Transcript KBBE.2013.2.2-02 Factors influencing the human gut

Program: Cooperation
Theme 2: Food, Agriculture and Fisheries,
and Biotechnology research
KBBE.2013.2.2-02
Factors influencing the human gut microbiome
and its effect on the development of diet-related
diseases and brain development
giugno 2012
Preliminary considerations
• The globalization of food market produces deep changes
in socioeconomic status, cultural traditions, population
growth, and agriculture are affecting diets worldwide.
• Understanding how our diet and nutritional status
influence the composition and dynamic operations of our
gut microbial communities, and the innate and adaptive
response of our immune system, represents an area of
scientific need, opportunity and challenge requested by
call Agriculture/Area-NUTRITION KBBE.2013.2.2-02.
Objectives
• Future Horizon of Nutrition (FUHONU) project
(KBBE.2013.2.2-02) would advance in understanding the
food-gut-brain interactivity across the life from children,
adolescents, and the elderly.
This goal will be reached through investigating how
changes of dietary components and the life-stiles get a
deep impact on constructing an healthy gut for
preventing auto-immune diseases and favoring an active
ageing.
AREA 2.2 Nutrition
• understanding dietary factors, specific needs and habits of
population groups as factor in the occurrence of diet-related
diseases and disorders including obesity and allergies.
• investigation of new dietary strategies,
• development and application of nutrigenomics and systems
biology,
• study of the interactions between nutrition, physiological and
psychological functions.
• reformulation of processed foods,
• development of novel foods and ingredients, dietetic foods and
foods with nutritional and health claims.
• investigation of traditional, local, and seasonal foods and diets
– to highlight the impact of certain foods and diets on health
– to develop integrated food guidance
KBBE.2013.2.2-02
Factors influencing the human gut microbiome and its effect on the
development of diet-related diseases and brain development
... a need to define a ‘healthy’ gut microbiome and to understand better
its ability to absorb and metabolise food components and to
influence energy expenditure and its role in diet-related diseases and
brain development
Future Horizon of Nutrition
understanding interrelation among:
 FOOD
 GUT MICROBIOTA
 IMMUNE FUNTIONS
to prevent obesity and auto-immune-illness
FUHONU
KBBE.2013.2.2-02 – Study’s area
To study effects of--
on
 human gut microbiome
 diet (including food
production methods)
 age, physical activity and
other lifestyle factors
 development of metabolic
syndrome and obesity
 brain development and
behavior
To identify
the specific species of the human gut microbiome
 predicting the metabolic syndrome, obesity and other co-morbidities
 influencing the regulation of developmental programming of the brain.
KBBE.2013.2.2-02 – Competencies
EXPERIENCE IN
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genetic
epigenetic
metagenomic
metabolomic
microbiological
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physiological
nutritional
immunological
experimental
computational
 to gain insights into factors influencing the effects
of human gut microbiota on metabolism
WE NEED
 epidemiological studies
 preclinical trials
 to demonstrate the role of the human gut microbiome
and the effects of the different factors
KBBE.2013.2.2-02 – Expected impact
• to increase the knowledge of human gut microbiome.
• impact on prevention of diet-related diseases with the
goal of promoting a healthy and active population
and a high quality of life,
• development of new approaches for prevention of
– metabolic syndrome,
– obesity
– metabolic impairment of the brain and other organs
by reshaping the gut microbiome
• through
– lifestyle changes,
– replacement therapies,
– development of pro- and prebiotics and
innovative personalised products.
FUHONU main topics
A) Human gut microbiome and diets
B) Development of metabolic syndrome and obesity
C) Gut flora and Brain development and behavior
A) “Human gut microbiome and diets”
• the highlight of FUHONU project will be addessed on how the food
through the activities of microbiome influences human health e.g. how
this "supra-organism," modify, through the dietary changes its interactions
with its human host interactions between nutrition, both physiological
and psychological functions
• Therefore FUHONU strategy is developed order to provide a deep insight
into the prevention of disease states, to get a normal human physiology
and psychology status at different condition of life-styles (age, physical
activity and other lifestyle approaches). In particular the investigation of
traditional, local and seasonal foods and diets will also be decisive to
highlight the impact of certain foods and diets on health, and to develop
integrated food guidance.
B) “Development of metabolic syndrome
and obesity”
• The obesity, to a large extent, is caused by an excessive load of nutrients
that are often dependent on the intake of so-called "junk food”. Obesity is
also associated with a high degree of chronic inflammation of the gut. In
fact, the intestinal inflammation contributes to insulin resistance, type 2
diabetes and cardiovascular disease, and other interactions that correlate
the metabolism with the immune system as most epidemiological studies
demonstrate.
• Researchers have recently been identified links between the gut
microbiota and obesity, and now is in vogue, the concept of "MicrObesity"
(microbes and obesity)
• The FUHONU research interest will be oriented to developing a systems
biology approach to study the molecular markers that may indicate
common underlying of obesity and other inflammatory diseases
generating from a response of the gut microbiome to advance in a better
contribution to human health.
C) “Gut flora and Brain development and
behavior”
• Literature on this theme show that gut flora may have the ability to induce
a change in the instintual behaviour. This represents a complex field of
multidisciplinary new research.
• To advance in this theme the FUHONU project will propose and test future
treatment on the relationship of Gut-Brain interactions, looking to
stimulate the change gut flora, working with voluntary groups accepting to
test preclinical trials made through the use of nutraceutical microencapsulations in order to explore in deeper the role of the human gut
microbiome and the effects of the different factors in a way to open a
future possibility of turning to new unconventional diet- therapy.
partner
Austria
Institute of Experimental and Clinical Pharmacology, Medical University of Graz
Prof. Peter Holzer
Belgium
Research Center for Gastrointestinal Disorders - Université Catholique de Louvain
Prof. Inge Depoortere
Belgium
Metabolism and Nutrition Research group - Université Catholique de Louvain
Prof. Patrice D. Cani
Canada
Psychology, Neuroscience - University of Western Ontari
Prof. Derrick MacFabe
France
Medical Faculty of Rouen University
Prof. Sergueï Fetissov
France
INRA/AgroParisTech
Prof. Francois Blachier
France
Preclinical Research Centre - Technopôle de Nancy
Dr Anaïs Duffaud
Austria
Institute of Experimental and Clinical Pharmacology, Medical University of Graz
Prof. Peter Holzer
Germany
Department of Human Molecular Genetics - University of Heidelberg
Prof Beate Niesler
Germany
Research Centre for Nutrition and Food Scienc - Technische Universität
Prof. Dr. Dirk Haller
Ireland
Alimentary Pharmabiotic Centre,Dept of Medicine - University College Cork
Prof Eamonn Quigley
Israel
Department of Chemistry - Ben-Gurion University of the Negev
Prof. Michael M. Meijler
New Zealand
Discipline of Nutrition,Faculty of Medical & Health Sciences - University of Auckland
Prof. Linette Ferguson
Norvay
Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of
Science and Technology
Prof. Duan Chen
Poland
Dept. of Bacteriology, Microbial Ecology and Parasitology, Jagiellonian University Medical College
Prof. Piotr B. Heczko, Prof. Piotr Kochan
Spain
Veterinary Faculty and Neuroscience Institute, Universitat Autònoma de Barcelona
Prof. Marcel Jimenez
Spain
Consejo Superior de Investigaciones Científicas
Prof. Yolanda Sanz
Spain
Instituto de Productos Lácteos de Asturias - Consejo Superior de Investigaciones Científicas
Prof. Clara G. de los Reyes-Gavilan
Spain
Dpt of Gastroenterology, Hospital Universitari Vall d'Hebron
Prof F.Aspiroz,F.Guarner, J-Santos
Sweden
Applied Nutrition and Food Chemistry - Lund University
Prof. Margareta Nyman
U.K
School of Science and Technology, Nottingham Trent University
Prof Stephen J Forsythe
USA
Animal Cancer Center - Colorado State University
Prof. Elizabeth Ryan
You can follow us and contact us
• Activities details are being finalized.
In September 2012 consensus meeting will held in Florence in both
physical presence and web presence for partners outside Europe.
•
PAOLO MANZELLI
President of EGO-CreaNet – University of Florence
EGOCREANET- VALIDATED EUROPEAN -PIC =959882416
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via Madonna del Piano 6, 50019 Sesto F.no, Firenze - Italy
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