Transcript Training Trends in the Pipeline Grants and the Peer Review

Alan Embry
Program Officer
Division of AIDS, NIAID, NIH
[email protected]
Ph.D. Career- NIAID
T32- Institutional training grant (NRSA)-has pre-& postdoc slots
F31- Individual minority predoc fellowship (NRSA)
F32- Individual postdoc fellowship (NRSA)
F33- Sr. postdoc fellowship (NRSA)
R03- Small Grant
R21- Exploratory/Developmental Research Grant
R01- Research grant
K02- Independent Scientist Award
K22- Research Scholar Development Award
K99/R00- Pathway to Independence Award
R37- Merit award
T32
F31
Graduate
student
F32
K99/
or K22
R03 R21 R01 K02
R00
T32
Ph.D.
Diversity Supplements
Faculty
Position
F33
Independent
PI
R37
M.D. Career - NIAID
T35- Short-term Training Grant for Health Professional Students
F33- Sr. Postdoctoral Fellowship (NRSA)
K08- Mentored Clinical Scientist Development Award
K23- Mentored Patient-Oriented Research Career Development Award
K24- Mid-Career Investigator in Patient-Oriented Research
Plus all mechanisms from Ph.D. track
T32
or
F32
T35
Medical
Student
M.D.
K08
K99/ R03
R21 R01 K02 F33 K24 R37
or K22
R00
K23
Clinical
Training
Diversity Supplements
Faculty
Position
Independent
PI
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Transition award for postdocs moving to positions of
assistant professor
Must have less than 5 years postdoctoral experience
Two-phased application
Phase 1
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Scientific merit
No institution yet
If applicant gets a fundable score, they have a year to find a
position as assistant professor
Phase 2
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Assistant Professor
Own lab
Significant start-up funds
Little teaching/no administrative responsibilities
http://grants.nih.gov/grants/guide/pa-files/PAR-09-068.html
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Transition award for postdocs moving to assistant professor
positions
Must have less than 5 years postdoctoral experience
Has mentored phase
Citizenship and green card not required- new feature for
any K
Has a mentored phase (K99) and an independent phase
(R00)
NIAID committed to only six awards
http://grants2.nih.gov/grants/guide/pa-files/PA-10-063.html
K22
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2 yr award
No mentored phase
Awardee gets funds at the
time of becoming asst.
professor
$150K (year 1) direct costs
+ $100K (year 2) direct
costs + 8% F&A
K99/R00
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3 year award only
Up to 1 yr mentored phase
($90K/yr)
Awardee becomes asst.
professor- No peer review
2 yr independent R phase
($249K/yr TC)
PhD
or
EOT for MDs
0 Yrs
Postdoc
Re-apply
If needed
R01
K22
or
K99
5 Yrs
Promotion
Tenure
Apply
For K22
or
K99
Assistant Professor
~11 Yrs
http://grants.nih.gov/training/kwizard/index.htm
MD-PhD
MD Only
Fiscal Year
PhD Only
2006
43
2005
2004
2003
2002
2001
2000
1999
1998
1997
1996
1995
1994
1993
1992
1991
1990
1989
1988
1987
1986
37
1985
1984
1983
1982
1981
1980
1979
1978
1977
41
1976
1975
1974
1973
1972
39
1971
35
1970
Average age
45
44.2
44
MD Only
43.9
42
41.8
MD-PhD
40
39.3
38
36.7
PhD Only
36
34.3
34
An ESI is a scientist who is within 10 years of either of the following:
 Terminal research degree
 Medical residency or equivalent
You can request an extension of your ESI status past the 10-year
window due to special circumstances.
Keep in mind that on a multiple PI application, all PIs must qualify as
new or ESI for the application to get either status.
http://funding.niaid.nih.gov/ncn/grants/new/portal.htm
A new investigator is a scientist who has not previously received a
significant independent NIH Research Award. The following are
grants that do not affect NI status:
 R00
 R03
 R15
 R21
 R34
 R56
 Fellowships (F)
 Career Development (K)
 Loan Repayment (L30, L32, L40, L50, L60)
 Training Grants (T32, T34, T35, T90, D43)
http://grants.nih.gov/grants/new_investigators/index.htm#definition
K22 – 19.2% (10)
R99 – 7.5% (6)
K08 – 49.3% (37)
R03 – 22.1% (58)
R21 – 21.3% (266)
R01 – 20.7% (533)
http://report.nih.gov/
Q: If ESIs receive stimulus funding will they still have ESI status?
A: It depends on the mechanism of ARRA support.
Q: When you have a K award, what are restrictions of receiving salary with
other NIH grants?
A: You cannot receive salary from any other source of federal funds.
Q: How can we apply for other NIH awards with no salary in the budget?
A: Some K awards allow for the potential to apply for R01s and obtain
salary support in the last 2 years of the grant (i.e. K08). You can be
on another PI’s grant with effort but no salary.
 Each K award is slightly different. Check the K Kiosk website for details
or contact a program officer with questions:
http://grants.nih.gov/training/careerdevelopmentawards.htm
http://funding.niaid.nih.gov/ncn/grants/default.htm
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Understand how NIH works
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Easy to disengage and only focus on the lab
Network with NIH staff
Talk to us at meetings, on the phone, by email
 If I don’t know you, how can I help you?
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Understand how NIH peer review works
Learn what works and what doesn’t in peer review
and funding
CSR
•Study Sections
INSTITUTES
•Scientific Rev. Grps.
•Contract Rev. Ctees.
•Research Project Grants (R01s)
•AREA Grants (R15s)
•Fellowships (F32s & F31s)
•SBIRs
•Shared Instrumentation Grants
•Small Grants (R03s)
•Exploratory/Developmental Grant (R21s)
•Program Project Grants (P01s)
•Center Grants (P30s)
•Training Grants (T32s)
•K Grants
•RFAs (some of which will be for R01s)
•Contracts
Submission of
application
CSR
CSR
Study Section
Advisory Council
CSR
Referral Office
Institute
Review Ctee.
INSTITUTE
FUNDING DECISION
NGA
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Proposed project is not novel or innovative
Even if project is successful will have questionable impact to the field
Failure to convince reviewers of scientific rational for proposed studies
Research is mainly descriptive or correlative –’looking at’ bad, testing good
Lack of clear, testable hypothesis – ‘fishing expedition’
Inadequate preliminary data to support a large investment
Unfocused research plan
Lack of experience in the proposed methodology
Insufficient publication record
Uncertainty concerning the future directions
Failure to consider potential pitfalls/alternative approaches
Unrealistically large amount of work
Lack of statistical considerations
http://enhancing-peer-review.nih.gov/restructured_applications.html
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The most critical page in the application
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It is a one page summary of the application
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Why is this problem significant?
What is the exciting preliminary data?
What are the hypothesis supported by the data?
How will this project significantly impact the field?
Make sure to emphasize important points that you absolutely
want the review to know
Make them want to keep reading
Simple list of your Aims is good
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Be general
Avoid long list of things you are going to do
http://enhancing-peer-review.nih.gov/restructured_applications.html
1.
2.
3.
4.
5.
Significance
Approach
Innovation
Investigator
Environment
What do reviewers look for when reading your grant?
http://enhancing-peer-review.nih.gov/guidance_reviewers.html
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Initial failure is common
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Learn from a failed submission and succeed
Study criticisms in summary statement
 Decide if problems are repairable
 Carefully address each criticism
 Keep a positive tone and attitude
 Introspection is important – be willing to critically
question your research and future directions
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NIAID training and career awards information
http://funding.niaid.nih.gov/ncn/training/default.htm
New and ESI
http://funding.niaid.nih.gov/ncn/grants/new/portal.htm
Revised New and Early Stage Investigator Policies
http://grants.nih.gov/grants/guide/notice-files/not-od-09-013.html
K Kiosk
http://grants.nih.gov/training/careerdevelopmentawards.htm
Reduction in effort for K-awardees:
http://grants.nih.gov/grants/guide/notice-files/not-od-08-065.html
Enhancing Peer Review at the NIH – Table of Page Limits effective Jan 25th, 2010
http://enhancing-peer-review.nih.gov/page_limits.html
Standard receipt/due dates
http://grants.nih.gov/grants/funding/submissionschedule.htm
Organization of DAIDS:
http://www3.niaid.nih.gov/about/organization/daids/