-2-methyl benzothiazole
2- Benzoxazole thiol
2-Hydroxy benzimidazole
3,6-Dimethoxy xanthone
6-Hydroxy quinoline
6-Methoxy quinoline
Julolidine
2.
3.
4.
1.
5.
6.
7.
8.
9.
CAS #
2107-69-9
95-26-1
399-75-7
2382-96-9
615-16-7
1214-24-0
580-16-15
5263-87-6
479-59-4
O
Chemical Name
5,6-dimethoxyindanone
2,5-Dimethylbenzothiazole
5-Fluoro-2-methylbenzothiazole
2-Benzoxazolethiol
2-Hydroxybenzimidazole
3,6-Dimethoxyxanthone
6-Hydroxyquinoline
6-Methoxyquinoline
Julolidine
O
H
N
N
N
OH
O
N
H
N
H
H3C-O
H3C-O
HO
O-CH3
S
N
N
To Contents
O
H3C
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S
CH3
N
H
CH3
F
N
H
19
etallocenes, Ligands
Ligand
5-Hexene-2-one
Vinyl cyclohexane
1,4-Bis(1-hydroxycyclopentyl) butadiyne
t-Butyl cyclopentadiene
Diphenyl fulvene
1,2,3,4-Tetramethyl cyclopentadiene
1,2,3,4,5-Pentamethyl cyclopentadiene
1.
2.
3.
4.
5.
6.
7.
8.
9.
Acetyl
10 .
Vinyl
11 .
1,1-Bis(diphenyl phosphino)
12 .
1,1-Bis(diphenyl phosphino)
13 .
Pentamethyl cyclopentadiene
14 .
Pentamethyl cyclopentadiene
15 . 1-dimethyl- 2,3,4,5-Tetramethyl cyclopentadiene
16 . 2,3,4,5-Tetramethylcyclopentadienyldimethylsilyl-t-butylamido
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metallocene
Ferrocene
ferrocene
ferrocene
ferrocene
ferrocene Pd (II)
titanium
titanium
silyl
titanium
tech
dichloride
trimethoxide
trichloride
t-butylamine
dichloride
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CAS #
109-49-9
695-12-5
104766-62-3
41539-65-5
2175-90-8
4249-10-9
4045-44-7
102-54-5
1271-55-2
1271-51-8
12150-46-8
72287-26-4
123927-75-3
12129-06-5
125542-04-3
135072-61-6
20
etallocenes, Ligands
CAS #
109-49-9
695-12-5
104766-62-3
41539-65-5
2175-90-8
4249-10-9
4045-44-7
102-54-5
1271-55-2
1271-51-8
12150-46-8
72287-26-4
123927-75-3
12129-06-5
125542-04-3
135072-61-6
Chemical Name
5-Hexene-2-one
Vinylcyclohexane
CH3
1,4-Bis(1-hydroxycyclopentyl) butadiyne
CH3
t-Butylcyclopentadiene
CH3
Diphenylfulvene
1,2,3,4-Tetramethylcyclopentadiene
1,2,3,4,5-Pentamethylcyclopentadiene
Ferrocene (Technical Grade)
Acetylferrocene
Vinylferrocene
1,1-Bis(diphenylphosphine) ferrocene
1,1-Bis(diphenylphosphine) ferrocene Palladium chloride
Pentamethylcyclopentadiene titanium trimethoxide
Pentamethylcyclopentadiene titanium trichloride
2,3,4,5-Tetramethylcyclopentadiene-1-dimethylsilyl-t-butylamine
2,3,4,5-Tetramethylcyclopentadienyldimethylsilyl-t-butylamido titanium dichloride
CH3
H3C
CH3
Si
NH
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CH3
H3C
CH3
CH3
CH3
CH3
21
Alkyl Sulfonates
HPLC: high purity Reagent Grade
Industrial surfactants
Dial-In properties
From C-2 to C-16
Salts; Na, K, Li etc
Alkyl sulfonic acids
Sodium <25 – 50 ppm
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Alkyl Sulfonates
(& their free acids)
SO3Na
or
CH3 (CH2)3 SO3Na
1-Butane sulfonic acid sodium salt
SO3Na • H2O
or
CH3(CH2)7SO3Na • H2O
1-Octane sulfonic acid sodium salt monohydrate
SO3Na
or
CH3(CH2)15SO3Na
1-Hexadecane sulfonic acid sodium salt
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23
Chlorendate- DBC
Cl Cl
Cl
Cl O
Cl
Cl
O-nBu
O-nBu
O
Tentative Specifciations
Appearance
Color (APHA):
Acid value (mg KOH/g):
Assay:
Properties
Specific gravity (20°C):
Ester value (mg KOH/g):
Refractive Index (25°C):
to Contents
slightly yellow transparent liquid
max 700
< 0.1
Develop GC method
1.380 - 1.400 g/cc
223 (no limit)
1.512 (no limit)
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Chlorendate- DEC, DBC, DEHC
Cl Cl
Cl
Cl O
Cl
O
Cl
CH3
O
O
CH3
Cl Cl
Cl
Cl
Cl Cl
H3C
Cl O
Cl
O
Cl
CH3
O
Cl O
Cl
Cl
O
O-nBu
O-nBu
CH3
O
H3C
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25
Contact Us
For more information contact:
Business Development
Robert W. Heldt
President
Tel +1(610) 874-4330
Fax +1(610) 874-3575
[email protected]
to Contents
Sales & Marketing
John C. Wetzel, Ph.D.
Director of Sales & Marketing
Tel +1(610) 874-4330
Cell +1(803) 414-8743
[email protected]
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