Transcript SEROLOGICAL TESTS FOR SYPHILIS
SYPHILIS
DIFINITATON
• SYPHILIS IS A CHRONIC INFLAMATORY INFECTIOUS
SEXUALLY TRANSMITTED DISEASE CAUSED BY
• TREPONEMA PELLIDUM- A SPIROCHETE • TRANSMITTED MOSTLY BY SEXUAL CONTACT WITH
INFECTED LESIONS OR BODY FLUIDS AND LESS COMMENLY THROUGH TRENSPLACENTLLY FROM MOTHER TO UNBORN CHILD & THROUGH BLOOD TRANSFUSIONS RARELY THROUGH ACCIDENTAL INOCULATION OR PUNCTURE WITH CANTAMINATED INSTUMENTS.
• DISEASE HAS GREAT VARIABILTY IN IT’S CLINICAL
PRSEANTATION AND COURSE- MIMICING VERY MANY DISEASES IN THE FIELD OF MEDICINE & SURGERY
• TREATED SUCSSESFULLY BY PENCILLINS UPTO
PRESUPTION
TREPONEMA PELLIDUM
SILVER STAIN
STAGES OF SYPHILIS AQUIED SYPHILIS REMISSION CONTACT 1/3 INFECTED | 9 TO 90 DAYS PRIMARY | 3 TO 12 WEEKS SECONDARY | 4 TO12 WEEKS EARY LATENT WITH IN 1 YEAR OF CONTACT | LATE LATENT MORE THEN 1 YEAR || / \\ TERTIARY LATE BENIGN-16% CARDIOVASULAR -9.5% NEUROSYPHILIS-6.5%
CLINICAL PRESENTATION
• CHANCRE
SYPHILITIC CHANCER
MULTIPLE PRIMARY LESIONS AT MALE ENITALIA
CHANCRE AT FEMALE GENITALIA
MACULAR SYPHILIDS
PAPULOPUSTULAR SYPHILIDS
MUCOUS PATCHES
CONDYLOMATA LATA
PRINATAL SYPHILIS
BULLOUS LESIONS AT SOLES IN PRINATAL SYPHILIS
SEROLOGICAL TESTS FOR SYPHILIS
1. SCREENING TEST
CARDIOLIPIN BASED NONTREPONEMAL TEST (REAGINIC TEST) FLOCULATION TEST -VDRL,RPR ANTIGEN IS CARDIOLIPIN+CHOLESTROL+LACITHIN ANTBODIES- IgM,IgG IN SERUM OF PATIENT BECOME REACTIVE IN 4 TO 5 WEEKS OF INFECTION REVERT TO NON REACTIVE WITH IN 4 TO 6 MONTS OF TRATMENT BIOLOGICAL FALSE REACTIVE TEST
2. SPECIFIC TREPONEMAL TEST
– SPECIFIC BUT POSITIVE IN -3 WEEKS AFTER INFECTION & REMAIN + EVEN AFTERTREATMNET FTA-ABS MOST SENSITIVE & SPECIFIC TEST, 95-100% MHA-TP CAPTIA (IgM)EIA U SEFUL IN DIAGNOSIS OF REINFECTION , CONGENITAL SYHILIS, NEUROSYPHILIS IS + IN CSF
INTERPRETATION OF STS
• • • • • • • • RPR MHA-TP CAPTIA IgM -
INCUBATING
-
NO SYPHILIS OR +VE EARLY PRIMARY SYPHILIS + + + PRIMARY/SECONDARY SYPHILIS + + EARLY INFECTION + + SYPHILIS LATE SECONDARY/LATENT + BIOLOGICAL FALSE POSITIVE + LATE INFECTION/ TREATED CASE/BIOLOGICAL FALSE POSITIVE > + > REINFECTION/RELAPSE