Evaluation of the effects of integrative treatment of vaginal infections in gynecology

Slavisa Stanisic

, MD, PhD, Prof. School of Medicine Pristina, Ob/Gyn, Vicepresident Serbian Society of Integrative Medicine, Vicepresident Serbian Ob/Gyn Associtaon

Momir Dunjic, MD, PhD, F.I.C.A.E., Cert. ORT-MD (3 Dan)

, Assoc. Prof. School of Medicine Pristina, Ob/Gyn, President Serbian Society of Integrative Medicine, Member of Board of European Society of Integrative Medicine

Tatjana Jevtic Milic ,

MD, Dermatovenerology, Health center of K.Mitrovica, Antiaging Committee Serbian Association for Integrative Medicine

INTRODUCTION

• Candida albicans is normally present in the body, and the vaginal mucosa. Infection of the vaginal mucosa is found in 50% of women under the age of 25 years, while 75% of women during their lifetime is at least one vaginal candidiasis .

• It becomes over-developed in cases of a low immune system, after the use of antibiotics, steroids or contraceptives, diabetes, disorders of vaginal acidity-pH.

• The mycotics can be transferred to a sexual partner, in whom, often, there is no manifestation of symptoms of infection, but they can retransmit the fungus. In this way the fungus can return, if both partners are not treated simultaneously.

Symptoms

Symptoms of vaginal infections are

 vaginal discharge (varying from white watery, to thick and sticky white secretion, with a consistency resembling cottage cheese),),       itching, burning, and sometimes rash, inflammation of the mucous membrane of the vulva and vagina, painful intercourse and painful urination

Treatment

Treatment involves the use of local antifungals      

miconazole Tioconazole Butoconazole Clotrimazole Nystatin Terconazole

- and sometimes systemic antifungals.

Of natural remedies, St John's wort is often used in the form of vaginal tablets, but it is often combined with other herbs, capsules with selected strains of probiotics for the regulation of vaginal flora.

Kandidol oil with eugenol is an active substance with a strong antimycotic effect. Administered with appropriate diet and oil for systemic use.

Kandidol oil

Eugenol, the main phenolic compounds of oil Kandidol has proven antifungal activity. Research results clearly show that eugenol very efficiently against Candida albicans and also has an effective anti-inflammatory and antifungal activity.

REFERENCES Antioxidant properties of the essential oil of Eugenia caryophyllata and its antifungal activity against a large number of clinical Candida species.

Chaieb K, Zmantar T, Ksouri R, Hajlaoui H, Mahdouani K, Abdelly C, Bakhrouf A.

Laboratoire d'Analyses et de Contrôle des Polluants Chimiques et Microbiologique de l'Environnement, Faculté de Pharmacie, Monastir, Tunisie.

Antioxidant activities of essential oil mixtures toward skin lipid squalene oxidized by UV irradiation.

Wei A, Shibamoto T. Department of Environmental Toxicology, University of California, Davis, California, USA.

In vitro activity of eugenol against Candida albicans biofilms.

He M, Du M, Fan M, Bian Z.

Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Luoyu Road 65, Wuhan, 430079, Hubei, China

AIM

The aim of the research study is testing the effectiveness of integrative therapies for the treatment of lower genital tract infections caused by yeast (Shroder Group VI) and synergistic effects of therapy in vaginal candidiasis

MATERIAL AND METHOD

The study was prospective, in the outpatient clinic, with the consent of the patient All patients were gynecologically examined and underwent colposcopy, Pap smear test and vaginal Candida. Those with positive results were divided into 3 groups according to the way of treatment: the first group with vaginal antifungal therapy, the second group with Kandidol therapy, and the third with both therapies.

RESULTS

Therapy effect was observed in all three groups of respondents.

In the first group there was a slight withdrawal of symptoms after 2 vaginal tablets or 48 hours after the initiation of the therapy. The complete therapy was to be continued in order to have a healing effect.

In the second group most symptoms disappeared in the first day, and a seven day therapy was needed for a healing effect . The group III symptoms disappeared in the highest percentage on the first day, and the period of both the treatment and healing period was reduced to 5 days .

dugoročni klinički efekat

First control start Second control Vag antimycotic Kandidol Both

1. day Duration therapy

Third control

10 day

Simptoms after 24 hours of therapy Simptoms

vaginal discharge itching inflammation of the mucous membrane of the vulva and vagina Burning rash painful intercourse painful urination total

III gr

20 1 2 3 0 2 20

%

71,5 3,6 7,1 10,7 0,0 7,1 100

I +II

40 16 8 10 16 3 40

%

43,0 17,2 8,6 10,8 17,2 3,2 100  2 = 12,1 df=9 p=0,034

Diagram of the effect of therapy in relation to the duration 120 100 80 60 40 20 0 I day II day III day v day Xday antimicotic therapy kandidol synergistic therapy

Efikasnost sinergije

efikasnost terapije što se tiče simptoma svraba bila je 100%, pojačanog sekreta oko 89%, pečenja pri mokrenju oko 93%, dispareunije oko 94%. bris VS nije više pokazivao infekciju kod 94,3% žena, a nakon celokupne terapije kod svih žena.

RESULTS

Statistically significant difference between the treatment groups I and II compared to III.

There was a statistically significant difference in the occurrence of relapses in the third group compared to the first two groups

CONCLUSION

There are many effective pharmaceutical drugs for the treatment of vaginal candidiasis, and many other methods that are reliable and effective.

The Integrative principle of the therapy that is based on sinergystic had a significantly better therapeutic effect, a shorter treatment time, fewer recurrences and fewer adverse effects.