BETA-G imuno®
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Transcript BETA-G imuno®
Prof dr Midhat Jašić
Beta glukani se nalaze u ćelijskim zidovima:
bakterija,
gljiva,
kvasaca,
algi,
lišajeva i
biljaka kao što su zob i ječam.
Ergosterol
Beta-(1,3/1,6)-D-glukan je dugolančani polisaharid
BETA-G imuno beta glukan izoliran iz kvasca Saccharomyces cerevisiae
Tip -glukana
Iz bakterija
Struktura
Opis
Linijski beta (1,3) glukan
IzIz gljive
glivica
Kratki beta (1,6) ogranci, beta (1,3)beta glukan
Iz Izkvasca
kvaca
Dugi beta (1,6) ogranci, beta (1,3) glukan
Iz žitarica
Linijski beta (1,3)/(1,4) glukan
Benefit
Ječam
Beta blukan
Zob
Beta glukan
Gljive
Beta glukan
Kvasac
Beta glukan
Imuni sistem
Ne
Ne
Da
Da
Kao dijetalno
vlakno
Da
Da
Ne
Da
Zdravlje srca
Da
Da
Ne
Da
Drugi
benefiti
Ne
Ne
Ne
Da
Započela 1941 s otkrićem Zymosana koji je
imunoaktivna tvar iz Ćelijskih zidova kvasca.
1960 je otkriven aktivni sastojak Zymosana Beta 1,3-1,6-glukan.
Oko 8500 naučnih radova o djelovanju Beta –
Glukana je objavljeno na PubMed
Poboljšanje imuniteta i podizanju odbrambenih
sposobnosti organizma
Prevenciji prehlade, gripe i drugih infekcija
Prevencija i pomoć pri inhibiciji rasta tumora
Smanjenje razine holesterola
Smanjenje posljedica izloženosti zračenju
.....
Beta glukani su poznati kao "modifikatori biološkog odgovora " zbog
sposobnosti da aktiviraju imunološki sistem.
Godfrey Chi-Fung Chan, Wing Keung Chan, and Daniel Man-Yuen Sze;
The effects of β-glucan on human immune and cancer cells; J Hematol Oncol. 2009; 2: 25.
β-glukana ulazi u makrofaga preko Dectin-1 receptora sa ili bez TLR-2/6.
Velike β-glukan molekule se rascjepkaju na manje fragmenate unutar makrofaga u
citoplazmi.
Mali β-glukan fragmenti se preuzimaju od strane granulocita, monocita i makrofaga preko
komplementa receptora (CR) -3.
Imunološki odgovor uključuje fagocitozu preko monoklonskih antitijela označenih tumorskih ć.
Miura, NN; Ohno N, Aketagawa J, Tamura H, Tanaka S, Yadomae T (January
1996). "Blood clearance of (1-->3)-beta-D-glucan in MRL lpr/lpr mice".
FEMS immunology and medical microbiology (England: Blackwell Publishing)
2013 (1): 51–57. ISSN 0928-8244. PMID 8821398.
Brown, GD; Gordon, S (2001 Sep 6). "Immune recognition. A new receptor for
beta-glucans.". Nature 413 (6851): 36–7. PMID 11544516.
Vetvicka, V; Dvorak B, Vetvickova J, Richter J, Krizan J, Sima P, Yvin JC (200703-10). "Orally administered marine (1-->3)-beta-D-glucan Phycarine
stimulates both humoral and cellular immunity". International journal of
biological macromolecules (England: Butterworth-Heinemann) 40 (4): 291–
298. doi:10.1016/j.ijbiomac.2006.08.009. PMID 16978690.
Babineau, TJ; Marcello P, Swails W, Kenler A, Bistrian B, Forse RA (November 1994). "Randomized phase I/II trial
of a macrophage-specific immunomodulator (PGG-glucan) in high-risk surgical patients". Annals of surgery
(United States: Lippincott Williams & Wilkins) 220 (5): 601–609. doi:10.1097/00000658-199411000-00002.
PMC 1234447. PMID 7979607.
Babineau, TJ; Hackford A, Kenler A, Bistrian B, Forse RA, Fairchild PG, Heard S, Keroack M, Caushaj P, Benotti P
(November 1994). "A phase II multicenter, double-blind, randomized, placebo-controlled study of three dosages
of an immunomodulator (PGG-glucan) in high-risk surgical patients". Archives of surgery (Chicago, Ill. : 1960)
(United States: American Medical Association) 129 (11): 1204–1210. ISSN 0004-0010. PMID 7979954.
Dellinger, EP; Babineau TJ, Bleicher P, Kaiser AB, Seibert GB, Postier RG, Vogel SB, Norman J, Kaufman D,
Galandiuk S, Condon RE (September 1999). "Effect of PGG-glucan on the rate of serious postoperative infection
or death observed after high-risk gastrointestinal operations. Betafectin Gastrointestinal Study Group". Archives
of surgery (Chicago, Ill. : 1960) (United States: American Medical Association) 134 (9): 977–983.
doi:10.1001/archsurg.134.9.977. PMID 10487593.
Onderdonk, AB; Cisneros RL, Hinkson P, Ostroff G (April 1992). "Anti-infective effect of poly-beta 1-6glucotriosyl-beta 1-3-glucopyranose glucan in vivo". Infection and immunity (United States: American Society
for Microbiology) 60 (4): 1642–1647. ISSN 0019-9567. PMC 257041. PMID 1548086.
Kernodle, DS; Gates H, Kaiser AB (March 1998). "Prophylactic Anti-Infective Activity of Poly-1-6-β-dGlucopyranosyl-1-3-β-d-Glucopyranose Glucan in a Guinea Pig Model of Staphylococcal Wound Infection".
Antimicrobial agents and chemotherapy (United States: American Society for Microbiology) 42 (3): 545–549.
ISSN 0066-4804. PMC 105496. PMID 9517930.
Browder, W; Williams D, Pretus H, Olivero G, Enrichens F, Mao P, Franchello A (May 1990). "Beneficial effect of
enhanced macrophage function in the trauma patient". Annals of surgery (United States: Lippincott Williams &
Wilkins) 211 (5): 605–612; discussion 612–613. ISSN 0003-4932. PMC 1358234. PMID 2111126.
^ Browder, IW; Williams DL, Kitahama A, Di Luzio NR (1984). "Modification of post-operative C. albicans sepsis
by glucan immunostimulation". International journal of immunopharmacology (England: Elsevier Science) 6 (1):
19–26. doi:10.1016/0192-0561(84)90030-4. PMID
Klinička multicentrična, randomizirana, duplo
slijepa, placebo kontrolisana studija
Sprovedena na 162 zdrave osobe koje sa čestim
prehladama
Beta glukan 1,3, 1,6 davat 81 osobi, a placebo 81.
Trajanje studije 16 sedmica
Beta glukan pomaže u prevenciji prehlade i dizanju
odbrambenih sposobnosti organizma sa visokom
signikantnošću gdje je p manje od 0,004.
Annegret Auinge, Linda Riede, Gordana Bothe, Regina Busch and Joerg Gruenwal:
Yeast (1,3)-(1,6)-beta-glucan helps to maintain the body’s defence against pathogens:
a double-blind, randomized, placebo-controlled, multicentric study in healthy subjects;
European Journal of Nutrition, 23. o1. 2013.
DiLuzio, NR; Williams DL, McNamee RB, Malshet VG (1980). "Comparative evaluation of the tumor inhibitory and
antibacterial activity of solubilized and particulate glucan". Recent results in cancer research. Fortschritte der
Krebsforschung. Progrès dans les recherches sur le cancer (Germany: Springer Verlag) 75: 165–172. ISSN 0080-0015.
PMID 7232829.
Morikawa, K; Takeda R, Yamazaki M, Mizuno D (April 1985). "Induction of tumoricidal activity of polymorphonuclear
leukocytes by a linear beta-1,3-D-glucan and other immunomodulators in murine cells". Cancer Research (United States:
American Association for Cancer Research) 45 (4): 1496–1501. ISSN 0008-5472. PMID 3156669.
Mansell, PW; Ichinose H, Reed RJ, Krementz ET, McNamee R, Di Luzio NR (March 1975). "Macrophage-mediated destruction
of human malignant cells in vivo". Journal of the National Cancer Institute (United States: Oxford University Press) 54 (3):
571–580. ISSN 0027-8874. PMID 1123850.
Sveinbjørnsson, B; Rushfeldt C, Seljelid R, Smedsrød B (May 1998). "Inhibition of establishment and growth of mouse liver
metastases after treatment with interferon gamma and beta-1,3-D-glucan". Hepatology (Baltimore, Md.) (United States:
Wiley) 27 (5): 1241–1248. doi:10.1002/hep.510270509. PMID 9581677.
Thompson, IM; Spence CR, Lamm DL, DiLuzio NR (November 1987). "Immunochemotherapy of bladder carcinoma with
glucan and cyclophosphamide". The American journal of the medical sciences (United States: Lippincott Williams & Wilkins)
294 (5): 294–300. doi:10.1097/00000441-198711000-00002. PMID 3425579.
Wakui, A; Kasai M, Konno K, Abe R, Kanamaru R, Takahashi K, Nakai Y, Yoshida Y, Koie H, Masuda H, et al. (April 1986).
"Randomized study of lentinan on patients with advanced gastric and colorectal cancer. Tohoku Lentinan Study Group". Gan
to kagaku ryoho. Cancer & chemotherapy (in Japanese) (Japan: Gan To Kagaku Ryohosha) 13 (4 pt 1): 1050–1059.
ISSN 0385-0684. PMID 3083785.
Daniel J. Allendorf, Jun Yan, Gordon, D. Ross, Richard D. Hansen, Jarek T., Baran, Krishnaprasad Subbarao, Li Wang, and
Bodduluri Haribabu. C5a-Mediated Leukotriene B4- Amplified Neutrophil Chemotaxis Is Essential in Tumor Immunotherapy
Facilitated by Anti-Tumor Monoclonal Antibody and β-Glucan. The Journal of Immunology, 2005, 174: 7050–7056.
Li B, Cai Y, Qi C, Hansen R, Ding C, Mitchell TC, Yan J. Orally administered particulate beta-glucan modulates
tumor-capturing dendritic cells and improves antitumor T-cell responses in cancer. Clin Cancer Res. 2010 Nov
1;16(21):5153-64. doi: 10.1158/1078-0432.CCR-10-0820. Epub 2010 Sep 20.
Vaclav Vetvicka. Glucan-immunostimulant, adjuvant, potential drug. World J Clin Oncol. 2011 February 10; 2(2):
115-119.
The Effect of Beta-glucan in Non-Small Cell Lung Cancer. 15:38 EDT 1st July 2013 | BioPortfolio
Patchen, ML; MacVittie TJ (April 1983). "Dose-dependent responses of murine
pluripotent stem cells and myeloid and erythroid progenitor cells following
administration of the immunomodulating agent glucan". Immunopharmacology
(Netherlands: Elsevier/North-Holland) 5 (4): 303–313. doi:10.1016/01623109(83)90046-2. PMID 6853144.
Patchen, ML; DiLuzio NR, Jacques P, MacVittie TJ (December 1984). "Soluble polyglycans
enhance recovery from cobalt-60--induced hemopoietic injury". Journal of biological
response modifiers (United States: Raven Press) 3 (6): 627–633. ISSN 0732-6580.
PMID 6512563.
Patchen, ML; MacVittie TJ, Wathen LM (1984-11-15). "Effects of pre- and postirradiation glucan treatment on pluripotent stem cells, granulocyte, macrophage and
erythroid progenitor cells, and hemopoietic stromal cells". Experientia (Switzerland:
Birkhäuser Verlag) 40 (11): 1240–1244. doi:10.1007/BF01946654. PMID 6500009.
Petruczenko, A (May–June 1984). "Glucan effect on the survival of mice after radiation
exposure". Acta physiologica Polonica (Poland: Panstwowy Zaklad Wydawnictw
Lekarskich) 35 (3): 231–236. ISSN 0044-6033. PMID 6537716.
Patchen, ML; MacVittie TJ (February 1986). "Comparative effects of soluble and
particulate glucans on survival in irradiated mice". Journal of biological response
modifiers (United States: Raven Press) 5 (1): 45–60. ISSN 0732-6580. PMID 3958754.
Bresson, Jean-Louis; Albert Flynn, Marina Heinonen, Karin Hulshof, Hannu Korhonen,
Pagona Lagiou, Martinus Løvik, Rosangela Marchelli, Ambroise Martin, Bevan Moseley,
Hildegard Przyrembel, Seppo Salminen, Sean (J.J.) Strain, Stephan Strobel, Inge Tetens,
Henk van den Berg, Hendrik van Loveren and Hans Verhagen (2009). "Scientific Opinion
on the substantiation of health claims related to beta glucans and maintenance of
normal blood cholesterol concentrations (ID 754, 755, 757, 801, 1465, 2934) and
maintenance or achievement of a normal body weight (ID 820, 823) pursuant to Article
13(1) of Regulation (EC) No 1924/2006". EFSA Journal 7 (9): 1254.
doi:10.2903/j.efsa.2009.1254. Retrieved 2 March 2011.
European Commission. "Regulation 1160/2011". on the authorisation and refusal of
authorisation of certain health claims made on foods and referring to the reduction of
disease risk. Official Journal of the European Union. Retrieved 14 November 2011.
Beta glukani održavaju normalne koncentracije holesterola u krvi, a mogu da se koriste i
u redukciji tjelesne težine (Soo Young i sur, 2006.).
Posredstvom beta glukana se smanjuje nivo holesterola i lipoproteina niske gustine u
serumu (Smith i sur, 2008; Talati i sur, 2009; Zechner-Krpan i sur, 2009; Wolever i sur,
2010).
EBM
Beta
G
JAK
Dobar
Obećava
Source:
PubMed,
Cochrane.
Org.
Beta glukan se nalazi na vrhu EBM preporuka
ali je slabo poznat liječnicima, farmaceutima i stanovništvu
pa ima mali broj pregleda na Googlu
Akutne infektivnih bolesti zbog virusa, bakterija i gljiva
Recidivirajuće i hronične upale
Postoperativni oporavak, sporo i slabo zacjelivanje povreda
Hematološke bolesti ( leukopenija, trombocitopenija, anemija)
Tumorske bolesti, izloženost hemoterapiji i zračenju
Ateroskleroza (smanjuje kolesterol, sprječava nastanak plaka)
Poboljšava imunitet organizma
Prevenira upale
Skraćuje trajanje infekcija
Poboljšava samocjeljenje na ćelijskom nivou
Pomaže u tretmanu raznih vrsta karcinoma
Olakšava nusefekte hemoterapije i zračenja
Smanjuje holesterol
Antioksidans-eliminira slobodne radikale